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| 1 | 上海26万妇女乳房自我检查随机试验显示文摘目的论证指导妇女进行乳房自我检查(BSE)是否能有效降低乳腺癌患者的死亡率。方法自1989年10月起,上海26.6万名年龄在30~64岁的妇女,随机进入指导组(132979名)和对照组(133085名)。在指导组,最初先由医务人员做规范的BSE手法演示,随后的4年中,使用BSE录像带进行二次强化教育,并定期进行BSE指导和在医务人员监察下进行BSE操作。本研究进行5年,全部活动均被记录。队列人群随访到2000年7月,乳腺癌患者的生存状况随访到2001年12月。统计分析采用Kaplan-Meier方法、Logrank检验以及Cox模型。结果指导组检出乳腺癌864例,其中死于乳腺癌133例;对照组检出乳腺癌896例,其中死于乳腺癌130例。两组乳腺癌病例的肿块大小、TNM分期和累积死亡率的差异均无统计学意义(P均>0.05)。但是指导组比对照组有较多和较小的纤维腺瘤被检出(P<0.01)。结论对人群开展BSE教育和指导,未能降低人群的乳腺癌死亡率;接受BSE教育的妇女比没有接受教育的妇女可检出较多的和较小的良性乳房肿块。 | 高道利 David BThomas Roberta M Ray 王文婉 Charlene J Allison 陈范良 Peggy Porter 胡永伟 赵关林 潘雷达 李雯瑾 武春园 Zakia Coriaty Ilonka Evans 林明纲 Helge Stalsberg Steven Gself | 2005 | 中华肿瘤杂志2005，27，6： | 14 |
| 2 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 3 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 4 | Mechanical properties of a biodegradable bone regeneration scaffold显示文摘 | Porter B D Oldham J B He S L | 2000 | J Biomech Eng2000，122，3： | 2 |
| 5 | The effect of liquid channeling on distillation plate efficiency显示文摘 | Porter K E Lockett M J Lim C T | 1972 | Trans IchemE1972，50，： | 2 |
| 6 | SAMMIE:A Computer-aided Ergonomics Design System显示文摘 | Case K Porter J M | 1980 | Engineering1980，220，： | 2 |
| 7 | Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study显示文摘 | Daniel J Drucker John B Buse Kristin Taylor David M Kendall Michael Trautmann Dongliang Zhuang Lisa Porter | 2008 | The Lancet2008，，9645： | 2 |
| 8 | Enhancing intestinal drug solubilisation using lipid-based delivery systems 显示文摘 | PORTER C J H POUTON C W CUINE J F | 2008 | Adv Drug Deliver Rev2008，60，6： | 1 |
| 9 | Tract-based spatialstatistics of magnetic resonance images to assess disease andtreatment effects in perinatal asphyxial encephalopathy 显示文摘 | Porter E J Counsell SJ Edwards AD | 2010 | Pediatr Res2010，68，： | 1 |
| 10 | Observation of a Negative Electron Affinity for Boron Nitride显示文摘 | Powers M J Benjamin M C Porter L M | 1995 | Appl Phys Left1995，67，39： | 1 |
| 11 | Sorption kinetic analysis for the removal of cadmium ions from effluents using bone char显示文摘 | CHEUNG C W PORTER J F MCKAY G | 2001 | Water Research2001，35，3： | 1 |
| 12 | The conversion of procyanidins and prodelphinidins to cuaniding and delphinidin显示文摘 | Porter L J Hrstich L N Chan B G | 1986 | Phytochemistry1986，25，： | 1 |
| 13 | Exploring the relationships between design measures and software quality in object oriented systems 显示文摘 | Briand L C Wust J Daly J W Porter D V | 2000 | Journal of Systems and Software2000，51，3： | 1 |
| 14 | Immunization of mice with poliovirus replicons expressing the C-fragment of tetanus toxin protects against lethal challenge with tetanus toxin显示文摘 | Porter DC Wang J Moldoveanu Z | 1997 | Vaccine1997，15，3： | 1 |
| 15 | Research Coordination Networks: Evidence of the Relationship Between Funded Interdisciplinary Networking and Scholarly Impact 显示文摘 | Porter A L Garner J Crowl T | 2012 | Bioscience2012，62，3： | 1 |
| 16 | The Determinants of National Innovative Capacity显示文摘 | FURMAN J L PORTER M E STERN S | 2002 | Research Policy2002，31，8： | 1 |
| 17 | Predictors of warm ischemia time and perioperative complications in a multicenter,international series of robot-assisted partial nephrectomy显示文摘 | Ficarra V Bhayani S Porter J | 2012 | Eur Urol2012，61，2： | 1 |
| 18 | Alternative approaches to the employee-organization rela- tionship:does investment in employees pay off显示文摘 | TSUI A S PEARCE J L PORTER L W TRIPOLI A M | 1997 | The A cademy of Management Journal1997，40，5： | 1 |
| 19 | Nanocomposite Fire Retardants-A Review显示文摘 | Porter D Metcalfe E Thomas M J K | 2000 | Fire Mater2000，24，1： | 1 |
| 20 | The first use of a combined value auction for transportation services显示文摘 | Ledyard J O Olson M Porter D | 2002 | Interfaces2002，32，5： | 1 |
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