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| 1 | Diagnosis of Crohn's disease in India where tuberculosis is widely prevalent显示文摘AIM:To define the parameters that positively predict diagnosis of Crohn's disease (CD) and differentiate it from gastrointestinal tuberculosis (GITB). METHODS:This prospective study over 3 years was carried out in the consecutive Indian patients with definite diagnosis of CD and equal numbers of patients with definite diagnosis of GITB. Demographic, clinical, laboratory, morphological and histological features were noted in all the patients. Serological tests such as p-ANCA, c-ANCA, IgA ASCA and IgG ASCA, were performed. Endoscopic biopsy and/or surgical tissue specimens were subjected to smear and culture for acid-fast bacilli (AFB) and tissue polymerase chain reaction for tuberculosis (TB PCR). Diagnosis of CD and GITB was based on the standard criteria. Data were analyzed using univariate Chi-square test and multiple logistic regression (MLR). RESULTS:The study is comprised of 26 patients with CD (age 36.6 ± 8.6 year, male:female, 16:10) and 26 patients with GITB (age 37.2 ± 9.6 year, male:female, 15:11). The following clinical variables between the two groups (CD vs TB) were significant in univariate analysis:duration of symptoms (58.1 ± 9.8 vs 7.2 ± 3.4 mo), diarrhoea (69.2% vs 34.6%), bleeding per rectum (30.7% vs 3.8%), fever (23.1% vs 69.2%), ascites (7.7% vs 34.6%) and extra-intestinal manifestations of inflammatory bowel disease (61.5% vs 23.1%). Of these, all except ascites and extra-colonic manifestations were found statistically significant by MLR. Accuracy of predicting CD was 84.62% based on the fever, bleeding P/R, diarrhoea and duration of symptoms while it was 63.4% when histology was reported as inflammatory bowel disease and 42.3% when there was recurrence of disease after surgery. Accuracy of predicting GITB was 73.1% when there was co-existing pulmonary lesions and/or abdominal lymphadenopathy;75% when tuberculosis was reported in histology;63.4% when granuloma was found in histology;82.6% when TB PCR was positive;and 61.5% when smear and/ or culture was positive for AFB. Serological test was not useful in differentiation of CD from GITB. Positivity rates for CD and GITB were:p-ANCA-3.8% and 3.8%, c-ANCA-3.8% and 0%, IgA ASCA-38.4% and 23.1%, and IgG ASCA-38.4% and 42.3%, respectively. CONCLUSION:Simple clinical parameters like fever, bleeding P/R, diarrhoea and duration of symptoms have the highest accuracy in differentiating CD from GITB. | Deepak N Amarapurkar Nikhil D Patel Priyamvada S Rane | 2008 | World Journal of Gastroenterology2008，14，5： | 24 |
| 2 | Eclipta prostrata leaf aqueous extract mediated synthesis of titanium dioxide nanoparticles显示文摘 | G. Rajakumar A. Abdul Rahuman B. Priyamvada V. Gopiesh Khanna D. Kishore Kumar P.J. Sujin | 2011 | Materials Letters2011，，： | 2 |
| 3 | Probiotic Bifidobac- terium species stimulate human SLC26A3 gene function and ex pression in intestinal epithelial cells显示文摘 | Kumar A Hecht C Priyamvada S etal | 2014 | Am J Physiol Cell Physiol2014，307，12： | 1 |
| 4 | The structure of Formylmethanofuran:Tetrahydromethanopterin Formyltransferase in complex with its coenzymes显示文摘 | Priyamvada Acharya Eberhard Warkentinl Ulrich Ermler | 2006 | Journal of Molecular Biology2006，357，3： | 1 |
