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| 1 | Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis显示文摘AIM To evaluate the antifibrotic effect ofdifferent doses of recombinant human Gamma-Interferon (IFN-γ) intwo rat models of hepaticfibrosis, and to observe its effect on moderatechronic hepatitis B virus fibrosis.METNODS Hepatic fibrosis was successfullyinduced in 150 and 196 rats by subcutaneousinjection of carbon tetrachloride (CCl4) andintraperitoneal injection of dimethylnitrosamine(DMN), respectively. Each of the two modeldose IFN-γ group (15 MU/kg per day, i.m. for 8group (1.67 MU/kg daily, i.m. for 8 weeks).Another group of 10 rats without any treatmentwas used as normal controls. At the end of theexperiment, semi-quantitative histopathologicalscores of inflammation and fibrosis, liver (αsmooth muscle actin (α-SMA) expression level,liver hydroxyl proline content and serumhyaluronic acid levels were compared. And 47medium chronic hepatitis B viral fibrosispatients were studied. They were given IFN-γtreatment, 100MU/day i.m. for the first threemonths and 100MU qod i.m. for the next sixmonths. Semi-quantitative pathological scoresof inflammation and fibrosis and serum hepaticfibrosis indices were compared within the 9months.RESULTS In animal experiment, thepathological fibrosis scores and liver hydroxylproline content were found to be significantlylower in rats treated with different doses of IFN-γ as compared with rats in fibrotic model groupinduced by either CCI4 or DMN, in a dose-dependent manner. For CCI4-induced model,pathological fibrosis scores in high, medium andIow doses IFN-γ groups were 5.10 ± 2.88, 7.70 ±3.53 and 8.00 ± 3.30, respectively, but the scorewas 14.60 ± 7.82 in fibrotic model group.Hydroxyl proline contents were 2.83 ± 1.18, 3.59± 1.22 and 4.80 ± 1.62, in the three IFN-γgroups, and 10.01 ± 3.23 in fibrotic model group.The difference was statistically significant(P<0.01). Similar results were found in DMN-induced model. Pathological fibrosis scoreswere 6.30±0.48, 8.10 ±2.72 and 8.30 ±2.58, inhigh, medium and Iow doses IFN-γ groups, and12.60 ± 3.57 in fibrotic model group. Hydroxylproline contents were 2.72 ± 0.58, 3.14 ± 0.71and 3.62 ± 1.02, in the three IFN-γ groups, and12.79 ± 1.54 in fibrotic model group. Thedifference was statistically significant(P<0.01). Serum hepatic fibrosis indicesdecreased significantly in the 47 patients afterIFN-γ treatment (HA: 433.38 ± 373.00 vs 281.57± 220.48; LN: 161.22± 41.02 vs 146.35 ± 44.67;PCⅢ: 192.59 ± 89.95 vs 156.98 ± 49.22; C-Ⅳ:156.30 ± 44.01 vs 139.14 ± 34.47) and thedifferences between the four indices weresignificant (P<0.05). Thirty-three patientsCONCLUSION All the three doses of IFN-γ areeffective in treating rat liver fibrosis induced byeither CCl4 or DMN, the higher the dose, thebetter the effect. And IFN-γ is effective forpatients with moderate chronic hepatitis B viralfibrosis. | Hong Lei Weng Wei Min Cai Rong Hua Liu Institute of Infectious Diseases, First Affiliated Hospital. Medical School. Zhejiang University, Hangzhou 310003, Zhejiang Province. China | 2001 | World Journal of Gastroenterology2001，7，1： | 53 |
| 2 | Intelligent transportation systems for smart cities:a progress review显示文摘To better meet the challenge of providing effective,low-cost,energy efficient transport services,the concept of intelligent transport systems(ITS) has been proposed and lauded as an innovative and promising solution for next generation transport networks.In this paper,the progress of ITS research around the world is briefly reviewed and current challenges are outlined,thereby offering further insight into ITS development for all researchers in this area. | XIONG Zhang SHENG Hao RONG WenGe COOPER Dave E | 2012 | Science China(Information Sciences)2012，55，12： | 16 |
| 3 | Chemical constituents from Schisandra sphenanthera显示文摘五味子 sphenanthera 的茎的化学成分第一次被描述。这调查导致了新酉分的 glycoside (1 ) 的隔离,与七已知的混合物一起。1 的结构被使用分光镜的技术分配,包括 2D NMR 系列。 | Rong Tao Li Zhi Ying Weng Jian Xin Pu Han Dong Sun | 2008 | Chinese Chemical Letters2008，19，6： | 11 |
| 4 | The altitude effect of ^(18)δO in precipitation and river water in the Southern Himalayas显示文摘The lapse rate of water isotopes is used in the study of the hydrologic cycle as well as in the estimation of uplift of the Tibetan Plateau.The greater elevation contrast in the Southern Himalayas allows for a detailed discussion about this lapse rate.We analyze variations of 18δO in precipitation and river water between 1320 m and 6700 m elevations in the Southern Himalayas,and calculate the specific lapse rate of water 18δO.The results show that the multi-year average lapse rate in precipitation over this region is 0.15‰/100 m.The one-year average lapse rate is 0.17‰/100 m from three sites along the Southern Himalayas.The two results agree,but are much lower than the global average of 0.28‰/100 m.This work also shows that there is a difference in precipitation 18δO lapse rate between the monsoon and non-monsoon seasons.The calculated precipitation lapse rate is much lower than that in surface water. | WEN Rong TIAN LiDe WENG YongBiao LIU ZhongFang ZHAO ZhongPing | 2012 | Chinese Science Bulletin2012，57，14： | 11 |
