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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Highly stretchable pseudocapacitors based on buckled reticulate hybrid electrodes显示文摘以便与高特定的电容和突出的 stretchability 开发优秀 pseudocapacitor 与在便携的未来和 bio-implantable 系统适用的另外的设备匹配,我们在三个重要方面上集中我们的研究:混合电影电极,在不同部件之间的接口,和在基于围单人赛的碳 nanotube/polyaniline (SWCNT/PANI ) 的 supercapacitors 的 stretchability 和电气化学的综合性能的 Stretchability 预先伸长的弹性体上的合成电影。由于中等的孔,弄弯的混合电影避免裂开它发生在常规可拉长的混合电极,和两个 435 F | Nan Zhang Pingshan Luan Weiya Zhou Qiang Zhang Le Cai Xiao Zhang Wenbin Zhou Qingxia Fan Feng Yang Duan Zhao YanchunWang Sishen Xie | 2014 | Nano Research2014，7，11： | 4 |
| 3 | Optical visualization and polarized light absorption of the single-wall carbon nanotube to verify intrinsic thermal applications显示文摘The predicted extraordinary properties of carbon nanotubes(CNTs)from theoretical calculations have great potential for many applications.However,reliable experimental determination of intrinsic properties at the single-tube level is currently a matter of concern,and many challenges remain because of the unhandled and nanoscale size of individual nanotubes.Here,we demonstrated a prototype to detect the intrinsic thermal conductivity of the single-wall carbon nanotube(SWCNT)and verify the significant non-resonant optical absorption behavior on tiny nanotubes by integrating the nanotube and ice into a new core-shell design.In particular,a reversible optical visualization method based on the individual suspended ultra-long SWCNT was first developed by wrapping a nanotube with ice in the cryogenic air environment.The light-induced thermal effect on the hybrid core-shell structure was used tomelt the ice shell,which subsequently acted as a temperature sensor to verify the intrinsic thermal conductivity of the core-like nanotube.More interestingly,we successfully determined for the first time the thermal response phenomenon of the tiny absorption cross section in SWCNT in the vertical-polarization configuration and the significant non-resonant absorption behavior in the parallel-polarization configuration.These investigations will provide a better understanding for the unique optical behaviors of CNT and enable the detection of intrinsic properties of various one-dimensional nanostructures such as nanotubes,nanowires,and nanoribbons. | Xiao Zhang Li Song Le Cai Xuezeng Tian Qiang Zhang Xiaoying Qi Wenbin Zhou Nan Zhang Feng Yang Qingxia Fan Yanchun Wang Huaping Liu Xuedong Bai Weiya Zhou Sishen Xie | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 4 | Prevalence of transmitted drug resistance mutations among patients infected with human immunodeficiency virus type 1 (HIV-1) in Henan Province, China显示文摘To the Editor:Even with the emergence of highly active antiretroviral therapy,human immunodeficiency virus type 1(HIV-1)remains a serious public health problem worldwide.The widespread use of antiretroviral therapy(ART)has,on the one hand,significantly improved life expectancy in patients infected with HIV-1;on the other hand,it has inevitably brought along with it a difficult problem—viral resistance.Viral resistance is a common phenomenon evolutionarily,particularly in patients with poor adherence and suboptimal drug levels. | Jinjin Liu Xiaohua Zhang Mingjie Hou Shuguang Wei Jie Ma Lixia Xu Xuan Yang Yan Sun Chunli Liu Qingxia Zhao Yuqi Huo | 2022 | Chinese Medical Journal2022，135，22： | 2 |
| 5 | Regeneration behaviors of Fe/Si‐2 and Fe–Mn/Si‐2 catalysts for C2H6 dehydrogenation with CO2 to C2H4显示文摘 | Longya Xu Jinxiang Liu Hong Yang Yide Xu Qingxia Wang Liwu Lin | 1999 | Catalysis Letters (-)1999，，2： | 1 |
| 6 | The Catalytic Dehydrogenation of c2h6 to c2h4 under non-Oxidative Conditions over the 6cr/g-al2o3Catalyst显示文摘 | Hong Yang Longya Xu Dechun Ji Qingxia Wang Liwu Lin | 2002 | Reaction Kinetics and Catalysis Letters2002，，1： | 1 |