| 5 | Oral administration of caffeic acid ameliorates the effect of cisplatin on brush border membrane enzymes and antioxidant system in rat intestine显示文摘 | ARIVARASU NA PRIYAMVADA S MAHMOOD R | 2013 | Exp Toxicol Pathol2013，65，1： | 1 |
| 6 | Spinal Muscular Atrophy: A Clinical and Research Update显示文摘 | Jennifer A. Markowitz Priyamvada Singh Basil T. Darras | 2012 | Pediatric Neurology2012，，1： | 1 |
| 7 | Structural Basis of Selection and thermostability of Laboratory Evolved Bacillus subtilis Lipase显示文摘 | Acharya Priyamvada Rajakumara Eerappa Sankaranarayanan Rajan | 2004 | J Mol Biol2004，341，： | 1 |
| 8 | Fatal Bilateral ACA Territory Infarcts after Pituitary Apoplexy:A Case Report and Literature Review显示文摘 | Sandeep Mohindra Priyamvada Kovai Rajesh Chhabra | 2010 | Skull base2010，20，4： | 1 |
| 9 | Potential Biomarkers and Their Applications for Rapid and Reliable Detection of Malaria显示文摘 | Priyamvada Jain Babina Chakma Sanjukta Patra Pranab Goswami Amogh A. Sahasrabuddhe | 2014 | BioMed Research International2014，，： | 1 |
| 10 | Oral administration of caf- feic acid ameliorates the effect of cisplatin on brush border membrane enzymes and antioxidant system in rat intestine 显示文摘 | N Arivarasu S Priyamvada R Mahmood | 2013 | Exp Toxicol Pathol2013，65，： | 1 |
| 11 | Structural basis of selection and thermostability of laboratory evolved Bacillis subtilis lipase显示文摘 | Priyamvada Acharya Eerappa Rajakumara Rajah Sankaranarayanan | 2004 | J Mol Biol2004，341，5： | 1 |
| 12 | Effect of trichloroethylene (TCE) toxicity on the enzymes of carbohydrate metabolism,brush border membrane and oxidative stress in kidney and other rat tissues显示文摘 | KHAN S PRIYAMVADA S KHAN SA | | 0，，7： | 1 |
| 13 | Conscious sedation for middle ear surgeries: A comparison between fentanyl-propofol and fentanyl-midazolam infusion显示文摘 | Raghu Thota Manasi Ambardekar Priyamvada Likhate | 2015 | Saudi Journal of Anaesthesia2015，，2： | 1 |
| 14 | Studies on the protective effect of dietary fish oil on uranyl-nitrate-indnced nephrotoxicity and oxidative damage in rat kidney 显示文摘 | Priyamvada S Khan S A Khan M W | 2010 | Prostaglandins Leukot Essent Fatty Acids2010，82，1： | 1 |
| 15 | In vivo terahertz imaging of rat skin burns显示文摘 | Priyamvada Tewari Colin P Kealey David B Bennett et a/ | 2012 | J Biomed Opt2012，17，04： | 1 |
| 16 | Suppression of thioredoxin-1 induces premature senescence in normal human fibroblasts显示文摘 | Jennifer J. Young Asmita Patel Priyamvada Rai | 2010 | Biochemical and Biophysical Research Communications2010，，3： | 1 |
| 17 | Caffeic acid inhibits chromium( VI)-induced oxidative stress and changes in brush border membrane enzymes in rat intestine 显示文摘 | ARIVARASU N A PRIYAMVADA S MAHMOOD R | 2012 | Biological Trace Element Research2012，148，2： | 1 |
| 18 | The Role of Calcium, Magnesium, and Zinc in Pre-Eclampsia显示文摘 | Seema Jain Priyamvada Sharma Shobha Kulshreshtha Govind Mohan Saroj Singh | 2010 | Biological Trace Element Research2010，，2： | 1 |
| 19 | A diagnostic PCR based assay for stripe rust resistance genein wheat 显示文摘 | Singh R Datta D Priyamvada | 2009 | Acta Phyto- pathologica et Entomologica H ungarica2009，44，1： | 1 |
| 20 | Influence of green tea on enzymes of carbohydrate metabolism,antioxidant defense,and plasma membrane in rat tissues显示文摘 | Khan SA Priyamvada S Arivarasu NA | 2007 | Nutrition2007，23，9： | 1 |
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