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| 1 | LncRNA Platr22 promotes super-enhancer activity and stem cell pluripotency显示文摘Super-enhancers(SEs)comprise large clusters of enhancers,which are co-occupied by multiple lineage-specific and master tran-scription factors,and play pivotal roles in regulating gene expression and cell fate determination.However,it is still largely un-known whether and how SEs are regulated by the noncoding portion of the genome.Here,through genome-wide analysis,wefound that tpng noncoding RNA(IncRNA)genes preferentially lie next to SEs.In mouse embryonic stem cells(mESCs),depletionof$E-associated IlncRNA transcripts dysregulated the activity of their nearby SEs.Specifically,we revealed a critical regulatoryrole of the IncRNA gene Platr22 in modulating the activity of a nearby SE and the expression of the nearby pluripotency regulatorZFP281.Through these regulatory events,Platr22 contributes to pluripotency maintenance and proper differentiation of mESCs.Mechanistically,Platr22 transcripts coat chromatin near the SE region and interact with DDX5 and hnRNP-L.DDX5 further recruitsp300 and other factors related to active transcription.We propose that these factors assemble into a transcription hub,thus pro-moting an open and active epigenetic chromatin state.0ur study highlights an unanticipated role for a class of lncRNAs in epige-netically controlling the activity and vulnerability to perturbation of nearby SEs for cell fate determination. | Pixi Yan Yuyang Lu Jing Niu Juntao Gao Michael Q.Zhang Yafei Yin Xiaohua Shen | 2021 | Journal of Molecular Cell Biology2021，13，4： | 2 |
| 2 | The Lobster Eye Imager for Astronomy Onboard the SATech-01 Satellite显示文摘The Lobster Eye Imager for Astronomy(LEIA),a pathfinder of the Wide-field X-ray Telescope of the Einstein Probe mission,was successfully launched onboard the SATech-01 satellite of the Chinese Academy of Sciences on2022 July 27.In this paper,we introduce the design and on-ground test results of the LEIA instrument.Using stateof-the-art Micro-Pore Optics(MPO),a wide field of view of 346 square degrees(18.6°×18.6°)of the X-ray imager is realized.An optical assembly composed of 36 MPO chips is used to focus incident X-ray photons,and four large-format complementary metal-oxide semiconductor(CMOS)sensors,each of size 6 cm×6 cm,are used as the focal plane detectors.The instrument has an angular resolution of 4’-8’(in terms of FWHM)for the central focal spot of the point-spread function,and an effective area of 2-3 cm^(2) at 1 keV in essentially all the directions within the field of view.The detection passband is 0.5-4 keV in soft X-rays and the sensitivity is2-3×10^(-11) erg s^(-1) cm^(-2)(about 1 milliCrab)with a 1000 s observation.The total weight of LEIA is 56 kg and the power is 85 W.The satellite,with a design lifetime of 2 yr,operates in a Sun-synchronous orbit of 500 km with an orbital period of 95 minutes.LEIA is paving the way for future missions by verifying in flight the technologies of both novel focusing imaging optics and CMOS sensors for X-ray observation,and by optimizing the working setups of the instrumental parameters.In addition,LEIA is able to carry out scientific observations to find new transients and to monitor known sources in the soft X-ray band,albeit with limited useful observing time available. | Z.X.Ling X.J.Sun C.Zhang S.L.Sun G.Jin S.N.Zhang X.F.Zhang J.B.Chang F.S.Chen Y.F.Chen Z.W.Cheng W.Fu Y.X.Han H.Li J.F.Li Y.Li Z.D.Li P.R.Liu Y.H.Lv X.H.Ma Y.J.Tang C.B.Wang R.J.Xie Y.L.Xue A.L.Yan Q.Zhang C.Y.Bao H.B.Cai H.Q.Cheng C.Z.Cui Y.F.Dai D.W.Fan H.B.Hu J.W.Hu M.H.Huang Z.Q.Jia C.C.Jin D.Y.Li J.Q.Li H.Y.Liu M.J.Liu Y.Liu H.W.Pan Y.L.Qiu M.Sugizaki H.Sun W.X.Wang Y.L.Wang Q.Y.Wu X.P.Xu Y.F.Xu H.N.Yang X.Yang B.Zhang M.Zhang W.D.Zhang Z.Zhang D.H.Zhao X.Q.Cong B.W.Jiang L.H.Li X.B.Qiu J.N.Sun D.T.Su J.Wang C.Wu Z.Xu X.M.Yang S.K.Zhang Z.Zhang N.Zhang Y.F.Zhu H.Y.Ban X.Z.Bi Z.M.Cai W.Chen X.Chen Y.H.Chen Y.Cui X.L.Duan Z.G Feng Y.Gao J.W.He T.He J.J.Huang F.Li J.S.Li T.J.Li T.T.Li H.Q.Liu L.Liu R.Liu S.Liu N.Meng Q.Shi A.T.Sun Y.M.Wang Y.B.Wang H.C.Wu D.X Xu Y.Q Yang Y.Yang X.S.Yu K.X.Zhang Y.L.Zhang Y.H.Zhang Y.T.Zhang H.Zhou X.C.Zhu J.S.Cheng L.Qin L.Wang Q.L.Wang M.Bai R.L.Gao Z.Ji Y.R.Liu F.L.Ma Y.J.Shi J.Su Y.Y.Tan J.Z.Tong H.T.Xu C.B.Xue G.F.Xue W.Yuan | 2023 | Research in Astronomy and Astrophysics2023，23，9： | 2 |
