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| 1 | Safety and efficacy of soluble guanylate cyclase stimulators in patients with heart failure: A systematic review and meta-analysis显示文摘BACKGROUND The utility of novel oral soluble guanylate cyclase(sGC)stimulators(vericiguat and riociguat),in patients with reduced or preserved ejection fraction heart failure(HFrEF/HFpEF)is currently unclear.AIM To determine the efficacy and safety of sGC stimulators in HF patients.METHODS Multiple databases were searched to identify relevant randomized controlled trials(RCTs).Data on the safety and efficacy of sGC stimulators were compared using relative risk ratio(RR)on a random effect model.RESULTS Six RCTs,comprising 5604 patients(2801 in sGC stimulator group and 2803 placebo group)were included.The primary endpoint(a composite of cardiovascular mortality and first HF-related hospitalization)was significantly reduced in patients receiving sGC stimulators compared to placebo[RR 0.92,95%confidence interval(CI):0.85-0.99,P=0.02].The incidence of total HF-related hospitalizations were also lower in sGC group(RR 0.91,95%CI:0.86-0.96,P=0.0009),however,sGC stimulators had no impact on all-cause mortality(RR 0.96,95%CI:0.86-1.07,P=0.45)or cardiovascular mortality(RR 0.94,95%CI:0.83-1.06,P=0.29).The overall safety endpoint(a composite of hypotension and syncope)was also similar between the two groups(RR 1.50,95%CI:0.93-2.42,P=0.10).By contrast,a stratified subgroup analysis adjusted by type of sGC stimulator and HF(vericiguat vs riociguat and HFrEF vs HFpEF)showed near identical rates for all safety and efficacy endpoints between the two groups at a mean follow-up of 19 wk.For the primary composite endpoint,the number needed to treat was 35,the number needed to harm was 44.CONCLUSION The use of vericiguat and riociguat in conjunction with standard HF therapy,shows no benefit in terms of decreasing HF-related hospitalizations or mortality. | Waqas Ullah Maryam Mukhtar Aws Al-Mukhtar Rehan Saeed Margot Boigon Donald Haas Eduardo Rame | 2020 | World Journal of Cardiology2020，12，10： | 3 |
| 2 | Effects of left ventricular assist device on pulmonary functions and pulmonary hemodynamics:A meta-analysis显示文摘BACKGROUND Given current evidence,the effect of left ventricular assist device(LVAD)implantation on pulmonary function tests remains controversial.AIM To better understand the factors contributing to the changes seen on pulmonary function testing and the correlation with pulmonary hemodynamics after LVAD implantation.METHODS Electronic databases were queried to identify relevant articles.The summary effect size was estimated as a difference of overall means and standard deviation on a random-effects model.RESULTS A total of four studies comprising 219 patients were included.The overall mean forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and diffusion lung capacity of carbon monoxide(DLCO)after LVAD implantation were significantly lower by 0.23 L(95%CI:0.11-0.34,P=00002),0.18 L(95%CI:0.03-0.34,P=0.02),and 3.16 mmol/min(95%CI:2.17-4.14,P<0.00001),respectively.The net post-LVAD mean value of the cardiac index was significantly higher by 0.49 L/min/m2(95%CI:0.31-0.66,P<0.00001)compared to pre-LVAD value.The pulmonary capillary wedge pressure and pulmonary vascular resistance were significantly reduced after LVAD implantation by 8.56 mmHg(95%CI:3.78-13.35,P=0.0004),and 0.83 Woods U(95%CI:0.11-1.55,P=0.02),respectively.There was no significant difference observed in the right atrial pressure after LVAD implantation(0.61 mmHg,95%CI:-2.00 to 3.32,P=0.65).Overall findings appear to be driven by studies using HeartMateII devices.CONCLUSION LVAD implantation might be associated with a significant reduction of the spirometric measures,including FEV1,FVC,and DLCO,and an overall improvement of pulmonary hemodynamics. | Waqas Ullah Casey Meizinger Zain Ali Ankur Panchal Rehan Saeed Donald C Haas Eduardo Rame | 2020 | World Journal of Cardiology2020，12，11： | 0 |
| 3 | Root-Of-Trust for Continuous Integration and Continuous Deployment Pipeline in Cloud Computing显示文摘Cloud computing has gained significant use over the last decade due to its several benefits,including cost savings associated with setup,deployments,delivery,physical resource sharing across virtual machines,and availability of on-demand cloud services.However,in addition to usual threats in almost every computing environment,cloud computing has also introduced a set of new threats as consumers share physical resources due to the physical co-location paradigm.Furthermore,since there are a growing number of attacks directed at cloud environments(including dictionary attacks,replay code attacks,denial of service attacks,rootkit attacks,code injection attacks,etc.),customers require additional assurances before adopting cloud services.Moreover,the continuous integration and continuous deployment of the code fragments have made cloud services more prone to security breaches.In this study,the model based on the root of trust for continuous integration and continuous deployment is proposed,instead of only relying on a single signon authentication method that typically uses only id and password.The underlying study opted hardware security module by utilizing the Trusted Platform Module(TPM),which is commonly available as a cryptoprocessor on the motherboards of the personal computers and data center servers.The preliminary proof of concept demonstrated that the TPM features can be utilized through RESTful services to establish the root of trust for continuous integration and continuous deployment pipeline and can additionally be integrated as a secure microservice feature in the cloud computing environment. | Abdul Saboor Mohd Fadzil Hassan Rehan Akbar Erwin Susanto Syed Nasir Mehmood Shah Muhammad Aadil Siddiqui Saeed Ahmed Magsi | 2022 | Computers, Materials & Continua2022，，11： | 0 |
| 4 | On-chip immunomagnetic bead swarm based on magnetic actuation and mechanical vibration for biological detection显示文摘Immunomagnetic bead(IMB)-based detection has great potential for biomedical applications.Passive and active strategies,including microfluidics and magnetic actuation methods,have been developed to mix IMBs and analytes efficiently.However,cost-effective on-site detection using a simple microfluidic chip is challenging,and miniaturization of the magnetic driving device is imperative for portability.In this study,we propose a novel mixing method for an on-chip IMB swarm via magnetic actuation and mechanical vibration.A microfluidic chip system coupled with double spiral magnetic coils and a vibration motor was fabricated.The aggregation behavior of IMBs under magnetic fields and the diffusion behavior of the IMB swarm under mechanical vibration were analyzed in detail.Based on the synergetic effects of magnetic actuation and mechanical vibration,we achieved the highly efficient capturing of Vibrio parahaemolyticus DNA and goat anti-human immunoglobulin G by mixing the IMB swarm with the microfluidic chip.In this case,the antigen detection rate could reach~94.4%.Given its fascinating features,such IMB-microfluidic detection demonstrates significant potential for biomedical applications. | PAN JingWen GONG De SAEED Rehan CAO KaiHeng CHEN KeHan SU Yuan ZHANG WenQiang XU WenTao CAI Jun ZHANG DeYuan | 2022 | Science China(Technological Sciences)2022，65，11： | 0 |
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