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| 1 | Outcomes of critically ill cancer patients with Acinetobacter baumannii infection显示文摘AIM: To describe the intensive care unit(ICU) outcomes of critically ill cancer patients with Acinetobacter baumannii(AB) infection.METHODS: This was an observational study that included 23 consecutive cancer patients who acquired AB infections during their stay at ICU of the National Cancer Institute of Mexico(INCan), located in Mexico City. Data collection took place between January 2011, and December 2012. Patients who had AB infections before ICU admission, and infections that occurred during the first 2 d of ICU stay were excluded. Data were obtained by reviewing the electronic health record of each patient. This investigation was approved by the Scientific and Ethics Committees at INCan. Because of its observational nature, informed consent of the patients was not required.RESULTS: Throughout the study period, a total of 494 critically ill patients with cancer were admitted to the ICU of the INCan, 23(4.6%) of whom developed AB infections. Sixteen(60.9%) of these patients had hematologic malignancies. Most frequent reasons for ICU admission were severe sepsis or septic shock(56.2%) and postoperative care(21.7%). The respiratory tract was the most frequent site of AB infection(91.3%). The most common organ dysfunction observed in our group of patients were the respiratory(100%), cardiovascular(100%), hepatic(73.9%) and renal dysfunction(65.2%). The ICU mortality of patients with 3 or less organ system dysfunctions was 11.7%(2/17) compared with 66.6%(4/6) for the group of patients with 4 or more organ system dysfunctions(P = 0.021). Multivariate analysis identified blood lactate levels(BLL) as the only variable independently associated with inICU death(OR = 2.59, 95%CI: 1.04-6.43, P = 0.040). ICU and hospital mortality rates were 26.1% and 43.5%, respectively.CONCLUSION: The mortality rate in critically ill patients with both HM, and AB infections who are admitted to the ICU is high. The variable most associated with increased mortality was a BLL ≥ 2.6 mmol/L in the first day of stay in the ICU. | Silvio A ?amendys-Silva Paulina Correa-García Francisco J García-Guillén María O González-Herrera Américo Pérez-Alonso Julia Texcocano-Becerra Angel Herrera-Gómez Patricia Cornejo-Juárez Abelardo Meneses-García | 2015 | World Journal of Critical Care Medicine2015，4，3： | 3 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Wetting angles and photocatalytic activities of illuminated TiO2 thin films 显示文摘 | V Rico P Romero J L Hueso | 2009 | Catalysis Today2009，143，： | 1 |
| 4 | The protein kinase Pstoll from traditional rice confers tolerance of phosphorus deficiency显示文摘 | Rico G Y Chin J H Tanaka J P Pesaresi P Catausan S Dalid C Loedin I S Mendoza E M T Wissuwa M Heucr S | 2012 | Nature2012，488，7412： | 1 |
| 5 | Changes in glutathione S-transferase activity in DDT resistant natural Mexican populations of Anopheles albimanus under different insecticide resistance management strategies显示文摘 | Patricia R P Américo D R Janet H | 2006 | Pesticide Biochemistry and Physiology2006，86，2： | 1 |
| 6 | Use of veteri- nary medicines, feed additives and probiotics in four major in- ternationally traded aquaculture species farmed in Asia显示文摘 | Rico A Tran Minh P Satapornvanit K | 2013 | Aq- uaculture2013，，： | 1 |
| 7 | Stability of Microfabricated High Aspect Ratio Structures in Poly (dimethylsiloxane)显示文摘 | Roca Cusachs P Rico F Martinez E | 2005 | Langmuir2005，21，12： | 1 |
| 8 | Approximate cost of theelimination of boron in desalinated water by reverse osmosis andion exchange resins显示文摘 | Ariasd M F C Bru L V Rico D P | 2011 | Desalination2011，273，23： | 1 |
| 9 | Probing mechanical properties of living cells by atomic force microscopy with blunted pyramidal cantilever tips显示文摘 | Rico F Roca-Cusachs P Gavara N | 2005 | Physical Review E2005，72，02： | 1 |
| 10 | On the Spatial and Temporal Links Between Vegetation, Climate, and Soil Moisture显示文摘 | RODRIGUEZ-ITURBE I D'OI-'A)RICO P PORPORATO A | 1999 | Water Resources Research1999，35，12： | 1 |
| 11 | Stability of microfabricated high aspect ratio structures in poly (dimethylsiloxane) 显示文摘 | Roca-Cusachs P Rico F Martinez E | 2005 | Langmuir2005，21，12： | 1 |
| 12 | Non-linear analysis of the tubular 'heart' joint by FEM and experimental validation 显示文摘 | Diaz J J D Nieto P J G Rico M F | 2007 | Journal of Constructional Steel Research2007，63，8： | 1 |
| 13 | Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients显示文摘 | Leung J M Sands L P Rico M | 2006 | Neurology2006，67，7： | 1 |
| 14 | Results of surgical treatment of hepatic hydatidosis:current therapeutic modifications显示文摘 | Moreno Gonzalez E Rico Selas P Martinez B | 1991 | World J Surg1991，15，2： | 1 |
| 15 | Quantitative detection of epidermal growth factor and interleukin-B in whole saliva of healthy individuals显示文摘 | Dafar A Rico P Isik A | 2014 | Journal of Immunological Methods2014，408，： | 1 |
| 16 | Study of mobile payment protocols and its performance evaluation on mobile devices 显示文摘 | Martinez P R Rico N F J Satizabal C | 2010 | International Journal of Information Technology and Management2010，9，3： | 1 |
| 17 | Carbofuran and malathion inhibit nucleotide hydrolysis in zebrafish brain membranes显示文摘 | SENGER M R RICO E P ROSEMBERG D B | 2005 | Toxicology2005，212，23： | 1 |
| 18 | Efficacy of iron and/ or zinc supplementation on cognitive performance of leadexposed Mexican schoolchildren: a randomized, placebocontrolled trial显示文摘 | Rico JA Kordas K Lopez P | 2006 | Pediatrics2006，117，3： | 1 |
| 19 | Efficacy and satisfaction of two minimally invasivetechniques for the treatment of proximal ureteral lithasis : a pro-spective and comparative study 显示文摘 | Budia A Trassierra M?Bahilo P’Broseta Rico E Oliver F Bor-onat F | 2009 | Eur Urol Suppl2009，8，： | 1 |
| 20 | Nosoeomial lung infections in adult intensive care units显示文摘 | Hernandez G Rico P Diaz E | 2008 | Microbes Infect2008，6，11： | 1 |
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