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| 1 | Microbiota-host interactions in irritable bowel syndrome: Epithelial barrier, immune regulation and brain-gut interactions显示文摘Irritable bowel syndrome(IBS) is a common, sometimes debilitating, gastrointestinal disorder worldwide. While altered gut motility and sensation, as well as aberrant brain perception of visceral events, are thought to contribute to the genesis of symptoms in IBS, a search for an underlying aetiology has, to date, proven unsuccessful. Recently, attention has been focused on the microbiota as a possible factor in the pathogenesis of IBS. Prompted by a number of clinical observations, such as the recognition of the de novo development of IBS following enteric infections, as well as descriptions of changes in colonic bacterial populations in IBS and supported by clinical responses to interventions, such as antibiotics and probiotics, that modify the microbiota, various approaches have been taken to investigating the microbiota-host response in IBS, as well as in animal models thereof. From such studies a considerable body of evidence has accumulated to indicate the activation or upregulation of both factors involved in bacterial engagement with the host as well host defence mechanisms against bacteria. Alterations in gut barrier function, occurring in response, or in parallel, to changes in the microbiota, have also been widely described and can be seen to play a pivotal role in generating and sustaining host immune responses both within and beyond the gut. In this manner a plausible hypothesis, based on an altered microbiota and/or an aberrant host response, for the pathogenesis, of at least some instances of IBS, can be generated. | Niall P Hyland Eamonn MM Quigley Elizabeth Brint | 2014 | World Journal of Gastroenterology2014，20，27： | 22 |
| 2 | Gastroenterology in developing countries:Issues and advances显示文摘Developing countries shoulder a considerable burden of gastroenterological disease. Infectious diseases in particular cause enormous morbidity and mortality. Diseases which afflict both western and developing countries are often seen in more florid forms in poorer countries. Innovative techniques continuously improve and update gastroenterological practice. However, advances in diagnosis and treatment which are commonplace in the West, have yet to reach many developing countries. Clinical guidelines, based on these advances and collated in resource-rich environments,lose their relevance outside these settings. In this two-part review, we first highlight the global burden of gastroenterological disease in three major areas: diarrhoeal diseases, hepatitis B, and Helicobacter pylori . Recent progress in their management is explored, with consideration of future solutions. The second part of the review focuses on the delivery of clinical services in developing countries. Inadequate numbers of healthcare workers hamper efforts to combat gastroenterological disease. Reasons for this shortage are examined, along with possibilities for increased specialist training. Endoscopy services, the mainstay of gastroenterology in the West, are in their infancy in many developing countries. The challenges faced by those setting up a service are illustrated by the example of a Nigerian endoscopy unit. Finally, we highlight the limited scope of many clinical guidelines produced in western countries. Guidelines which take account of resource limitations in the form of 'cascades' are advocated in order to make these guidelines truly global. Recognition of the different working conditions facing practitioners worldwide is an important step towards narrowing the gap between gastroenterology in rich and poor countries. | Kate L Mandeville Justus Krabshuis Nimzing Gwamzhi Ladep Chris JJ Mulder Eamonn MM Quigley Shahid A Khan | 2009 | World Journal of Gastroenterology2009，15，23： | 8 |
| 3 | Changing face of irritable bowel syndrome显示文摘最近的年在我们急躁的肠症候群(IBS ) 的理解见证巨大的进步。这是在个人并且为折磨的个人的社会工作与重要症状和缺陷联系的真正全球的疾病,是明显的。在我们内脏 flora-mucosal 相互作用,伤寒神经系统和大脑勇气轴的理解的进展至少在 IBS 在症状的致病导致了实质的进步并且向这混乱的基本病原学提供了一些提示,在一些潜水艇人口。我们盼望治疗将针对病理生理学并且也许的一时间,甚至到主要病原学。同时,一个模型基于为肠的发炎的一个主要角色服役集成各种各样的海滨,它贡献 IBS 的演讲。 | Eamonn MM Quigley | 2006 | World Journal of Gastroenterology2006，12，1： | 6 |
| 4 | CD52 expression in hairy cell leukemia显示文摘 | Quigley MM Bethel KJ Sharpe RW | 2003 | Am J Hematol2003，74，： | 1 |
| 5 | The study of gemcitabine in combination with other chemotherapeutic agents as an effective treatment for prostate cancer 显示文摘 | Muenchen HJ Quigley MM Pilat MJ | 2000 | Anticancer Res2000，20，2： | 1 |
| 6 | Simultaneous electromyography and manometry of the anal sphincters in parkinsonian patients:technical considerations显示文摘 | Normand MM Ashraf W Quigley EM | 1996 | Muscle Nerve1996，19，1： | 1 |
| 7 | Masquerade without a mass: an unusual cause of severe acute pancreatitis显示文摘 | To CA Quigley MM Saven A | 2013 | J Gastrointest Oncol2013，4，1： | 1 |
| 8 | IL6 suppression provides renal protection independent of blood pressure in a murine model of salt-sensitive hypertension显示文摘 | Manhiani MM Quigley JE Socha MJ | 2005 | Kidney Blood Press Res2005，30，4： | 1 |
| 9 | Dyspepsia显示文摘 | Eamonn MM Quigley John Keohane | 2008 | Current Opinion in Gastroenterology2008，，6： | 1 |
| 10 | CD52 expression in hairy cell leukemia显示文摘 | Quigley MM Bethel KJ Sharpe RW | 2003 | Am J Hematol2003，74，4： | 1 |
| 11 | Prostate tumor alignment and continuous, real-time adaptive radiation therapy using electromagnetic fiducials: Clinical and cost-utility analyses显示文摘 | Quigley MM Mate TP Sylvester JE | 2009 | Urol Oncol2009，27，5： | 1 |
| 12 | IL6 suppression provides renal protection independent of blood pressure in a murine model of salt-sensitive hypertension 显示文摘 | Manhiani MM Quigley JE Soeha MJ | 2007 | Kidney Blood Press Res2007，30，4： | 1 |
| 13 | The study of gemcitabine in combination with other chemotherapeutic agents as an effective treatment for prostate cancer 显示文摘 | Muenchen HJ Quigley MM Pilat MJ | 2000 | Anticancer Res2000，20，2： | 1 |
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