| 7 | The relationship between treatment-induced hypertension and efficacy of anlotinib in recurrent or metastatic esophageal squamous cell carcinoma显示文摘Objective:In this post-hoc analysis,we evaluated anlotinib treatment-induced hypertension as a potential predictive factor of efficacy in esophageal squamous cell carcinoma(ESCC)patients.Methods:A total of 109 patients enrolled in the anlotinib group in a phase 2 trial were included.The tumor response was assessed by computed tomography at week 3,week 6,and then every 6 weeks until progressive disease was observed.The primary endpoint of the study was progression free survival(PFS).The secondary endpoints included overall survival(OS)and objective response rate(ORR).Results:In all patients,the median PFS was 3.02 months[95%confidence interval(CI):2.63–3.65 months]and the OS was 6.11 months(95%CI:4.40–7.79 months).The ORR was 7.34%(95%CI:3.22%–13.95%).A total of 59(54%)patients were diagnosed with treatment-induced hypertension(Group A),and the remaining patients(n=50,46%)were in Group B.Baseline prognostic factors were similar between the 2 groups.Patients in Group A had a longer PFS and OS and higher ORR.When stratifying patients using a previously known history of hypertension,treatment-induced hypertension was a predictor only for patients without previous hypertension,who had longer PFS[hazard ratio(HR):0.40,95%CI:0.24–0.68]and OS(HR:0.37,95%CI:0.21–0.67).Conclusions:We showed,for the first time,a correlation between treatment-induced hypertension and better prognoses in recurrent or metastatic ESCC patients treated with anlotinib,without a previously known history of hypertension.Treatment-induced hypertension may be a simple and low cost predictor for anlotinib antitumor efficacy in these patients,which may also reflect the intended target inhibition. | Yan Song Juxiang Xiao Wentao Fang Ping Lu Qingxia Fan Yongqian Shu Jifeng Feng Shu Zhang Yi Ba Yang Zhao Ying Liu Chunmei Bai Yuxian Bai Yong Tang Jie He Jing Huang | 2021 | Cancer Biology & Medicine2021，18，2： | 1 |
| 8 | Influence of infiltration on energy consumption of a winery building显示文摘 | Hejiang SUN Qingxia YANG | 2014 | Frontiers in Energy2014，8，1： | 0 |
| 9 | The Characteristics of Putaohua Reservoir and Development Strategies in Xujiaweizi Baxin Oilfield显示文摘With the using of new full 3 - D interpretative technology, the carefully interpretation of the micro - amplitude structures and faults by the reprocessed 3 -D seismic data in IES (Interactive Exploration System) interpretative system of Sun workstation is obtained. Because of the application of the well - advanced predictive technique for reservoir lithological changes, the predictive accuracy rate of drilling for 31 wells drilled in 1996 achieved 100 % and the economic and social benefits are desirable. | GUO Qingxia(Exploration and Development Research Institute of Daqing Oilfield, Heilongjiang 163453, P. R.China)YANG Haibo( The Advanced Personnel Training Center of Daqing Oilfield, Heilongjiang 163453, P,R, China) | 2002 | Global Geology2002，7，1： | 0 |
| 10 | Comment on:the tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer-related deaths worldwide(1).Resident immune cell populations within the liver,which is considered the largest immune organ,increase the pathological complexity of HCC(2).Innate lymphoid cells(ILCs),recently identified leukocytes,are a family of innate immune cells with similar characters to T lymphocytes.ILCs largely exist in intestinal mucosal tissue and regulate intestinal inflammation,mucosal defense,and tissue repair in gut disease processes(3).Unlike T cells,ILCs lack antigen-specific receptors;therefore,they cannot directly mediate antigen-specific responses(4).However,they can be activated by cytokines and/or natural cytotoxic receptors(such as NKp44)(5).ILCs are a highly heterogeneous cell population with high plasticity.Based on the expression of transcription factors and the production of different cytokines,ILCs can be divided into ILC1,ILC2,and ILC3,which are counterparts of the three main helper T cell subsets(Th1,Th2,and Th17)(6).Although ILCs can be detected in various tumor types,their specific contribution to tumor immunity is yet to be thoroughly elucidated. | Lixia Xu Qingxia Yang Ce Tang Ming Kuang | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 0 |
| 11 | Paclitaxel and cisplatin with or without cetuximab in metastatic esophageal squamous cell carcinoma:a randomized,multicenter phase II trial显示文摘Lack of effective targeted therapy in metastatic esophageal squamous cell carcinoma(ESCC)underscores the urgent need for identifying new treatment approaches for this challenging disease.We sought to assess the addition of cetuximab to paclitaxel-cisplatin chemotherapy for first-line treatment in patients with metastatic ESCC.In this randomized,multicenter,open-label,phase II clinical trial,patients were randomized to receive paclitaxel-cisplatin(TP)(paclitaxel[175 mg/m^(2) intravenously(i.v.)on day 1 of every 3-week cycle]and cisplatin[75 mg/m^(2) i.v.on day 1 of every 3-week cycle])and TP plus cetuximab(CTP)(cetuximab,400 mg/m^(2) i.v.on day 1 of week 1,followed by 250 mg/m^(2) weekly). | Zhihao Lu Yanqiao Zhang Qingxia Fan Yueyin Pan Da Jiang Ping Lu Jingdong Zhang Xianglin Yuan Jifeng Feng Shujun Yang Wenbin Yue Lin Zhao Yunhua Xu Jinhua Luo Lin Shen | 2022 | The Innovation2022，3，3： | 0 |
