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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Targeting the tran- scription factor Nrf2 to ameliorate oxidative stress and in- flammation in chronic kidney disease 显示文摘 | Ruiz S Pergola PE Zager RA | 2013 | Kidney Int2013，83，6： | 1 |
| 3 | Heavy metals in sediments of the Tecate River Mexico显示文摘 | WAKIDA F T LARA RUIZ D TEMORES PE A J | 2008 | Environmental Geology2008，54，3： | 1 |
| 4 | Assessing lake eutrophication using chironomids:understanding the nature of community response in different lake types 显示文摘 | LANGDONADON PE RUIZ ZO BRO-DERSEN KL | 2006 | Freshwater Biology2006，51，3： | 1 |
| 5 | Toughening by nanostructure显示文摘 | Ruiz -Pe'rez L Royston G J Fairclough J P A | 2008 | Polymer2008，49，21： | 1 |
| 6 | Olfactory Bulbectomy Induced Oxidative and Cell Damage in Rat: Protective Effect of Melatonin显示文摘 | Tasset I Medina F J Pe?a J Jimena I Mu?oz M Del Carmen Salcedo M Ruiz C Feijóo M Montilla P Túnez I | 2010 | Physiological Research2010，，1： | 1 |
| 7 | Targeting the transcrip- tion factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease 显示文摘 | Ruiz S Pergola PE Zager RA Vaziri ND | 2013 | Kidney Int2013，83，6： | 1 |
| 8 | Finite element modeling of the AP1000 nuclear island for seismic analyses at generic soil and rock sites显示文摘 | Leonardo Tu?ón-Sanjur Richard S. Orr Sener Tinic Diego Pe?a Ruiz | 2007 | Nuclear Engineering and Design2007，，12： | 1 |
| 9 | Norfloxacin Modulates the Inflammatory Response and Directly Affects Neutrophils in Patients With Decompensated Cirrhosis显示文摘 | Pedro Zapater Rocío Ca?o Lucía Llanos Antonio J. Ruiz–Alcaraz Sonia Pascual Claudia Barquero Rocío Moreu Pablo Bellot José F. Horga Carlos Mu?oz Jara Pérez Pilar García–Pe?arrubia Miguel Pérez–Mateo José Such Rubén Francés | 2009 | Gastroenterology2009，，5： | 1 |
| 10 | An enhanced MITOMAP with a global mtDNA mutational phylogeny 显示文摘 | RUIZ PE LOTY MT PROCACCIO V | 2007 | Nucleic Acids Res2007，35，： | 1 |
| 11 | GasChromatography- Mass Spectrometry Method for the Determinationof Free Amino Acids as Their Dimethyl- tert- butylsilyl ( TBDMS)Derivatives in Animal Source Food显示文摘 | Jime^nez- Martiln E A Ruiz J Pe^rez- Palacios T | 2012 | Journal of Agricultural andFood Chemistry2012，60，10： | 1 |
| 12 | Regulatory role of PI 3 K ‐protein kinase B on the release of interleukin‐1β in peritoneal macrophages from the ascites of cirrhotic patients显示文摘 | A. Tapia‐Abellán A. J. Ruiz‐Alcaraz G. Antón M. Miras‐López R. Francés J. Such M. Martínez‐Esparza P. García‐Pe?arrubia | 2014 | Clin Exp Immunol2014，，3： | 1 |
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