|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Programmed death-1 expression is associated with the disease status in hepatitis B virus infection显示文摘AIM: To define the potential role of programmed death-1/programmed death-ligand (PD-1/PD-L) pathway in different hepatitis B virus (HBV) infection disease status; we examined the expression of PD-1 on antigen specific CD8+ T cells in peripheral blood of patients with chronic hepatitis B (CHB) and acute exacerbation of hepatitis B (AEHB) infection. METHODS: The PD-1 level on CD8+ T lymphocytes and the number of HBV specifi c CD8+ T lymphocytes in patients and healthy controls (HCs) were analyzed by staining with pentameric peptide-human leukocyte antigen2 (HLA2) complexes combined with flow cytometry. Real-time quantitative polymerase chain reaction (PCR) was used to measure the serum HBV-DNA levels. RESULTS: The level of PD-1 expression on total CD8+ T cells in CHB patients (13.86% ± 3.38%) was significantly higher than that in AEHB patients (6.80%± 2.19%, P < 0.01) and healthy individuals (4.63% ± 1.23%, P < 0.01). Compared to AEHB patients (0.81% ± 0.73%), lower frequency of HBV-specific CD8+ T cells was detected in chronic hepatitis B patients (0.37% ± 0.43%, P < 0.05). There was an inverse correlation between the strength of HBV-specific CD8+ T-cell response and the level of PD-1 expression. Besides, there was a significant positive correlation between HBV viral load and the percentage of PD-1 expression on CD8+ T cells in CHB and AEHB subjects (R = 0.541, P < 0.01). However, PD-1 expression was not associated with disease flare-ups as indicated by alanine aminotransferase (ALT) levels (R = 0.066, P > 0.05). CONCLUSION: Our results confirm previous reports that HBV specific CD8+ T-cell response in the peripheral blood is more intense in patients with AEHB than in chronic hepatitis B with persistent viral infection. Moreover, there is a negative correlation between the level of PD-1 and the intensity of virus specific CD8+T cell response. | Plan Ye Zhi-Hong Weng Shu-Ling Zhang Jian-Ao Zhang Lei Zhao Ji-Hua Dong Sheng-Hua Jie Ran Pang Rong-Hua Wei | 2008 | World Journal of Gastroenterology2008，14，28： | 25 |
| 2 | Evaluation of Petroleum System in Xihu Depression, East China Sea Shelf Basin显示文摘According to the theory of petroleum system and the characteristics of petroleum geology, the Xihu depression in the East China Sea shelf basin is divided into four petroleum systems: the Pinghu Formation as source rock and the Huagang Formation as reservoir rock, the Huagang Formation as source rock and reservoir rock, the Paleocene as source rock and the burial-hill as reservoir rock, and the Miocene as source rock and reservoir rock. The system with the Pinghu Formation as source rock and the Huagang Formation as reservoir rock is the most important one in the depression, which has high hydrocarbon generation and accumulation efficiency and is the most important object to hydrocarbon exploration at present. | Ye Jiaren L■ Delin Faculty of Earth Resources , China University of Geosciences, Wuhan 430074 Gu Huirong Planning & Designing Institute, Shanghai Offshore Petroleum Bureau, Shanghai 200120 | 2001 | Journal of China University of Geosciences2001，12，4： | 2 |
| 3 | Efficiency of sediment transport by flood and its control in the Lower Yellow River显示文摘This paper presents the characteristics of sediment transport by flood in the Lower Yellow River with the reach from Huayuankou to Gaocun, which is regarded as a typical braided pattern. The Artificial Neural Network Model on Water Use for Sediment Transport (WUST) by flood was established based on the measured data from 1980 to 1998. Consequently, simulations of controlling process of sediment transport by flood were made in terms of the control theory under different scenarios. According to the situation of sediment transport by flood in the Lower Yellow River, Open-Loop control system and feedback control system were adopted in system design. In the Open-Loop control system, numerical simulations were made to reveal the