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| 1 | Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring显示文摘树鼯有一种靠近的关系到首领并且在生物医学的研究比啮齿类动物有许多优点。然而,基因操作方法的缺乏妨碍了这个动物的更宽的使用。Spermatogonial 干细胞(SSC ) 成功地在文化被扩展了允许复杂基因在老鼠和老鼠编辑。这里,没有干细胞性质的损失,我们为树鼯 SSC 的长期的扩大描述一个文化系统。在我们的学习,胸腺房间抗原 1 被用来充实树鼯 SSC。定序 RNA 分析表明表明小径的 Wnt/-catenin 在无差别的 SSC 是活跃的,但是是在 SSC 区别的开始之上的 downregulated。树鼯的暴露到 recombinant Wnt3a 蛋白质的主要 SSC 在文化的起始的段落期间提高了 SSC 的幸存。当 feeder 被发现为树鼯 SSC 增长必要,树鼯 Sertoli 房间,然而并非老鼠使用胚胎的成纤维细胞,导致柔韧的房间扩大和长期的文化。扩展的树鼯 SSC 是有提高的绿色的 transfected 荧光灯表示 lentiviral 向量的蛋白质(EGFP ) 。在进消毒的成年的男树鼯睾丸的移植以后,标注 EGFP 的 SSC 能恢复精子发生并且成功地产生转基因的后代。而且,这些 SSC 对 CRISPR/Cas9-mediated 基因修正合适。在有编辑的基因的联合的树鼯 SSC 接近膨胀的一个文化系统的发展用树鼯为精确染色体操作铺平道路。 | Chao-Hui Li Lan-Zhen Yan Wen-Zan Ban Qiu TH Yong Wu Lin Wang Rui Bi Shuang Ji Yu-Hua Ma Wen-Hui Nie Long-Bao Lv Yong-Gang Yao Xu-Dong Zhao Ping Zheng | 2017 | Cell Research2017，27，2： | 22 |
| 2 | TGF-alpha deficency results in hair follicle and eye abnormalities in targeted and waved-1 mice显示文摘 | Luetteke NC Qiu TH Lee DC | 1993 | Cell1993，73，2： | 1 |
| 3 | TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice显示文摘 | Luetteke NC Qiu TH Peiffer RL | 1993 | Cell1993，73，2： | 1 |
| 4 | Glycoprotein microarrays with multi-lectin detection:unique lectin binding patterns as a tool for classifying normal,chronic pancreatitis and pancreatic cancer sera显示文摘 | Zhao J Patwa TH Qiu W | 2007 | J Proteome Res2007，6，5： | 1 |
| 5 | Single local instillation of Staphylococcus aureus peptidoglycan prevents diabetes-induced impaired wound healing显示文摘 | Qiu JG Chang TH Steinberg J J | 1998 | Wound Repair Regen1998，6，5： | 1 |
| 6 | Influence of patients' attitude on doctors' satisfaction with the doctor-patient relationship 显示文摘 | Xie Z Qiu ZQ Zhang TH | 2009 | Journal of Beijing Institute2009，41，2： | 1 |
| 7 | Glycoprotein microarrays with multi-lectin detection: unique lectin binding patterns as a tool for classifying normal, chronic pancreatitis and pancreat iccancer sera显示文摘 | Zhao J Patwa TH Qiu W | 2007 | J Proteome Res2007，6，： | 1 |
| 8 | Characterizationof mice deficient in the Src familynonreceptor tyrosine kinase Frk/rak 显示文摘 | Chandrasekharan S Qiu TH Alkharouf N | 2002 | Mol Cell Biol2002，22，14： | 1 |
| 9 | TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice显示文摘 | Luetteke NC Qiu TH Peiffer RL | 1993 | Cell1993，2373，2： | 1 |
| 10 | Aspirin versus heparin to prevent myocardial infarction during the acute phase of unstable angina显示文摘 | Théroux P Waters D Qiu S | | 0，，5： | 1 |
| 11 | The gennme of the mesopolyploid crop species Brassica rapa 显示文摘 | Wang X Wang H Wang J Sun R Wu J Liu S Bai Y Mun JH Bancroft I Cheng F Huang S Li X Hua W Wang J Wang X Freeling M Pires JC Paterson AH Chalhoub B Wang B Hayward A Sharpe AG Park BS Weisshaar B Liu B Li B Liu B Tong C Song C Duran C Peng C Geng C Koh C Lin C Edwards D Mu D Shen D Soumpourou E Li F Fraser F Conant G Lassalle G King G J Bonnema G Tang H Wang H Belcram H Zhou H Hirakawa H Abe I-I Guo H Wang H Jin H Parkin IA Batley J Kim JS Just J l i J Xu J Deng J Kim JA Li J Yu J Meng J Wang J Min J Poulain J Wang J Hatakeyama K Wu K Wang L Fang L Trick M Links MG Zhao M Jin M Ramchiary N Drou N Berkman PJ Cai Q Huang Q Li R Tabata S Cheng S Zhang S Zhang S Huang S Sato S Sun S Kwon SJ Choi SR Lee TH Fan W Zhao X Tan X Xu X Wang Y Qiu Y Yin Y l i Y Du Y Liao Y Lira Y Narusaka Y Wang Y Wang Z Li Z Wang Z Xiong Z Zhang Z Brassica rapa Genome Sequencing Project Consortium | 2011 | Nature Genetics2011，43，10： | 1 |
| 12 | Targeted inacti- vation of the EGF and amphiregulin genes reveals dis- tinct roles for EGF receptor ligands in mouse mammary gland development 显示文摘 | Luetteke NC Qiu TH Fenton SE | 1999 | Development1999，126，12： | 1 |
| 13 | Effects of the Chinese herb compo- nent phellopterin on the increase in cytosolic free calcium in PC12 eells显示文摘 | Li TH He L Qiu JB | 2007 | DrugDevRes2007，68，2： | 1 |
| 14 | Plasma endothelin-1 levels in stable and unstable angina显示文摘 | Qiu s Th e roux P Marcil M | 1993 | cardilogy1993，82，1： | 1 |
| 15 | The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase显示文摘 | Luetteke NC Phillips HK Qiu TH | 1994 | Genes Dev1994，8，4： | 1 |
| 16 | TGF alpha deficiencyresults in hair follicle and eye abnormalities in targeted andwaved-1mice显示文摘 | Luetteke NC Qiu TH Peiffer RL | 1993 | Cell1993，73，2： | 1 |
| 17 | Single local instillation of Staphylococcus aureus peptidoglyean prevents diabetes-induced impaired wound healing 显示文摘 | Qiu JG Chang TH Steinberg JJ | 1998 | Wound Repair Regen1998，6，5： | 1 |
| 18 | TGF alpha defi-ciency results in hair follicle and eye abnormalities in tar- geted and waved-1 mice显示文摘 | ] Luetteke NC Qiu TH Peiffer RL | 1993 | Ce111993，73，2： | 1 |
| 19 | The mouse waved- 2 phenotype results from a point mutation in the EGF re- ceptor tyrosine kinase显示文摘 | Luetteke N C Phillips HK Qiu TH | 1994 | Genes Dev1994，8，4： | 1 |
| 20 | Influence of patients'attitude on doctors'satisfaction with the doctor-patient relationship显示文摘 | Me Z Qiu ZQ Zhang TH | 2009 | Beijing Da Xue Xue Boa2009，41，2： | 1 |
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