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| 1 | Effects of Y and Ce on Microstructures and Properties of Nb-Si System Composites显示文摘The effects of yttrium and cerium on microstructures and properties of Nb-Si system composites were investigated by scanning electron microscopy( SEM), energy dispersive spectrum(EDS), X-ray diffraction(XRD) and high temperature oxidation experiments.It is found that the coarse primary silicide phase became finer and more homogeneous with Y and Ce addition.The results of high temperature oxidation experiments show that the oxidation rates of NbSi system composites with an appropriate amount of Y and Ce decrease compared with those of alloys without Y or Ce addition, and oxidation products mainly distribute along the phase boundaries between the Nb solid solution and silicide. | Qu Shiyu Han Yafang Song Jinxia Xiao Chengbo Song Liguo | 2004 | Journal of Rare Earths2004，22，z1： | 4 |
| 2 | Effects of Ti, Al and Hf on niobium silcides formation in the Nb-Si in situ composites显示文摘The effects of alloying elements Ti, Al and Hf on niobium silicides formation in the Nb-Si in situ composites have been investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD) and transmission electron microscopy (TEM). The binary, ternary and multicomponent alloys have been fabricated by vacuum non-consumable arc melting method. The results show that Ti tends to stabilize Nb3Si phase, while Al promotes the direct formation of β-Nb5Si3 phase with a tetrahedral D8m structure. Exceptionally, it seems that Hf is beneficial to the formation of γ-Nb5Si3 phase with a hexangular D88 structure. For the multicomponent Nb-Si in situ composites, the cooperative effects of different elements on niobium silicides formation basically maintain the character of ternary system. | QU ShiYu HAN YaFang KANG YongWang | 2009 | Science China(Technological Sciences)2009，52，1： | 4 |
| 3 | Pre-oxidation enhanced cyanobacteria removal in drinking water treatment: A review显示文摘Cyanobacterial bloom has many adverse effects on source water quality and drinking water production. The traditional water treatment process can hardly achieve satisfactory removal of algae cells. This review examines the impact of pre-oxidation on the removal of cyanobacteria by solid-liquid separation processes. It was reported that the introduction of chemical oxidants such as chlorine, potassium permanganate, and ozone in algae-laden water pretreatment could improve algae removal by the subsequent solid-liquid separation processes. However, over dosed oxidants can result in more serious water quality risks due to significant algae cell lysis and undesirable intracellular organic matter release. It was suggested that moderate pre-oxidation may enhance the removal of cyanobacteria without damaging algae cells. In this article, effects of moderate pretreatment on the solid-liquid separation processes(sedimentation, dissolved air flotation, and membrane filtration) are reviewed. | Jing Qi Baiwen Ma Shiyu Miao Ruiping Liu Chengzhi Hu Jiuhui Qu | 2021 | Journal of Environmental Sciences2021，33，12： | 3 |
| 4 | Thermo-mechanical fatigue behavior of nickel-base powder metallurgy superalloy FGH96 under tension-tension loading显示文摘Thermo-mechanical fatigue(TMF) behavior of FGH96,a nickel-base powder metallurgy superalloy,has been studied under tension-tension loading at the temperature range from 550 to 720 ℃.The results show that TMF fracture mode is intergranular for the in-phase(IP),but transgranular cleavage-like for the out-of-phase(OP) samples.The total content of Al,Ti and Nb in the γ phases for the IP or OP samples and the partitioning ratio of γ /γ in these elements for the IP samples are relatively higher at the lower strain amplitude,which is consistent with the case of the γ size that is larger at the lower strain amplitude,the lattice parameter misfit is negative and the absolute value is lower at the lower strain amplitude that is correlative with the change of the γ morphology.The deformation at the lower strain amplitude is mainly dominated by the dislocation lines and dislocation pairs in the matrix channels,at the higher strain amplitude dominated by the large numbers of superlattice stacking faults within the γ phases. | Yuli GU Yuhuai HE Shiyu QU Guodong ZHANG Fei ZHENG Chunhu TAO | 2010 | Acta Metallurgica Sinica(English Letters)2010，23，2： | 2 |
| 5 | On the theory of thermal elastohydrodynamic lubrication at high slide-roll ratios-line contact solution显示文摘 | YANG Peiran QU Shiyue CHANG Qiuying | 2001 | ASME Journal of Tribology2001，123，1： | 1 |
