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| 1 | Clear mortality gap caused by graft macrosteatosis in Chinese patients after cadaveric liver transplantation显示文摘Background:Liver transplantation(LT)is one of the most effective surgical treatment for patients with end-stage liver disease.Steatosis is a contributor for inferior graft quality.But its impact and safety on transplantation was less assessed in Chinese patients.Methods:Graft steatosis and related information involved in recipients,donors and surgical procedures were retrospectively collected from 239 patients.Results:Donor macrosteatosis(MaS)caused about 2.14 and 2.80 folds of increment on patient and graft mortality.Dose-response analysis revealed prominent risk of grafts on overall patient/organ mortality when MaS content exceeded 10%(P<0.05).Noteworthy,deaths were only observed in MaS group when concurrent with extremely higher post-transplant alanine aminotransferase(ALT,64%).However,microsteatosis(MiS)grafts didn’t affect outcomes after LT.In a cohort of Chinese patients,MaS had comprehensive effects on post-transplant outcomes with relatively lower safety threshold at 10%.Mortality gap caused by MaS grafts was observed in patients with severer ischemia reperfusion injury.Conclusions:Our study revealled the graft MaS affected the post-transplant outcomes in lower risk cutoff in Chinese patients.Further study is worthy to validate these results and investigate inner mechanism under the phenomenon. | Zhengtao Liu Wenchao Wang Li Zhuang Jingfeng Liu Shuping Que Dan Zhu Linfang Dong Jian Yu Lin Zhou Shusen Zheng | 2020 | Hepatobiliary Surgery and Nutrition2020，9，6： | 2 |
| 2 | ABT-263 induces G1/G0-phase arrest, apoptosis and autophagy in human esophageal cancer cells in vitro显示文摘 | Qing-huan LIN Fu-chang QUE Chun-ping GU De-sheng ZHONG Dan ZHOU Yi KONG Le YU Shu-wen LIU | 2017 | Acta Pharmacologica Sinica2017，38，12： | 2 |
| 3 | Pim-3 protects against cardiomyocyte apoptosis in anoxia/reoxygenation injury via p38-mediated signal pathway显示文摘 | Dan Liu Ming He Bo Yi Wu-hua Guo Ai-ling Que Ji-xiang Zhang | 2009 | International Journal of Biochemistry and Cell Biology2009，，11： | 1 |
| 4 | Identification of marker genes associated with N6-methyladenosine and autophagy in ulcerative colitis显示文摘BACKGROUND Both N6-methyladenosine(m6A)methylation and autophagy are considered relevant to the pathogenesis of ulcerative colitis(UC).However,a systematic exploration of the role of the com-bination of m6A methylation and autophagy in UC remains to be performed.AIM To elucidate the autophagy-related genes of m6A with a diagnostic value for UC.METHODS The correlation between m6A-related genes and autophagy-related genes(ARGs)was analyzed.Finally,gene set enrichment analysis(GSEA)was performed on the characteristic genes.Additionally,the expression levels of four characteristic genes were verified in dextran sulfate sodium(DSS)-induced colitis in mice.RESULTS GSEA indicated that BAG3,P4HB and TP53INP2 were involved in the inflammatory response and TNF-αsignalling via nuclear factor kappa-B.Furthermore,polymerase chain reaction results showed significantly higher mRNA levels of BAG3 and P4HB and lower mRNA levels of FMR1 and TP53INP2 in the DSS group compared to the control group.CONCLUSION This study identified four m6A-ARGs that predict the occurrence of UC,thus providing a scientific reference for further studies on the pathogenesis of UC. | Xiao-Yan Liu Dan Qiao Ya-Li Zhang Zi-Xuan Liu You-Lan Chen Ren-Ye Que Hong-Yan Cao Yan-Cheng Dai | 2024 | World Journal of Clinical Cases2024，12，10： | 0 |
