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| 1 | A mouse model of weight-drop closed head injury:emphasis on cognitive and neurological deficiency显示文摘Traumatic brain injury(TBI) is a leading cause of death and disability in individuals worldwide.Producing a clinically relevant TBI model in small-sized animals remains fairly challenging.For good screening of potential therapeutics,which are effective in the treatment of TBI,animal models of TBI should be established and standardized.In this study,we established mouse models of closed head injury using the Shohami weight-drop method with some modifications concerning cognitive deficiency assessment and provided a detailed description of the severe TBI animal model.We found that 250 g falling weight from 2 cm height produced severe closed head injury in C57BL/6 male mice.Cognitive disorders in mice with severe closed head injury could be detected using passive avoidance test on day 7 after injury.Findings from this study indicate that weight-drop injury animal models are suitable for further screening of brain neuroprotectants and potentially are similar to those seen in human TBI. | Igor Khalin Nor Laili Azua Jamari Nadiawati Bt Abdul Razak Zubaidah Bt Hasain Mohd Asri bin Mohd Nor Mohd Hakimi bin Ahmad Zainudin Ainsah Bt Omar Renad Alyautdin | 2016 | Neural Regeneration Research2016，11，4： | 2 |
| 2 | Protective effects of Rutin against methanol induced acute toxic optic neuropathy:an experimental study显示文摘AIM:To determine the effects of Rutin on methanol induced optic neuropathy and compare the results with the effects of ethanol.METHODS:Totally 30 rats were divided into 5 groups,with 6 rats in each group as follows:healthy controls(C),methotrexate(MTX),methotrexate+methanol(MTM),methotrexate+methanol+ethanol(MTME) and methotrexate+ methanol+Rutin(MTMR).In all rabbits except those of the control group,MTX,diluted in sterile serum physiologic,0.3 mg/kg per oral was applied for 7 d by the aid of a tube.After this procedure to the rats of MTM,MTME and MTMR groups,20% methanol with a dose of 3 g/kg per oral was given by the aid of a tube.In MTME group,4 h after the application of methanol,20% ethanol was applied by the same way with a dose of 0.5 g/kg.On the other hand,in MTMR group 4 h after the application of methanol,Rutin,which was dissolved in distilled water,was applied by the same way with a dose of 50 mg/kg.RESULTS:There were statistically significant differences in tissue 8-hydroxy-2 deoxyguanine(8-OHdG),interleukin-1β(IL-1β),tumor necrosis factor-alpha(TNF-α),malondialdehyde(MDA),myeloperoxidase(MPO).glutathione peroxidase(t GSH) and superoxide dismutase(SOD) levels between groups(P<0.001).In MTMR group tissue 8-OHdG,IL-1β,MDA,and MPO levels were similar with the healthy controls but significantly different than the other groups.In histopathological evaluations,in MTX group there was moderate focal destruction,hemorrhage and decrease innumber of astrocytes and oligodendrocytes;in MTM group there was severe destruction and edema with decrease in number of astrocytes and oligodendrocytes;in MTME group there was mild hemorrhage,mild edema,mildly dilated blood vessels with congestion while in MTMR group,optic nerve tissue was resembling the healthy controls.CONCLUSION:Rutin may prevent methanol-induced optic neuropathy via anti-inflammatory effects and decreasing the oxidative stress.New treatment options are warranted in this disease to avoid loss of vision in patients. | Nurdan Gamze Tasli Ferda Keskin Cimen Yücel Karakurt Turgay Ucak Renad Mammadov Bahadir Suleyman Nezahat Kurt Halis Suleyman | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 2 |
| 3 | Selective synthesis of light olefins form CO and H2 with iron supported catalysts显示文摘 | Barrault J Renad C | 1983 | Nouv J Chim1983，7，： | 1 |
| 4 | Direct Evidence That Polysorbate-80-Coated Poly(Butylcyanoacrylate) Nanoparticles Deliver Drugs to the CNS via Specific Mechanisms Requiring Prior Binding of Drug to the Nanoparticles显示文摘 | J?rg Kreuter Peter Ramge Valery Petrov Stefan Hamm Svetlana E. Gelperina Britta Engelhardt Renad Alyautdin Hagen von Briesen David J. Begley | 2003 | Pharmaceutical Research2003，，3： | 1 |
| 5 | Delivery of loperamide across the blood - brain barrier with polysorbate 80- coated polybutylcyanoacrylate nanoparticles 显示文摘 | Renad NA Valery EP Klaus L | 1997 | Pharmaceutical Research1997，14，3： | 1 |
| 6 | Taxifolin attenuates ischemia-reperfusion induced oxidative ovarian damage in rats显示文摘Objective:To investigate preventive effects of taxifolin on ischemia-reperfusion induced oxidative ovarian damage in rats.Methods:A total of 18 female Wistar albino rats were randomly and equally divided into three groups:the sham group,the ovarian ischemia reperfusion group,and the 50 mg/kg taxifolin+ovarian ischemia reperfusion group.The ovarian ischemia reperfusion and taxifolin+ovarian ischemia reperfusion groups were exposed to ischemia for 2 h and then followed by two-hour reperfusion protocol.Biochemical and histopathologic examinations were performed on the extracted ovaries.Results:Levels of malondialdehyde and cyclooxygenase-2 were increased,while reduced-glutathione and cyclooxygenase-1 were decreased in the ovarian ischemia reperfusion group.However,these values were reversed in the taxifolin+ovarian ischemia reperfusion group.Similarly,the number of primordial and developing follicules decreased in the ovarian ischemia reperfusion group,while they were within normal range in the taxifolin+ovarian ischemia reperfusion group.Conclusions:Ischemia followed by reperfusion leads to oxidative stress-related ovarian injury,and taxifolin may be useful for protecting ovarian tissue from such injury. | Sevil Kiremitli Tunay Kiremitli Umit Nayki Nesrin Yilmaz Can Turkler Kemal Dinc Renad Mammadov Gulce Naz Yazici Mine Gulaboglu Nihal Cetin | 2021 | Asian pacific Journal of Reproduction2021，10，4： | 0 |
| 7 | Intermolecular coupling enhanced thermopower in single-molecule diketopyrrolopyrrole junctions显示文摘Sorting out organic molecules with high thermopower is essential for understanding molecular thermoelectrics.The intermolecular coupling offers a unique chance to enhance the thermopower by tuning the bandgap structure of molecular devices,but the investigation of intermolecular coupling in bulk materials remains challenging.Herein,we investigated the thermopower of diketopyrrolopyrrole(DPP)cored single-molecule junctions with different coupling strengths by varying the packing density of the self-assembled monolayers(SAM)using a customized scanning tunneling microscope break junction(STM-BJ)technique.We found that the thermopower of DPP molecules could be enhanced up to one order of magnitude with increasing packing density,suggesting that the thermopower increases with larger neighboring intermolecular interactions.The combined density functional theory(DFT)calculations revealed that the closely-packed configuration brings stronger intermolecular coupling and then reduces the highest occupied molecular orbital(HOMO)-lowest unoccupied molecular orbital(LUMO)gap,leading to an enhanced thermopower.Our findings offer a new strategy for developing organic thermoelectric devices with high thermopower. | Chao Fang Renad Almughathawi Qingqing Wu Wenqiang Cao Hang Chen Songjun Hou Yu Gu Hewei Zhang Yi Zhao Jueting Zheng Guopeng Li Jia Shi Junyang Liu Bing-Wei Mao Zitong Liu Colin J.Lambert Wenjing Hong | 2023 | National Science Open2023，2，1： | 0 |
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