| 6 | Effects of chronic dexamethasone administration on hyperglycemia and insulin release in goats显示文摘Background: Dexamethasone(Dex), a synthetic glucocorticoid, is among the most commonly used drugs worldwide in animals and humans as an anti-inflammatory and immunosuppressive agent. GC has profound effects on plasma glucose level and other metabolic conditions. However, the effect of prolonged use of Dex on glucose metabolism in ruminants is still unclear.Results: Ten goats were randomly assigned to two groups: the control goats were injected with saline, and the Dex-treated goats were intramuscularly injected daily for 21 d with 0.2 mg/kg Dex. The results showed that plasma glucose and insulin concentrations were significantly increased after Dex administration(P < 0.05). Additionally, the content of hepatic glycogen was also markedly increased in Dex-treated goats(P < 0.01), while the content of glycogen in dorsal longissimus was unchanged by Dex(P > 0.05). The expression of several key genes, involved in blood glucose regulation, was detected by real-time PCR in the small intestine, skeletal muscle and liver. The expression of glucose transporter type 2(GLUT2), sodium-glucose transporter 1(SGLT1) and sodium-potassium ATPase(Na-K/ATPase) in the small intestine were generally increased by Dex, and GLUT2 m RNA expression was significantly up-regulated(P < 0.05). In liver, the expression of genes involved in gluconeogenesis including glucose-6-phosphatase catalytic subunit(G6 PC), cytosolic form of phosphoenolpyruvate carboxykinase(PCK1) and pyruvate carboxylase(PC), were significantly down-regulated by Dex. However, the protein expression levels of PCK1 & PCK2 were significantly increased by Dex, suggesting a post-transcriptional regulation. In dorsal longissimus, the m RNA expression of genes associated with gluconeogenesis and the insulin signaling pathway were generally upregulated by Dex, but the m RNA expression of two markers of muscle atrophy, namely F-box protein 32(FBXO32/Atrogin1) and muscle RING-finger protein 1(Mu RF1), was not altered by Dex.Conclusions: Taken together, these results indicate that chronic administration of a low dosage of Dex induces hyperglycemia mainly through gluconeogenesis activation in the goat liver. | Liqiong Niu Qu Chen Canfeng Hua Yali Geng Liuping Cai Shiyu Tao Yingdong Ni Ruqian Zhao | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 1 |
| 7 | Application of high-frequency magnetotelluric method in porphyry copper deposit exploration:a case study of Duobaoshan deposit area显示文摘The Duobaoshan mine area in Heilongjiang is located in the northeast section of Xingmeng orogenic belt and is in the west side of Hegang Mountain-Heihe fault zone. There exist many deposits in this area,and its metallogenic conditions are superior,which has been one of the hotspots in geological prospecting and metallogenic research in Northeast China. On the basis of previous studies,the authors used the EH-4 electromagnetic imaging system to carry out the data acquisition of three survey lines in Woduhe Village,Duobaoshan Town,Nenjiang County. Through the analysis of apparent resistivity section under TE and TM polarization modes,integrating regional geological data,it is concluded that:(1) the electrical characteristics of the metal ore in this area show a relatively low resistance,and according to its resistivity difference with surrounding rocks,the geometrical structures and apparent resistivity parameters of the low resistivity bodies in the lower section of the survey line are defined,and the electrical anomalies can be identified;(2)faults F1 and F2 may have a good metallogenic environment,so they are recommended for further exploration;(3) low resistance metal ore bodies have good correlation with local small structures or faults,which may play an iconic role for the delineation of key target areas;(4) in the process of using apparent resistivity to define the geometric structures of ore bodies underground,comprehensive analysis integrating the advantages of TE and TM models should be carry out to achieve more reliable inversion results. | LIU Caihua QU Xin FENG Xuan TTAN You LIU Yang QIAO Hanqing WANG Shiyu | 2017 | Global Geology2017，20，4： | 1 |
| 8 | Simplifed multigrid technique for the numerical solution to the steady-state and transient EHL line contacts and the arbitrary entrainment EHL point contacts显示文摘 | Wang Jing Qu Shiyue Yang Peiran | 2001 | Tribology2001，34，3： | 1 |