| 12 | First report of Leptosphaeria sclerotioides on Brassica napus in Northwestern China显示文摘In 2020,diseased seedlings of winter oilseed rape(Brassica napus)with cankered taproots as well as abundant sclerotium-like structures in the soil surrounding the roots were found in Longxi County of Gansu province of northwestern China.A fungus with production of pycnidia was isolated from the diseased roots,and it was identified based on morphological characteristics,molecular phylogeny(ITS,LSU)and PCR detection with the specific primers.The fungus was identified as Leptosphaeria sclerotioides Gruyter,Aveskamp&Verkley[anamorph:Phoma sclerotioides(Preuss)ex Sacc.].Re-inoculation of isolates of P9 and P10 of L.sclerotioides on winter oilseed rape(B.napus cultivar‘Zhongshuang No.9’)in Wuhan caused formation of abundant sclerotium-like structures in soil surrounding the roots,but failed to produce root cankers as those observed in Gansu possibly due to lack of long peroid of low-temperature conditioning in Wuhan.In spite of this,plant height,pod number and seed yield of oilseed rape were significantly reduced in the treatment with L.sclerotioides P9 and P10,compared to the control treatment.To the best of our knowledge,this is the first report of L.sclerotioides on B.napus in China and the finding broadened our understanding about the natural distribution of this psychrophilic fungus. | Mingxue Shang Xing Lyv Jing Zhang Mingde Wu Long Yang Qingxia Guan Guoqing Li | 2023 | Oil Crop Science2023，8，2： | 0 |
| 13 | Wellsite Evaluation Method of Undercompacted Formation显示文摘Staring from the view point of practical application, based on large amount of pressure well - logging data home and abroad, the author demonstrated how to distinguish overpressure Formation using wellsite data through selected methods such as drilling parameters, rock cutting analysis, drilling fluid parameters, and electric welline logs. | Guo Qingxia Wei Xinghua Hu Yutao Yang Haibo | 2000 | Global Geology2000，5，2： | 0 |
| 14 | The Application of Quantitative Fluorescence Techniques in China显示文摘The introduction of multi-methods of Geo-logging at wellsite has become the major measurement of oil & gas exploration. From the early stage of manually geo-logging to the modern mudlogging with new techonlogies of MWD, LWD and QFT etc. The new technologies have played very important roles in the exploring of oil & gas. Being one of the newest technology of mudlogging, QFT has been widely used in oilfield for about 3 years. When it is put in operation in some oilfields of China in 1997, its advantages in oil & gas detection at wellsite have been continuously recognized,especially in the detection of shows of light oil and condensed oil. A set of powerful classification standard of resource rock oil bearing grades and the interpretation standards have been summarized by the application of the quantitative fluorescencelogging techniques (QFT) in Basins of China, together with gas-logging data, and other information got from the Geo-logging procedures at wellsite. | Hu Yutao Yang Haibo Guo Qingxia | 2000 | Global Geology2000，5，2： | 0 |
| 15 | INVESTIGATION OF DAMAGES CAUSED BY ABRASION AND IMPACT OF GRAVEL BED LOAD ON HYDRAULIC STRUCTURES显示文摘When gravel bed load deposits are sluiced from hydraulic structures, the mo- tion of bed load over the apron, as is well known, may consist of sliding, rolling and saltation. At times, saltation may become so intensive that gravels have been observed to jump clear out of the water surface. The movement of gravel bed load may cause serious damages to the hydraulic structures through abrasion and im- pact. The extent of damage depends upon a number of factors, such as rock prop- erties of gravels, flow conditions, configuration as well as the strength of materials of hydraulic structures. In most cases the movement of gravel bed load takes place in ribbons in plan, consequently, the lateral distribution of damages is uneven, and protective measures to be adopted against abrasion and impact should be applied to the key part most frequently attacked by the gravel bed load. Possible repair should be anticipated in the layout of structures in order to facilitate the operation. | TAN Ying, ZHANG Wei, LI Qingxia and YANG Xiaoqing ②IRTCES ③Department of River Studies. The Yangtze River Scientific Research Institute ④Sichuan Provincial Design Institute of Water Conservancy and Hydroelectric Power ⑤Institute of Water Conservancy and Hydroelectric Power Research. | 1991 | International Journal of Sediment Research1991，6，2： | 0 |
