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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Conductance of a molecular junction显示文摘 | Reed M A Zhou C Muller C J | 1997 | Science1997，278，： | 1 |
| 3 | Predicting residual stresses and distortion when welding aeroengine alloys显示文摘 | Oddy A S Reed R C | 1998 | Canadian Aeronautics and Space Journal1998，44，2： | 1 |
| 4 | Convergence properties of the Nelder-Mead simplex method in low dimensions显示文摘 | Lagarias J C Reeds J A Wright M H | 1998 | SIAM Journal of Optimization1998，9，1： | 1 |
| 5 | Atomic probes: a search for conduction through a single molecule显示文摘 | C J Muller B J Vleeming M A Reed | 1996 | Nanotechnology1996，7，： | 1 |
| 6 | Nanofiber technology for burn care显示文摘 | Hromadka M Reed C Han L | 2008 | J Burn Care Res2008，29，5： | 1 |
| 7 | Geno- type-phenotype con elation in X-linked Alport syndrome显示文摘 | BEKHEIRNIA M R REED B GREGORY M C | 2010 | Jo- urnal of the American Society of Nephrology (JASN)2010，21，5： | 1 |
| 8 | Advances in gelled- electrolyte technology for valve- regulated lead- acid batteries 显示文摘 | Lambert D W H Greenwood P H J Reed M C | 2002 | Journal of Power Sources2002，107，2： | 1 |
| 9 | Conductance of a mo0lecular junction 显示文摘 | Reed M A Zhou C Muller C J | 1997 | Xcience1997，278，5336： | 1 |
| 10 | Conductance of a molecular junction显示文摘 | M A Reed C Zhou C J Muller | 1997 | Science1997，278，10： | 1 |
| 11 | Convergence properties of the Nelder-Mead simplex method in low dimensions 显示文摘 | Lagarias J C Reeds J A Wright M H | 1998 | SIAM Journal of Optimization1998，9，1： | 1 |
| 12 | Effects of mutations and glycosylations on STS activity: a site-directed mutagenesis study显示文摘 | Stengel C Newman S P Day J M Tutill H J Reed M J Purohit A | 2008 | Molecular and Cellular Endocrinology2008，283，1： | 1 |
| 13 | Evaluation of analytical methods for determining pesticides in baby foods and adult duplicate-diet samples 显示文摘 | Chuang J C Hart K Chang J S Boman L E Van Emon J M Reed A W | 2001 | Analytica Chimica Acta2001，444，1： | 1 |
| 14 | Conductance of a molecular junction显示文摘 | Reed M A Zhou C Muller C J | 1997 | Science1997，278，： | 1 |
| 15 | Creep of CMSX-4 superalloy single crystals:effects of rafting at high temperature显示文摘 | Reed R Matan N Cox D Rist M Rae C | 1999 | Acta Materialia1999，47，： | 1 |
| 16 | Mor- phology, genesis, and distribution of nanometer- scale pores in siliceous mudstones of the Mississippi an Barnett Shale 显示文摘 | Loucks R G Reed R M Ruppel S C | 2009 | Journal of Sedimentary Re search2009，79，： | 1 |
| 17 | Femtoce|ls: Past, present, and future 显示文摘 | ANDREWS J G CLAUSSEN H DOHLER M RANGAN S REED M C | 2012 | IEEE JSAC on Femtocellular Networks2012，30，3： | 1 |
| 18 | Caregiver Burden in Alzheimer's Disease: Differential Associations in Adult-Child and Spousal Caregivers in the GERAS Observational Study 显示文摘 | Reed C Belger M Dell' agnel!o G | 2014 | Dement Geriatr Cogn Dis Extra2014，4，1： | 1 |
| 19 | Morphology,genesis, and distribution of nanometer-scale pores in siliceous mudstones of the Mississippian Barnett Shale显示文摘 | Loucks R G Reed R M Ruppel S C etal | 2009 | Journal of Sedimentary Research2009，79，12： | 1 |
| 20 | Multi-laboratory validation of a standard method for quantifying proanthocyanidins in cranberry powders显示文摘 | Prior R L Fan E Ji H P Howell A Nio C Payne M J Reed J | 2010 | Journal of the Science of Food and Agriculture2010，90，9： | 1 |
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