|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 依那西普对银屑病患者疲劳和抑郁症状的临床疗效:一项双盲、随机、安慰剂对照、III期试验显示文摘Background: Psoriasis has substantial psychological and emotional effects. We assessed the effect of etanercept, an effective treatment for the clinical symptoms of psoriasis, on fatigue and symptoms of depression associated with the condition. Methods: 618 patients with moderate to severe psoriasis received double-blind treatment with placebo or 50 mg twice-weekly etanercept. The primary efficacy endpoint was a 75% or greater improvement from baseline in psoriasis area and severity index score (PASI 75) at week 12. Secondary and other endpoints included the functional assessment of chronic illness therapy fatigue (FACIT-F) scale, the Hamilton rating scale for depression (Ham-D), the Beck depression inventory (BDI), and adverse events. Efficacy analyses were based on the allocated treatment. Analyses and summaries of safety data were based on the actual treatment received. This study is registered with ClinicalTrials.gov with the identifier NCT00111449. Findings: 47% (147 of 311) of patients achieved PASI 75 at week 12, compared with 5% (15 of 306) of those receiving placebo (p< 0.0001; difference 42% , 95% CI 36- 48). Greater proportions of patients receiving etanercept had at least a 50% improvement in Ham-D or BDI at week 12 compared with the placebo group; patients treated with etanercept also had significant and clinically meaningful improvements in fatigue (mean FACIT-F improvement 5.0 vs 1.9; p< 0.0001, difference 3.0, 95% CI 1.6- 4.5). Improvements in fatigue were correlated with decreasing joint pain, whereas improvements in symptoms of depression were less correlated with objective measures of skin clearance or joint pain. Interpretation: Etanercept treatment might relieve fatigue and symptoms of depression associated with this chronic disease. | Tyring S. Gottlieb A. Papp K. R. Krishnan 王琼(译) | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，3： | 4 |
| 2 | Growth, Optical, Mechanical, Dielectric and Theoretical Studies on Potassium Pentaborate Tetrahydrate (KB_5O_8·4H_2O) Single Crystal by Modified Sankaranarayanan-Ramasamy Method显示文摘A nonlinear optical single crystal of potassium pentaborate tetrahydrate (KB5O8·4H2O) has been grown from aqueous solution by using unidirectional crystal growth method of Sankaranarayanan-Ramasamy (SR) with a due modification in the growth assembly. Potassium pentaborate crystal of 60 mm length and 10 mm diameter has been grown along (100) plane with a growth rate of 3 mm per day within a period of 20 days. The grown crystal was subjected to single crystal X-ray diffraction analysis to confirm that the crystal belongs to the orthorhombic system. Some fundamental data such as valance electron plasma energy, Penn gap, Fermi energy and electronic polarizability of the grown crystal were calculated. The presence of borate in the grown crystal was confirmed by Fourier transform infrared (FTIR) spectroscopy. The optical transmission property of the grown crystal was analyzed using ultra violet (UV) visible spectral analysis. Surface morphology of the growth plane was observed using scanning electron microscopy (SEM). The mechanical strength of the crystals was found out using Vickers microhardness test along the growth axis. Frequency dependent dielectric constant of the grown crystal was studied for various temperatures along (100) plane. | C. Justin Raj S. Krishnan S. Dinakaran J. Mary Linet R. Uthrakumar R. Robert S. Jerome Das | 2009 | Journal of Materials Science & Technology2009，25，6： | 2 |
| 3 | Factor-analytic study of the Yale Global Tic Severity Scale显示文摘 | Eric A. Storch Tanya K. Murphy Melanie Fernandez Mohan Krishnan Gary R. Geffken Ashley R. Kellgren Wayne K. Goodman | 2006 | Psychiatry Research2006，，1： | 1 |
| 4 | Preparation of sol-gel-derived Ca1?x Sr x ZrO3 perovskite dielectric thin films显示文摘 | T. Yu C. H. Chen Y. K. Lu X. F. Chen W. Zhu R. G. Krishnan | 2007 | Journal of Electroceramics (-)2007，，1： | 1 |