| 3 | Study of integration of forward osmosis and biological process:Membrane performance under elevated salt environment显示文摘 | W.C.L.Lay Q.Zhang J.Zhang | | 0，，1： | 1 |
| 4 | 查看详情显示文摘 | X.T.Liu Q.Zhang J.Y.Liang | | 0，，： | 1 |
| 5 | Extent of prophylactic postoperative radiotherapy after radical surgery of thoracic esophageal squamous cell carcinoma显示文摘 | J.‐C.Lu H.Tao Y.‐Q.Zhang W.‐W.Zha P.‐D.Qian F.Li K.‐X.Xu | 2008 | Diseases of the Esophagus2008，，6： | 1 |
| 6 | Protective effects of Forsythia suspensa extract against oxidative stress induced by diquat in rats显示文摘 | T.Lu X.L.Piao Q.Zhang | | 0，，02： | 1 |
| 7 | A personal journey on cracking the genomic codes显示文摘In February 2001,the IHGSC(International Human Genome Sequencing Consortium)[1]and Celera Genomics[2]each reported draft sequences providing a first overall view of the human genome.On the occasion of the 20th anniversary celebration,I would like to provide some of my personal account on how the HGP(Human Genome Project)has impacted my academic research interests and to offer some candid advice for the new comers.1. | Michael Q.Zhang | 2021 | Quantitative Biology2021，9，1： | 1 |
| 8 | 查看详情显示文摘 | Hu S Gong Y. J Xu Q. H Liu X.L.Zhang Q.Zhang L.L.Dou T | | 0，，： | 1 |
| 9 | Drosophila homolog of the intellectual disability-related long-chain acyl-CoA synthetase 4 is required for neuroblast proliferation显示文摘Mutations in long-chain acyl-CoA synthetase 4 (ACSL4) are associated with non-syndromic X-linked intellectual disability (ID). However, the neural functions of ACSL4 and how loss of ACSL4 leads to ID remain largely unexplored. We report here that mutations in Acsl, the Drosophila ortholog of human ACSL3 and ACSL4, result in developmental defects of the mushroom body (MB), the center of olfactory learning and memory. Specifically, Acsl mutants show fewer MB neuroblasts (Nbs) due to reduced proliferation activity and premature differentiation. Consistently, these surviving Nbs show reduced expression of cyclin E, a key regulator of the G1-to S-phase cell cycle transition, and nuclear mislocalization of the transcriptional factor Prospero, which is known to repress self-renewal genes and activate differentiating genes. Furthermore, RNA-seq analysis reveals downregulated Nb-and cell-cyclerelated genes and upregulated neuronal differentiation genes in Acsl mutant Nbs. As Drosophila Acsl and human ACSL4 are functionally conserved, our findings provide novel insights into a critical and previously unappreciated role of Acsl in neurogenesis and the pathogenesis of ACSL4-related ID. | Mingyue Jia Danqing Meng Mo Chen Tingting Li Yong Q.Zhang Aiyu Yao | 2019 | Journal of Genetics and Genomics2019，46，1： | 1 |
| 10 | Sensitivity of Botrytis cinerea from vegetable greenhouses to boscalid显示文摘 | C. Q.Zhang S. K.Yuan H. Y.Sun Z. Q.Qi M. G.Zhou G. N.Zhu | 2007 | Plant Pathology2007，，4： | 1 |
| 11 | Rapid and sensitive detection of Escherichia coli O157:H7 in bovine faeces by a multiplex PCR显示文摘 | Y.Hu Q.Zhang J.C.Meitzler | | 0，，： | 1 |
| 12 | 查看详情显示文摘 | C.Zhang Y.Chen R.Wang X.Chen J.Li Y.Ma Q.Zhang H.Zhou Z.Yan B.Shen Q.Zhou D.Shang and C.Ge | | 0，，： | 1 |
| 13 | Cloud computing:State-of-the-art and research challenges显示文摘 | Q.Zhang L.Cheng R.Boutaba | | 0，，01： | 1 |