| 5 | Paclitaxel-loaded and folic acid-modified PLGA nanomedicine with glutathione response for the treatment of lung cancer显示文摘Targeted delivery and smart response of nanomedicine hold great promise for improving the therapeutic efficacy and alleviating the side effects of chemotherapy agents in cancer treatment.However,availability of only a few studies that discuss organic nanomedicines with these properties limits the development prospects of nanomedicines.In the present study,folic acid(FA)-targeted delivery and glutathione(GSH)smart responsive nanomedicine were rationally designed for pacli-taxel(PTX)delivery for the treatment of lung cancer.Compared with other stimuli-responsive nanomedicines,this nanocarrier was not only sensitive to biologically relevant GSH for on-demand drug release but also biodegradable into biocompatible products after fulfilling its delivery task.The nanomedicine first entered tumor cells via FA and its receptor-mediated endocytosis.After the lysosomal escape,poly(lactic-co-glycolic acid)(PLGA)nanomedicine was triggered by a higher level of GSH and released its cargo into the tumor microenvironment.In vitro and in vivo results revealed that the PLGA nanomedicine not only inhibited the proliferation and promoted the apoptosis of lung cancer cells significantly but also possessed less toxic side effects when compared with free PTX.Therefore,the proposed drug delivery system demonstrates the potential of a multifunctional nano-platform to enhance bioavailability and reduce the side effects of chemotherapy agents. | Wang Yao Jialiang Yao Fangfang Qian Zujun Que Pan Yu Tianle Luo Dan Zheng Zhanxia Zhang Jianhui Tian | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 0 |
| 6 | Single-cell RNA-sequencing combined with bulk RNA-sequencing analysis of peripheral blood reveals the characteristics and key immune cell genes of ulcerative colitis显示文摘BACKGROUND Ulcerative colitis(UC)is a complicated disease caused by the interaction between genetic and environmental factors that affects mucosal homeostasis and triggers an inappropriate immune response.Single-cell RNA sequencing(scRNA-seq)can be used to rapidly obtain the precise gene expression patterns of thousands of cells in the intestine,analyze the characteristics of cells with the same phenotype,and provide new insights into the growth and development of intestinal organs,the clonal evolution of cells,and immune cell changes.These findings can provide new ideas for the diagnosis and treatment of intestinal diseases.To identify clinical phenotypes and biomarkers that can predict the response of UC patients to specific therapeutic drugs and thus aid the diagnosis and treatment of UC.METHODS Using the Gene Expression Omnibus(GEO)database,we analyzed peripheral blood cell subtypes of patients with UC by scRNA-seq combined with bulk RNA sequencing(RNA-seq)to reveal the core genes of UC.We then combined weighted gene correlation network analysis(WGCNA)and least absolute shrinkage and selection operator(LASSO)analysis to reveal diagnostic markers of UC.RESULTS After processing the scRNA-seq data,we obtained data from approximately 24340 cells and identified 17 cell types.Through intercellular communication analysis,we selected monocyte marker genes as the candidate gene set for the prediction model.Construction of a WGCNA coexpression network identified RhoB,cathepsin D(CTSD)and zyxin(ZYX)as core genes.Immune infiltration analysis showed that these three core genes were strongly correlated with immune cells.Functional enrichment analysis showed that the differentially expressed genes were closely related to immune and inflammatory responses,which are associated with many challenges in the diagnosis and treatment of UC.CONCLUSION Through scRNA-seq analysis,LASSO diagnostic model building and WGCNA,we identified RhoB,CTSD and ZYX as core genes of UC that are closely related to monocyte infiltration that may serve as diagnostic markers and molecular targets for UC therapeutic intervention. | Yan-Cheng Dai Dan Qiao Chen-Ye Fang Qiu-Qin Chen Ren-Ye Que Tie-Gang Xiao Lie Zheng Li-Juan Wang Ya-Li Zhang | 2022 | World Journal of Clinical Cases2022，10，33： | 0 |
| 7 | Vapor transport deposition of Sb_(2)Se_(3)thin films for photodetector application显示文摘Antimony selenide is a promising semiconductor with great application potential in the fields of optoelectronic devices.In this work,the vapor transport deposition(VTD)method is employed to prepare Sb_(2)Se_(3)films on substrates.The influence of deposition temperature,distance between the Sb_(2)Se_(3)sources and substrate,and the deposition holding time on the film morphology is investigated in detail.The deposited Sb_(2)Se_(3)thin film is employed to fabricate photodetector with a structure of ITO/SnO_(2)/Sb_(2)Se_(3)/Au,where the spin-coated SnO_(2)film is used as the buffer layer.The device demonstrates relative high responsivity in the range of 300-1000 nm with a maximum value of 312mAW^(-1)at 750 nm. | Sen Wen Xingtian Yin Haixia Xie Yuxiao Guo Jie Liu Dan Liu Wenxiu Que Huan Liu Weiguo Liu | 2020 | Journal of Advanced Dielectrics2020，10，4： | 0 |