| 5 | High mobility group box protein‐1 promotes cerebral edema after traumatic brain injury via activation of toll‐like receptor 4显示文摘 | Melissa D. Laird Jessica S. Shields Sangeetha Sukumari‐Ramesh Donald E. Kimbler R. David Fessler Basheer Shakir Patrick Youssef Nathan Yanasak John R. Vender Krishnan M. Dhandapani | 2014 | Glia2014，，1： | 1 |
| 6 | A hybrid finite element model for simulation of electromagnetic acoustic transducer (EMAT) based plate waves显示文摘 | R. Dhayalan Krishnan Balasubramaniam | 2010 | NDT and E International2010，，6： | 1 |
| 7 | Photocatalytic production of hydrogen from electrodeposited p - Cu 2 O film and sacrificial electron donors显示文摘 | Sashikala Somasundaram C. Raman Nair Chenthamarakshan Norma R. de Tacconi Krishnan Rajeshwar | 2007 | International Journal of Hydrogen Energy2007，，： | 1 |
| 8 | Adsorption of Reactive Dye on Chitin显示文摘 | G. Annadurai M. Chellapandian M. R. V. Krishnan | 1999 | Environmental Monitoring and Assessment1999，，1： | 1 |
| 9 | Effect of low-dose omega-3 fatty acids substitution on blood pressure, hyperinsulinemia and dyslipidemia in Indians with essential hypertension: A pilot study显示文摘 | A. Bhise P. V. Krishnan R. Aggarwal M. Gaiha J. Bhattacharjee | 2005 | Indian Journal of Clinical Biochemistry2005，，2： | 1 |
| 10 | Fenretinide Induces Ubiquitin‐Dependent Proteasomal Degradation of Stearoyl‐CoA Desaturase in Human Retinal Pigment Epithelial Cells显示文摘 | William Samuel R. Krishnan Kutty Todd Duncan Camasamudram Vijayasarathy Bryan C. Kuo Krysten M. Chapa T. Michael Redmond | 2014 | J. Cell. Physiol2014，，8： | 1 |
| 11 | Iontophoretic skin permeation of peptides: an investigation into the influence of molecular properties, iontophoretic conditions and formulation parameters显示文摘 | Gayathri Krishnan Michael S. Roberts Jeffrey Grice Yuri G. Anissimov Hamid R. Moghimi Heather A. E. Benson | 2014 | Drug Delivery and Translational Research2014，，3： | 1 |
| 12 | Thermoelasticity, pseudoelasticity and the memory effects associated with martensitic transformations显示文摘 | H. Warlimont L. Delaey R. V. Krishnan H. Tas | 1974 | Journal of Materials Science1974，，9： | 1 |
| 13 | Greater MRI lesion volumes in elderly depressed subjects than in control subjects显示文摘 | Warren D. Taylor James R. MacFall Martha E. Payne Douglas R. McQuoid David C. Steffens James M. Provenzale Ranga Rama Krishnan | 2005 | Psychiatry Research: Neuroimaging2005，，： | 1 |
| 14 | Analysis of bovine serum albumin adsorption on calcium phosphate and titanium surfaces显示文摘 | Haitong Zeng Krishnan K. Chittur William R. Lacefield | 1999 | Biomaterials1999，，4： | 1 |
| 15 | Synthesis of a non-linear feedback system with significant plant-ignorance for prescribed system tolerances显示文摘 | K. R. Krishnan I. M. Horowitz | 1974 | International Journal of Control1974，，4： | 1 |
| 16 | Internet banking services and credit union performance显示文摘 | Krishnan Dandapani Gordon V. Karels Edward R. Lawrence | 2008 | Managerial Finance2008，，6： | 1 |
| 17 | O057 : Long-term follow-up of treatment-emergent resistance-associated variants in NS3, NS5A and NS5B with paritaprevir/r-, ombitasvir- and dasabuvir-based regimens显示文摘 | P. Krishnan R. Tripathi G. Schnell T. Reisch J. Beyer T. Dekhtyar M. Irvin W. Xie L. Larsen T. Podsadecki T. Pilot-Matias C. Collins | 2015 | Journal of Hepatology2015，，： | 1 |
| 18 | Thermoelasticity, pseudoelasticity and the memory effects associated with martensitic transformations显示文摘 | L. Delaey R. V. Krishnan H. Tas H. Warlimont | 1974 | Journal of Materials Science1974，，9： | 1 |
| 19 | Immunochemical studies on the role of the Golgi complex in protein-body formation in rice seeds显示文摘 | H. B. Krishnan V. R. Franceschi T. W. Okita | 1986 | Planta1986，，4： | 1 |
| 20 | Incorporation of blast resistance into “PRR78”, an elite Basmati rice restorer line, through marker assisted backcross breeding显示文摘 | Vikas K. Singh Atul Singh S.P. Singh Ranjith K. Ellur Vikas Choudhary S. Sarkel Devinder Singh S. Gopala Krishnan M. Nagarajan K.K. Vinod U.D. Singh R. Rathore S.K. Prashanthi P.K. Agrawal J.C. Bhatt T. Mohapatra K.V. Prabhu A.K. Singh | 2011 | Field Crops Research2011，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员