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| 1 | High-fat-induced intestinal permeability dysfunction associated with altered fecal bile acids显示文摘AIM:To investigate whether high-fat-feeding is associated with increased intestinal permeability via alterations in bile acid metabolism.METHODS:Male C57Bl/6J mice were fed on a high-fat (n=26) or low-fat diet (n=24) for 15 wk.Intestinal permeability was measured from duodenum,jejunum,ileum and colon in an Ussing chamber system using 4 kDa FITC-labeled dextran as an indicator.Fecal bile acids were analyzed with gas chromatography.Segments of jejunum and colon were analyzed for the expression of farnesoid X receptor (FXR) and tumor necrosis factor (TNF).RESULTS:Intestinal permeability was significantly increased by high-fat feeding in jejunum (median 0.334 for control vs 0.393 for high-fat,P=0.03) and colon (0.335 for control vs 0.433 for high-fat,P=0.01),but not in duodenum or ileum.The concentration of nearly all identified bile acids was significantly increased by high-fat feeding (P<0.001).The proportion of ursodeoxycholic acid (UDCA) in all bile acids was decreased (1.4%±0.1% in high-fat vs 2.8%±0.3% in controls,P<0.01) and correlated inversely with intestinal permeability (r=-0.72,P=0.01).High-fat feeding also increased jejunal FXR expression,as well as TNF expression along the intestine,especially in the colon.CONCLUSION:High-fat-feeding increased intestinal permeability,perhaps by a mechanism related to bile acid metabolism,namely a decreased proportion of fecal UDCA and increased FXR expression. | Lotta K Stenman Reetta Holma Riitta Korpela | 2012 | World Journal of Gastroenterology2012，18，9： | 19 |
| 2 | Probiotic Leuconostoc mesenteroides ssp. cremoris and Streptococcus thermophilus induce IL-12 and IFN-γ production显示文摘AIM: To investigate the capacity of potentially probiotic strains from six bacterial genera to induce cytokine production alone or in combinations in order to identify potential enhancing or synergistic effects in order to select probiotic bacteria for in vivo purposes. METHODS: Cytokine production in human peripheral blood mononuclear cells (PBMC) in response to stimulation with eleven different potentially probiotic bacterial strains from Streptococcus , Lactobacillus , Bifidobacterium , Lactococcus , Leuconostoc and Propionibacterium genera was analysed. Production and mRNA expression of TNF-α, IL-12, IFN-γ and IL-10 were determined by ELISA and Northern blotting, respectively. RESULTS: All tested bacteria induced TNF-α production. The best inducers of Th1 type cytokines IL-12 and IFN-γ were Streptococcus and Leuconostoc strains. All Bifidobacterium and Propionibacterium strains induced higher IL-10 production than other studied bacteria. Stimulation of PBMC with any bacterial combinations did not result in enhanced cytokine production suggesting that different bacteria whether gram-positive or gram- negative compete with each other during host cell interactions.CONCLUSION: The probiotic S. thermophilus and Leuconostoc strains are more potent inducers of Th1 type cytokines IL-12 and IFN-γ than the probiotic Lactobacillus strains. Bacterial combinations did not result in enhanced cytokine production. | Riina A Kekkonen Elina Kajasto Minja Miettinen Ville Veckman Riitta Korpela Ilkka Julkunen | 2008 | World Journal of Gastroenterology2008，14，8： | 9 |
| 3 | Even low-grade inflammation impacts on small intestinal function显示文摘Independent of the cause and location,inflammation-even when minimal-has clear effects on gastrointestinal morphology and function.These result in altered digestion,absorption and barrier function.There is evidence of reduced villus height and crypt depth,increased permeability,as well as altered sugar and peptide absorption in the small intestine after induction of inflammation in experimental models,which is supported by some clinical data.Identification of inflammatory factors which may promote the process of gastrointestinal dysfunction as well as clinical research to verify experimental observations of inflammatory modulation of gastrointestinal function are required.Moreover,nutritional strategies to support functional restitution are needed. | Katri Peuhkuri Heikki Vapaatalo Riitta Korpela | 2010 | World Journal of Gastroenterology2010，16，9： | 9 |
