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| 1 | N-doped defective carbon with trace Co for efficient rechargeable liquid electrolyte-/all-solid-state Zn-air batteries显示文摘Simple synthesis of multifunctional electrocatalysts with plentiful active sites from earth-abundant materials is especially fascinating. Here, N-doped defective carbon with trace Co(1.5 wt%) was prepared via a scalable one pot solid pyrolysis process. The sample exhibits efficient bifunctional OER/ORR activity in alkaline, mainly ascribed to the unique micro-mesoporous structure(1–3 nm), high population of graphitic-N doping(up to 49.0%), abundant defects and the encapsulated Co nanoparticles with graphitized carbon. The according rechargeable liquid Zn-air batteries showed excellent performance(maximum power density of 154.0 mW cm^(-2); energy density of 773 Wh kg^(-1) at 5 mA cm^(-2) and charging-discharging cycling stability over 100 cycles). As a proof-of-concept, the flexible, rechargeable all-solid-state Zn-air batteries were constructed, and displayed a maximum power density as high as 45.9 mW cm^(-2), among the top level of those reported previously. | Zhiyan Chen Qichen Wang Xiaobin Zhang Yongpeng Lei Wei Hu Yao Luo Yaobing Wang | 2018 | Science Bulletin2018，63，9： | 14 |
| 2 | Primary closure versus T-tube drainage in laparoscopic common bile duct exploration: a meta-analysis of randomized clinical trials显示文摘 | Xiangsong Wu Yong Yang Ping Dong Jun Gu Jianhua Lu Maolan Li Jiasheng Mu Wenguang Wu Jiahua Yang Lin Zhang Qichen Ding Yingbin Liu | 2012 | Langenbeck’s Archives of Surgery2012，，6： | 4 |
| 3 | Auxin response factor 6A regulates photosynthesis,sugar accumulation,and fruit development in tomato显示文摘Auxin response factors(ARFs)are involved in auxin-mediated transcriptional regulation in plants.In this study,we performed functional characterization of SlARF6A in tomato.SlARF6A is located in the nucleus and exhibits transcriptional activator activity.Overexpression of SlARF6A increased chlorophyll contents in the fruits and leaves of tomato plants,whereas downregulation of SlARF6A decreased chlorophyll contents compared with those of wild-type(WT)plants.Analysis of chloroplasts using transmission electron microscopy indicated increased sizes of chloroplasts in SlARF6A-overexpressing plants and decreased numbers of chloroplasts in SlARF6A-downregulated plants.Overexpression of SlARF6A increased the photosynthesis rate and accumulation of starch and soluble sugars,whereas knockdown of SlARF6A resulted in opposite phenotypes in tomato leaves and fruits.RNA-sequence analysis showed that regulation of SlARF6A expression altered the expression of genes involved in chlorophyll metabolism,photosynthesis and sugar metabolism.SlARF6A directly bound to the promoters of SlGLK1,CAB,and RbcS genes and positively regulated the expression of these genes.Overexpression of SlARF6A also inhibited fruit ripening and ethylene production,whereas downregulation of SlARF6A increased fruit ripening and ethylene production.SlARF6A directly bound to the SAMS1 promoter and negatively regulated SAMS1 expression.Taken together,these results expand our understanding of ARFs with regard to photosynthesis,sugar accumulation and fruit development and provide a potential target for genetic engineering to improve fruit nutrition in horticulture crops. | Yujin Yuan Xin Xu Zehao Gong Yuwei Tang Mengbo Wu Fang Yan Xiaolan Zhang Qian Zhang Fengqing Yang Xiaowei Hu Qichen Yang Yingqing Luo Lihua Mei Wenfa Zhang Cai-Zhong Jiang Wangjin Lu Zhengguo Li Wei Deng | 2019 | Horticulture Research2019，6，1： | 3 |
| 4 | Ginsenoside Rh2 suppresses colon cancer growth by targeting the miR-150-3p/SRCIN1/Wnt axis显示文摘Ginsenoside Rh2,which is extracted from ginseng,exerts antitumor activity.Recent studies suggest that Rh2 may suppress the growth of colon cancer(CC)in vitro.However,the underlying mechanism remains unclear.In this study,we identified the relative levels of miR-150-3p in CC tissues and cells by a comprehensive strategy of data mining,computational biology,and real-time reverse transcription PCR(qRT-PCR)experiments.The regulatory effects of miR-150-3p/SRCIN1 on the proliferative and invasive abilities of CC cells are evaluated by CCK-8,EdU,wound healing,and transwell assays.Cell cycle-and apoptosis-related protein levels are assessed by western blot analysis.An in vivo tumor formation assay was conducted to explore the effects of