relationship between average discharge of flood and the WUST with varying sediment concentrations. The results demonstrate that sediment concentration has significant influence on the controlling process of flood flow to WUST. It is practical and efficient to control WUST if sediment concentration is less than 20 kg/m3. In the feedback control system, controlling processes of sediment concentration and flood discharge for sediment transport were simulated respectively under given conditions, and it was found that sediment transport process could be controlled completely by sediment concentration and discharge at the inlet of the reach from Huayuankou to Gaocun. Using the same method, controlling processes of sediment transport by flood in other reaches in the Lower Yellow River were also simulated. For the case of sediment concentration being 20 kg/m3, the optimized controlling discharge ranges from 2390 to 2900 m3/s in the lower reach of Huayuankou. This study is also of significance to flood control and flushing sediment in the Lower Yellow River with proper operation modes of Xiaolangdi Reservoir. | NI Jinren1, LIU Xiaoyong2, LI Tianhong1, ZHAO Ye’an3 & JIN Ling1 1. Department of Environmental Engineering, Peking University The Key Laboratory of Water and Sedi- ment Sciences, Ministry of Education, Beijing 100871, China 2. General Institute of Water Resources and Hydropower Planning and Design, Ministry of Water Re- sources, Beijing 100011, China 3. The Yellow River Conservancy Commission, Zhengzhou 450003, China | 2004 | Science China(Technological Sciences)2004，47，z1： | 2 |
| 4 | Tea polyphenols exerts anti-hepatitis B virus effects in a stably HBV-transfected cell line显示文摘 | YE Plan ZHANG Shuling ZHAO Lei | 2009 | Journal of Huazhnng University of Science and Technology: Medical Sciences2009，29，2： | 1 |
| 5 | THE CHARACTERISTICS OF TYPHOON DISASTER AND MITIGATION COUNTERMEASURES IN GUANGDONG | Ye Wen (City and Resource Planning Department of Zhongshan University, Guangzhou 510275,China) | 2003 | Natural Disaster Reduction in China2003，，3： | 0 |
| 6 | Spatial Layout of Modern Agriculture in Tianjin Binhai New Area显示文摘As the trial site of comprehensive reform of China, Tianjin Binhai New Area (TBNA) is facing the problem of how to promote the balanced urban and | YE Wei,Chief Planner,Branch of Tianjing Binhai New Area,Tianjin Institute of Urban Planning and Design,Tianjin,P. R. China. ZHU Liming,Deputy Director and Senior Planner,Branch of Tianjin Binhai New Area,Tianjing Institute of Urban Planning and Design,Tianjin,P. R. China. LIU Shaoyin,Director of the Strategic Planning Program,Tianjin Huahui Consulting Ltd. of Environmental Planning and Design,Tianjin,P. R. China. Editorial Department | 2007 | China City Planning Review2007，16，4： | 0 |
| 7 | Channels and Legal Framework for Power Sector Financing in China显示文摘Since early 1980s, in particular during the period of '7th and 8th Five-year Plan'(1986- 1995), China’s power sector has adopted successfully the policy of multichannel and diversified financing to raise funds as well as encouraging to introduce foreign funds for its development and has got tremendous achievements. This paper describes the channels and methods to raise funds from both domestic and international market to meet huge demand of funds amounting to 690 billion yuan RMBfor the sector development during 'gth Fiveyear Plan' period (1996-2000) in the wake of overall reform and achievements in the past decade. This paper also presents the legal framework supporting to suit for the methods and channels of the financing. Some suggestions have been made. | Ye Rongsi(Vice Chairman Board of Directors China Electricity Council)Ouyang Changyu(Deputy Director planning Department Ministry of Electric Power ) | 1997 | Electricity1997，，3： | 0 |
| 8 | Inorganic salts sector:great negative impact in near future,worries over economic performance of enterprises | Ye Lijun China National Petroleum and Chemical Planning Institute | 2007 | China Chemical Reporter2007，，22： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员