| 4 | Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells显示文摘AIM: To analyze the ability of nine different potentially probiotic bacteria to induce maturation and cytokine production in human monocyte-derived dendritic cells (moDCs). METHODS: Cytokine production and maturation of moDCs in response to bacterial stimulation was analyzed with enzyme-linked immunosorbent assay (ELISA) and flow cytometric analysis (FACS), respectively. The kinetics of mRNA expression of cytokine genes was determined by Northern blotting. The involvement of different signaling pathways in cytokine gene expression was studied using specific pharmacological signaling inhibitors. RESULTS: All studied bacteria induced the maturation of moDCs in a dose-dependent manner. More detailed analysis with S. thermophilus THS, B. breve Bb99, and L. lactis subsp. cremoris ARH74 indicated that these bacteria induced the expression of moDC maturationmarkers HLA class Ⅱ and CD86 as efficiently as pathogenic bacteria. However, these bacteria differed in their ability to induce moDC cytokine gene expression. S. thermophilus induced the expression of pro-inflammatory (TNF-α, IL-12, IL-6, and CCL20) and Th1 type (IL-12 and IFN-γ) cytokines, while B. breve and L. lactis were also potent inducers of anti- inflammatory IL-10. Mitogen-activated protein kinase (MAPK) p38, phosphatidylinositol 3 (PI3) kinase, and nuclear factor-kappa B (NF-κB) signaling pathways were shown to be involved in bacteria-induced cytokine production. CONCLUSION: Our results indicate that potentially probiotic bacteria are able to induce moDC maturation, but their ability to induce cytokine gene expression varies significantly from one bacterial strain to another. | Sinikka Latvala Taija E Pietil Ville Veckman Riina A Kekkonen Soile Tynkkynen Riitta Korpela Ilkka Julkunen | 2008 | World Journal of Gastroenterology2008，14，36： | 8 |
| 5 | Enhanced Photocatalytic Activity of TiO2 Nanofibers and Their Flexible Composite Films: Decomposition of Organic Dyes and Efficient H2 Generation from Ethanol-Water Mixtures显示文摘与磅和 Pd nanoparticles 装饰的 TiO2 nanofibers 在各种各样的 photocatalytic 过程被综合了并且学习。在水里的器官的染料的分解的优秀 photocatalytic 行为,灵活独立纤维素 / 催化剂的表面上的器官的污点的降级合成电影并且在从乙醇用的氢的产生推迟了并且使不能调动催化剂被表明。基于 nanofiber 的 TiO2 材料的表演是在某情况 outperformstheir 的竞争 withand 常规基于 nanoparticle 的对应物。在所有情况中,装饰 Pd 的 TiO2 nanoparticles 和 nanofibers 证明了比他们的基于磅的对应物更有效,它能在在 TiO2 和金属 nanoparticles 之间的接触根据缩放 nano 的 Schottky 接口的形成被解释。形成纤维素 / 催化剂 composites 的可行性提供在大区域的涂层和独立电影利用光催化剂材料的一个新奇方法。 | Ming-Chung Wu Andras Sapi Anna Avila Maria Szabo Jussi Hiltunen Mika Huuhtanen Geza Toth Akos Kukovecz Zoltan Konya Riitta Keiski Wei-Fang Su Heli Jantunen Krisztian Kordas | 2011 | Nano Research2011，4，4： | 7 |
| 6 | Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults显示文摘AIM: To evaluate the effects of three potentially anti- inflammatory probiotic bacteria from three different genera on immune variables in healthy adults in a clinical setting based on previous in vitro characterization of cytokine responses. METHODS: A total of 62 volunteers participated in this randomized, double-blind and placebo-controlled parallel group intervention study. The volunteers were randomized to receive a milk-based drink containing either Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis ssp. lactis Bb12 (Bb12), or Propionibacterium freudenreichii ssp. shermanii JS (PJS) or a placebo drink for 3 wk. Venous blood and saliva samples were taken at baseline and on d 1, 7 and 21. Fecal samples were collected at baseline and at the end of intervention. RESULTS: The serum hsCRP expressed as the median AUC0-21 (minus baseline) was 0.018 mg/L in the placebo group, -0.240 mg/L in the LGG group, 0.090 mg/L in the Bb12 group and -0.085 mg/L in the PJS group (P = 0.014). In vitro production of TNF-α from in vitro cultured peripheral blood mononuclear cells (PBMC) was significantly lower in subjects receiving LGG vs placebo. IL-2 production from PBMC in the Bb12 group was significantly lower compared with the other groups. CONCLUSION: In conclusion, probiotic bacteria have strain-specific anti-inflammatory effects in healthy adults. | Riina A Kekkonen Netta Lummela Heli Karjalainen Sinikka Latvala Soile Tynkkynen Salme Jrvenp Hannu Kautiainen Ilkka Julkunen Heikki Vapaatalo Riitta Korpela | 2008 | World Journal of Gastroenterology2008，14，13： | 6 |
