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| 1 | Diagnosis of Crohn's disease in India where tuberculosis is widely prevalent显示文摘AIM:To define the parameters that positively predict diagnosis of Crohn's disease (CD) and differentiate it from gastrointestinal tuberculosis (GITB). METHODS:This prospective study over 3 years was carried out in the consecutive Indian patients with definite diagnosis of CD and equal numbers of patients with definite diagnosis of GITB. Demographic, clinical, laboratory, morphological and histological features were noted in all the patients. Serological tests such as p-ANCA, c-ANCA, IgA ASCA and IgG ASCA, were performed. Endoscopic biopsy and/or surgical tissue specimens were subjected to smear and culture for acid-fast bacilli (AFB) and tissue polymerase chain reaction for tuberculosis (TB PCR). Diagnosis of CD and GITB was based on the standard criteria. Data were analyzed using univariate Chi-square test and multiple logistic regression (MLR). RESULTS:The study is comprised of 26 patients with CD (age 36.6 ± 8.6 year, male:female, 16:10) and 26 patients with GITB (age 37.2 ± 9.6 year, male:female, 15:11). The following clinical variables between the two groups (CD vs TB) were significant in univariate analysis:duration of symptoms (58.1 ± 9.8 vs 7.2 ± 3.4 mo), diarrhoea (69.2% vs 34.6%), bleeding per rectum (30.7% vs 3.8%), fever (23.1% vs 69.2%), ascites (7.7% vs 34.6%) and extra-intestinal manifestations of inflammatory bowel disease (61.5% vs 23.1%). Of these, all except ascites and extra-colonic manifestations were found statistically significant by MLR. Accuracy of predicting CD was 84.62% based on the fever, bleeding P/R, diarrhoea and duration of symptoms while it was 63.4% when histology was reported as inflammatory bowel disease and 42.3% when there was recurrence of disease after surgery. Accuracy of predicting GITB was 73.1% when there was co-existing pulmonary lesions and/or abdominal lymphadenopathy;75% when tuberculosis was reported in histology;63.4% when granuloma was found in histology;82.6% when TB PCR was positive;and 61.5% when smear and/ or culture was positive for AFB. Serological test was not useful in differentiation of CD from GITB. Positivity rates for CD and GITB were:p-ANCA-3.8% and 3.8%, c-ANCA-3.8% and 0%, IgA ASCA-38.4% and 23.1%, and IgG ASCA-38.4% and 42.3%, respectively. CONCLUSION:Simple clinical parameters like fever, bleeding P/R, diarrhoea and duration of symptoms have the highest accuracy in differentiating CD from GITB. | Deepak N Amarapurkar Nikhil D Patel Priyamvada S Rane | 2008 | World Journal of Gastroenterology2008，14，5： | 24 |
| 2 | In vivo toxicity screening programs using metabonomics显示文摘 | Robosky LC Robertson DG Baker DJ Rane S Reily MD | 2002 | Comb Chem High Throughput Screen2002，5，8： | 2 |
| 3 | High temperature index for field evalua tion of heat tolerance in wheat varieties 显示文摘 | Rane J Nagarajan S | 2004 | Agricultural Systems2004，79，2： | 1 |
| 4 | Efficient Prins cyclization in environmentally benign method using ion exchange re- sin catalyst显示文摘 | More G P Rane M Bhat S V | 2012 | Green Chem Lett Rev2012，5，1： | 1 |
| 5 | MicroRNA with a macrofunction 显示文摘 | Rane S Sayed D Abdellatif M | 2007 | Cell Cycle2007，6，15： | 1 |
| 6 | The feasibility of singleport laparoscopic chnlecystectomy: a pilot study of 20 cases显示文摘 | Ran P P Bhagwat S M Rane A | 2008 | HPB ( Oxford )2008，10，5： | 1 |
| 7 | Water-to-water heat transfer in tube-tube heat exchanger-experimental and analytical study显示文摘 | Milind V Rane Madhukar S Tandale | 2005 | Applied Thermal Engineering2005，25，： | 1 |
| 8 | Influence of surfactants treatment on silver powder and its thick films 显示文摘 | RANE S B SETH T PHATAK G J | 2003 | Mater Lett2003，57，20： | 1 |
| 9 | MicroRNA-21targets Sprouty2and promotes cellular outgrowths显示文摘 | Sayed D Rane S Lypowy J | 2008 | Mol Biol Cell2008，19，8： | 1 |
| 10 | Downregulation of miR-1 9 9 a derepresses hypoxia-inducible factor-1 alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes显示文摘 | RANE S HE M SAYED D | 2009 | Circ Res2009，104，7： | 1 |
| 11 | Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes显示文摘 | Rane S He M Sayed D | 2009 | Circ Res2009，104，7： | 1 |
| 12 | Clinical evaluation of a novel laparoscopic port (R-port ) and e- volution of the single laparoscopic port procedure (SLiPP)显示文摘 | Rane A Kommu S Eddy B Abe C Bonkat G Reich O | 2007 | J Endourol2007，21，1： | 1 |
| 13 | Effect of inorganic binders on the properties of silver thick films 显示文摘 | RANE S B SETH T PHATAK G J | 2004 | J Mater Sci: Mater Electron2004，15，： | 1 |
| 14 | Effect of inorganic binders on the properties of silver thick films显示文摘 | Rane S B Seth T Phatak G J | 2004 | Materials in Electronics2004，15，： | 1 |
| 15 | An antagonism between the AKT and beta-adrenergic signaling pathways mediatedthrough their reciprocal effects on miR-199a-5p 显示文摘 | Rane S He M Sayed D | 2010 | CEL- LULAR SIGNALLING2010，22，7： | 1 |
| 16 | MicroRNA-21 tar- gets sprouty2 and promotes cellular outgrowths 显示文摘 | SAYED D RANE S LYPOWY J | 2008 | Mol Biol Cell2008，19，： | 1 |
| 17 | Characterization of the abnormal pancreatic development,reduced growth and infertility in Cdk4 mutant mice显示文摘 | Mettus R V Rane S G | 2003 | Oncogene2003，22，52： | 1 |
| 18 | Relationship ofbeta-catenin and postchemotherapy histopathologic changes with overall survival in patients with hepatoblastoma 显示文摘 | Gupta K Rane S Das A | 2012 | J Pediatr Hematol Oncol2012，34，8： | 1 |
| 19 | Morphological study of HDPE blown films by SAXS, SEM and TEM: a relationship between the melt elasticity parameter and lameUae orientation 显示文摘 | Prasad A Shroff R Rane S | 2001 | Polymer2001，42，： | 1 |
| 20 | Distributed Video Coding 显示文摘 | GIROD B AARON A RANE S et ol | 2005 | Proceedings of IEEE2005，93，1： | 1 |
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