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| 1 | Current status and prospects of clinical proteomics studies on detection of colorectal cancer:Hopes and fears显示文摘Colorectal adenocarcinoma (CRC) is the third most com-mon type of cancer and the fourth most frequent cause of death due to cancer worldwide. Given the natural history of CRC, early diagnosis appears to be the most appropriate tool to reduce disease-related mortality. A fi eld of recent interest is clinical proteomics, which was reported to lead to high sensitivity and specifi cities for early detection of several solid tumors. This emerging fi eld uses mass spectrometry-based protein profi les/pat-terns of easy accessible body fluids to distinguish cancer from non-cancer patients. These discrepancies may be a result of: (1) proteins being abnormally produced or shed and added to the serum proteome, (2) proteins clipped or modified as a consequence of the disease process, or (3) proteins subtracted from the proteome owing to disease-related proteolytic degradation path-ways. Therefore, protein pattern diagnostics would pro-vide easy and reliable tools for detection of cancer. This paper focuses on the current status of clinical proteomics research in oncology and in colorectal cancer especially, and will re? ect on pitfalls and fears in this relatively new area of clinical medicine, which are reproducibility issues and pre-analytical factors, statistical issues, and identifi -cation and nature of discriminating proteins/peptides. | ME de Noo RAEM Tollenaar AM Deelder LH Bouwman | 2006 | World Journal of Gastroenterology2006，12，41： | 3 |
| 2 | Isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver:recent trends and perspectives显示文摘 | Rothbarth J Tollenaa RAEM Schellens JHM | 2004 | Eur J Cancer2004，40，： | 1 |
| 3 | Isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver:recent trends and perspectives显示文摘 | Rothbarth J Tollenaa RAEM Schellens JHM | 2004 | Eur J Cancer2004，40，： | 1 |
| 4 | Risk factors for anastomotic failure after total mesorectal excision of rectal cancer 显示文摘 | Peeters KCMJ Tollenaar RAEM Marijnen CAM | 2005 | Br J Surg2005，92，： | 1 |
| 5 | Effect of TDZ on plant regenration from mature seeds in pea (Pisum sativum)显示文摘 | Zhihui S Tzitzikas M Raem akers K | 2009 | In Vitro Cellular and Developmental Biology-Plant2009，45，： | 1 |
| 6 | Comorbidity of mental disorders with alcohol and other drug abuse 显示文摘 | Regier DA Farmer MD Raem DS | 1990 | JAMA1990，246，19： | 1 |
| 7 | CD36 gene is associated with thickness of atheromatous plaque and ankle-brachial index in patients with early coronary artery disease显示文摘 | RaeME Safranow K Rac M | 2012 | Kardiol Pol2012，70，9： | 1 |
| 8 | IsCD36 gene polymorphism in region encoding lipid-binding domain associated with early onset CAD? 显示文摘 | RaeME Safranow K KurzawskiG | | Gene0，530，1： | 1 |
| 9 | 一个厌食症患者的自述显示文摘我以前一直是个胖乎乎的孩子,但我吃东西却非常挑剔。吃饭时,妈妈做的饭菜总是被我剩下。到了13岁,我开始留意自己的外表,并且把自己和其他人进行比较。我迷恋上了班里的一个女孩——我希望在她面前有个好形象,于是开始强迫性地锻炼。然后我开始限制饮食, | raeme Dalling crimethink | 2011 | 恋爱.婚姻.家庭(养生)2011，，2： | 0 |
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