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| 1 | Photosensitizer Nanoparticles Boost Photodynamic Therapy for Pancreatic Cancer Treatment显示文摘Patients with pancreatic cancer(PCa)have a poor prognosis apart from the few suitable for surgery.Photodynamic therapy(PDT)is a minimally invasive treatment modality whose efficacy and safety in treating unresectable localized PCa have been corroborated in clinic.Yet,it suffers from certain limitations during clinical exploitation,including insufficient photosensitizers(PSs)delivery,tumor-oxygenation dependency,and treatment escape of aggressive tumors.To overcome these obstacles,an increasing number of researchers are currently on a quest to develop photosensitizer nanoparticles(NPs)by the use of a variety of nanocarrier systems to improve cellular uptake and biodistribution of photosensitizers.Encapsulation of PSs with NPs endows them significantly higher accumulation within PCa tumors due to the increased solubility and stability in blood circulation.A number of approaches have been explored to produce NPs co-delivering multi-agents affording PDT-based synergistic therapies for improved response rates and durability of response after treatment.This review provides an overview of available data regarding the design,methodology,and oncological outcome of the innovative NPs-based PDT of PCa. | Huanyu Yang Renfa Liu Yunxue Xu Linxue Qian Zhifei Dai | 2021 | Nano-Micro Letters2021，13，2： | 3 |
| 2 | Security-aware Signal Packing Algorithm for CAN-based Automotive Cyber-physical Systems显示文摘Network and software integration pose severe challenges in cyber-security for controller area network(CAN)-based automotive cyber-physical system(ACPS), therefore we employ message authentication code(MAC) to defend CAN against masquerade attack, but the consequent bandwidth overhead makes it a necessity to find the tradeoff among security, real-time and bandwidth utilization for signal packing problem(SPP) of CAN.A mixed-security signal model is firstly proposed to formally describe the properties and requirements on security and real-time for signals, and then a mixed-integer linear programming(MILP)formulation of SPP security-aware signal packing(SASP) is implemented to solve the tradeoff problem, where the bandwidth utilization is improved and the requirements in both security and real-time are met. Experiments based on both society of automotive engineers(SAE) standard signal set and simulated signal set showed the effectiveness of SASP by comparing with the state-of-the-art algorithm. | Yong Xie Liangjiao Liu Renfa Li Jianqiang Hu Yong Han Xin Peng | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，4： | 2 |
| 3 | Non-destructive estimation of peach SSC and firmness by mutispectral reflectance imaging显示文摘 | Liu Muhua Fu Peng Cheng Renfa | 2007 | New Zealand Journal of Agricultural Research2007，50，： | 1 |
| 4 | Spatial control of robust transgene expression in mouse artery endothelium under ultrasound guidance显示文摘Dear Editor,Dysfunctional vascular endothelial cells(ECs)contribute to the pathophysiology of several cardiovascular diseases,such as atherosclerosis and its life-threatening complications.1 Gene therapy can be a valuable approach to modulate endothelial cell function for the prevention of atherosclerosis.However,there is still a lack of method for transgene expression in vascular endothelium.2 Herein,an effective and specific strategy was established for noninvasive spatial control of transgene expression into the target region of the mouse artery without systemic spillover using an ultrasound and microbubble(MB)guided adenoassociated viral vector(UMGAAV)(Supplementary Fig.S1).To the best of our knowledge,this is the first report on noninvasive spatial control of transgene expression in arterial endothelium in vivo. | Renfa Liu Shuai Qu Yunxue Xu Hanjoong Jo Zhifei Dai | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 5 | Imaging-guided gene delivery:seeing is delivering显示文摘To the editor:Gene therapy is considered a promising treatment option for several diseases,including neuromuscular disease,cardiovascular diseases,immunodeficiencies,and cancer.However,the promise of gene therapy is largely compromised by a lack of suitable gene delivery systems.