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| 1 | In vivo evaluation of anti-oxidant and anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models显示文摘 | Rajesh Kumar Gupta Achyut Narayan Kesari Sandhya Diwakar Ameetabh Tyagi Vibha Tandon Ramesh Chandra Geeta Watal | 2008 | Journal of Ethnopharmacology2008，，1： | 2 |
| 2 | Results of titanium elastic nailing in paediatric femoral diaphyseal fractures report of 30 cases显示文摘 | Divesh Jalan Rajesh Chandra VK Sharma | 2013 | Chinese Journal of Traumatology2013，16，2： | 1 |
| 3 | Design, synthesis, and structure-activity relationship of no- vel thiophene derivatives for β-amyloid plaque imaging 显示文摘 | Rajesh Chandra Mei Ping Kunga Hank F Kung | 2006 | Bioorganic & Medicinal Chemistry Letters2006，16，： | 1 |
| 4 | Wavelet filtering applied to time-average digital speckle pattern interferometry fringes显示文摘 | Rajesh Kumar Shashi Kumar Singh Chandra Shakher | 2001 | Optical & Laser Technology2001，33，： | 1 |
| 5 | New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaques 显示文摘 | Rajesh Chandra Shunichi Oya Mei Ping Kung | 2007 | J Med Chem2007，50，： | 1 |
| 6 | In-silico and in-vitro evaluation of docetaxel and berberine as potential p53 modulating apoptotic inducers in oral squamous cell carcinoma显示文摘Objective:To investigate the interaction of p53 with docetaxel and berberine and their anticancer activities against oral squamous cell carcinoma.Methods:The interaction between p53 with docetaxel and berberine was investigated and their mechanisms of action against oral squamous cell carcinoma were studied.Toxicity studies were performed to determine any toxic impact of the drugs on the vital organs of tested animals.Results:In silico results revealed the molecular interaction of docetaxel and berberine with p53 and the molecules were found to be potential p53 inducers.Docetaxel and berberine inhibited the proliferation of cancer cells in a concentration-dependent manner.Flow cytometry analysis revealed that docetaxel and berberine at IC50 concentrations upregulated the expression of p53 in oral squamous cell carcinoma cells,thus triggering apoptotic cell death.In addition,no toxicity was observed in the liver and kidney tissues of mice after docetaxel and berberine treatment.Conclusions:Docetaxel and berberine significantly suppressed the proliferation of oral cancer cells by activating p53 expression and causing apoptotic cell death.Both compounds can be potential agents for the treatment of oral cancer,with little to no toxicity at the tissue level. | Smrutipragnya Samal Rajesh Kumar Meher Debasmita Dubey Showkat Ahmad Mir Binata Nayak Mahesh Chandra Sahu Pradeep Kumar Naik Goutam Rath Santosh Kumar Swain | 2022 | Asian Pacific Journal of Tropical Biomedicine2022，12，12： | 1 |
| 7 | Nickel catalysed steam gasification of chars obtained from coal-alkali reaction at 600 ℃ 显示文摘 | Rajesh Chandra Srivastava Jagdish Sinha Sunil Kumar Srivastava | 2003 | Fuel2003，82，： | 1 |
| 8 | Analysis of hepatitis B virus X gene phylogeny, genetic variability and its impact on pathogenesis: Implications in Eastern Indian HBV carriers显示文摘 | Sibnarayan Datta Arup Banerjee Partha Kumar Chandra Avik Biswas Rajesh Panigrahi Pradip Kumar Mahapatra Chinmoy Kumar Panda Shekhar Chakrabarti Sujit Kumar Bhattacharya Runu Chakravarty | 2008 | Virology2008，，2： | 1 |
| 9 | GPS measured static and kinematic offsets at near and far field of the 2011 Mw 9.0 Tohoku-Oki earthquake显示文摘The Mw 9.0 Tohoku-Oki earthquake that hit the mainland Japan on 11 th March, 2011 had resulted a devastating Tsunami due to an active thrusting between the Pacific and the North American Plates. Static and kinematic offsets at the offshore epicentre of the Mw 9.0 event remain unanswered and being investigated along with their near and far field limiting distances from the epicentre. Accordingly, offset measurements from 60 continuously operating IGS and GEONET GNSS stations were radially classified from the epicentre and interpreted with analytical models to find their linear offset decay rates. Co-and post-seismic static positional anomaly offsets of sixty days show almost all near field stations had strong or appreciable eastward or south eastward static shifts. Near stations(<250 km) showed both kinematic and static offsets. GEONET station ’0175’ showed maximum resultant static offset of-4.5 m, which diminishes approximately 1-2 cm at far sites like SMST and AIRA. Characteristic decay duration(’b’) of the mean kinematic co-seismic shift(’a’)of near field stations was 17.28 s during earthquake hours with an