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| 1 | Diabetic neuropathic pain:Physiopathology and treatment显示文摘Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes,which affects over 90% of the diabetic patients.Although pain is one of the main symptoms of diabetic neuropathy,its pathophysiological mechanisms are not yet fully known.It is widely accepted that the toxic effects of hyperglycemia play an important role in the development of this complication,but several other hypotheses have been postulated.The management of diabetic neuropathic pain consists basically in excluding other causes of painful peripheral neuropathy,improving glycemic control as a prophylactic therapy and using medications to alleviate pain.First line drugs for pain relief include anticonvulsants,such as pregabalin and gabapentin and antidepressants,especial y those that act to inhibit the reuptake of serotonin and noradrenaline.In addition,there is experimental and clinical evidence that opioids can be helpful in pain control,mainly if associated with first line drugs.Other agents,including for topical application,such as capsaicin cream and lidocaine patches,have also been proposed to be useful as adjuvants in the control of diabetic neuropathic pain,but the clinical evidence is insufficient to support their use.In conclusion,a better understanding of the mechanisms underlying diabetic neuropathic pain will contribute to the search of new therapies,but also to the improvement of the guidelines to optimize pain control with the drugs currently available. | Anne K Schreiber Carina FM Nones Renata C Reis Juliana G Chichorro Joice M Cunha | 2015 | World Journal of Diabetes2015，6，3： | 34 |
| 2 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 3 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 4 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 5 | Degradation of chitosan and starch by 360kHz ultrasound显示文摘 | Renata C B Bozena R Salah L | 2005 | Carbohydrate Polymers2005，60，2： | 1 |
| 6 | Carotid Artery Stenosis:Intraindividual Correlations of 3D Time-of flight MR Angiography, Contrast-enhanced MR Angiography, Conventional DSA, and Rotational Angiography for Detection and Grading显示文摘 | Anzalone N Scomazzoni F Renata C | 2005 | Radiology2005，236，1： | 1 |
| 7 | Analysis of a hydrometallurgical route to recover base metals from spent re- chargeable batteries by liquid-liquid extraction with Cyanex 272 显示文摘 | DANUZA P M GERMANO D RENATA C A E | 2006 | Journal of Power Source2006，159，2： | 1 |
| 8 | Isolation of a lectin and a galactoxyloglucan from Mucuna sloanei seeds显示文摘 | DANIELE M A TEIXEIRA-S(A) FANY REICHER BRAGA RENATA C | 2009 | Phytochemistry2009，70，1718： | 1 |
| 9 | On line identification of further flavones C- and O- glycosides from sugarcane by HPLC- UV-MS 显示文摘 | Renata C Janete HY Emerson FQ | 2006 | Phytochem Analysis2006，17，5： | 1 |
| 10 | Ventilator associated pneumoniain an adult clinical surgical intensive care unit of a brazilian university hospital:incidence,risk factors,etiology,and antibiotic resistance显示文摘 | Laurade A Carolina V Renata C | | 0，，01： | 1 |
| 11 | Biomechanical puplping with whiterot fungi显示文摘 | SETLIFF E C RENATA MARTON GRANZOW S G | 1990 | Tappi J1990，73，14： | 1 |
| 12 | High - resolution genotypie analysis of the genus Aeromonas by AFLP finger- printing 显示文摘 | GEERT H RENATA C PAUL J | 1996 | Int J Syst Bacteriol1996，，4： | 1 |
| 13 | Ventilator - associated pneu- monia in an adult clinical surgical intensive care unit of a brazilian uni- versity hospltal: incidence, risk factors, etiology, and antibiotic resist- ance 显示文摘 | Laura de A Carolina V Renata C | 2008 | Braz J Infect Dis2008，12，1： | 1 |
| 14 | Encapsulationefficiency and oxidative stability of flaxseed oil microencapsulatedby spray drying using different combinations of wall materials显示文摘 | Helena C F Carneiro Renata V Tonon | 2013 | Journal of Food Engineering2013，115，4： | 1 |
| 15 | Degradation of chitosan and starch by 360 kHz ultrasound显示文摘 | Renata C B Bozena R Salah L | 2005 | Carbohydrate Polymers2005，60，2： | 1 |
| 16 | parabens in male infertility-Is there a mitochondrial connection 显示文摘 | Tavares Renata S Martins fatima C Oliveira Paulo J | 2009 | Reproductive Toxicology2009，27，1： | 1 |
| 17 | Bone morphogenetic protein-4 reguldates its own expression in cultured osteoblasts显示文摘 | Renata CP Sheih R Emezto C | 2000 | J Cell Physiol2000，182，： | 1 |
| 18 | Noninvasive in vivo quantitative assessment of fat conent in human liver显示文摘 | Ricci C Renata Eugenio G | 1997 | Journal of Hepatology1997，27，： | 1 |
| 19 | Simultaneous con- trol of Capsaicinoids release from polymeric nanocapsules 显示文摘 | Renata V C Moacir K Fernanda S P | 2011 | Nanoscienee and Nanatechnology2011，11，3： | 1 |
| 20 | Multidrug-resistant Pseudomounas qeruginosa andAcinetobacter baumanni:resistance mechanisms and implica-tion for theraphy显示文摘 | Alexandre P Zavascki Celilia G Carvalhaes Renata C Pica′o | 2010 | Expert Rev Anti Infet Ther2010，8，1： | 1 |
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