| 5 | Smart City Architecture: A Technology Guide for Implementation and Design Challenges显示文摘Urban development is becoming increasingly reliant on effective use of intelligent services.In the process of providing better services to all citizens and improving the efficiency of administration processes,the concept of a smart city has been lauded as a promising solution for the coming challenge of global urbanization.However,due to the broad scope of smart cities their definition has not been standardized,thus proposed architectures are diverse.This work proposes a new architecture from the perspective of the data that underpins all the functionality of smart cities.The proposed architecture is discussed,outlining design challenges and offering insight into the development of smart cities. | RONG Wenge XIONG Zhang COOPER Dave LI Chao SHENG Hao | 2014 | China Communications2014，11，3： | 9 |
| 6 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 7 | Clinical observation of gastric bypass in treatment of type 2 diabetes显示文摘 | PU Yong-dong LI Jing-quan CAO Zhi-yu WANG Li HU Xiao DONG Li-guo LI Yue-min ZHAO Hua-zhou QIN Rong YANG Bo HE Jiao-miao WU You-jun WANG Yi LU Gang ZHANG Bo WANG Yue LIU Wei-ping WENG Jian-feng | 2012 | Chinese Medical Journal2012，，11： | 8 |
| 8 | High glucose causes apoptosis of rabbit corneal epithelial cells involving activation of PERK-eIF2α-CHOP-caspase-12 signaling pathway显示文摘AIM: To investigate the effect of high concentration of glucose(HCG) on double stranded RNA-activated protein kinase-like ER kinase(PERK)-eukaryotic initiation factor-2α(eIF2α)-transcription factor C/EBP homologous protein(CHOP)-cysteine aspartate specific proteinase(caspase-12) signaling pathway activation and apoptosis in rabbit corneal epithelial cells(RCECs). METHODS: RCECs were treated by different concentrations of glucose for 0-48 h. The expressions of PERK, p-PERK, eIF2α, p-eIF2α, 78 k Da glucose-regulated protein 78(GRP78), CHOP, B-cell lymphoma 2(Bcl-2), B-cell lymphoma-2-associated X protein(Bax) and caspase-12 were determined by Western blot. Apoptosis was detected by TUNEL assay. Meanwhile, the function of PERK-eI F2α-CHOP-caspase-12 signaling pathway activation in high glucose-induced apoptosis was evaluated using PERK inhibitor, GSK2606414. RESULTS: HCG significantly promoted the expression of p-PERK, p-eIF2α, GRP78, CHOP, Bax and cleaved caspase-12 in RCECs(P<0.05), while remarkably decreased the expression of Bcl-2 and caspase-12(P<0.05), and the alterations caused by glucose were in concentration-and time-dependent manners. Meanwhile, PERK and eIF2α expressions were not affected in all groups(P>0.05). TUNEL assay showed that the apoptosis rate of RCECs in the HCG group increased significantly in contrast with that in the normal concentration of glucose or osmotic pressure control group(P<0.05), and the apoptosis rate increased with the increase of glucose concentration within limits(P<0.05). GSK2606414 down-regulated the expression of p-PERK and p-eI F2α in the HCG group(P<0.05), while still did not affect the expression of PERK and eIF2α among groups(P>0.05). Correspondingly, GSK2606414 also significantly reduced the apoptosis rate induced by high glucose(P<0.05). CONCLUSION: HCG activates PERK-eIF2α-CHOPcaspase-12 signaling pathway and promotes apoptosis of RCECs. | Pan-Pan Yao Min-Jie Sheng Wen-Hao Weng Yin Long Hao Liu Li Chen Jia-Jun Lu Ao Rong Bing Li | 2019 | International Journal of Ophthalmology(English edition)2019，12，12： | 7 |
| 9 | Hot Working of High Nitrogen Austenitic Stainless Steel显示文摘With hot rolling in laboratory and Gleeble thermal simulator,the hot working of a high nitrogen austenitic stainless steel(HNASS)was researched.The results showed that dynamic recovery(DRV)and dynamic recrystallization(DRX)in HNASS occurred during hot working,and both of them had well-defined stress peaks in flow curves under different conditions.During hot rolling experiment at temperature from 950 to 1050 ℃,recrystallization phenomenon does not take place in test material until the deformation ratio is up to 40%.Recrystallization influences remarkably the strength and ductility of material,and the test HNASS possesses better combination of strength with ductility.According to the curve of θ-σ(strain hardening rate-steady state stress),the DRX critical strain of test material was determined.Also,the activation energy of hot working was calculated to be 746.5 kJ/mol and the equation of hot working was obtained. | LANG Yu-ping ZHOU Yong RONG Fan CHEN Hai-tao WENG Yu-qing SU Jie | 2010 | Journal of Iron and Steel Research(International)2010，17，10： | 5 |