| 9 | Effects of V and Al on Microstructure and Room Temperature Fracture Toughness of Nb-Si In-situ Composites显示文摘The effect of alloying elements V and Al on microstructure and room temperature fracture toughness of an experimental Nb-Si in-situ composite was investigated. The Nb-Si alloys with different amount of V and Al were prepared by non-consumable arc-melting furnace. The experimental results showed that with the addition of V and Al, the microstructure of the Nb-Si materials transformed from Nbss+Nb3Si to Nbss+Nb5Si3 and the lattice parameters of Nbss phase decreased, and the alloying element V promoted the formation of the finer Nbss structure. It was observed that the room temperature fracture toughness was improved by the addition of V and Al, and the optimum room-temperature fracture toughness of the material appeared in the alloy with 2.6at.%V and 3.6at.%Al. The improvement of room temperature fracture toughness may be mainly attributed to the increment of the volume fraction of Nbss phase and the decrement of the silicide phase size. | Kang Yongwang Qu Shiyu Song Jinxia Han Yafang | 2009 | 稀有金属材料与工程2009，38，A03： | 1 |
| 10 | Side-Chain Engineering of Organic Crystals for Lasing Media with Tunable Flexibility显示文摘Abundant high-performance organic crystals have been reported in the past decades;however,applications of crystalline materials are seriously restricted by their notorious brittleness.Recently,some organic crystals have been designed to be deformable in response to stress,light,heat,or humidity;nevertheless,the development of flexible organic crystals currently relies on a molecular framework design.So far there is no effective strategy for constructing organic crystals with tunable flexibility based on the same luminescent skeleton.Herein,we propose a side-chain engineering strategy aimed at facilely modulating the mechanical compliance of organic crystals.Subtly changing the side chains of a single-benzeneπ-skeleton greatly alters the mechanical behaviors while maintaining the unique optical functions of the produced crystals.Optical waveguides and amplified spontaneous emissions were measured to evaluate the application potentials of the flexible crystals as soft optical transducing media.We anticipate that the proposed strategy will be expanded to regulate the mechanical compliance of other organic crystals with unique emission properties.In addition,the applications attempted preliminarily here highlight the superiority of“crystal flexibility”in flexible optoelectronics for some special application scenarios that require complex and shape changeable optical circuits. | Baolei Tang Shiyue Tang Cheng Qu Kaiqi Ye Zuolun Zhang Hongyu Zhang | 2023 | CCS Chemistry2023，5，10： | 1 |
| 11 | Simplified multigrid technique for the numerical solution to the steady-state and transient EHL line contacts and the arbitrary entrainment EHL point contacts显示文摘 | Wang Jing Qu Shiyue Yang Peiran | 2001 | Tribology International2001，34，： | 1 |
| 12 | On the theory of thermal elastohydrodynamic lubrication at high slide-roll ratios- line contact solution 显示文摘 | Yang Peiran Qu Shiyue Chang Qiuying | 2001 | ASME Jouranl of Tribology2001，123，： | 1 |
| 13 | Microstructure and properties of refractory niobium-silicide-based composites显示文摘 | Qu Shiyu Han Yafang Song Liguo | 2005 | Materials Science Forum Vols2005，，： | 1 |
| 14 | Simplified multilevel tech-nique for the numerical solution to the steady-state and transientEHL line contacts and the arbitrary entrainment EHL point con-tacts显示文摘 | Wang Jing Qu Shiyue Yang Peiran | 2001 | Tribology International2001，34，： | 1 |
| 15 | Simplified multigrid technique for the numerical solution to the steady-state and transient EHL line contacts and the arbitrary entrainment EHL point contacts显示文摘 | WANG Jing QU Shiyue YANG Peiran | 2001 | Tribology International2001，34，3： | 1 |
| 16 | On the theory of thermal elastohydrodynamic lubrication at high slide-roll ratios in line contact solution显示文摘 | Peiran Yang Shiyue Qu | 2001 | Transactions of ASME Journal of Tribology2001，123，1： | 1 |
| 17 | On the theory of thermal elastohydrodynamic lubrication at high slide-roll ratios circular glass-steel contact solution at opposite sliding显示文摘 | Feng Guo Peiran Yang Shiyue Qu | 2001 | Transactions of ASME Journal of Tribology2001，123，4： | 1 |
