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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Evaluation the reinforcing effects of choice in comparison to reinforcement rate 显示文摘 | Rachel H T Wayne W F Stephanie A C | 1998 | Research in Developmental Disabilities1998，19，2： | 1 |
| 3 | Evaluation the reinforcing effects of choice in comparison to reinforcement rate显示文摘 | Rachel H T Wayne W F Stephanie A C | 1998 | Research in Developmental Disabilities1998，19，2： | 1 |
| 4 | Prevalence of and Risk Factors for Hepatic Steatosis and Nonalcoholic Fatty Liver Disease in People With Type 2 Diabetes: the Edinburgh Type 2 Diabetes Study显示文摘 | Williamson Rachel M Price Jackie F Glancy Stephen Perry Elisa Nee Lisa D Hayes Peter C Frier Brian M Van Look Liesbeth A F Johnston Geoffrey I Reynolds Rebecca M Strachan Mark W J | 2011 | Diabetes Care2011，，5： | 1 |
| 5 | Rapid and sensi- tive liquid chromatography-tandem mass spectrometry for the quantitation of epirubicin and identification of metabo- lites in biological samples 显示文摘 | Rachel W Gillian MM John C | 2007 | Talanta2007，72，4： | 1 |
| 6 | In vitro fermentation properties of selected fructooligosaccharide-containing vegetables and in vivo colonic microbial populations are affected by the diets of healthy human infants显示文摘 | ELIZABETH A F TERRY F H RACHELL C W | 2002 | Human Nutrition and Metabolism2002，132，8： | 1 |
| 7 | Optimizing Timetable Synchronization for Rail Mass Transit 显示文摘 | RACHEL C W TONY W Y KWOK W F | 2008 | Transportation Science2008，42，1： | 1 |
| 8 | Safety reporting in randomized trials of mental health interventions显示文摘 | Panagiotis N P Rachel C Kristian W | 2004 | Am J Psychiatry2004，161，： | 1 |
| 9 | Evaluation the Reinforcing Effects of Choice in Comparison to Reinforcement Rate 显示文摘 | RACHEL HT WAYNE W F STEPHANIE A C | 1998 | Research in Developmental Disabilities1998，19，2： | 1 |
| 10 | 'Reauirements capture': theory and practice 显示文摘 | RACHEL C ANDREW B W | 1998 | Technovation1998，18，8： | 1 |
| 11 | Requirements capture: theory and practice 显示文摘 | Rachel C Andrew B W | 1998 | Technovation1998，18，89： | 1 |
| 12 | Optimizing timetable synchronization for rail mass transit显示文摘 | Wong Rachel C W Yuen Tony W Y Fung Kwok Wah | 2008 | Transportation Science2008，42，1： | 1 |
| 13 | Clonogenicity of human endometrial epithelial and stromal cells显示文摘 | RACHEL W S C KJIANA ES CAROLINE E G | 2004 | Biology of Reproduction2004，70，： | 1 |
| 14 | Pantonvalentine leukocidin-positive methicillin-resistant staphylococcus au reus lung infection in patients with cystic fibrosis显示文摘 | Arnon Elizur Rachel C Orscheln Thomas W Ferkol | 2007 | Chest2007，131，6： | 1 |
| 15 | Requirements capture: theory and practice显示文摘 | RACHEL C ANDREW B W | 1998 | Technovation1998，18，89： | 1 |
| 16 | Optimizing Timetable Synchronization for Rail Mass Transit 显示文摘 | Rachel C W Wong Tony W Y Yuen Kwok Wab Fung Janny M Y Leung | 2008 | Transportation Science2008，42，1： | 1 |
| 17 | Protein Inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life显示文摘 | Kelly A W Rachel K Heather C | 2004 | Molecular and Cellular Biology2004，24，12： | 1 |
| 18 | Optimizing time table synchronization for rail mass transit显示文摘 | Wong Rachel C W Yuen Tony W Y Fung Kwokwah | 2008 | Transportion Science2008，42，1： | 1 |
| 19 | Mating type-specific cell-cell recognition of Saccharomyces cerevisiae: cell wall attachment and active sites of a-and alpha-agglutinin 显示文摘 | Cappellaro C Baldermann C Rachel R Tanner W | 1994 | EMBO J (S0261-4189)1994，13，20： | 1 |
| 20 | Leung,Optimizing timetable synchronization for rail mass transit显示文摘 | Rachel C W Wong Tony W Y Yuen Kwok Wah Fung | 2008 | Transportation Science2008，42，1： | 1 |
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