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| 1 | Hepatocellular carcinoma: Advances in diagnosis, management, and long term outcome显示文摘Hepatocellular carcinoma(HCC) remains a common and lethal malignancy worldwide and arises in the setting of a host of diseases. The incidence continues to increase despite multiple vaccines and therapies for viruses such as the hepatitis B and C viruses. In addition, due to the growing incidence of obesity in Western society, there is anticipation that there will be a growing population with HCC due to non-alcoholic fatty liver disease. Due to the growing frequency of this disease, screening is recommended using ultrasound with further imaging using magnetic resonance imaging and multi-detector computed tomography used for further characterization of masses. Great advances have been made to help with the early diagnosis of small lesions leading to potential curative resection or transplantation. Resection and transplantation maybe used in a variety of patients that are carefully selected based on underlying liver disease. Using certain guidelines and clinical acumen patients may have good outcomes with either resection or transplantation however many patients are inoperable at time of presentation. Fortunately, the use of new locoregional therapies has made down staging patients a potential option making them potential surgical candidates. Despite a growing population with HCC, new advances in viral therapies, chemotherapeutics, and an expanding population of surgical and transplant candidates might all contribute to improved long-term survival of these patients. | Adam S Bodzin Ronald W Busuttil | 2015 | World Journal of Hepatology2015，7，9： | 22 |
| 2 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 3 | 鼻阻力测压与鼻声反射测量的相关性研究显示文摘目的探讨主动后鼻阻力测压仪的参数——鼻阻力(nasal resistance,NR)与鼻声反射测量仪的参数——鼻腔容积(nasal cavity volume,NV)、鼻腔最小横截面积(minimal cross sectional area,MCSA)间是否具有相关性。方法应用主动后鼻阻力测压法和鼻声反射测量法对316例有鼻阻塞的患者进行前瞻性研究。根据减充血前双侧鼻阻力(bilateral NR,BNR)将患者分为2组,组1:BNR减充血前≤0.25 Pa/cm^3·s,组2:BNR减充血前>0.25 Pa/cm^3·s。Spearman等级相关分析研究上述两种客观测量法的参数在全体研究对象及各组中的相关性。结果在使用减充血剂前、后,316例患者单侧鼻阻力(unilateral NR,UNR)与单侧鼻腔容积(unilateral NV,UNV)、单侧鼻腔最小横截面积(unilateral MCSA,UMCSA)间均存在显著性负相关(P值均=0.000);组1(104例)和组2(212例)在减充血前、后的UNR与UNV、UMCSA间均存在显著性负相关(P值均=0.000)。鼻阻力与鼻腔最小横截面积的相关系数均大于鼻阻力与鼻气道容积的相关系数。结论在有鼻阻塞的患者中,NR、NV及MCSA存在负相关,MCSA是影响NR的主要因素。 | 张革化 李源 Ronald S Fenton Philip Cole Richard Rival Philip Solomon | 2008 | 中国耳鼻咽喉头颈外科2008，15，10： | 8 |
| 4 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 5 | Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade显示文摘 | Clifford R Jack David S Knopman William J Jagust Leslie M Shaw Paul S Aisen Michael W Weiner Ronald C Petersen John Q Trojanowski | 2010 | Lancet Neurology2010，，1： | 4 |
| 6 | Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation显示文摘Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, how ever, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement. One active ingredient in this supplement is hydroxycitric acid, an active ingredient also found in weight-loss supplements banned by the Food and Drug Administration in 2009 for hepatotoxicity. Heightened awareness of the dangers of dietary supplements such as Garcinia cambogia is imperative to prevent hepatoxicity and potential fulminant hepatic failure in additional patients. | Keri E Lunsford Adam S Bodzin Diego C Reino Hanlin L Wang Ronald W Busuttil | 2016 | World Journal of Gastroenterology2016，22，45： | 3 |
| 7 | Hyperspectral Vegetation Indices and Their Relationships with Agricultural Crop Characteristics显示文摘 | Prasad S Thenkabail Ronald B Smith Eddy De Pauw | 2000 | Remote Sensing of Environment2000，，2： | 2 |
| 8 | Pharmacokinetics of melamine in pigs following intravenous administration显示文摘 | RONALD E B GEOF S SHARON E M | 2008 | Food and Chemical Toxicology2008，46，： | 1 |
| 9 | Electroconvulsive Seizures Increase the Expression of MAP Kinase Phosphatases in Limbic Regions of Rat Brain显示文摘 | Masafumi Kodama1 David S Russell Ronald S Duman | 2005 | Neuropsychopha rmacology2005，，30： | 1 |
| 10 | Hyperspectral vegetation indices and their relationship with agricuhural crop characteristics 显示文摘 | PRASD S T RONALD B S EDDY D P | 2000 | Remote Sensing Environment2000，71，2： | 1 |
| 11 | The effects of dry extrusion of rapeseed with other feedstuffs upon its nutritional value and anti-thyroid activity显示文摘 | RONALD R S | 1986 | J Sci Food Agrie1986，37，： | 1 |
| 12 | Segmenting multispectral Landsat TM images into field units显示文摘 | CAROLYN E RONALD J IMANTS S | 2002 | IEEE Transactions on Geoscience and Remote Sensing2002，40，5： | 1 |
| 13 | Use of LCD panel for calibrating structured-light-based range sensing system 显示文摘 | ZHAN S RONALD C | 2008 | IEEE Transactions on Instrumentation and Measurement2008，57，11： | 1 |
| 14 | Myc Family Oncogenes in the Development of Normal and Neoplastic Cell显示文摘 | Ronald A D Nicole S A Fredrck W A | 1991 | Adv Cancer Res1991，57，： | 1 |
| 15 | Methodology for Thermal Evaluation of Multichip Modules 显示文摘 | Lall Balwant S Guenin Bruce M Molnar Ronald J | 1995 | IEEE Trans Comp Packg Manufa Technol Part A1995，18，4： | 1 |
| 16 | Higher-grade transformation of follicle center lymphoma is associated with somatic mutation of the 5 noncoding regulatory region of the BCL-6 gene显示文摘 | Izidore S L Ronald L | 2000 | Blood2000，96，2： | 1 |
| 17 | Quantitative monitoring of gene expression patters with a complementary DNA microarray显示文摘 | Schena M Dari S Ronald W | 1995 | Science1995，270，： | 1 |
| 18 | Phenolics of apple pear and white grape juice and their changes with processing and storage review显示文摘 | Geogre A S Ronald E W | 1992 | Agric Food Chert1992，，40： | 1 |
| 19 | A comparison of the catalytic activities of Ga13-, Al13-, GaAl12- and chromium-pillared interlayered clay minerals and Ga-H-ZSM-5 zeolite in the dehydrocyclodimerization of propane显示文摘 | Bradley S M Ronald A K | 1993 | Journal of Cataly- sis1993，142，： | 1 |
| 20 | The network structure of Social Capital 显示文摘 | Ronald S Burt | 2007 | Research in Organizational Behavior2007，22，： | 1 |
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