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1篇 您的检索式：作者名="R.Lyle Hood"

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		题名	作者	年代	出处	被引量
	1	Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device显示文摘Convection-enhanced delivery(CED) is a promis ing technique leveraging pressure-driven flow to increase penetration of infused drugs into interstitial spaces. We have developed a fiberoptic microneedle device for inducing local sub-lethal hyperthermia to further improve CED drug distribution volumes, and this study seeks to quantitatively characterize this approach in agarose tissue phantoms. Infusions of dye were conducted in 0.6%(w/w) agarose tissue phantoms with isothermal conditions at 15 °C, 20 °C, 25 °C, and 30 °C. Infusion metrics were quantifled using a custom shadowgraphy setup and imageprocessing algorithm. These data were used to build an empirical predictive temporal model of distribution volume as a function of phantom temperature. A second set of proof of-concept experiments was conducted to evaluate a novel fiberoptic device capable of generating local photothermal heating during fluid infusion. The isothermal infusions showed a positive correlation between temperature and distribution volume, with the volume at 30 °C showing a 7-fold increase at 100 min over the 15 °C isothermal case. Infusions during photothermal heating(1064 nm at 500 mW) showed a similar eff ect with a 3.5-fold increase at 4 h over the control(0 mW). These results and analyses serve to provide insight into and characterization of heat-mediated enhancement of volumetric dispersal.	R.Lyle Hood Rudy T.Andriani Tobias E.Ecker John L.Robertson Christopher G.Rylander	2015	Engineering2015，1，3：	2

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