miR-150-3p on tumor growth.Furthermore,bioinformatics and dual luciferase reporter assays are applied to determine the functional binding of miRNA to mRNA of the target gene.Finally,the relationship between Rh2 and miR-150-3p was further verified in SW620 and HCT-116 cells.miR-150-3p is downregulated in CC tissues and cell lines.Functional assays indicate that the upregulation of miR-150-3p inhibits tumor growth both in vivo and in vitro.In addition,SRCIN1 is upregulated in CC and predicts a poor prognosis,and it is the direct target for miR-150-3p.Moreover,the miR-150-3p mimic decreases Topflash/Fopflash-dependent luciferase activity,resulting in the inhibition of Wnt pathway activity.Rh2 can suppress the growth of CC by increasing miR-150-3p expression.Rh2 alleviates the accelerating effect on Wnt pathway activity,cell proliferation/migration,and colony formation caused by miR-150-3p inhibition.Rh2 inhibits the miR-150-3p/SRCIN1/Wnt axis to suppress colon cancer growth. | Shipeng Li Wenfeng Han Qichen He Yang Wang Gang Jin Youcheng Zhang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，4： | 2 |
| 5 | Role of polymorphisms of the IGF2 and IGFBP3 genes and risk of gastric carcinoma in China显示文摘 | Gu Jun Li Maolan Dong Ping Lu Jianhua Tan Zhujun Wu Xiangsong Mu Jiasheng Zhang Lin Wu Wenguang Ding Qichen Yang Jiahua Cao Yang Ding Qian Weng Hao Liu Yingbin | 2014 | Chinese Medical Journal2014，，3： | 2 |
| 6 | Pharmacological inhibition of SRC-1 phase separation suppresses YAP oncogenic transcription activity显示文摘Dear Editor,Yes-associated protein(YAP)is a transcriptional coactivator that plays an essential role in promoting cell proliferation,development and stem cell fate.1 Aberrant YAP activation is prevalent in diverse types of human solid cancers. | Guangya Zhu Jingjinq Xie Zhenzhen Fu Mingliang Wang Qichen Zhang Hao He Zijun Chen Xin Guo Jidong Zhu | 2021 | Cell Research2021，31，9： | 2 |
| 7 | A role for p21‐activated kinase 7 in the development of gastric cancer显示文摘 | Jun Gu Keqiang Li Maolan Li Xiangsong Wu Lin Zhang Qichen Ding Wenguang Wu Jiahua Yang Jiasheng Mu Hao Wen Qian Ding Jianhua Lu Yuan Hao Lei Chen Wenjie Zhang Songgang Li Yingbin Liu | 2012 | FEBS J2012，，1： | 1 |
| 8 | Primary closure versus T-tube drainage in laparoscopic common bile duct exploration: a meta-analysis of randomized clinical trials显示文摘 | Xiangsong Wu Yong Yang Ping Dong Jun Gu Jianhua Lu Maolan Li Jiasheng Mu Wenguang Wu Jiahua Yang Lin Zhang Qichen Ding Yingbin Liu | 2012 | Langenbeck’s Archives of Surgery2012，，6： | 1 |
| 9 | Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride显示文摘 | Huating Li Qichen Fang Fei Gao Jia Fan Jian Zhou Xiaoying Wang Huizhen Zhang Xiaoping Pan Yuqian Bao Kunsan Xiang Aimin Xu Weiping Jia | 2010 | Journal of Hepatology2010，，5： | 1 |
| 10 | Nephrocyte-neurocyte interaction and cellular metabolic analysis on membrane-integrated microfluidic device显示文摘Cell-cell interaction and cell metabolic analysis provide new opportunities for better understanding of critical biochemical processes. Advanced microfluidic technologies enable to create more realistic in vitro microenvironment by spatial and temporal control of cell growth and co-culture. In this work, we design a microfluidic device to achieve the co-culture of PC12 cells and 293 cells, and study in vitro cell-cell interaction via cell metabolic analysis by mass spectrometry. The membraneintegrated microfluidic device was firstly used for cell co-culture, and the cellular metabolite was further investigated by mass spectrometer(MS). Our results showed that the differentiation of PC12 cells could be successfully induced by m NGF and also greatly influenced by the microchannel treatment of fetal bovine serum(FBS) solution. The identification of cell morphology, microtubule-associated protein 2(MAP-2) expression and viability of differentiated PC12 cells were conducted before 293 cells being introduced into the top microfluidic channels and stimulated to secrete cell metabolism products. The developed microfluidic device is a potentially useful tool for high throughput of cell-cell interaction study. | Qichen Zhuang Shiqi Wang Jie Zhang Ziyi He Haifang Li Yuan Ma Jin-Ming Lin | 2016 | Science China Chemistry2016，59，2： | 1 |
| 11 | A role for p21‐activated kinase 7 in the development of gastric cancer显示文摘 | Jun Gu Keqiang Li Maolan Li Xiangsong Wu Lin Zhang Qichen Ding Wenguang Wu Jiahua Yang Jiasheng Mu Hao Wen Qian Ding Jianhua Lu Yuan Hao Lei Chen Wenjie Zhang Songgang Li Yingbin Liu | 2012 | FEBS J2012，，1： | 1 |
