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| 1 | Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes显示文摘Background:To test clinically relevant factors associated with quantitative artifact-free deep capillary plexus(DCP)metrics in patients with diabetes mellitus(DM).Methods:563 eligible eyes(221 with no diabetic retinopathy[DR],135 with mild DR,130 with moderate DR,and 77 with severe DR)from 334 subjects underwent optical coherence tomography-angiography(OCT-A)with a swept-source OCT(Triton DRI-OCT,Topcon,Inc.,Tokyo,Japan).Strict criteria were applied to exclude from analysis those DCP images with artifacts and of poor quality,including projection artifacts,motion artifacts,blurriness,signal loss,B-scan segmentation error,or low-quality score.A customized MATLAB program was then used to quantify DCP morphology from the artifact-free DCP images by calculating three metrics:foveal avascular zone(FAZ),vessel density(VD),and fractal dimension(FD).Results:166(29.5%)eyes were excluded after quality control,leaving in the analysis 397 eyes(170 with no DR,101 with mild DR,90 with moderate DR,36 with severe DR)from 250 subjects.In the multiple regression models,larger FAZ area was associated with more severe DR(β=0.687;p=0.037),shorter axial length(AL)(β=−0.171;p=0.003),thinner subfoveal choroid thickness(β=−0.122;p=0.031),and lower body mass index(BMI)(β=−0.090;p=0.047).Lower VD was associated with more severe DR(β=−0.842;p=0.001),shorter AL(β=0.107;p=0.039),and poorer visual acuity(VA)(β=−0.133;p=0.021).Lower FD was associated with more severe DR(β=−0.891;p<0.001)and with older age(β=−0.142;p=0.004).Conclusions:Quantitative artifact-free DCP metrics are associated with VA,DR severity,AL,subfoveal choroidal thickness,age,and BMI in diabetic patients.The effects of ocular and systemic factors should be considered for meaningful interpretations of DCP changes in DM patients. | Fang Yao Tang Erica O.Chan Zihan Sun Raymond Wong Jerry Lok Simon Szeto Jason C.Chan Alexander Lam Clement C.Tham Danny S.Ng Carol Y.Cheung | 2020 | Eye and Vision2020，7，1： | 7 |
| 2 | An efficient method for privacy preserving location queries显示文摘最近,保存地点询问的隐私的问题吸引了许多研究。然而,有很少工作,集中于在地点隐私保藏和地点质问信息收集之间的折衷。处理这种折衷,我们建议坚持的隐私地点质问(PLQ ) ,保存地点质问处理的有效隐私框架。没有揭示用户地点信息,这个框架能启用基于地点的质问。框架能也便于基于地点的服务供应商关于基于的地点收集一些信息查询,它在实践是有用的。也就是, PLQ 由三个关键部件组成在顾客方面,在服务器方面的隐私询问处理器,和连接顾客和服务器的另外的信任第三方的地点 anonymizer。地点 anonymizer 基于一个地图层次模糊用户地点进一个 cloaked 区域。地图层次包含根据真实地形被划分的精确区域。隐私质问处理器处理请求近邻居(NN ) 地点基于质问。多角形(CHP ) 的新凸的壳算法用一个多角形 cloaked 区域为近邻居的询问被建议。我们高效地,进程地点基于的算法罐头查询的试验性的结果表演。 | Yubao LIU Xiuwei CHEN Zhan LI Zhijie LI Raymond Chi-Wing WONG | 2012 | Frontiers of Computer Science2012，6，4： | 5 |
| 3 | Drug development in targeting ion channels for brain edema显示文摘Cerebral edema is a pathological hallmark of various central nervous system(CNS)insults,including traumatic brain injury(TBI)and excitotoxic injury such as stroke.Due to the rigidity of the skull,edema-induced increase of intracranial fluid significantly complicates severe CNS injuries by raising intracranial pressure and compromising perfusion.Mortality due to cerebral edema is high.With mortality rates up to 80%in severe cases of stroke,it is the leading cause of death within the first week.Similarly,cerebral edema is devastating for patients of TBI,accounting for up to 50%mortality.Currently,the available treatments for cerebral edema include hypothermia,osmotherapy,and surgery.However,these treatments only address the symptoms and often elicit adverse side effects,potentially in part due to non-specificity.There is an urgent need to identify effective pharmacological treatments for cerebral edema.Currently,ion channels represent the third-largest target class for drug development,but their roles in cerebral edema remain ill-defined.The present review aims to provide an overview of the proposed roles of ion channels and transporters(including aquaporins,SUR1-TRPM4,chloride channels,glucose transporters,and proton-sensitive channels)in mediating cerebral edema in acute ischemic stroke and TBI.We also focus on the pharmacological inhibitors for each target and potential therapeutic strategies that may be further pursued for the treatment of cerebral edema. | Zheng-wei Luo Andrea Ovcjak Raymond Wong Bao-xue Yang Zhong-ping Feng Hong-shuo Sun | 2020 | Acta Pharmacologica Sinica2020，41，10： | 3 |
