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| 1 | Von Hippel-Lindau tumor suppressor pathways&corresponding therapeutics in kidney cancer显示文摘The identification and application of the Von Hippel-Lindau(VHL)gene is a seminal breakthrough in kidney cancer research.VHL and its protein p VHL are the root cause of most kidney cancers,and the cascading pathway below them is crucial for understanding hypoxia,in addition to the aforementioned tumorigenesis routes and treatments.We reviewed the history and functions of VHL/pVHL and Hypoxia-inducible factor(HIF),their well-known activities under low-oxygen environments as an E3 ubiquitin ligase and as a transcription factor,respectively,as well as their non-canonical functions revealed recently.Additionally,we discussed how their dysregulation promotes tumorigenesis:beginning with chromosome 3 p-arm(3p)loss/epigenetic methylation,followed by two-allele knockout,before the loss of complimentary tumor suppressor genes leads cells down predictable oncological paths.These different pathways can ultimately determine the grade,outcome,and severity of the deadliest genitourinary cancer.We finished by investigating current and proposed schemes to therapeutically treat clear cell renal cell carcinoma(cc RCC)by manipulating the hypoxic pathway utilizing Vascular Endothelial Growth Factor(VEGF)inhibitors,mammalian target of rapamycin complex 1(mTORC1)inhibitors,small molecule HIF inhibitors,immune checkpoint blockade therapy,and synthetic lethality. | Maxwell Shulman Rachel Shi Qing Zhang | 2021 | Journal of Genetics and Genomics2021，48，7： | 4 |
| 2 | Constitutive expression of feedback-insensitive cystathionine γ-synthase increases methionine levels in soybean leaves and seeds显示文摘Soybean(Glycine max(L.) Merr.) is a major crop that provides plant-origin protein and oil for humans and livestock.Although the soybean vegetative tissues and seeds provide a major source of high-quality protein,they suffer from low concentration of an essential sulfur-containing amino acid,methionine,which significantly limits their nutritional quality.The level of methionine is mainly controlled by the first unique enzyme of methionine synthesis,cystathione γ-synthase(CGS).Aiming to elevate methionine level in vegetative tissues and seeds,we constitutively over-expressed a feedback-insensitive Arabidopsis CGS(At D-CGS) in soybean cultivars,Zigongdongdou(ZD) and Jilinxiaoli 1(JX).The levels of soluble methionine increased remarkably in leaves of transgenic soybeans compared to wild-type plants(6.6-and 7.3-fold in two transgenic ZD lines,and 3.7-fold in one transgenic JX line).Furthermore,the total methionine contents were significantly increased in seeds of the transgenic ZD lines(1.5-to 4.8-fold increase) and the transgenic JX lines(1.3-to 2.3-fold increase) than in the wild type.The protein contents of the transgenic soybean seeds were significantly elevated compared to the wild type,suggesting that the scarcity of methionine in soybeans may limit protein accumulation in soybean seeds.The increased protein content did not alter the profile of major storage proteins in the seeds.Generally,this study provides a promising strategy to increase the levels of methionine and protein in soybean through the breeding programs. | YU Yang HOU Wen-sheng Yael Hacham SUN Shi WU Cun-xiang Ifat Matityahu SONG Shi-kui Rachel Amir HAN Tian-fu | 2018 | Journal of Integrative Agriculture2018，17，1： | 4 |
| 3 | Hollow titania spheres from layered precursor deposition on sacrificial colloidal core显示文摘 | FRANK C SHI Xiang-yang RACHEL A | 2001 | Adv Mater2001，13，10： | 1 |
| 4 | Reduced cardiac output is associated with decreased mitochondrial efficiency in the non-ischemic ventricular wall of the acute myocardial-infarcted dog显示文摘心脏性的吃惊是在与尖锐心肌的梗塞(MI ) 就医的病人之中的死亡的领先的原因。为尖锐的泵失败理解机制因此是重要的。这研究的目的是在一个尖锐 MI 狗模型检验是否 mitochondrial 在 non-ischemic 墙区域以内的简历精力充沛的功能与泵失败被联系。前面的 MI 经由左前面的下降的结扎(男孩) 在狗被生产冠的动脉,那导致了大约 30% 左室的墙的一种犯尺寸。解开的血液动力学的地位, mitochondrial 功能,免费激进的生产和 mitochondrial 的大小蛋白质 3 (UCP3 ) 表示在 24 h 时期上被决定。血液动力学的大小揭示了 >
在在 24 h 帖子梗塞的心脏的输出的 50% 减小什么时候与基线相比。活体检视样品在尖锐梗塞期间从以后的 non-ischemic 墙被获得。当与在内的 ADP/O 比率相比一样有或没有十六酸酸(PA ) 取样时,为从在 6 h 和 24 h 的 non-ischemic 心肌层的孤立的线粒体的 ADP/O 比率被减少。GTP 抑制(PA ) 刺激了在从 non-ischemic 墙的孤立的线粒体的 4 呼吸在 6 h 和 24 h 增加了 7% 和 33% 的状态梗塞以后分别地什么时候与相比假冒并且梗塞前样品。这将建议线粒体被解开,这被从这些一样的活体检视样品在西方的污点上观察的 UCP3 表示的联系增加支持。从电子测量的冠的湾穴的血样品顺磁的回声(EPR ) 方法在 6 h 和 24 h 在基线上在反应的氧种类(ROS ) 显示出增加梗塞以后。在结论, mitochondrial 由于尖锐梗塞的简历精力充沛的 ADP/O 比率在 non-ischemic 墙以内是反常的。线粒体看起来精力充沛地被解开,这与衰退被联系泵功能。免费激进的生产可以与解开的正式就职被联系在线粒体的蛋白质。 | Zakaria A Almsherqi Craig S McLachlan Malgorzata B Slocinska Francis E Sluse Rachel Navet Nikolai Kocherginsky Iouri Kostetski Dong-Yun Shi Shan-Lin Liu Peter Mossop Yuru Deng | 2006 | Cell Research2006，16，3： | 1 |
