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| 1 | Effects and safety of natriuretic peptides as treatment of cirrhotic ascites:A systematic review and meta-analysis显示文摘BACKGROUND Natriuretic peptides are involved in the cascade of pathophysiological events occurring in liver cirrhosis,counterbalancing vasoconstriction and anti-natriuretic factors.The effects of natriuretic peptides as treatment of cirrhotic ascites have been investigated only in small studies,and definitive results are lacking.AIM To examine the effects and safety of natriuretic peptides in cirrhosis patients with ascites.METHODS We searched MEDLINE,Web of Science,Scopus,Cochrane Library and Embase for all available studies applying intravenous administration of any natriuretic peptide to patients suffering from cirrhotic ascites.Inclusion was not limited by treatment duration or dose,or by follow-up duration.Both randomised controlled trials and non-randomised studies were eligible for inclusion.The primary outcome was change in renal sodium excretion.Secondary outcomes included safety measures and changes in renal water excretion,plasma aldosterone concentration,and plasma renin activity.RESULTS Twenty-two studies were included.Atrial natriuretic peptide(ANP)was the only intensively studied treatment.Sodium excretion increased in response to continuous ANP infusion and was more pronounced when infusion rates of>30 ng/kg/min were administered compared with≤30 ng/kg/min(P<0.01).Moreover,natriuresis was significantly higher in study subgroups with mild/moderate ascites compared with moderate/severe and refractory ascites(P<0.01).ANP infusions increased renal water excretion,although without reaching a statistically significant dose-response gradient.Plasma aldosterone concentration and plasma renin activity were significantly lower at baseline in study subgroups achieving a negative sodium balance in response to an ANP administration compared with treatment non-responders(P<0.01).Blood pressure decreases occurred less frequently when ANP doses≤30 ng/kg/min were applied.The quality of evidence for a natriuretic response to ANP was low,mainly due to small sample sizes and considerable between-study heterogeneity.Data were sparse for the other natriuretic peptides;B-type natriuretic peptide and urodilatin.CONCLUSION Intravenous ANP infusions increase sodium excretion in patients with cirrhotic ascites.Continuous infusion rates>30 ng/kg/min are the most effective.However,safety increases with infusion rates≤30 ng/kg/min. | Rasmus Hvidbjerg Gantzel Mikkel Breinholt Kjær Peter Jepsen Niels Kristian Aagaard Hugh Watson Lise Lotte Gluud Henning Grønbæk | 2022 | World Journal of Hepatology2022，14，4： | 1 |
| 2 | Glucose Transporter Gene Expression in Bovine Mammary Gland显示文摘 | ZHAO F Q RASMUS K O OHN J K | 1999 | Anim Sci1999，77，： | 1 |
| 3 | Electrical anisotropy of gas hydrate-bearing sand reservoirs in the Gulf of Mexico显示文摘 | Cook AE Anderson BI Rasmus J Sun K Li Qiming Collett TS | 2012 | Marine and Petroleum Geology2012，34，1： | 1 |
| 4 | Greenness in semi-arid areas across the globe 1981-2007: An Earth Observing Satellite based analysis of trends an drivers显示文摘 | Fensholt Rasmus Langanke T Rasmussen K | 2012 | Remote Sensing of Environment2012，121，6： | 1 |
| 5 | Myocardial regenera-tion induced by granulocyte-colony-stimuiating factor mobi-lization of stem cells in patients with acute or chronic ischaemicheart disease: a non-invasive alternative for clinical stem celltherapy显示文摘 | Jens K Rasmus S R Yongzhong W | 2006 | European Heart Journal2006，27，： | 1 |
| 6 | FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles显示文摘The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental studies.Over the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and habitats.Yet,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains challenging.In order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis levels.Combining the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,respectively.This resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental stud-ies.In order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS sequences.On the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold. | Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urmas Kõljalg Leho Tedersoo | 2020 | Fungal Diversity2020，，6： | 1 |
| 7 | China and climate justice:moving beyond statism显示文摘 | Paul G H Alice S Y C Rasmus K | 2013 | International Environmental Agreements2013，，13： | 1 |
| 8 | Fabrication of highly insulating foam glass made from CRT panel glass显示文摘 | Jakob K Rasmus R P Yue Y Z | 2015 | Ceramics International2015，41，8： | 1 |
| 9 | The mechanism of foaming and thermal conductivity of glasses foamed with Mn O2显示文摘 | Rasmus R P Jakob K Yuan Z Y | 2015 | Journal of Non-Crystalline Solids2015，425，： | 1 |