| 4 | Henkel Technologies and Products for China Aerospace显示文摘Epoxy structural adhesives and composites have been in use for many years for the construction of aerospace vehicles. Henkel provides many epoxy products. Many other resin systems have been evaluated and several, such as imide, phenolic and cyanate ester, have also achieved significant use. Henkel’s newly developed “Epsilon” chemistry demonstrates unique features that benefit application in aerospace structure that use adhesives and composites. | Michael Cichon Helen Wei Li Alex Wong Stan Lehmann Raymond Wong | 2006 | 材料工程2006，34，5： | 3 |
| 5 | Blockade of the swelling-induced chloride current attenuates the mouse neonatal hypoxic-ischemic brain injury in vivo显示文摘胀大导致 Cl 电流的激活(我 Cl,胀大 ) 在新生的组织缺氧局部缺血期间(嗨) 可以导致大脑损坏。Hypoxic-ischemic 大脑损害在出生不满一月的婴儿以及尖锐死亡引起长期的神经病学的病态。在这研究,我们调查了角色我 Cl,胀大在用选择 blocker 的 hypoxic-ischemic 大脑损害的 , 4-(2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl ) oxybutyric 酸(DCPIB ) 。在主要有教养的外皮的神经原, 30% 张力减退的答案的灌注激活我 Cl,胀大是的 , 完全由 DCPIB (10 mol/L ) 的申请堵住了。角色我 Cl,胀大在在 vivo 的新生的 hypoxic-ischemic 大脑损害的 在一个修改新生的 hypoxic-ischemic 大脑损害模型被评估。在收到 ischemic 侮辱前,老鼠小狗与 DCPIB 被注射(10 mg/kg, ip ) 。我们发现有 DCPIB 的那个预告的处理显著地减少了用 TTC 染色, Nissl 染色和整个大脑成像估计的大脑损坏,并且改进了在 neurobehavioural 测试评估的感觉运动、门厅的恢复结果(即趋地性 reex,和峡谷回避 reex ) 。这些结果证明 DCPIB 在新生的 hypoxic-ischemic 大脑损害上有 neuroprotective 效果,并且 I Cl,胀大 可以为 hypoxic-ischemic encephalopathy 的处理用作一个治疗学的目标。 | Raymond WONG Ahmed ABUSSAUD Joseph WH LEUNG Bao-feng XU Fei-ya LI Sammen HUANG Nai-hong CHEN Guan-lei WANG Zhong-ping FENG Hong-shuo SUN | 2018 | Acta Pharmacologica Sinica2018，39，5： | 3 |
| 6 | Viral-Human Chimeric Transcript Predisposes Risk to Liver Cancer Development and Progression显示文摘 | Chi-Chiu Lau Tingting Sun Arthur K.K. Ching Mian He Jing-Woei Li Alissa M. Wong Ngai Na Co Anthony W.H. Chan Pik-Shan Li Raymond W.M. Lung Joanna H.M. Tong Paul B.S. Lai Henry L.Y. Chan Ka-Fai To Ting-Fung Chan Nathalie Wong | 2014 | Cancer Cell2014，，3： | 2 |
| 7 | Lack of evidence of active lytic replication of Epstein-Barr and cytomegaloviruses in patients with systemic lupus erythematosus显示文摘LackofevidenceofactivelyticreplicationofEpsteinBarrandcytomegalovirusesinpatientswithsystemiclupuserythematosusLauChakSing,... | Lau Chak Sing, Yuen Yung, Chan Hung and Wong Raymond Woon Sing | 1998 | Chinese Medical Journal1998，，7： | 2 |
| 8 | Querying business process model repositories显示文摘 | Jianmin Wang Tao Jin Raymond K. Wong Lijie Wen | 2014 | World Wide Web2014，，3： | 2 |
| 9 | Hollow silica reinforced magnesium nanocomposites with enhanced mechanical and biological properties with computational modeling analysis for mandibular reconstruction显示文摘The present study investigates Mg-SiO2 nanocomposites as biodegradable implants for orthopedic and maxillofacial applications.The effect of presence and progressive addition of hollow silica nanoparticles(0.5,1,and 1.5)vol.%on the microstructural,mechanical,degradation,and biocompatibility response of pure Mg were investigated.Results suggest that the increased addition of hollow silica nanoparticles resulted in a progressive increase in yield strength and ultimate compressive strength with Mg-1.5 vol.%SiO2 exhibiting superior enhancement.The response of Mg-SiO2 nanocomposites under the influence of Hanks’balanced salt solution revealed that the synthesized composites revealed lower corrosion rates,indicating rapid dynamic passivation when compared with pure Mg.Furthermore,cell adhesion and proliferation of osteoblast cells were noticeably higher than pure Mg with the addition of 1 vol.%SiO2 nanoparticle.The biocompatibility and the in vitro biodegradation of the Mg-SiO2 nanocomposites were influenced by the SiO2 content in pure Mg with Mg-0.5 vol.%SiO2 nanocomposite exhibiting the best corrosion resistance and biocompatibility when compared with other nanocomposites.Enhancement in mechanical,corrosion,and biocompatibility characteristics of Mg-SiO2 nanocomposites developed in this study are also compared with properties of other metallic biomaterials used in alloplastic mandibular reconstruction in a computational model. | Somasundaram Prasadh Vyasaraj Manakari Gururaj Parande Raymond Chung Wen Wong Manoj Gupta | 2020 | International Journal of Oral Science2020，12，4： | 2 |