| 10 | Structural information aware deep semi-supervised recurrent neural network for sentiment analysis显示文摘 | Wenge RONG Baolin PENG Yuanxin OUYANG Chao LI Zhang XIONG | 2015 | Frontiers of Computer Science2015，9，2： | 5 |
| 11 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
| 12 | Enhanced Learning Resource Recommendation Based on Online Learning Style Model显示文摘Smart learning systems provide relevant learning resources as a personalized bespoke package for learners based on their pedagogical needs and individual preferences.This paper introduces a learning style model to represent features of online learners.It also presents an enhanced recommendation method named Adaptive Recommendation based on Online Learning Style(AROLS),which implements learning resource adaptation by mining learners’behavioral data.First,AROLS creates learner clusters according to their online learning styles.Second,it applies Collaborative Filtering(CF)and association rule mining to extract the preferences and behavioral patterns of each cluster.Finally,it generates a personalized recommendation set of variable size.A real-world dataset is employed for some experiments.Results show that our online learning style model is conducive to the learners’data mining,and AROLS evidently outperforms the traditional CF method. | Hui Chen Chuantao Yin Rumei Li Wenge Rong Zhang Xiong Bertrand David | 2020 | Tsinghua Science and Technology2020，25，3： | 3 |
| 13 | Distribution features of oil and preventive countermeasures in Meizhou Bay,China显示文摘MeizhouBayisinthemiddleofthewesterncoastofTaiwanstraits.Theseaareaisabout546km2.Itis,withdeepwaterandsmoothsea,anaturalgoodha... | Wang Xian, Chen Yu wang, Li Weng quan, Zheng Ai rong Department of Oceanography, Xiamen University, Xiamen 361005, China | 1999 | Journal of Environmental Sciences1999，11，1： | 3 |
| 14 | Formative Assessment of Programming Language Learning Based on Peer Code Review: Implementation and Experience Report显示文摘In programming courses, the traditional assessment approach tends to evaluate student performance by scoring one or more project-level summative assignments. This approach no longer meets the requirements of a quality programming language education. Based on an upgraded peer code review model, we propose a formative assessment approach to assess the learning of computer programming languages, and develop an online assessment system(OOCourse) to implement this approach. Peer code review and inspection is an effective way to ensure the high quality of a program by systematically checking the source code. Though it is commonly applied in industrial and open-source software development, it is rarely taught and practiced in undergraduate-level programming courses. We conduct a case study using the formative assessment method in a sophomore level Object-Oriented Design and Construction course with more than 240 students. We use Moodle(an online learning system) and some relevant plugins to conduct peer code review. We also conduct data mining on the running data from the peer assessment activities. The case study shows that formative assessment based on peer code review gradually improved the programming ability of students in the undergraduate class. | Qing Sun Ji Wu Wenge Rong Wenbo Liu | 2019 | Tsinghua Science and Technology2019，24，4： | 2 |
| 15 | Osteoblast behaviors on titania nanotube and mesopore layers显示文摘Titania nanotubes and mesopores with different diameter sizes were prepared by electrochemical oxidation of titanium.The responses of osteoblastic cells isolated from Sprague–Dawley rats to the nanotube and mesopore layers were investigated in sequential events of cell adhesion,morphology,actin cytoskeleton,proliferation,differentiation,and mineralization.Nano-structural features,especially diameters of the nanotubes and mesopores,obviously influenced on cell behaviors in the sequential events.The cells showed better proliferation and differentiation abilities on the specimens with the nanotubes and mesopores than on flat titanium disk.Higher levers of calcium mineralization were observed on the nanotube and mesopore layers.The cells adhered much faster onto the nanotubes with about 170nm diameter and the mesopores with about 400nm diameter than onto flat titanium disk and 50nm nanotubes.There is an appropriate range of the tube/pore sizes,and in this present work,titania nantubes with 170nm diameter is the best for enhancing functions of osteoblasts. | Yan Zhang Rong Luo Jing Tan Jianxin Wang Xiong Lu Shuxin Qu Jie Weng Bo Feng | 2017 | Regenerative Biomaterials2017，4，2： | 2 |