| 5 | The adenoviral E1A protein relieves gene repression by receptors in v/vo displaces corepressors and unliganded thyroid hormone显示文摘 | Yukiyasu Sato Andrew Ding Rachel A Heimeier Ahmed F Yousef Joe S Mymryk Paul G Walfish Yun-Bo Shi | 2009 | Cell Research2009，19，6： | 0 |
| 6 | Elite,transformable haploid inducers in maize显示文摘The introduction of alleles into commercial crop breeding pipelines is both time consuming and costly.Two technologies that are disrupting traditional breeding processes are doubled haploid(DH)breeding and genome editing(GE).Recently,these techniques were combined into a GE trait delivery system called HI-Edit(Haploid Inducer-Edit).In HI-Edit,the pollen of a haploid inducer line is reprogrammed to deliver GE traits to any variety,obviating recurrent selection.For HI-Edit to operate at scale,an efficient transformable HI line is needed,but most maize varieties are recalcitrant to transformation,and haploid inducers are especially difficult to transform given their aberrant reproductive behaviors.Leveraging marker assisted selection and a three-tiered testing scheme,we report the development of new Iodent and Stiff Stalk maize germplasm that are transformable,have high haploid induction rates,and exhibit a robust,genetically-dominant anthocyanin native trait that may be used for rapid haploid identification.We show that transformation of these elite‘‘HI-Edit”lines is enhanced using the BABYBOOM and WUSCHEL morphogenetic factors.Finally,we evaluate the HI-Edit performance of one of the lines against both Stiff Stalk and non-Stiff Stalk testers.The strategy and results of this study should facilitate the development of commercially scalable HI-Edit systems in diverse crops. | Brent Delzer Dawei Liang David Szwerdszarf Isadora Rodriguez Gonzalo Mardones Sivamani Elumalai Francine Johnson Samson Nalapalli Rachel Egger Erin Burch Kerry Meier Juan Wei Xiujuan Zhang Huaping Gui Huaibing Jin Huan Guo Kun Yu Yubo Liu Becky Breitinger Ana Poets Jason Nichols Wan Shi David Skibbe Qiudeng Que Timothy Kelliher | 2024 | The Crop Journal2024，12，1： | 0 |
| 7 | Isolated sacral injuries: Postoperative length of stay, complications, and readmission显示文摘AIM: To investigate inpatient length of stay(LOS), complication rates, and readmission rates for sacral fracture patients based on operative approach.METHODS: All patients who presented to a large tertiary care center with isolated sacral fractures in an 11-year period were included in a retrospective chart review. Operative approach(open reduction internal fixation vs percutaneous) was noted, as well as age, gender, race, and American Society of Anesthesiologists' score. Complications included infection, nonunion and malunion, deep venous thrombosis, and hardware problems; 90-d readmissions were broken down into infection, surgical revision of the sacral fracture, and medical complications. LOS was collected for the initial admission and readmission visits if applicable. Fisher's exact and non-parametric t-tests(Mann-Whitney U tests) were employed to compare LOS, complications, and readmissions between open and percutaneous approaches.RESULTS: Ninety-four patients with isolated sacral fractures were identified: 31(30.4%) who underwentopen reduction and internal fixation(ORIF) vs 63(67.0%) who underwent percutaneous fixation. There was a significant difference in LOS based on operative approach: 9.1 d for ORIF patients vs 6.1 d for percutaneous patients(P = 0.043), amounting to a difference in cost of $13590. Ten patients in the study developed complications, with no significant difference in complication rates or reasons for complications between the two groups(19.4% for ORIF patients vs 6.3% for percutaneous patients). Eight patients were readmitted, with no significant difference in readmission rates or reasons for readmission between the two groups(9.5% percutaneous vs 6.5% ORIF).CONCLUSION: There is a significant difference in LOS based on operative approach for sacral fracture patients. Given similar complications and readmission rates, we recommend a percutaneous approach. | Vasanth Sathiyakumar Hanyuan Shi Rachel V Thakore Young M Lee David Joyce Jesse Ehrenfeld William T Obremskey Manish K Sethi | 2015 | World Journal of Orthopedics2015，6，8： | 0 |
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