|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | circadian clock circuitry in colorectal cancer显示文摘Colorectal cancer is the most prevalent among digestive system cancers.Carcinogenesis relies on disrupted control of cellular processes,such as metabolism,proliferation,DNA damage recognition and repair,and apoptosis.Cell,tissue,organ and body physiology is characterized by periodic fluctuations driven by biological clocks operating through the clock gene machinery.Dysfunction of molecular clockworks and cellular oscillators is involved in tumorigenesis,and altered expression of clock genes has been found in cancer patients.Epidemiological studies have shown that circadian disruption,that is,alteration of bodily temporal organization,is a cancer risk factor,and an increased incidence of colorectal neoplastic disease is reported in shift workers.In this review we describe the involvement of the circadian clock circuitry in colorectal carcinogenesis and the therapeutic strategies addressing temporal deregulation in colorectal cancer. | Gianluigi Mazzoccoli Manlio Vinciguerra Gennaro Papa Ada Piepoli | 2014 | World Journal of Gastroenterology2014，20，15： | 4 |
| 2 | Lack of association between UGT1A7,UGT1A9,ARP,SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients显示文摘AIM: To investigate simultaneously UGT1A7, UGT1A9, ARP, SPINK and CFTR genes to verify whether genetic polymorphisms predispose to the development of pancreatic cancer (PC). METHODS: Genomic DNA of 61 pancreatic cancer patients and 105 healthy controls (HC) were analyzed. UGT1A7 genotyping was determined by PCR-RFLP analysis. Specific PCR and sequencing were used to analyze genetic variants of UGT1A9, ARP, SPINK1 and CFTR genes. RESULTS: Four different alleles (*1: WT; *2: N129K and R131K; *3: N129K, R131K, and W208R; and *4: W208R) in UGT1A7 and three different alleles (*1: WT; *4: Y242X; and *5: D256N) in UGT1A9 were detected. All UGT1A polymorphisms were observed at similar frequency in PC patients and HC. Seven different alleles in ARP were found in PC patients and HC at similar frequency. The SPINK1 mutations N34S and P55S occurred in five PC patients with a prevalence (4.1%) not significantly different from that observed (2.0%) in HC. The only CFTR ΔF508 mutation was recognized in three PC patients with a prevalence (4.9%) similar to HC. CONCLUSION: UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms are not associated with PC in Italian patients. | Ada Piepoli Annamaria Gentile Maria Rosa Valvano Daniela Barana Cristina Oliani Rosa Cotugno Michele Quitadamo Angelo Andriulli Francesco Perri | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 3 | Peripheral Chemoreceptor Hypersensitivity: An Ominous Sign in Patients With Chronic Heart Failure显示文摘 | Piotr Ponikowski Tuan Peng Chua Stefan D. Anker Darrel P. Francis Wolfram Doehner Waldemar Banasiak Phillip A. Poole-Wilson Massimo F. Piepoli Andrew J.S. Coats | 2001 | Circulation: Journal of the American Heart Association2001，，： | 2 |
| 4 | Tripling survival from sudden cardiac arrest via early defibrillation without traditional ed- ucation in cardiopulmonary resuscitation 显示文摘 | Capucci A Aschieri D Piepoli MF | 2002 | Circulation2002，106，9： | 1 |
| 5 | DNA Methyltransferases 1 and 3b Expression in Huh-7 Cells Expressing HCV Core Protein of Different Genotypes显示文摘 | Giorgia Benegiamo Manlio Vinciguerra Gianluigi Mazzoccoli Ada Piepoli Angelo Andriulli Valerio Pazienza | 2012 | Digestive Diseases and Sciences2012，，6： | 1 |
