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| 1 | Comparative effectiveness of adipose-derived mesenchymal stromal cells in the management of knee osteoarthritis:A meta-analysis显示文摘BACKGROUND Osteoarthritis(OA)is the most common joint disorder,is associated with an increasing socioeconomic impact owing to the ageing population.AIM To analyze and compare the efficacy and safety of bone-marrow-derived mesenchymal stromal cells(BM-MSCs)and adipose tissue-derived MSCs(AD-MSCs)in knee OA management from published randomized controlled trials(RCTs).METHODS Independent and duplicate electronic database searches were performed,including PubMed,EMBASE,Web of Science,and Cochrane Library,until August 2021 for RCTs that analyzed the efficacy and safety of AD-MSCs and BM-MSCs in the management of knee OA.The visual analog scale(VAS)score for pain,Western Ontario McMaster Universities Osteoarthritis Index(WOMAC),Lysholm score,Tegner score,magnetic resonance observation of cartilage repair tissue score,knee osteoarthritis outcome score(KOOS),and adverse events were analyzed.Analysis was performed on the R-platform using OpenMeta(Analyst)software.Twenty-one studies,involving 936 patients,were included.Only one study compared the two MSC sources without patient randomization;hence,the results of all included studies from both sources were pooled,and a comparative critical analysis was performed.RESULTS At six months,both AD-MSCs and BM-MSCs showed significant VAS improvement(P=0.015,P=0.012);this was inconsistent at 1 year for BM-MSCs(P<0.001,P=0.539),and AD-MSCs outperformed BM-MSCs compared to controls in measures such as WOMAC(P<0.001,P=0.541),Lysholm scores(P=0.006;P=0.933),and KOOS(P=0.002;P=0.012).BM-MSC-related procedures caused significant adverse events(P=0.003)compared to AD-MSCs(P=0.673).CONCLUSION Adipose tissue is superior to bone marrow because of its safety and consistent efficacy in improving pain and functional outcomes.Future trials are urgently warranted to validate our findings and reach a consensus on the ideal source of MSCs for managing knee OA. | Sathish Muthu Sandesh C Patil Naveen Jeyaraman Madhan Jeyaraman Prakash Gangadaran Ramya Lakshmi Rajendran Eun Jung Oh Manish Khanna Ho Yun Chung Byeong-Cheol Ahn | 2023 | World Journal of Orthopedics2023，14，1： | 2 |
| 2 | NEW TOXOPLASMA GONDII GENOTYPES ISOLATED FROM FREE-RANGE CHICKENS FROM THE FERNANDO DE NORONHA, BRAZIL: UNEXPECTED FINDINGS显示文摘 | Dubey J P Rajendran C Costa D G C Ferreira L R Kwok O C H Qu D Su C Marvulo M F V Alves L C Mota R A Silva J C R | 2010 | The Journal of Parasitology2010，，4： | 2 |
| 3 | Heuristic algorithms for scheduling in no-wait flow shop 显示文摘 | GANGADHARAN R RAJENDRAN C | 1993 | International Journal of Production Economics1993，32，3： | 1 |
| 4 | Critical Analysis of Spare Parts Using the AHP显示文摘 | Gajpal P P Ganesh L S Rajendran C | | International Journal of Production Economics0，35，3： | 1 |
| 5 | Heuristic algorithms for continuous flow-shop problem 显示文摘 | RAJENDRAN C CHAUDHURI D | 1990 | Naval Research Logistics1990，37，5： | 1 |
| 6 | Ant-colony algorithms for permutation flow-shop sequencing 显示文摘 | Rajendran C Ziegler H | 2004 | Computer and Operation Research2004，31，5： | 1 |
| 7 | Dispatching rules for scheduling in assembly jobshops, part 1 显示文摘 | Reeja M K Rajendran C | 2000 | International Journal of Production Research2000，38，9： | 1 |
| 8 | Effect of beheading on juice quality characteristics and sugar yield of sweet sorghum显示文摘 | Rajendran C Ramamoorthy K Backiyarani S | 2000 | Journal of Agronomy and Crop Science2000，185，1： | 1 |
| 9 | Measurement of vertices in model pump-intake bay by PIV显示文摘 | Rajendran V P Patel V C | 2000 | Journal of Hydraulic Engineering ASCE2000，126，5： | 1 |
| 10 | Chemical bath deposition synthesis of sub-micron ZnS-coated polystyrene显示文摘 | HUANG K J RAJENDRAN P LIDDELL C M | 2007 | Journal of Colloid and Interface Science2007，308，1： | 1 |
| 11 | New dispatching rules for shop scheduling: a step forward显示文摘 | JAYAMOHAN M S RAJENDRAN C | 2000 | Int J of Production Research2000，38，3： | 1 |
| 12 | Epoxy-cyanate ester shapememory thermoset:some aspects of phase transition,viscoelasticityand shape memory characteristics显示文摘 | Rajendran B Kumar K S Nair C P | 2013 | Polymers for AdvancedTechnologies2013，24，62： | 1 |
| 13 | A comparative study of dispatching rules in dynamic flow shops and job shops显示文摘 | RAJENDRAN C HOLTHAUS O | 1999 | European Journal of Operational Research1999，116，1： | 1 |
| 14 | Scheduling in Dynamic Assembly Job-shops with Jobs Having Different Holding and Tardiness Costs 显示文摘 | Thiagarajan S Rajendran C | 2003 | International Journal of Production Research2003，41，18： | 1 |
| 15 | Equivalent continuum modeling of graphene sheet 显示文摘 | Reddy C D Rajendran S Liew K M | 2005 | Int J Nanosci2005，4，： | 1 |
| 16 | Scheduling in Dynamic Assembly Jobshops to Minimize the Sum of Weighted Earliness, Weighted Tardiness and Weighted Flowtime of Jobs显示文摘 | Thiagarajan S Rajendran C | 2005 | Computers and Industrial Engineering2005，49，4： | 1 |
| 17 | A multistage parallel processor flow shop problem with minimum flowtime显示文摘 | Rajendran C Chaudhuri D | 1992 | European Journal of Operational Research1992，57，： | 1 |
| 18 | Equilibrium configu- ration and elastic properties of finite graphene 显示文摘 | Reddy C D Rajendran S Liew K M | 2006 | Nano- technology2006，17，： | 1 |
| 19 | A genetic algorithm for solving the fixedcharge transportation model:Twostage problem显示文摘 | ANTONY AROKIA DURAI RAJ KRAJENDRAN C | 2012 | Computers and Operations2012，39，： | 1 |
| 20 | Criticality analysis of spare parts using the analytic hierarchy process显示文摘 | Gaipal P Ganesh L Rajendran C | 1994 | International Journal of Production Economics1994，35，35： | 1 |
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