| 10 | Non-invasive imaging for subclinical coronary atherosclerosis in patients with peripheral artery disease 显示文摘 | RASMUS S R ANDREAS K BIRGER H | 2014 | Curt Atheroscler Rep2014，16，6： | 1 |
| 11 | Mesen chymal stem cells inhibit the expression of CD25 (interleukin-2 receptor) and CD38 on phytohaem agglutinin-ac tivatde lymphocytes显示文摘 | Le-Blanc K Rasmus son I Gotherstrom C | 2004 | Scand J Immunol2004，60，： | 1 |
| 12 | A food-grade cloning system for industrial strains of Lactococcus lactis显示文摘 | Kim I S RASMUS L ANNETTE K | 2000 | Applied and Environmental Microbiology2000，66，4： | 1 |
| 13 | A food-grade cloning system for industrial strains of Lactococcus lactis显示文摘 | Rasmus L Annette K | 2000 | Apphed and Environmental Microbiology2000，66，4： | 1 |
| 14 | Promoted Ru on high-surface area graphite for efficient miniaturized production of hydrogen from ammonia显示文摘 | Rasmus Z S Asbjorn K Ulrich Q | 2006 | Catal Lett2006，112，12： | 1 |
| 15 | Correction to:FungalTraits:a user friendly traits database of fungi and fungus-like stramenopiles显示文摘Correction to:Fungal Diversity(2020)105:116 http://gffzzd3cc09b8251d45dfspb9cc9p99fnx6kww.ffgz.tsg.suse.edu.cn/10.1007/s13225-020-00466-2 There were errors in the name of author LászlóG.Nagy and in affiliation no.31 in the original publication.The original article has been corrected. | Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks LászlóIrinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew P.Nelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urmas Kõljalg Leho Tedersoo | 2021 | Fungal Diversity2021，，2： | 0 |
| 16 | In vivo cardiac pacemaker function of differentiated human mesenchymal stem cells from adipose tissue transplanted into porcine hearts显示文摘BACKGROUND Mesenchymal stem cells(MSC)modified by gene transfer to express cardiac pacemaker channels such as HCN2 or HCN4 were shown to elicit pacemaker function after intracardiac transplantation in experimental animal models.Human MSC derived from adipose tissue(haMSC)differentiate into cells with pacemaker properties in vitro,but little is known about their behavior after intracardiac transplantation.AIM To investigate whether haMSC elicit biological pacemaker function in vivo after transplantation into pig hearts.METHODS haMSC under native conditions(nhaMSC)or after pre-conditioning by medium differentiation(dhaMSC)(n=6 pigs each,5×106 cells/animal)were injected into the porcine left ventricular free wall.Animals receiving PBS injection served as controls(n=6).Four weeks later,total atrioventricular(AV)-block was induced by radiofrequency catheter ablation,and electronic pacemaker devices were implanted for backup stimulation and heart rate monitoring.Ventricular rate and rhythm of pigs were evaluated during a follow-up of 15 d post ablation by 12-lead-ECG with heart rate assessment,24-h continuous rate monitoring recorded by electronic pacemaker,assessment of escape recovery time,and pharmacological challenge to address catecholaminergic rate response.Finally,hearts were analyzed by histological and immunohistochemical investigations.RESULTS In vivo transplantation of dhaMSC into the left ventricular free wall of pigs elicited spontaneous and regular rhythms that were pace-mapped to ventricular injection sites(mean heart rate 72.2±3.6 bpm;n=6)after experimental total AV block.Ventricular rhythms were stably detected over a 15-d period and were sensitive to catecholaminergic stimulation(mean maximum heart rate 131.0±6.2 bpm;n=6;P<0.001).Pigs,which received nhaMSC or PBS presented significantly lower ventricular rates(mean heart rates 47.2±2.5 bpm and 37.4±3.2 bpm,respectively;n=6 each;P<0.001)and exhibited little sensitivity towards catecholaminergic stimulation(mean maximum heart rates 76.4±3.1 bpm and 60.5±3.1 bpm,respectively;n=6 each;P<0.05).Histological and immunohistochemical evaluation of hearts treated with dhaMSC revealed local clusters of transplanted cells at the injection sites that lacked macrophage or lymphocyte infiltrations or tumor formation.Intense fluorescence signals at these sites indicated membrane expression of HCN4 and other pacemaker-specific proteins involved in cardiac automaticity and impulse propagation.CONCLUSION dhaMSC transplanted into pig left ventricles sustainably induced rate-responsive ventricular pacemaker activity after in vivo engraftment for four weeks.The data suggest that pre-conditioned MSC may further differentiate along a pacemakerrelated lineage after myocardial integration and may establish superior pacemaker properties in vivo. | Fabrice F Darche Rasmus Rivinius Ann-Kathrin Rahm Eva Köllensperger Uwe Leimer Günter Germann Miriam Reiss Michael Koenen Hugo A Katus Dierk Thomas Patrick A Schweizer | 2020 | World Journal of Stem Cells2020，12，10： | 0 |