| 16 | O-GIcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis显示文摘Dear Editor,O-GIcNAcylation is a nutrient sensor that is particularly sensitive to environmental glucose(Hardiville and Hart,2014).Glucose can be converted to UDP-GIcNAc through the hexosamine biosynthetic pathway,providing a substrate for O-GIcNAcylation.Two enzymes participate in this reversible modification,O-GIcNAc transferase(OGT),which adds a single GIcNAc residue to the serine/threonine sites of proteins,and O-GIcNAcase(OGA),which removes the residue(Yang and Qian,2017). | Fan Yu Te Li Yanchao Sui Qingxia Chen Song Yang Jia Yang Renjie Hong Dengwen Li Xiumin Yan Wei Zhao Xueliang Zhu Jun Zhou | 2020 | Protein & Cell2020，11，11： | 0 |
| 17 | Self-assembly of three Ag-polyoxovanadates frameworks for their efficient construction of C–N bond and detoxification of simulant sulfur mustard显示文摘Three imidazole-modified Ag-polyoxovanadates frameworks(APFs)with a controllable molar ratio of Ag+to polyoxovanadates(POVs)[Ag(IM)_(2)]_(2)V_(4)O_(12)·2Ag(IM)_(2)(APF-1),[Ag_(2)(1-eIM)_(4)]_(2)[Ag(1-eIM)_(2)]_(3)·2Ag(1-eIM)_(2)·3(1-HeIM)[V_(10)O_(28)]_(2)(APF-2)and[Ag(1-pIM)_(2)]_(3)[HV_(10)O_(28)]·2Ag(1-pIM)_(2)·2H_(2)O(APF-3)(IM=imida-zole;1-eIM=1-ethylimidazole and 1-pIM=1-propylimidazole)have been successfully achieved by self-assembly of POVs,Ag+cations,and three different imidazole derivatives.Interestingly,the molar ratios of Ag+to POVs vary from 4:1,4.5:1 to 5:1 by changing the vanadium resources and imidazole deriva-tives.Notably,the coordination environment of Ag+cations and the structure of POVs in the APFs are also different.Specifically,for APF-1,the four Ag atoms adopt three-coordinated and four-coordinated geometries,respectively,and Ag-imidazole complexes and[V_(4)O 1_(2)]_(4)−cluster form the one-dimensional polymeric chains.While Ag atoms in APF-2 and APF-3 exhibit two-,four-and five-coordinated geome-tries for APF-2,four-,five-and six-coordinated geometries for APF-3,respectively.These Ag+cations and decavanadate clusters are assembled into the 2D supramolecular structure through the Ag-O bonds and Ag…Ag argentophilic interaction.Remarkably,thus-obtained APF-2 can serve as powerful efficient hetero-geneous catalyst for construction of C–N bond and detoxification of simulant sulfur mustard(yields up to 99%),which enable successful recycling for three cycles with remained catalytic activities and structure stability. | Xianqiang Huang Yanan Cui Jinhong Zhou Yalin Zhang Guodong Shen Qingxia Yao Jikun Li Zechun Xue Guoping Yang | 2022 | Chinese Chemical Letters2022，33，5： | 0 |
| 18 | Zfhx3 is essential for progesterone/progesterone receptor signaling to drive ductal side-branching and alveologenesis in mouse mammary glands显示文摘Progesterone(Pg)/progesterone receptor(PR) signaling drives mammary gland side-branching and alveologenesis, but the mechanisms through which Pg/PR signaling functions remain to be clarified.Using in vitro and in vivo models and histological and molecular analyses, we determined the role of Zfhx3 transcription factor in mammary gland development driven by Pg/PR signaling. Postnatal deletion of Zfhx3 in mouse mammary epithelial cells attenuated side-branching morphogenesis and alveologenesis. These effects were undetectable in the absence of Pg/PR signaling. During the estrus cycle, Zfhx3 expression corresponded to that of Pg, being at the highest level at the diestrus stage; Zfhx3 deletion inhibited mammary gland branching more potently at diestrus than estrus stage. Loss of Zfhx3 not only attenuated the expansion of stem/progenitor cells driven by Pg/PR signaling, but also impaired the function of Pg/PR signaling in the transcriptional activation of multiple genes. In addition, Pg/PR signaling significantly expanded PR-and Zfhx3-positive epithelial cells, and induced the physical association of ZFHX3 with PR. These findings establish Zfhx3 as an integral transcription factor of Pg/PR signaling in driving side-branching and alveologenesis during mammary gland development. | Gui Ma Ang Gao Yinan Yang Yuan He Xi Zhang Baotong Zhang Zhiqian Zhang Mei Li Xing Fu Dan Zhao Rui Wu Leilei Qi Qingxia Hu Juan Li Liya Fu Zhengmao Zhu Jin-Tang Dong | 2019 | Journal of Genetics and Genomics2019，46，3： | 0 |
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