| 3 | Exploring the potential of porous silicas as a carrier system for dissolution rate enhancement of artemether显示文摘Malaria is a parasitic and vector determined blood-conceived infectious disease transmitted through infected mosquitoes. Anti-malarial drug resistance is a major health problem, which hinders the control of malaria. A Results of a survey of drug-resistant malaria demonstrated safe proclivity to nearby all anti-malarial regimes accessible except from artemisinin and its derivatives. Artemether is a BCS class IV drug effective against acute and severe falciparum malaria;hence there is a strong need to improve its solubility. Silica is one of the most widely studied excipients. Silica can be used in solubility enhancement by preparing its solid solution/dispersion with the drug. The objective of this research was to improve dissolution rate of Artemether using non-precipitated porous silica(Aeroperl 300 Pharma) and precipitated silica like EXP. 9555, EXP. 9560, and EXP. 9565. Specific surface area calculated from BET method of porous silicas viz. APL 300(A), Exp. 9555(B), Exp. 9560(C), Exp. 9565(D) was found to be 294.13 m^2/g(A), 256.02 m^2/g(B), 213.62 m^2/g(C) and 207.22 m^2/g(D) respectively.The drug release from the developed formulation was found to be significantly higher as compared to neat ARM. This improved solubility and release kinetics of ARM may be attributed to high surface area, improved wettability and decreased crystallinity. Solid-state characterization of the developed optimized formulation F3 was carried out with respect to FTIR chemical imaging, XRD,SEM, and DSC. All the porous silicas which we have explored in the present context showed a significant capability as a carrier for solubility enhancement of ARM. | Jaywant N.Pawar Harita R.Desai Kailas K.Moravkar Deepak K.Khanna Purnima D.Amin | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，6： | 0 |
| 4 | Clinical features and management of ureteric stump syndrome:Single-centre experience and contemporary literature review显示文摘Dear editor,“Ureteric stump syndrome(USS)”is a rare entity(incidence 0.8%–1.0%)with left-over in situ distal-ureter being the culprit[[1],[2],[3]].The presentation may be recurrent urinary tract infection(UTI),flank/abdominal pain,or hematuria[1,4].Although only few of the patients require intervention(approximately 1.1%–10%)[[1],[2],[3]],either with open excision of the stump[[1],[2],[3]]or via minimally invasive endoscopic approach[5,6],prompt diagnosis is often delayed.During simple nephrectomy,dilemma exists whether to consider concomitant total ureterectomy to eliminate the future risk of USS[4],or to consider subtotal-ureterectomy along with nephrectomy[[1],[2],[3]].In this letter,we present a retrospective analysis of clinical presentation,diagnostic approach,and management of three patients of USS(Table 1)treated at our centre and try to solve all these dilemmas. | Krishnendu Biswas Abhishek G.Singh Arvind P.Ganpule Ravindra B.Sabnis Mahesh R.Desai | 2022 | Asian Journal of Urology2022，9，2： | 0 |
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