| 18 | A biomimetic liver cancer on-a-chip reveals a critical role of LIPOCALIN-2 in promoting hepatocellular carcinoma progression显示文摘Hepatic stellate cells(HSCs)represent a significant component of hepatocellular carcinoma(HCC)microenvironments which play a critical role in tumor progression and drug resistance.Tumor-ona-chip technology has provided a powerful in vitro platform to investigate the crosstalk between activated HSCs and HCC cells by mimicking physiological architecture with precise spatiotemporal control.Here we developed a tri-cell culture microfluidic chip to evaluate the impact of HSCs on HCC progression.Onchip analysis revealed activated HSCs contributed to endothelial invasion,HCC drug resistance and natural killer(NK)cell exhaustion.Cytokine array and RNA sequencing analysis were combined to indicate the iron-binding protein LIPOCALIN-2(LCN-2)as a key factor in remodeling tumor microenvironments in the HCC-on-a-chip.LCN-2 targeted therapy demonstrated robust anti-tumor effects both in vitro 3D biomimetic chip and in vivo mouse model,including angiogenesis inhibition,sorafenib sensitivity promotion and NK-cell cytotoxicity enhancement.Taken together,the microfluidic platform exhibited obvious advantages in mimicking functional characteristics of tumor microenvironments and developing targeted therapies. | Peiliang Shen Yuanyuan Jia Weijia Zhou Weiwei Zheng Yueyao Wu Suchen Qu Shiyu Du Siliang Wang Huilian Shi Jia Sun Xin Han | 2023 | Acta Pharmaceutica Sinica B2023，13，11： | 0 |
| 19 | Myeloid peroxisome proliferator-activated receptor α deficiency accelerates liver regeneration via IL-6/STAT3 pathway after 2/3 partial hepatectomy in mice显示文摘Background:Liver regeneration is a fundamental process for sustained body homeostasis and liver function recovery after injury.Emerging evidence demonstrates that myeloid cells play a critical role in liver regeneration by secreting cytokines and growth factors.Peroxisome proliferator-activated receptorα(PPARα),the target of clinical lipid-lowering fibrate drugs,regulates cell metabolism,proliferation,and survival.However,the role of myeloid PPARαin partial hepatectomy(PHx)-induced liver regeneration remains unknown.Methods:Myeloid-specific PPARa-deficient(Ppara^(Mye−/−))mice and the littermate controls(Ppara^(fl/fl))were subjected to sham or 2/3 PHx to induce liver regeneration.Hepatocyte proliferation and mitosis were assessed by immunohistochemical(IHC)staining for 5-bromo-2'-deoxyuridine(BrdU)and Ki67 as well as hematoxylin and eosin(H&E)staining.Macrophage and neutrophil infiltration into livers were reflected by IHC staining for galectin-3 and myeloperoxidase(MPO)as well as flow cytometry analysis.Macrophage migration ability was evaluated by transwell assay.The mRNA levels for cell cycle or inflammation-related genes were measured by quantitative real-time RT-PCR(qPCR).The protein levels of cell proliferation related protein and phosphorylated signal transducer and activator of transcription 3(STAT3)were detected by Western blotting.Results:Ppara^(Mye−/−)mice showed enhanced hepatocyte proliferation and mitosis at 32 h after PHx compared with Ppara^(fl/fl)mice,which was consistent with increased proliferating cell nuclear antigen(Pcna)mRNA and cyclinD1(CYCD1)protein levels in Ppara^(Mye−/−)mice at 32 h after PHx,indicating an accelerated liver regeneration in Ppara^(Mye−/−)mice.IHC staining showed that macrophages and neutrophils were increased in Ppara^(Mye−/−)liver at 32 h after PHx.Livers of Ppara^(Mye−/−)mice also showed an enhanced infiltration of M1 macrophages at 32 h after PHx.In vitro,Ppara-deficient bone marrow-derived macrophages(BMDMs)exhibited markedly enhanced migratory capacity and upregulated M1 genes Il6 and Tnfa but downregulated M2 gene Arg1 expressions.Furthermore,the phosphorylation of STAT3,a key transcript factor mediating IL6-promoted hepatocyte survival and proliferation,was reinforced in the liver of Ppara^(Mye−/−)mice after PHx.Conclusions:This study provides evidence that myeloid PPARαdeficiency accelerates PHx-induced liver regeneration via macrophage polarization and consequent IL-6/STAT3 activation,thus providing a potential target for manipulating liver regeneration. | Guomin Xie Yanting Song Na Li Zhenzhen Zhang Xia Wang Ye Liu Shiyu Jiao Ming Wei Baoqi Yu Yan Wang Hua Wang Aijuan Qu | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 0 |
| 20 | SIDE STREETS AND ALLEYS:HIDDEN HAVENS OF TRANQUILITY显示文摘Aspringtime gradually fades away,signs of summer begin to pop up throughout the capital city.Beijing has many magnificent streets and avenues,but its small and often zigzagging lanes and hutong(alleys)are where much of the unique charm can be found.With the city's economic and social development over the years,its side streets and alleys have become even more attractive than ever before. | Wang Wei Feng Yongguo(Photos) Jin Jianhui(Photos) Lu Shiyue(Photos) Qu Bowei(Photos) | 2021 | Beijing2021，，19： | 0 |
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