| 12 | A role for p21‐activated kinase 7 in the development of gastric cancer显示文摘 | Jun Gu Keqiang Li Maolan Li Xiangsong Wu Lin Zhang Qichen Ding Wenguang Wu Jiahua Yang Jiasheng Mu Hao Wen Qian Ding Jianhua Lu Yuan Hao Lei Chen Wenjie Zhang Songgang Li Yingbin Liu | 2012 | FEBS J2012，，1： | 1 |
| 13 | Downregulated expression of hepatoma-derived growth factor (HDGF) reduces gallbladder cancer cell proliferation and invasion显示文摘 | Maolan Li Jun Shen Xiangsong Wu Bingtai Zhang Rui Zhang Hao Weng Qian Ding Zhujun Tan Guofeng Gao Jiasheng Mu Jiahua Yang Yijun Shu Runfa Bao Qichen Ding Wenguang Wu Yang Cao Yingbin Liu | 2013 | Medical Oncology2013，，2： | 1 |
| 14 | NLK is a key regulator of proliferation and migration in gallbladder carcinoma cells显示文摘 | Zhujun Tan Maolan Li Wenguang Wu Lin Zhang Qichen Ding Xiangsong Wu Jiasheng Mu Yingbin Liu | 2012 | Molecular and Cellular Biochemistry2012，，1： | 1 |
| 15 | Synthesis and characterization of N -(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride for potential application in gene delivery显示文摘 | Bo Xiao Ying Wan Xiaoyu Wang Qichen Zha Haoming Liu Zhiye Qiu Shengmin Zhang | 2011 | Colloids and Surfaces B: Biointerfaces2011，，： | 1 |
| 16 | Cross-Modal Interaction and Integration Through Stimulus-Specific Adaptation in the Thalamic Reticular Nucleus of Rats显示文摘Stimulus-specific adaptation(SSA),defined as a decrease in responses to a common stimulus that only partially generalizes to other rare stimuli,is a widespread phenomenon in the brain that is believed to be related to novelty detection.Although cross-modal sensory processing is also a widespread phenomenon,the interaction between the two phenomena is not well understood.In this study,the thalamic reticular nucleus(TRN),which is regarded as a hub of the attentional system that contains multi-modal neurons,was investigated.The results showed that SSA existed in an interactive oddball stimulation,which mimics stimulation changes from one modality to another.In the bimodal integration,SSA to bimodal stimulation was stronger than to visual stimulation alone but similar to auditory stimulation alone,which indicated a limited integrative effect.Collectively,the present results provide evidence for independent cross-modal processing in bimodal TRN neurons. | Yumei Gong Yuying Zhai Xinyu Du Peirun Song Haoxuan Xu Qichen Zhang Xiongjie Yu | 2022 | Neuroscience Bulletin2022，38，7： | 0 |
| 17 | Nano-refinement of the face-centered cubic Zr(Fe,Cr)_(2)secondary phase particles in Zircaloy-4 alloy via localized-shearing/bending-driven fracture under high-temperature compression显示文摘Nanoparticles are extensively introduced to improve the mechanical,physical,and chemical properties of alloys.In the present study,the underlying nano-refinement mechanisms of face-centered cubic Zr(Fe,Cr)_(2)secondary phase particles(SPPs)that precipitated in Zircaloy-4 alloy under high-temperature compression were investigated in detail by utilizing high-resolution transmission electron microscopy(HRTEM)and conventional TEM techniques.The frequently observed Zr(Fe,Cr)_(2)SPPs were incoherent with the matrix and exhibited brittle fracture behaviors without measurable plasticity.HRTEM observations revealed two mechanisms underlying the nano-refinement of incoherent micro-sized SPPs via localized shear fracture on{11¯2}SPP and nanoprecipitate-assisted bending fracture,respectively.The latter was,for the first time,found to occur when the movements of large SPPs were blocked by nanometer-sized SPP during alloy deformation.Accordingly,two force models were proposed to visualize their potential nano-refinement processes.The knowledge attained from this study sheds new light on the deformation behaviors of Zr(Fe,Cr)_(2)SPPs and their associated size refinement mechanisms under high-temperature compression,and is expected to greatly benefit the process optimization of zirconium alloys to achieve precipitate nano-refinement. | Fuzhou Han Geping Li Fusen Yuan Wenbin Guo Jie Ren Qichen Wang Yingdong Zhang Ali Muhammad Chengze Liu Hengfei Gu | 2023 | Journal of Materials Science & Technology2023，，34： | 0 |
