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| 1 | Regulation of extracellular signal-regulated kinase 1/2 influences hippocampal neuronal survival in a rat model of diabetic cerebral ischemia显示文摘Activation of extracellular signal-regulated kinase 1/2 has been demonstrated in acute brain ischemia. We hypothesized that activated extracellular signal-regulated kinase 1/2 can protect hippocampal neurons from injury in a diabetic model after cerebral ischemia/reperfusion. In this study, transient whole-brain ischemia was induced by four-vessel occlusion in normal and diabetic rats, and extracellular signal-regulated kinase 1/2 inhibitor(U0126) was administered into diabetic rats 30 minutes before ischemia as a pretreatment. Results showed that the number of surviving neurons in the hippocampal CA1 region was reduced, extracellular signal-regulated kinase 1/2 phosphorylation and Ku70 activity were decreased, and pro-apoptotic Bax expression was upregulated after intervention using U0126. These findings demonstrate that inhibition of extracellular signal-regulated kinase 1/2 activity aggravated neuronal loss in the hippocampus in a diabetic rat after cerebral ischemia/reperfusion, further decreased DNA repairing ability and accelerated apoptosis in hippocampal neurons. Extracellular signal-regulated kinase 1/2 activation plays a neuroprotective role in hippocampal neurons in a diabetic rat after cerebral ischemia/ reperfusion. | Yaning Zhao Jianmin Li Qiqun Tang Pan Zhang Liwei Jing Changxiang Chen Shuxing Li | 2014 | Neural Regeneration Research2014，9，7： | 10 |
| 2 | Impaired tumor angiogenesis and VEGF- induced pathway in endothelial CD146 knockout mice显示文摘 | Qiqun Zeng Zhenzhen Wu Hongxia Duan Xuan Jiang Tao Tu Di Lu Yongting Luo Ping Wang Lina Song Jing Feng Dongling Yang Xiyun Yan | 2014 | Protein & Cell2014，5，6： | 6 |
| 3 | Brown and beige fat: the metabolic function, induction, and therapeutic potential显示文摘脂肪质的织物是为精力动态平衡的一个重要机关。白脂肪质的织物存储在 triglycerides 形式的精力,而棕色的 adipocytes 和最近识别的米黄色的 adipocytes 被专攻由在血处理葡萄糖和清楚的 triglycerides 的生热作用或贡献浪费体力。在棕色的脂肪质的织物活动和身体质量之间的反的关联对身体脂肪累积建议它的保护的角色。因此,棕色或米黄色的脂肪质的织物的招募和激活为增加精力开销成为特别地呼吁的目标。Angiogenesis 和同情的神经信号是为褐和米黄色的脂肪质的织物开发,以及为他们的新陈代谢的函数的基本决定因素。包括 BMP 的秘书因素能导致发展,褐的激活或米黄色的脂肪质的织物,它似乎为治疗学的开发有希望。 | Shuwen Qian Haiyan Huang Qiqun Tang | 2015 | Frontiers of Medicine2015，9，2： | 5 |
| 4 | Expression and characterization of the first kunitz domain of human tissue factor pathway inhibitor-2显示文摘 | Desheng Kong Duan Ma Hao Bai Hongshen Guo Xu Cai Wei Mo Qiqun Tang Houyan Song | 2004 | Biochemical and Biophysical Research Communications2004，，4： | 1 |
| 5 | Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes显示文摘Dear Editor,Obesity is caused by an imbalance between energy intake and expenditure,and has become a global epidemic with over 650 million adults affected.Adipose tissues in mammals are composed of white adipose tissue(WAT)and classical brown adipose tissue(BAT),and their balance is highly related to the occurrence of obesity.The browning of white adipocytes results in“beige”or“brite”adipocytes,which appear functionally similar to classical brown adipocytes,and can be detected in WAT deposits of animals that have been exposed to cold or other inducers(Fu et al.,2015). | Zhaomeng Cui Yang Liu Wei Wan Yuyan Xu Yehui Hu Meng Ding Xin Dou Ruina Wang Hailing Li Yongmei Meng Wei Li Wei Jiang Zengxia Li Yiming Li Minjia Tan Dengke KMa Yu Ding Jun OLiu Cheng Luo Biao Yu Qiqun Tang Yongjun Dang | 2021 | Protein & Cell2021，12，6： | 1 |
| 6 | Lysyl oxidase inhibition enhances browning of white adipose tissue and adaptive thermogenesis显示文摘Accumulating evidence from both animal and human studies suggests that activation of beige fat increases cellular energy expenditure,ultimately reducing adiposity.Here,we report the central role of adipocyte-derived lysyl oxidase(Lox)in the formation of thermogenic beige fat.Mice exposed to cold or aβ3 agonist showed drastically lower Lox expression in thermogenically activated beige fat.Importantly,inhibition of Lox activity with BAPN stimulated biogenesis of beige fat in inguinal white adipose tissue(iWAT)under housing conditions and potentiated cold-induced adaptive thermogenesis and beiging in both iWAT and epididymal white adipose tissue(eWAT).Notably,white adipocytes with Lox repression undergo transdifferentiation into beige adipocytes which can be suppressed by tumor necrosis factor-α(TNFα)via ERK activation.This work provides new insight into the molecular control to expand beige fat by Lox inhibition and suggest the potential for utilizing inhibitor of Lox to treat the emerging epidemics of obesity and diabetes. | Chun Xing Duo Jiang Yang Liu Qiqun Tang Haiyan Huang | 2022 | Genes & Diseases2022，9，1： | 1 |
