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		题名	作者	年代	出处	被引量
	1	Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction显示文摘AIM: To characterise the effect of energy restriction (ER) on liver lipid and primary metabolite profile by using metabolomic approach. We also investigated whether the effect of energy restriction can be further enhanced by modif ication of dietary protein source and calcium. METHODS: Liver metabolomic profile of lean and obese C57Bl/6J mice (n = 10/group) were compared with two groups of weight-reduced mice. ER was performed on control diet and whey protein-based high-calcium diet (whey + Ca). The metabolomicanalyses were performed using the UPLC/MS based lipidomic platform and the HPLC/MS/MS based primary metabolite platform. RESULTS: ER on both diets significantly reduced hepatic lipid accumulation and lipid droplet size, while only whey + Ca diet significantly decreased blood glucose (P < 0.001) and serum insulin (P < 0.01). In hepatic lipid species the biggest reduction was in the level of triacylglycerols and ceramides while the level of cholesterol esters was significantly increased during ER. Interestingly, diacylglycerol to phospholipid ratio, an indicator of relative amount of diabetogenic diglyceride species, was increased in the control ER group, but decreased in the whey + Ca ER group (P < 0.001, vs obese). ER on whey + Ca diet also totally reversed the obesity induced increase in the relative level of lipotoxic ceramides (P < 0.001, vs obese; P > 0.05, vs lean). These changes were accompanied with up-regulated TCA cycle and pentose phosphate pathway metabolites. CONCLUSION: ER-induced changes on hepatic metabolomic profile can be significantly affected by dietary protein source. The therapeutic potential of whey protein and calcium should be further studied.	Taru K Pilvi Tuulikki Seppnen-Laakso Helena Simolin Piet Finckenberg Anne Huotari Karl-Heinz Herzig Riitta Korpela Matej Orei Eero M Mervaala	2008	World Journal of Gastroenterology2008，14，28：	1
	2	Antihypertensive opioid-like milk peptide α-lactorphin: lack of effect on behavioural tests in mice显示文摘	Ijas Hanna Collin Marika Finckenberg Piet	2004	International Dairy Journal2004，14，：	1
	3	Dexmedetomidine preconditioning ameliorates kid ney ischemia-reperfusion injury显示文摘	Juha Lempiainen Piet Finckenberg Eero MA Mervaala	2014	Pharma Res Per2014，2，00：	1
	4	Juhani Angiotenginll induces connective tissue growth factor gene via cabineurin dependent pathways 显示文摘	Piet Finckenberg KaiJa Inkinen	2010	America Journal Pathology2010，163，：	1
	5	Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation显示文摘	Eveliina Tauriainen Mira Luostarinen Essi Martonen Piet Finckenberg Miia Kovalainen Anne Huotari Karl-Heinz Herzig Anne Lecklin Eero Mervaala Maria Luz Fernandez	2011	Journal of Nutrition and Metabolism2011，，：	1
	6	Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation显示文摘	Eveliina Tauriainen Mira Luostarinen Essi Martonen Piet Finckenberg Miia Kovalainen Anne Huotari Karl-Heinz Herzig Anne Lecklin Eero Mervaala Maria Luz Fernandez	2011	Journal of Nutrition and Metabolism2011，，：	1
	7	Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes显示文摘	Agnieszka Biala Eveliina Tauriainen Antti Siltanen Jin Shi Saara Merasto Marjut Louhelainen Essi Martonen Piet Finckenberg Dominik N. Muller Eero Mervaala	2010	Blood Pressure2010，，3：	1

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