| 6 | Contribution of muscle afferent to the hemodynamic,autonomic,and ventilatory responses to exercise in patients with chronic heart failure:effects of physical training显示文摘 | Piepoli M Clark AL Volterrani M | 1996 | Circulation1996，93，5： | 1 |
| 7 | Importance of char- acteristics and modalities of physical activity and exer- cise in the management of cardiovascular health in indi- viduals with cardiovascular disease (part Ⅲ) 显示文摘 | Vanhees L Rauch B Piepoli M | 2012 | Eur J Prey Cardiol2012，19，6： | 1 |
| 8 | Cardiopulmonary exercise testing in systolic heart failure in 2014: the evolving prognostic role: a position paper from the Committee on Exercise Physiology and Training of the Heart Failure Association of the ESC显示文摘 | Corra U Piepoli MF Adamopoulos S | 2014 | Eur J Heart Fail2014，16，9： | 1 |
| 9 | Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalence显示文摘 | Perri F Piepoli A Bonvicini C | 2005 | Cytokine2005，30，5： | 1 |
| 10 | Promoter methylation correlates with reduced NDRG2 expression in advanced colon tumour 显示文摘 | Piepoli A Cotugno R Merla G | 2009 | BMC Med Genomies2009，2，： | 1 |
| 11 | Secondary prevention through cardiac rehabilitation: physical activity counselling and exercise training: key components of the position paper from the Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation 显示文摘 | European Association of Cardiovascular Prevention and Rehabilitation Committee for Science Guidelines Corru U Piepoli MF Carru F | 2010 | Eur Heart J2010，31，： | 1 |
| 12 | Interleukins 1 beta and 6 induce functional alteration of rat colonic motility: an in vitor study显示文摘 | Natale L Piepoli AL De Salvia MA | 2003 | Eur J Clin Invest2003，33，8： | 1 |
| 13 | Hypothalamus- hypophysis-thyroid axis function in healthy aging显示文摘 | Mazzoccoli G Pazienza V Piepoli A | 2010 | J Biol Regul Homeost Agents2010，24，4： | 1 |
| 14 | Glutamate signaling in chondrocytes and the potential involvement of NMDA rece- ptors in cell proliferation and inflammatory gene expression显示文摘 | Piepoli T Mennuni L Zerbi S | 2009 | Osteoarthritis Cartilage2009，17，8： | 1 |
| 15 | Exercise training meta-analysis of trials in patients with chronic heart failure 显示文摘 | Piepoli MF Davos C Francis DP | 2004 | BMJ2004，328，7433： | 1 |
| 16 | Combined Increased Chemosensitivity to Hypoxia and Hypercapnia as a Prognosticator in Heart Failure显示文摘 | Alberto Giannoni Michele Emdin Francesca Bramanti Giovanni Iudice Darrel P. Francis Antonio Barsotti Massimo Piepoli Claudio Passino | 2009 | Journal of the American College of Cardiology2009，，： | 1 |
| 17 | The role of oral IC antiarrhythmic drugs in terminating atrial fibrillatiton 显示文摘 | CAPUCCI A VILLANI G Q PIEPOLI M F | 1999 | Current Opin Cardiol1999，14，： | 1 |
| 18 | Mutation analysis of the cystic fibrosis transmembrane concuctance regular(CFTR) gene,the cationic trypsinogen(PRSS 1) gene,and the serine protease inhibitor,Kazal type 1(SPINK 1) gene in patients with alcoholic chronic pancreatitis显示文摘 | Perri F Piepoli A Stanziale P | 2003 | Eur J Hum Genet2003，11，9： | 1 |
| 19 | Reduced Peripheral Skeletal Muscle Mass and Abnormal Reflex Physiology in Chronic Heart Failure显示文摘 | Massimo F. Piepoli Agnieszka Kaczmarek Darrel P. Francis L Ceri Davies Mathias Rauchhaus Ewa A. Jankowska Stefan D. Anker Alessandro Capucci Waldemar Banasiak Piotr Ponikowski | 2006 | Circulation2006，，： | 1 |
| 20 | Effect of aerobic train-ing on walking capacity and maximal exercise tolerance in patientswith multiple sclerosis:A randomized crossover controlled study显示文摘 | Rampello A Franceschini M Piepoli M | 2007 | Phys Ther2007，87，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员