| 18 | Low-coordination environment design of single Co atoms for efficient CO_(2) photoreduction显示文摘Photocatalytic carbon dioxide(CO_(2))to carbon monoxide(CO)offers a promising way for both alleviating the greenhouse effect and meeting the industrial demand.Herein,we constructed a Co single-atom catalyst with intentional low-coordination environment design on porous ZnO(denoted as Co1/ZnO).Impressively,Co1/ZnO exhibited a remarkable activity with a CO yield rate of 22.25 mmol·g^(-1)·h^(-1) and a selectivity of 80.2%for CO_(2) photoreduction reactions under visible light.The incorporation of single Co atoms provided an additional photo-generated electron transfer channel,which suppressed the carrier recombination of photocatalysts.Moreover,the unsaturated Co active sites were capable to adsorb CO_(2) molecule spontaneously,thus facilitating the activation of CO_(2) molecule during CO_(2) reduction course. | Zhentao Ma Qingyu Wang Limin Liu Rong-Ao Zhang Qichen Liu Peigen Liu Lihui Wu Chengyuan Liu Yu Bai Yida Zhang Haibin Pan Xusheng Zheng | 2024 | Nano Research2024，17，5： | 0 |
| 19 | Distributed collaborative complete coverage path planning based on hybrid strategy显示文摘Collaborative coverage path planning(CCPP) refers to obtaining the shortest paths passing over all places except obstacles in a certain area or space. A multi-unmanned aerial vehicle(UAV) collaborative CCPP algorithm is proposed for the urban rescue search or military search in outdoor environment.Due to flexible control of small UAVs, it can be considered that all UAVs fly at the same altitude, that is, they perform search tasks on a two-dimensional plane. Based on the agents’ motion characteristics and environmental information, a mathematical model of CCPP problem is established. The minimum time for UAVs to complete the CCPP is the objective function, and complete coverage constraint, no-fly constraint, collision avoidance constraint, and communication constraint are considered. Four motion strategies and two communication strategies are designed. Then a distributed CCPP algorithm is designed based on hybrid strategies. Simulation results compared with patternbased genetic algorithm(PBGA) and random search method show that the proposed method has stronger real-time performance and better scalability and can complete the complete CCPP task more efficiently and stably. | ZHANG Jia DU Xin DONG Qichen XIN Bin | 2024 | Journal of Systems Engineering and Electronics2024，35，2： | 0 |
| 20 | Novel gold nanoparticles targeting somatostatin receptor subtype two with near-infrared light for neuroendocrine tumour therapy显示文摘Neuroendocrine tumours(NETs)are rare cancers with positive somatostatin receptor 2(SSTR2)expression,and treatment strategies for NETs are not satisfactory.Nanomaterial-mediated therapy targeting SSTR2 in NETs is very promising.This study firstly combined mesoporous silica-coated gold nanorods(AuNRs@mSiO_(2))and targeting-SSTR2 dodecane tetraacetic acidtyrosine3-octreotate(DOTA-TATE)into AuNRs@mSiO_(2)@DOTA-TATE to investigate NETs inhibition under near-infrared light.AuNRs@mSiO_(2)@DOTA-TATE showed good photothermal conversion efficiency.In vitro,under light irradiation,the cell viability significantly decreased with increasing AuNR@mSiO_(2)@DOTA-TATE concentration;in two successfully established neuroendocrine tumour organoids with SSTR2 expression,AuNRs@mSiO_(2)@DOTA-TATE with light inhibited tumours significantly better than AuNRs@mSiO_(2) with light.In vivo,the SSTR2-targeting ability and biodistribution of AuNRs@mSiO_(2)@DOTA-TATE were confirmed with AuNRs@mSiO_(2)@64Cu-DOTA-TATE under micro-positron emission tomography/computed tomography(micro-PET/CT);in the AuNRs@mSiO_(2)@DOTA-TATE with laser group,the tumour surface temperature increased rapidly,with tumour volumes similar to those in the octreotide group and significantly lower than those in other groups.There was no significant difference in mice body weight between the AuNRs@mSiO_(2)@DOTA-TATE with laser group and other groups.No significant inflammatory lesions or cell necrosis was found in the main organs.In summary,we presented a feasible strategy to construct AuNRs@mSiO_(2)@DOTA-TATE with good photothermal conversion efficiency,targetingSSTR2 ability,significant antitumour effects,and good biocompatibility,warranting further explorations of AuNRs@mSiO_(2)@DOTA-TATE for NETs therapy applications. | Qichen Chen Zilin Li Jiangyuan Yu Qing Xie Haizhen Lu Yiqiao Deng Jinghua Chen Wenjia Zhu Li Huo Yizhou Zhang Wei Song Jianqiang Lan Jianqiang Cai Zhen Huang Zixi Wang Hong Zhao | 2022 | Nano Research2022，15，10： | 0 |
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