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| 1 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 2 | Regularization of Po-functions in box variational inequality problem显示文摘 | Ravindran G Gowda M S | 2000 | SIAM J Optim2000，11，： | 1 |
| 3 | Influence of microbial phytase on apparent ileal aminl acid digestibility of feedstuffs for broilers显示文摘 | Ravindran V Cabahug S Ravindran G | 1999 | Poult Sci1999，78，： | 1 |
| 4 | Nutritional assessment of yam (Dioscorea alata) tubers显示文摘 | Wanasundera J P Ravindran G | 1994 | Plant Food Hum Nutr1994，46，： | 1 |
| 5 | Analysis of complications in 1000 cases of posterior chamber intraocular lens implantation显示文摘 | Sudhakar J Ravindran RD Natchiar G | 1989 | Indian J Ophthalmol1989，37，1： | 1 |
| 6 | Seed protein of millets:amino acid composition,proteinase inhibitors and in-vitro protein digestibility显示文摘 | Ravindran G | 1992 | Food Chemistry1992，44，1： | 1 |
| 7 | Influence of particle size and xylanase supplementation on the performance, energy utilisation, digestive tract parameters and digesta viscosity of broiler starters显示文摘 | Amerah A M Ravindran V Lentle R G | 2008 | Br Poult Sci2008，49，4： | 1 |
| 8 | Microbial phytase improves performance, apparent metabolisable energy and ileal amino acid digestibility of broilers fed a lysine-deficient diet显示文摘 | Ravindran V Selle P H Ravindran G | 2001 | Poult Sci2001，80，： | 1 |
| 9 | Ground-state properties and relative stability between the LIO2 and DO, phases of Ni3Al by Nb substitution显示文摘 | RAVINDRAN P SUBRAMONIAM G ASOKAMANI R | 1996 | Phys Rev B1996，53，3： | 1 |
| 10 | Aberrant expression of CD133 and musashi-1 in preneoplastic and neoplastic human oral squamous epithelium and their correlation with clinicopathological factors显示文摘 | Ravindran G Devaraj H | | 0，，08： | 1 |
| 11 | In- fluence of whole wheat feeding on the development of gastrointestinal tract and performance of broiler chick- ens 显示文摘 | RAVINDRAN V WU Y B THOMAS D G | 2006 | Australian Journal of Agricultural Research2006，57，1： | 1 |
| 12 | Studies On millets:Proximate composition,min-eral composition,and phytate and oxalate contents显示文摘 | Ravindran G | 1991 | Food Chemistry1991，39，1： | 1 |
| 13 | Cutaneous manifes- tations of internal malignancy显示文摘 | Ayyamperumal A Tharini G Ravindran V | 2012 | Indian J Dermatol2012，57，4： | 1 |
| 14 | In- fluence of feed particle size on the performance, en- ergyutilization,digestive tract development, and di- gesta parameters of broiler starters fed wheat - or corn - based diets 显示文摘 | Amerah A M Ravindran V Lentle R G | 2008 | Poultry Science2008，，87： | 1 |
| 15 | Influence of method of whole wheat inclusion and xylanase supplementation on the performance,apparent metabolisable energy,digestive tract measurements and gut morphology of broilers显示文摘 | WU Y B RAVINDRAN V THOMAS D G | 2004 | British Poultry Science2004，45，3： | 1 |
| 16 | Influence of particle size on the performance, digesta characteristics and energy utilisation of broilers fed maize and wheat based diets 显示文摘 | Amerah A M Ravindran V Lentle R G | 2007 | Proceedings of the Australian Poultry Science Symposium2007，，19： | 1 |
| 17 | Intelligent decision making in multi-agent robot soccer system through compounded artificial neural networks显示文摘 | Jolly K G Ravindran K P Vijayakumar R | 2007 | Robotics and Autonomous Systems2007，55，7： | 1 |
| 18 | Influence of xylanase supplementation on the apparent metabolizable energy and ileal amino acid digestibility in a diet containing wheat and oats, and on the per- formance of three strains of broiler chickens 显示文摘 | RAVINDRAN V HEW L I RAVINDRAN G | 1999 | Aus- tralian Journal of Agricultural Research1999，50，7： | 1 |
| 19 | Assessment of pluripotency and multilineage differentiation potentialof NTERA-2 cells as a model for studying human embryonic stem cells Cell Prolif 显示文摘 | Pal R Ravindran G | 2006 | 39(6):585-5982006，39，6： | 1 |
| 20 | Feed particle size:implications on the digestion and performance of poultry显示文摘 | AMERAH A M RAVINDRAN V LENTLE R G | 2007 | World’s Poultry Science Journal2007，63，3： | 1 |
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