| 14 | Upper and lower solution method for fourth-order four-point boundary value problems显示文摘 | Q.Zhang S.Chen J.Lu(') | | 0，，： | 1 |
| 15 | BF3 · Et2O-catalyzed direct carbon carbon bond formation of α-EWG ketene-(S,S)-acetals and alcohols and synthesis of unsymmetrical biaryls显示文摘 | Q.Zhang S.Sun | | 0，，01： | 1 |
| 16 | Experimental Physiology –Research Paper: Exercise training combined with angiotensin II receptor blockade reduces oxidative stress after myocardial infarction in rats显示文摘 | XiaohuaXu WeiyanZhao WenhanWan Lisa L.Ji Anthony S.Powers John M.Erikson John Q.Zhang | 2010 | Experimental Physiology2010，，10： | 1 |
| 17 | Influence of an Electronic Field on the GMI Effect of Fe-based Nanocrystalline Microwire显示文摘In this work, a Fe-based nanocrystalline microwire of 20 mm in length and 25 μm in diameter was placed in the center of a 316 stainless steel pipe. The pipe was 500 μm in diameter and a little shorter than the microwire. A series of voltages were applied on the pipe to study the influence of the electrical field on the Giant-Magneto-Impedance(GMI) effect of the microwire. Experimental results showed that the electronic field between the wire and the pipe reduced the hysteresis of the GMI effect. The results were explained based on equivalent circuit and eddy current consumptions analysis. | Q.Zhang D.L.Chen X.Li P.X.Yang J.H.Chu Z.J.Zhao | 2013 | Nano-Micro Letters2013，5，1： | 1 |
| 18 | In Situ Growth of Mesoporous SnO显示文摘 | Z.Wen Q.Wang Q.Zhang J.Li | 2007 | Adv Funct Mater2007，，15： | 1 |
| 19 | HC-MAC:a hardware constrained cognitive MAC for effiicient spectrum management显示文摘 | J.Jia Q.Zhang X.Shen | | 0，，： | 1 |
| 20 | Polarization modulation with optical lock-in detection reveals universal fluorescence anisotropy of subcellular structures in live cells显示文摘The orientation of fluorophores can reveal crucial information about the structure and dynamics of their associated subcellular organelles.Despite significant progress in super-resolution,fluorescence polarization microscopy remains limited to unique samples with relatively strong polarization modulation and not applicable to the weak polarization signals in samples due to the excessive background noise.Here we apply optical lock-in detection to amplify the weak polarization modulation with super-resolution.This novel technique,termed optical lock-in detection super-resolution dipole orientation mapping(OLID-SDOM),could achieve a maximum of 100 frames per second and rapid extraction of 2D orientation,and distinguish distance up to 50 nm,making it suitable for monitoring structural dynamics concerning orientation changes in vivo.OLID-SDOM was employed to explore the universal anisotropy of a large variety of GFP-tagged subcellular organelles,including mitochondria,lysosome,Golgi,endosome,etc.We found that OUF(Orientation Uniformity Factor)of OLID-SDOM can be specific for different subcellular organelles,indicating that the anisotropy was related to the function of the organelles,and OUF can potentially be an indicator to distinguish normal and abnormal cells(even cancer cells).Furthermore,dual-color super-resolution OLID-SDOM imaging of lysosomes and actins demonstrates its potential in studying dynamic molecular interactions.The subtle anisotropy changes of expanding and shrinking dendritic spines in live neurons were observed with real-time OLID-SDOM.Revealing previously unobservable fluorescence anisotropy in various samples and indicating their underlying dynamic molecular structural changes,OLID-SDOM expands the toolkit for live cell research. | Meiling Guan Miaoyan Wang Karl Zhanghao Xu Zhang Meiqi Li Wenhui Liu Jing Niu Xusan Yang Long Chen Zhenli Jing Micheal Q.Zhang Dayong Jin Peng Xi Juntao Gao | 2022 | Light(Science & Applications)2022，11，1： | 1 |
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