| 17 | The Global Soil Mycobiome consortium dataset for boosting fungal diversity research显示文摘Fungi are highly important biotic components of terrestrial ecosystems,but we still have a very limited understanding about their diversity and distribution.This data article releases a global soil fungal dataset of the Global Soil Mycobiome consortium(GSMc)to boost further research in fungal diversity,biogeography and macroecology.The dataset comprises 722,682 fungal operational taxonomic units(OTUs)derived from PacBio sequencing of full-length ITS and 18S-V9 variable regions from 3200 plots in 108 countries on all continents.The plots are supplied with geographical and edaphic metadata.The OTUs are taxonomically and functionally assigned to guilds and other functional groups.The entire dataset has been corrected by excluding chimeras,index-switch artefacts and potential contamination.The dataset is more inclusive in terms of geographical breadth and phylogenetic diversity of fungi than previously published data.The GSMc dataset is available over the PlutoF repository. | Leho Tedersoo Vladimir Mikryukov Sten Anslan Mohammad Bahram Abdul Nasir Khalid Adriana Corrales Ahto Agan Aída-M.Vasco-Palacios Alessandro Saitta Alexandre Antonelli Andrea C.Rinaldi Annemieke Verbeken Bobby P.Sulistyo Boris Tamgnoue Brendan Furneaux Camila Duarte Ritter Casper Nyamukondiwa Cathy Sharp César Marín D.Q.Dai Daniyal Gohar Dipon Sharmah Elisabeth Machteld Biersma Erin K.Cameron Eske De Crop Eveli Otsing Evgeny A.Davydov Felipe E.Albornoz Francis Q.Brearley Franz Buegger Genevieve Gates Geoffrey Zahn Gregory Bonito Indrek Hiiesalu Inga Hiiesalu Irma Zettur Isabel C.Barrio Jaan Pärn Jacob Heilmann-Clausen Jelena Ankuda John Y.Kupagme Joosep Sarapuu Jose G.Maciá-Vicente Joseph Djeugap Fovo József Geml Juha M.Alatalo Julieta Alvarez-Manjarrez Jutamart Monkai Kadri Põldmaa Kadri Runnel Kalev Adamson Kari A.Bråthen Karin Pritsch Kassim I.Tchan Kęstutis Armolaitis Kevin D.Hyde Kevin K.Newsham Kristel Panksep Lateef A.Adebola Louis J.Lamit Malka Saba Marcela Eda Silva Cáceres Maria Tuomi Marieka Gryzenhout Marijn Bauters Miklós Bálint Nalin Wijayawardene Niloufar Hagh-Doust Nourou S.Yorou Olavi Kurina Peter E.Mortimer Peter Meidl RHenrik Nilsson Rasmus Puusepp Rebeca Casique-Valdés Rein Drenkhan Roberto Garibay-Orijel Roberto Godoy Saleh Alfarraj Saleh Rahimlou Sergei Põlme Sergey V.Dudov Sunil Mundra Talaat Ahmed Tarquin Netherway Terry W.Henkel Tomas Roslin Vladimir E.Fedosov Vladimir G.Onipchenko WAErandi Yasanthika Young Woon Lim Meike Piepenbring Darta Klavina Urmas Kõljalg Kessy Abarenkov | 2021 | Fungal Diversity2021，，6： | 0 |
| 18 | Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4(ITIH4)in Autoimmune Cholestatic Liver Diseases显示文摘Background and Aims:There is an unmet need for new bi-omarkers to improve diagnostics and prognostics in primary biliary cholangitis(PBC)and primary sclerosing cholangitis(PSC).Inter-α-inhibitor heavy chain 4(ITIH4)is an abun-dant,liver-produced protein,and its synthesis may be al-tered in liver diseases.We investigated whether ITIH4 plas-ma concentrations were affected in PBC and PSC patients.Methods:We developed an immunoassay specific for ITIH4 and determined ITIH4 plasma concentrations in 66 PBC,126 PSC,92 autoimmune hepatitis(AIH),67 chronic hepatitis C(CHC),33 alcoholic hepatitis(AH)patients and 138 healthy controls(HCs).Hepatic ITIH4 expression was investigated by immunohistochemistry in PBC.Results:The mean plas-ma concentration of ITIH4 was almost doubled in PBC[409μg/mL(95%CI:388-431)]and 35%higher in PSC[308μg/mL,(95%CI:296-319)]compared with HCs[226μg/mL(95%CI:221-231);p<0.001].In PBC patients,ITIH4 correlated with IgM(rho=0.49,p<0.001).Responders to ursodeoxycholic acid treatment(UDCA)had lower levels of ITIH4 than incomplete responders[395μg/mL(95%CI:364-425)]vs.460μg/mL(95%CI:421-498);p=0.02].Four weeks of UDCA treatment had no effect(p=0.19).In-creased ITIH4 immunohistochemical staining was seen in a liver biopsy from a PBC patient.ITIH4 levels in AIH[224μg/mL(95%CI:208-241)]and HCs were similar(p=0.8).ITIH4 levels were lower in AH[199μg/mL(95%CI:175-223)]and CHC[202μg/mL(192-212)]patients than in HCs(p<0.05).Conclusions:The plasma concentration of ITIH4 was highly elevated in patients with PBC and PSC,suggesting that ITIH4 should be further investigated as a biomarker in cholestatic liver disease. | Tea Lund Laursen Lars Bossen Rasmus Pihl Anne Troldborg Thomas Damgaard Sandahl Annette Gudmann Hansen Trine Folserass Mette Vesterhus Henning Grønbæk Steffen Thiel | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 0 |
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