| 7 | PCR-RFLP analysis of cytochrome b gene does not support Coilia ectenes taihuensis being a subspecies of Coilia ectenes显示文摘 | Chen Qiqun Lu Daru | 2005 | Journal of Genetic2005，84，3： | 1 |
| 8 | CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis显示文摘 | Tianxia Jiang Jie Zhuang Hongxia Duan Yongting Luo Qiqun Zeng Kelong Fan Huiwen Yan Di Lu Zhongde Ye Junfeng Hao Jing Feng Dongling Yang Xiyun Yan | 2012 | Blood2012，，11： | 1 |
| 9 | Apolipoprotein E mimetic peptide protects against diffuse brain injury显示文摘Apolipoprotein E plays a crucial role in inhibiting chronic neurodegenerative processes. However, its impact on neurological function following diffuse brain injury is still unclear. This study was designed to evaluate the therapeutic effects and mechanisms of action of apolipoprotein E mimetic peptide on diffuse brain injury. Apolipoprotein E mimetic peptide was administered into the caudal vein of rats with diffuse brain injury before and after injury. We found that apolipoprotein E mimetic peptide significantly decreased the number of apoptotic neurons, reduced extracellular signal-regulated kinase1/2 phosphorylation, down-regulated Bax and cytochrome c expression, decreased malondialdehyde content, and increased superoxide dismutase activity in a dose-dependent manner. These experimental findings demonstrate that apolipoprotein E mimetic peptide improves learning and memory function and protects against diffuse brain injury-induced apoptosis by inhibiting the extracellular signal-regulated kinase1/2-Bax mitochondrial apoptotic pathway. | Yaning Zhao Jianmin Li Qiqun Tang Junling Gao Changxiang Chen Liwei Jing Pan Zhang Shuxing Li | 2014 | Neural Regeneration Research2014，9，5： | 1 |
| 10 | The payment of single sickness in medical care system in China显示文摘 | YANG SHUDONG ZHANG XIAO SHEN QIQUN | 2006 | Southeast Univ(Med Se Ed)2006，25，01： | 1 |
| 11 | Morphological Variation of Coilia Mystus (Clupeiformes: Engraulidae) in Three Chinese Estuaries显示文摘 | Qiqun Cheng | 2010 | Journal of Life Sciences2010，4，6： | 0 |
| 12 | In vivo investigation on the role of tumor vascular marker CD146 molecule in embryonic vasculogenesis and tumor angiogenesis显示文摘CD146 molecule, the surface marker of tumor vascular, plays a key role in the proliferation and migration of vascular endothelial cell. However, due to lack of suitable animal model, | Qiqun Zeng1, Xiyun Yan.National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China | 2009 | 生物物理学报2009，25，S1： | 0 |
| 13 | Biochemical Composition and Nutritional Value of the Muscle Tissue of Yellowback Seabream, Evynnis Tumifrons, from the East China Sea显示文摘 | Lianjun Xia Qiqun Cheng Jianxue Lu Junli Hou Jian Xin Min Liu | 2011 | Journal of Life Sciences2011，5，1： | 0 |
| 14 | Current Situations and Recommendations for Development of Agricultural Sci-Tech Park District of Luzhou City显示文摘The agricultural science and technology park is a demonstration carrier for the assembly and integration of agricultural technology,the transformation of scientific and technological achievements and the modern agricultural production. It is an inevitable choice and important way to realize the transformation from traditional agriculture to modern agriculture. This paper reviewed the construction background,functional characteristics and development history of agricultural science and technology parks. It analyzed the current development situations of the provincial agricultural science and technology parks in Jiangyang District,Luzhou City of Sichuan Province. Then,it summarized its experience in park construction and compared with surrounding national and provincial agricultural science and technology parks. It found existing problems including insufficient industry-university-research integration,low level of agricultural intensification,weak functions of public service platforms and brand effect,and insufficient exploration of tourism resources. In view of these problems,it came up with recommendations for development of agricultural Sci-Tech Park District of Luzhou City,including gathering scientific and technological resources,enhancing scientific and technological support,strengthening the high-quality development of the park economy,and building a national 4 A-level excellent scenic spot. | Guoping DU Xiangjuan ZHU Qiqun XIONG Min NI Yuancai SHUI | 2021 | Asian Agricultural Research2021，13，11： | 0 |
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