EW component shift >1.5 m. Spatial models of projected N-S static and kinematic offsets show their asymmetrical distributions around the epicentre with maximum model offset of-1.84 m displaced towards south at-45 km north of the epicentre. The Tohoku-Oki earthquake produced a resultant kinematic offset of-10.2 m towards East at its offshore epicentre;while the estimated near field static offset is ~9.82 m. However, both estimates are bigger than double the resultant offset measured value(~4.3 m) in the Japanese mainland using GPS. The difference in the kinematic and static near field offsets highlight that the near surface had elastic or in-elastic kinematic strain dissipation as against the lithospheric level viscoelastic static response, which resulted rapid kinematic strain release(1.12 cm/km)within the limiting radius of ~220 km from the Tohoku-Oki epicentre. | Param K.Gautam Rajesh Sathyaseelan John P.Pappachen Naresh Kumar Arkoprovo Biswas George Philip ChANDra P.Dabral Sanjit K.Pal | 2019 | Geodesy and Geodynamics2019，10，3： | 1 |
| 10 | Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals显示文摘 | Rajesh Kumar Gupta Achyut Narayan Kesari P.S. Murthy R. Chandra V. Tandon Geeta Watal | 2005 | Journal of Ethnopharmacology2005，，： | 1 |
| 11 | Hydropericardi-um syndrome:current state and future developments显示文摘 | Manu Asthana Rajesh Chandra Rajesh Kumar | 2013 | Arch Vi-rol2013，158，5： | 1 |
| 12 | Development of nanocolloidal gold based immunochromatographic assay for rapid detection of transgenic vegetative insecticidal protein in genetically modified crops显示文摘 | Rajesh Kumar Chandra K. Singh Suchitra Kamle Rajeshwar P. Sinha Raj K. Bhatnagar Devendra N. Kachru | 2010 | Food Chemistry2010，，4： | 1 |
| 13 | Cytokines, MMP-2, and MMP-9 levels in patients with a solitary cysticercus granuloma显示文摘 | Rakesh Lalla Ravindra Garg Hardeep Malhotra Amita Jain Rajesh Verma Chandra Pandey Gyan Singh Praveen Sharma | 2015 | Neurology India2015，，2： | 1 |
| 14 | Wavelet filtering applied to time-average digital speckle pattern interferometry fringes 显示文摘 | Rajesh Kumar Shashi Kumar Singh Chandra Shakher | 2001 | Optics&Laser Technology2001，33，8： | 1 |
| 15 | Anti-cancer effects of sitagliptin,vildagliptin,and exendin-4 on triple-negative breast cancer cells via mitochondrial modulation显示文摘Triple-negative breast cancer(TNBC)cell line MDA-MB-231 is known for Warburg metabolism and defects in mitochondria.On the other hand,dipeptidyl peptidase-IV(DPP-IV)inhibitors such as sitagliptin and vildagliptin and GLP-1 agonist exendin-4 are known to improve mitochondrial functions as well as biogenesis,but no study has evaluated the influence of these drugs on mitochondrial biogenesis on metastatic breast cancer cell line.We have recently reported anticancer effects of 5-aminoimidazole-4-carboxamide riboside on MDA-MB-231 cells via activation of AMP-dependent kinase(AMPK),which activates the downstream transcription factors PGC-1α,PGC-1β,or FOXO1 for mitochondrial biogenesis;above-mentioned incretin-based therapies are also known to activate AMPK.This study evaluated the effects of sitagliptin,vildagliptin,and exendin-4 on MDA-MB-231 cells and the underlying changes in mitochondrial biogenesis,were examined.Treatment with sitagliptin(100μM),vildagliptin(100μM),and exendin-4(10 nM)for 72 h to MDA-MB-231 cells led to a decrease in viability indicated by MTT assay,cell migration by scratch,and transwell migration assays,accompanied with marginal reduction in cell numbers along with the apoptotic appearance,the rate of apoptosis,and decreased lactate content in conditioned medium.These changes in the cancer phenotype were accompanied by an increase in the mitochondrial DNA to nuclear DNA ratio,increased MitoTracker green and red staining,and increased expression of transcription factors PGC-1α,NRF-1,NRF-2,TFAM,and HO-1.Pre-treatment of cells with these incretin-based drugs followed by 48 h treatment with 1μM doxorubicin increased doxorubicin sensitivity as observed by a decrease in viability by MTT assay.Thus,sitagliptin,vildagliptin,and exendin-4 exert their beneficial effects on TNBC cells via an increase in mitochondrial biogenesis that helps to switch Warburg metabolism into anti-Warburg effect.Therapeutic response was in the order of:sitagliptin>vildagliptin>exendin-4. | POOJA JAISWAL VERSHA TRIPATHI ANSHUL ASSAIYA DHARMENDRA KASHYAP RAHUL DUBEY ANAMIKA SINGH JANESH KUMAR HEM CHANDRA JHA RAJESH SHARMA AMIT KUMAR DIXIT HAMENDRA SINGH PARMAR | 2022 | BIOCELL2022，46，12： | 0 |
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