[1,2]Gene delivery approaches using common gene vectors including viral and nonviral vectors typically rely on specific targeting moieties or tissue tropism of the vectors.However,not all tissues possess unique receptors suitable for targeted gene delivery.This issue can be potentially solved by introducing external physical stimuli,such as ultrasound,magnetic force,heat,and light,which can guide the transgene expression independent of the intrinsic properties of the cells of interest.31 In addition,such physical stimuli can be integrated with medical imaging,thus making imaging-guided gene delivery possible.In this scenario,physical stimuli are applied to the area of interest guided by medical imaging and can then trigger robust transgene expression in selected areas. | Shuai Qu Renfa Liu Zhifei Dai | 2022 | Journal of Bio-X Research2022，5，4： | 0 |
| 6 | THE PARALLEL MULTISPLITTING METHOD FOR CONSISTENT SYMMETRIC POSITIVE(SEMI-)DEFINITE SYSTEMS显示文摘Main resultsTheorem 1 Let A be an n×n symmetric positive semidefinite matrix and let | Liu Zhongyun (dept.of Math.,Shanghai Univrsity,Shanghai 200436,PRC)Yinyueli(Light Industry Higher Training School,Changsha 410015,PRC)Li Renfa(Dept.of Comput.Sci.,Hunan University,Changsha 410082,PRC) | 2000 | Numerical Mathematics A Journal of Chinese Universities(English Series)2000，9，S1： | 0 |
| 7 | Current trends and key considerations in the clinical translation of targeted fluorescent probes for intraoperative navigation显示文摘The rapid development of fluorescence imaging for intraoperative navigation has spurred further development of targeted fluorescent probes in the past decade.Only a few nontargeted dyes,including indocyanine green and methylene blue,are currently applied for fluorescence guided surgery in the clinic.While no targeted fluorescent probes have been approved for the clinic,a number of them have entered clinical trials.These probes have emission wavelengths in the visible and near infrared(NIR)-I(700-900 nm)range.Among them,activatable probes and nanoprobes have generated special interest.Compared with NIR-I fluorescent probes,NIR-II(1000-1700 nm)fluorescent probes exhibit better intravital performance in terms of increased penetration depths,reduced tissue autofluorescence,and higher signalto-background ratios.However,more challenges are expected before the successful translation of NIR-II probes from bench to bedside.This review provides a brief overview of targeted fluorescent probes under clinical evaluation and recent achievements in the field of NIR-II fluorescence imaging.In addition,we outline key considerations concerning the design of fluorescent probes for clinical translation. | Renfa Liu Yunxue Xu Kun Xu Zhifei Dai | 2021 | Aggregate2021，2，3： | 0 |
| 8 | Photodynamic eradication of intratumoral microbiota with bacteria-targeted micelles overcomes gemcitabine resistance of pancreatic cancer显示文摘Increasing evidence suggests that intratumoral microbiota plays a pivotal role in tumor progression,immunosurveillance,metastasis,and chemosensitivity.Particularly,in pancreatic ductal adenocarcinoma,tumor-resident Gammaproteobacteria could transform the chemotherapeutic drug gemcitabine(Gem)into its inactive form,thus rendering chemotherapy ineffective.Herein,a strategy for selectively eradicating intratumoral bacteria was described for overcoming Gem resistance in a pancreatic cancer animal model.An antimicrobial peptide was linked with photosensitizer through a poly(ethylene glycol)chain,which can self-assemble into micelles with a diameter of∼20 nm.The micelles could efficiently kill bacteria under light irradiation by inducing membrane depolarization,thereby inhibiting Gem metabolism.In a bacteria-resident pancreatic cancer animal model,the selective photodynamic eradication of intratumoral bacteria was demonstrated to efficiently reverse Gem resistance.This research highlights antibacterial photodynamic therapy as a promising adjuvant strategy for cancer therapy by modulating intratumoral microbiota. | Renfa Liu Huanyu Yang Shuai Qu Peipei Yang Xin Zhi Yunxue Xu Zhifei Dai Linxue Qian | 2024 | Aggregate2024，5，1： | 0 |
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