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		题名	作者	年代	出处	被引量
	1	GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation显示文摘Bone metastases occur in patients with advanced-stage prostate cancer(PCa). The cell-cell interaction between PCa and the bone microenvironment forms a vicious cycle that modulates the bone microenvironment, increases bone deformities, and drives tumor growth in the bone. However, the molecular mechanisms of PCa-mediated modulation of the bone microenvironment are complex and remain poorly defined. Here, we evaluated growth differentiation factor-15(GDF15) function using in vivo preclinical PCa-bone metastasis mouse models and an in vitro bone cell coculture system. Our results suggest that PCa-secreted GDF15 promotes bone metastases and induces bone microarchitectural alterations in a preclinical xenograft model. Mechanistic studies revealed that GDF15 increases osteoblast function and facilitates the growth of PCa in bone by activating osteoclastogenesis through osteoblastic production of CCL2 and RANKL and recruitment of osteomacs. Altogether, our findings demonstrate the critical role of GDF15 in the modulation of the bone microenvironment and subsequent development of PCa bone metastasis.	Jawed Akhtar Siddiqui Parthasarathy Seshacharyulu Sakthivel Muniyan Ramesh Pothuraju Parvez Khan Raghupathy Vengoji Sanjib Chaudhary Shailendra Kumar Maurya Subodh Mukund Lele Maneesh Jain Kaustubh Datta Mohd Wasim Nasser Surinder Kumar Batra	2022	Bone Research2022，10，1：	2
	2	Multidisciplinary design optimization on vehicle tailor rolled blank design显示文摘	C. H. Chuang R. J. Yang G. Li K. Mallela P. Pothuraju	2008	Structural and Multidisciplinary Optimization2008，，6：	1
	3	A systematic review of Gymnema sylvestre in obesity and diabetes management显示文摘	Ramesh Pothuraju Raj Kumar Sharma Jayasimha Chagalamarri Surender Jangra Praveen Kumar Kavadi	2014	J. Sci. Food Agric2014，，：	1
	4	Optimization and validation of a fast RP-HPLC method for the determination of dobutamine in rat plasma:Pharmacokinetic studies in healthy rat subjects显示文摘A novel isocratic reverse phase high performance liquid chromatography(RP-HPLC)with photo diode array(PDA)detection method for the determination of dobutamine(DBT)in rat plasma was developed and validated after optimization of various chromatographic conditions and other experimental parameters.Homoveratrylamine was used as an internal standard.Methanol was used as the extracting solvent for the preparation of plasma samples.Samples were separated on a Symmetry C18(250 mm x 4.6 mm i.d.,5μm)analytical column.Acetonitrile and 15mM potassium dihydrogen phosphate(pH 5.0 with 0.3%TEA)(20:80,v/v)was used.The column oven temperature was optimized at 35°C and the flow rate was 0.8 mL/min.The detection wavelength was fixed at 230 nm for entire analysis.The calibration curve was found to be linear over the concentration range of 50-2000 ng/mL(r^2=0.9992).The limit of quantification(LOQ)of the method was 50 ng/mL.The%RSD values of accuracy and precision values for intra and inter days were<15%at quality control(QC)concentrations.Recovery,stability and robustness were studied within the acceptable range according to 1CH guidelines.The method was efficiently applied to a pharmacokinetic study in healthy Wistar rats.	Ramesh Thippani Nageswara Rao Pothuraju Nageswara Rao Ramisetti Saida Shaik	2013	Journal of Pharmaceutical Analysis2013，3，6：	0

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