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| 1 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 2 | ATR-FTIR: studies of poly ( propylene oxide)/polybutadiene hi-soft segment urethane/urea membranes 显示文摘 | Queiroz D P De Pinho M N Dias C | 2003 | Macromolecules2003，36，11： | 1 |
| 3 | Expression of transcription factors NF-kappaB and AP-1 in nasal polyposis 显示文摘 | Valera FC Queiroz R Scrideli C | 2008 | Clin Exp Allergy2008，38，4： | 1 |
| 4 | Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power显示文摘 | Isabel C F R Ferreira Maria-Jo(a)o R P Queiroz Miguel Vilas-Boas | | 0，，： | 1 |
| 5 | The influence of cul-ture conditions on mycelial structure and eellulase production by Trichoderma reese/Rut C-30显示文摘 | Domingues F C Queiroz J A Cabral J M S | 2000 | Enzyme and Microbial Technolo-gy2000，26，5： | 1 |
| 6 | Adaptive vibration control of an axially moving string 显示文摘 | DE QUEIROZ M S DAWSON D M RAHN C D | 1999 | Journal of Vibration and Acoustics1999，121，1： | 1 |
| 7 | Finite element modeling of composite beams with full and partial shear connection 显示文摘 | Queiroz F D Vellasco P C G S Nethercot D A | 2007 | Journal of Constructional Steel Research2007，63，4： | 1 |
| 8 | Nodal analysis of switched-current filters显示文摘 | DE QUEIROZ A C M PINHEIRO P R M CALDBA L P | 1993 | IEEE Transactions on Circuits And Systems-Ⅱ Analog And Digital Signal Procesing1993，40，1： | 1 |
| 9 | Determination of trace amounts of rare-earth elements in highly pure neodymium oxide by sector field inductively coupled plasma mass spectrometry (ICP-SFMS) and high-performance liquid chromatography(HPLC) techniques显示文摘 | Pedreira W R Sarkis J E S Silva Queiroz C A | 2003 | Journal of Solid State Chemistry2003，171，： | 1 |
| 10 | Heterofueans from Dictyota menstrualis have anticoagulant activity 显示文摘 | ALBUQUERQUE I R Queiroz K C | 2004 | Braz J Med Biol Res2004，37，： | 1 |
| 11 | Geographic distribution of vacA allelic types of Helicobacter pylori显示文摘 | Leen–Jan Van Doorn Céu Figueiredo Francis Mégraud Salvador Pena Peter Midolo Dulciene Maria De Magalh?es Queiroz Fátima Carneiro Bart Vanderborght Maria Da Glória F. Pegado Ricardo Sanna Wink De Boer Peter M. Schneeberger Pelayo Correa Enders K.W. Ng John | 1999 | Gastroenterology1999，，4： | 1 |
| 12 | A Peircean Approach to' Information' and its Relationship with Bateson' s and Jablonka's Ideas显示文摘 | QUEIROZ J EMMECHE C EL-HANI C N | 2008 | The American Journal of Semiotics2008，24，13： | 1 |
| 13 | Analysis of the coffee harvesting process using an electromagnetic shaker 显示文摘 | Santos F L Queiroz D M Pinto F A C | 2010 | Acta Scientiarum Agronomy2010，32，37： | 1 |
| 14 | Identification of pumpkin populations as resistance sources against the Zucchini yellow virus (ZYMV)显示文摘 | Moura M da C C L Zerbini E M da Silva D J H de Queiroz M A | 2005 | Horticultura Brasileira2005，23，： | 1 |
| 15 | Expression of transcription factors NF-κB and AP-1 in nasal polyposis显示文摘 | Valera FCP Queiroz R Scrideli C | 2008 | Clin Exp Allergy2008，38，4： | 1 |
| 16 | Characterizing subpopulations of neoplasic cells in serous effusion 显示文摘 | Queiroz C Barral-Netto M Baechi CE | 2001 | Acta Cytal2001，45，1： | 1 |
| 17 | The effect of magnetic field on ion hydration and sulfate scale formation显示文摘 | Igor B Silva Joao C Queiroz Neto Denise F S Petri | 2015 | Col- loids and Surfaces A: Physicochemical and Engineering Aspects2015，465，1： | 1 |
| 18 | New dihydroalkyl- hexenones from Lannea edulis 显示文摘 | Queiroz E F Kuhl C Terreaux C | 2003 | J Nat Prod2003，66，： | 1 |
| 19 | Comparative study of the expression of cellular cycle proteins in cervical intraepithelial lesions 显示文摘 | Queiroz C Silva TC Alves VA | 2006 | Pathol Res Pract2006，202，10： | 1 |
| 20 | Fractionation oftrichoderma reesei cellulases by hydrophobic interaction chromatography on phenyl-sepharose 显示文摘 | TOMAZ C T QUEIROZ J A | 2004 | Biotechnol Lett2004，26，3： | 1 |
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