| 8 | The behavior of cesium adsorption on zirconyl pyrophosphate显示文摘Zirconyl pyrophosphate(ZrP_2O_7) was prepared and Cs adsorption behavior was studied.Results show that the distribution coefficient of Cs adsorption on ZrP_2O_7 was about 2800 mL/g.Ion exchange capacity of ZrP_2O_7 was0.35 mmol/g.In dynamic tests,Cs can be separated from other fission products very well by ZrP_2O_7.The ZrP_2O_7was stable both at high temperatures and in high concentration of nitric acid.The Cs adsorption by ZrP_2O_7 is a monolayer and chemical adsorption. | feng-li song xiao-wei yang xiao-long li wei he dan lü ji que chun-long zhang shan-gui zhao shi-jun wang yun-tao liu | 2016 | Nuclear Science and Techniques2016，27，3： | 0 |
| 9 | Peutz-Jeghers syndrome: a report of 5 cases显示文摘Peutz-Jeghers syndrome (PJS), also known as hereditary intestinal polyposis syndrome, is an autosomal dominant genetic disease characterized by the development of benign hamartomatous polyps in the gastrointestinal tract and hyperpigmented macules on the lips and oral mucosa. Here, we reported 5 cases of PJS and our experience about its diagnosis and treatment. | Wang Xingwei Fan Chaoqiang Que Dan Guo Hong Wang Lei Ling Xianlong Deng Lei Zhao Xiaoyan | 2011 | Journal of Medical Colleges of PLA(China)2011，26，4： | 0 |
| 10 | Clinicopathological features and expression of regulatory mechanism of the Wnt signaling pathway in colorectal sessile serrated adenomas/polyps with different syndrome types显示文摘BACKGROUND Colorectal cancer(CRC)is the third most common cancer worldwide,with the fourth highest mortality among all cancers.Reportedly,in addition to adenomas,serrated polyps,which account for 15%-30%of CRCs,can also develop into CRCs through the serrated pathway.Sessile serrated adenomas/polyps(SSAs/Ps),a type of serrated polyps,are easily misdiagnosed during endoscopy.AIM To observe the difference in the Wnt signaling pathway expression in SSAs/Ps patients with different syndrome types.METHODS From January 2021 to December 2021,patients with SSAs/Ps were recruited from the Endoscopy Room of Shanghai Traditional Chinese Medicine-Integrated Hospital,affiliated with Shanghai University of Traditional Chinese Medicine.Thirty cases each of large intestine damp-heat(Da-Chang-Shi-Re,DCSR)syndrome and spleen-stomach weakness(Pi-Wei-Xu-Ruo)syndrome were reported.Baseline comparison of the general data,typical tongue coating,colonoscopy findings,and hematoxylin and eosin findings was performed in each group.The expression of the Wnt pathway-related proteins,namelyβ-catenin,adenomatous polyposis coli,and mutated in colorectal cancer,were analyzed using immunohistochemistry.RESULTS Significant differences were observed with respect to the SSAs/Ps size between the two groups of patients with different syndrome types(P=0.001).The other aspects did not differ between the two groups.The Wnt signaling pathway was activated in patients with SSAs/Ps belonging to both groups,which was manifested asβ-catenin protein translocation into the nucleus.However,SSAs/Ps patients with DCSR syndrome had more nucleation,higherβ-catenin expression,and negative regulatory factor(adenomatous polyposis coli and mutated in colorectal cancer)expression(P<0.0001)than SSA/P patients with Pi-Wei-Xu-Ruo syndrome.In addition,the SSA/P size was linearly correlated with the related protein expression.CONCLUSION Patients with DCSR syndrome had a more obvious Wnt signaling pathway activation and a higher risk of carcinogenesis.A high-quality colonoscopic diagnosis was essential.The thorough assessment of clinical diseases can be improved by combining the diseases of Western medicine with the syndromes of traditional Chinese medicine. | Dan Qiao Xiao-Yan Liu Lie Zheng Ya-Li Zhang Ren-Ye Que Bing-Jing Ge Hong-Yan Cao Yan-Cheng Dai | 2023 | World Journal of Clinical Cases2023，11，9： | 0 |
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