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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Evaluation of recently isolated Australian tropical microalgae for the enrichment of the dietary value of brine shrimp, Artemia nauplii显示文摘 | Thinh Luong-Van Renaud S M Parry D L | 1999 | Aquaculture1999，170，： | 2 |
| 3 | A rapid and reliable method for metabolite extraction in yeast using boiling buffered ethanol 显示文摘 | Gonzalez B Francois J Renaud M | 1997 | Yeast1997，13，14： | 1 |
| 4 | Worst case propagated uncertainty of multidisciplinary systems in robust design optimization显示文摘 | GU X Y RENAUD J E BATILL S M | 2000 | Structural and Multidisciplinary Optimization2000，20，3： | 1 |
| 5 | Ovarian thecoma associated with a large quantity of ascites and elevated serum CA125 and CA15-3显示文摘 | RENAUD M C PLANTE M ROY M | 2002 | J Obstet Gynaecol Can:JOGC2002，24，12： | 1 |
| 6 | Vaginal radical hysterectomy versus abdominal radical hysterectomy in the treatment of early-stage cervical cancer显示文摘 | Roy M Plante M Renaud MC | 1996 | Gynecol Oncol1996，62，3： | 1 |
| 7 | Comparison between open-site and below-canopy climatic conditions in Switzerland during the exceptionally hot summer of 2003显示文摘 | Renaud V Rebetez M | 2009 | Agricultural and Forest Meteorology2009，149，5： | 1 |
| 8 | Analysis of multiple pesticide residues in tobacco using pressurized liquid extraction,automated solid-phase extraction clean-up and gas chromatography-tandem mass spectrometry显示文摘 | Haib J Hofer I Renaud J M | | 0，，： | 1 |
| 9 | Combined laparoscopic and vaginal radical surgery in cervical cancer 显示文摘 | Renaud M C Plante M Roy M | 2000 | Gynecol Oncol2000，79，59： | 1 |
| 10 | Effect of temperature on growth, chemical composition and fatty acid composition of tropical Australian microalgae grown in batch cultures 显示文摘 | RENAUD S M THINH L V LAMBRINIDIS G | 2002 | Aquaculture2002，2，： | 1 |
| 11 | Endovascular fenestration in aortic dissection with acute malperfusion syndrome: immediate and late follow-up显示文摘 | Midulla M Renaud A Martinelli T | 2011 | J ThoracCardiovascSurg2011，142，1： | 1 |
| 12 | Analysis of Multiple Pesticide Residues in Tobacco Using Pressurized Liquid Extraction, Automated Solid-phase Extraction Clean-up and Gas Chromatography-Tandem Mass Spectrometry显示文摘 | HAIB J HOFER I RENAUD J M | 2003 | Journal of Chromatography A2003，1020，： | 1 |
| 13 | Crash- worthiness Design Using Topology Optimization 显示文摘 | PATEL N M KANG B S RENAUD J E | 2009 | Journal of Mechanical Design2009，131，6： | 1 |
| 14 | CMOS pixels for subretinal implantable prosthesis 显示文摘 | MAZZA M RENAUD P BERTRAND D et at | 2005 | IEEE Sensors Journal2005，5，1： | 1 |
| 15 | Worst Case Propagated Uncertainty of Multidisciplinary Systems in Robust Design Optimization显示文摘 | Gu Xiaoyu Renaud J E Batill S M | 2000 | Structural and Multidisciplinary Optimization2000，20，3： | 1 |
| 16 | AIDA, a class Ⅰ metabotropic glutamate-receptor antagonist limits kainite-induced hippocampal dysfunction 显示文摘 | Renaud J Emond M Meillcur S | 2002 | Epilepsia2002，43，11： | 1 |
| 17 | Lymph node metastases in low-grade endometrial stromal sarcoma 显示文摘 | Riopel J Plante M Renaud MC | 2005 | Gynecol Oncol2005，96，： | 1 |
| 18 | Communication and tracking infiastructure of mobile agent system显示文摘 | DESBIENS J LAVOIE M RENAUD F | 1998 | System Sciences1998，，： | 1 |
| 19 | Simple vaginal trachelectomy in early-stage low-risk cervical cancer:a pilot study of 16 cases and review of the literature显示文摘 | Plante M Gregoire J Renaud MC | 2013 | Int J Gynecol Cancer2013，23，5： | 1 |
| 20 | The vaginal radical trachelectomy:an update of a series of 125 cases and 106pregnancies显示文摘 | Plante M Gregoire J Renaud MC | 2011 | Gynecol Oncol2011，121，2： | 1 |
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