| 16 | Hierarchical Spatial Reasoning and Case of Way-Finding显示文摘Human beings use hierarchies to simplify their conceptual models of reality and to perform reasoning more efficiently. Hierarchical structures are conceptually imposed on space and allow performance of complex tasks in very large contexts easily. Hierarchical spatial reasoning is an important method for solving spatial problems. This paper briefly discusses the definition and frame of hierarchical spatial reasoning and its application to way-finding of road networks. | WENG Min JIANG Shanshan QU Rong | 2008 | Geo-Spatial Information Science2008，11，4： | 2 |
| 17 | A Review of Co-processing of Kitchen Waste and Municipal Residual Sludge显示文摘In this paper,the methods of kitchen waste disposal in recent years were summed up,and the advantages and disadvantages of the current treatment methods were analyzed. At the same time,it has been found that the co-processing of kitchen waste and residual sludge not only has dealt with both kitchen waste and residual sludge,but also the carbon and nitrogen ratio and moisture content of the mixture are balanced,and increases the processing efficiency significantly. It has a certain processing advantage. At present,most research is about the anaerobic digestion of kitchen waste and residual sludge,and the process is more mature,but the study of VFAs accumulation is still insufficient. Aerobic composting is still in the early stage of development,and there are few studies on it at home and abroad. Meanwhile,prospects for the kitchen waste recycling were made in this article. | Han Houfeng Zhuang Pingfang Liu Mei Rong Zhenying Weng Yisong Chen Qingguo Sun Jingya | 2018 | Meteorological and Environmental Research2018，9，4： | 2 |
| 18 | miR-10b promotes porcine immature Sertoli cell proliferation by targeting the DAZAP1 gene显示文摘MicroRNAs(miRNAs) have been widely identified in porcine testicular tissues and implicated as crucial regulators of proliferation, apoptosis, and differentiation in porcine spermatogenesis related cells. However, the function roles of most of the miRNAs that have been identified in Sertoli cells are poorly understood. In the present study, six experiments were conducted to study the regulatory role of miR-10b in porcine immature Sertoli cells. In experiment 1, the results showed that the relative mRNA expression level of miR-10b in porcine testicular tissues decreased quadratically(P<0.001) with increasing age, while the relative mRNA expression level of DAZAP1 gene increased(P<0.001). In addition, the mRNA expression of miR-10b was negatively(P<0.01) correlated with DAZAP1 mRNA expression(r=–0.550). In experiment 2, the results from the bioinformatic analysis and a luciferase reporter assay demonstrated that miR-10b directly targeted the DAZAP1 gene in porcine immature Sertoli cells. DAZAP1 mRNA and protein expressions were both regulated(P<0.05) by miR-10b. In experiments 3 to 5, the over-expression of miR-10b or the siRNA-mediated knockdown of the DAZAP1 gene promoted(P<0.05) porcine immature Sertoli cell proliferation, as determined by the Cell Counting Kit-8(CCK-8) assay and the 5-Ethynyl-2′-deoxyuridine(EdU) assay. However, an annexin V-FITC/PI staining assay and the expression of cell survival-related genes indicated that over-expression of miR-10b or knockdown of DAZAP1 had no effect(P>0.05) on porcine immature Sertoli cell apoptosis. In experiment 6, the co-transfection treatment results showed that miR-10b promoted(P<0.05) porcine immature Sertoli cell proliferation by targeting DAZAP1 gene. Overall, these experiments demonstrated that miR-10b promotes porcine immature Sertoli cell proliferation by targeting the DAZAP1 gene. | WENG Bo RAN Mao-liang CAo Rong PENG Fu-zhi LUo Hui GAo Hu TANG Xiang-wei YANG An-qi CHEN Bin | 2019 | Journal of Integrative Agriculture2019，18，8： | 2 |
| 19 | A hierarchical similarity based job recommendation service framework for university students显示文摘 | Rui LIU Wenge RONG Yuanxin OUYANG Zhang XIONG | 2017 | Frontiers of Computer Science2017，11，5： | 1 |
| 20 | Molecular epidemiology of Echovirus 30 in Fujian, China between 2001 and 2011显示文摘 | Xiu‐hui Yang Yan‐sheng Yan Yu‐wei Weng Ai‐hua He Hong‐rong Zhang Wei Chen Yong Zhou | 2013 | J. Med. Virol2013，，： | 1 |
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