| 10 | Mining top-K frequent itemsets from data streams显示文摘 | Raymond Chi-Wing Wong Ada Wai-Chee Fu | 2006 | Data Mining and Knowledge Discovery2006，13，2： | 1 |
| 11 | Valsartan benefits left ventricular structure and function in heart failure: Val-HeFT echocardiographic study显示文摘 | Maylene Wong Lidia Staszewsky Roberto Latini Simona Barlera Alberto Volpi Yann-Tong Chiang Raymond L Benza Sidney O Gottlieb Thomas D Kleemann Franco Rosconi Pieter M Vandervoort Jay N Cohn | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
| 12 | Efficient skyline querying with variable user preferences on nominal attributes 显示文摘 | Raymond Chi-Wing Wong Ada Wai-Chee Fu Jian Pei | 2008 | Proceedings of the VLDB Endowment2008，1，1： | 1 |
| 13 | Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV)显示文摘The sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted the establishment of a global scientific network subsuming most of the traditional rivalries in the competitive field of virology. Within months of the SARS outbreak, collaborative work revealed the identity of the disastrous pathogen as SARS-associated coronavirus (SARS-CoV). However, although the rapid identification of the agent represented an important breakthrough, our understanding of the deadly virus remains limited. Detailed biological knowledge is crucial for the development of effective countermeasures, diagnostic tests, vaccines and antiviral drugs against the SARS-CoV. This article reviews the present state of molecular knowledge about SARS-CoV, from the aspects of comparative genomics, molecular biology of viral genes, evolution, and epidemiology, and describes the diagnostic tests and the anti-viral drugs derived so far based on the available molecular information. | Raymond Kin Hi Hui Raymond Tsz Yeung Wong Chi Wai Yip Frederick Chi Ching Leung | 2003 | Genomics, Proteomics & Bioinformatics2003，1，4： | 1 |
| 14 | Modified Joint Weibull approach to determine Load Enhancement Factors显示文摘 | James Giancaspro Winson Taam Raymond Wong | 2008 | International Journal of Fatigue2008，，4： | 1 |
| 15 | Apoptosis and Other Cell Death Mechanisms after Retinal Detachment: Implications for Photoreceptor Rescue显示文摘 | Lo Amy C Y Woo Tiffany T Y Wong Raymond L M Wong David | 2011 | 2011，，： | 1 |
| 16 | Siltuximab for multicentric Castleman’s disease: a randomised, double-blind, placebo-controlled trial显示文摘 | Frits van Rhee Raymond S Wong Nikhil Munshi Jean-Francois Rossi Xiao-Yan Ke Alexander Foss? David Simpson Marcelo Capra Ting Liu Ruey Kuen Hsieh Yeow Tee Goh Jun Zhu Seok-Goo Cho Hanyun Ren James Cavet Rajesh Bandekar Margaret Rothman Thomas A Puchalski M | 2014 | Lancet Oncology2014，，9： | 1 |
| 17 | Financial Statement Frauds and Auditor Sanctions: An Analysis of Enforcement Actions in China显示文摘 | Michael Firth Phyllis L. L. Mo Raymond M. K. Wong | 2005 | Journal of Business Ethics2005，，4： | 1 |
| 18 | Financial Statement Frauds and Auditor Sanctions: An Analysis of Enforcement Actions in China显示文摘 | Michael Firth Phyllis L. L. Mo Raymond M. K. Wong | 2005 | Journal of Business Ethics2005，，4： | 1 |
| 19 | A single nucleotide polymorphism of interleukin‐6 gene is related to plasma adrenomedullin levels显示文摘 | Hoi Kin Wong Kwok Leung Ong Raymond Y. H. Leung Tai Hing Lam Graham Neil Thomas Karen S. L. Lam Bernard M. Y. Cheung | 2013 | Clin Endocrinol2013，，4： | 1 |
| 20 | Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study显示文摘 | Raymond C.S. Seet Katherine Kasiman Jan Gruber Soon-Yew Tang Meng-Cheong Wong Hui-Meng Chang Yiong-Huak Chan Barry Halliwell Christopher P. Chen | 2009 | Atherosclerosis2009，，1： | 1 |
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