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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Midnight serum cortisol as a marker of increased cardiovascular risk in patients with a clinically inapparent adrenal adenoma显示文摘 | Bovio S Pia A | 2005 | Eur J of Endo2005，153，： | 1 |
| 4 | Study of preozonation influence on the physical-chemical treatment of textile wastewater显示文摘 | S Barredo Damas M I Iborra Clar A Bes Pia | 2005 | Desalination2005，182，： | 1 |
| 5 | Low-dose monitored mitotane treatment achieves the therapeutic range with manageable side effects in patients with adrenocortical cancer显示文摘 | Pia A Berruti A | 2000 | J Clin Endocrinol Metab2000，85，6： | 1 |
| 6 | Cerebrospianl fluid β-Amyloid(1-42) in Alzheimer disease显示文摘 | Niels A Camilla H Pia D | 1999 | Arch Neurol1999，56，： | 1 |
| 7 | Abiraterone and increased survival in metastatic prostate cancer 显示文摘 | Berruti A Pia A Terzolo M | 2011 | N Engl J Med2011，365，8： | 1 |
| 8 | Assignment of the ^13C and ^16N NMR spectra of the antitumour antibiotic streptonigrin 显示文摘 | Pia I A Ian J L Margaret M H | 2002 | Magn Reson Chem2002，40，4： | 1 |
| 9 | Screening of bacteria,isolated from PAH-contaminated soils,for production of biosyrfactants and bioemulsifiers显示文摘 | Pia A Willumsen Ulrich Karlson | | 0，，05： | 1 |
| 10 | Subclinical Cushing's syndrome:definition and management显示文摘 | Terzolo M Pia A Reimondo G | 2012 | Clin Endocrino12012，76，1： | 1 |
| 11 | A variable neighborhood descent algo- rithm for a real waste collection problem with mobile depots 显示文摘 | Pia D A Filippi C | 2006 | Int Trans Oper Res2006，13，： | 1 |
| 12 | Effects of probiotic bifiform on efficacy of Helicobacter pylori infection treatment显示文摘 | Iakovenko E P Grigor'ev PIa Iakovenko A V | 2006 | Ter Arkh2006，78，2： | 1 |
| 13 | Polymorphism in the manganese superoxide dismutase (MnSOD) gene and risk of breast cancer in young women 显示文摘 | MALIN B MARIE A PIA PW | 2005 | J Cancer Res Clin Oncol2005，131，7： | 1 |
| 14 | The relationship between sleep and epilepsy:the effect oncognitive functioning in children显示文摘 | Parisi P Bruni O Pia Villa M Verrotti A Miano S Luchetti A | 2010 | Dev Med Child Neurol2010，52，9： | 1 |
| 15 | Riboflavin-overproducing strains of Lactobacillus fermentum for riboflavin-enriched bread显示文摘 | Pasquale Russo Vittorio Capozzi Mattia Pia Arena Giuseppina Spadaccino María Teresa Due?as Paloma López Daniela Fiocco Giuseppe Spano | 2014 | Applied Microbiology and Biotechnology2014，，8： | 1 |
| 16 | Real time PCR protocol for the detection of porcine parvovirus infield samples 显示文摘 | Sonja Wilhelm a Pia Zimmermann b Hans Joachim Sel- bitz c Uwe Truyen | 2006 | J Virological Meth2006，34，： | 1 |
| 17 | Subclinical Cushing's Syndrome: definition and management 显示文摘 | Terzolo M Pia A Reimondo G | 2012 | Clin Endocrinol (Oxf)2012，76，1： | 1 |
| 18 | Switchable ionic liquid ( SILs ) based on glycerol and acid gases 显示文摘 | Ikenna A Pasi V Pia D | 2011 | RSC Ad- vances2011，1，： | 1 |
| 19 | Ammonia chemistry below 1 400 K under fuel-rich conditions in a flow reactor显示文摘 | Φyvind Skreiberg a Pia Kilpinen Peter Glarborg | 2004 | Combustion and Flame2004，136，： | 1 |
| 20 | Role of the mitogen-activated protein kinase Hoglp in morphogenesls and virulence of Candida albicans显示文摘 | Monge R A Garcia FN Molero G Diez Orejas R Gustin M PIa J | 1999 | Baeteriol1999，181，： | 1 |
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