| 7 | Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome显示文摘AIM:To investigate the pathophysiology of irritable bowel syndrome(IBS)by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.METHODS:Fifteen IBS patients fulfilling the Rome Ⅱcriteria,and nine healthy volunteers were included in the study.A combined lipidomics(UPLC/MS)and metabolomics(GC×GC-TOF)approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.RESULTS:Overall,lipid levels were elevated in patients with IBS.The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines.Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides,glycosphingolipids,and di-and triacylglycerols.Among the metabolites,the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects(P=0.03).CONCLUSION:IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile.Especially,there was an increase in several lipid species such as lysophospholipids and ceramides. | Kajsa Kajander Eveliina Myllyluoma Sinikka Kyrnpalo Martin Rasmussen Pentti Sipponen Ismo Mattila Tuulikki Seppnen-Laakso Heikki Vapaatalo Matej Orei Riitta Korpela | 2009 | World Journal of Gastroenterology2009，15，48： | 5 |
| 8 | Diabetes:特殊免疫细胞亚群或促进1型糖尿病发展显示文摘发表在国际杂志Diabetes上的一项最新研究中,来自东芬兰大学的研究人员通过研究发现,最近描述的一种T细胞亚群或许在1型糖尿病的发生上扮演着关键性的中枢角色;这种名为滤泡T辅助细胞的T细胞亚群在1型糖尿病开始阶段时水平处于增加之中,而且这种现象和疾病相关的常见自身抗体的存在直接相关。 | Tyyne Viisanen Emmi-Leena Ihantola Kirsti Näntö-Salonen Heikki Hyöty Noora Nurminen Jenni Selvenius Auni Juutilainen Leena Moilanen Jussi Pihlajamäki Riitta Veijola Jorma Toppari Mikael Knip Jorma Ilonen Tuure Kinnunen | 2017 | 现代生物医学进展2017，17，4： | 5 |
| 9 | Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells显示文摘AIM:To investigate the effects of four probiotic bacteria and their combination on human mast cell gene expression using microarray analysis.METHODS:Human peripheral-blood-derived mast cells were stimulated with Lactobacillus rhamnosus (L.rhamnosus) GG (LGG),L.rhamnosus Lc705 (Lc705),Propionibacterium freudenreichii ssp.shermanii JS (PJS) and Bifidobacterium animalis ssp.lactis Bb12 (Bb12) and their combination for 3 or 24 h,and were subjected to global microarray analysis using an Affymetrix GeneChip Human Genome U133 Plus 2.0 Array.The gene expression differences between unstimulated and bacteria-stimulated samples were further analyzed with GOrilla Gene Enrichment Analysis and Visualization Tool and MeV Multiexperiment Viewer-tool.RESULTS:LGG and Lc705 were observed to suppress genes that encoded allergy-related high-affinity IgE receptor subunits α and γ (FCER1A and FCER1G,respectively) and histamine H4 receptor.LGG,Lc705 and the combination of four probiotics had the strongest effect on the expression of genes involved in mast cell immune system regulation,and on several genes that encoded proteins with a pro-inflammatory impact,such as interleukin (IL)-8 and tumour necrosis factor alpha.Also genes that encoded proteins with anti-inflammatory functions,such as IL-10,were upregulated.CONCLUSION:Certain probiotic bacteria might diminish mast cell allergy-related activation by downregulation of the expression of high-affinity IgE and histamine receptor genes,and by inducing a pro-inflammatory response. | Anna Oksaharju Matti Kankainen Riina A Kekkonen Ken A Lindstedtt Petri T Kovanen Riitta Korpela Minja Miettinen | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 10 | High-sensitivity C-reactive protein in paediatric inflammatory bowel disease显示文摘AIM:To study whether high-sensitivity C-reactive protein(hs-CRP) measurement can aid the assessment of disease activity and glucocorticoid treatment in paediatric inflammatory bowel disease(IBD).METHODS:CRP levels were measured in 39 children with IBD undergoing colonoscopy [median age 12.8 years,Crohn's disease(CD) n=20],in 22 other children with IBD followed for acute response to glucocorticoids,and in 33 paediatric non-IBD patients.When standard CRP level was below detection limit(<5mg/L),hs-CRP was analyzed.RESULTS:Sixty-four percent(25/39) of the children with IBD undergoing colonoscopy displayed undetectable(<5mg/L) standard CRP levels.Of these,the hs-CRP measurement could not differentiate between active(median,0.2 mg/L,range,0.007-1.37,n=17) or quiescent(0.1 mg/L,0.01-1.89,n=8,P=NS) disease.Patients with ileocolonic CD had higher CRP levels(14mg/L,0.06-45,n=13) than patients with no ileal involvement(0.18 mg/L,0.01-9,n=7,P<0.01) or ulcerative colitis(UC)(0.13 mg/L,0.007-23,P<0.05).In children with active IBD treated with systemic glucocorticoids,the standard CRP was undetectable in 59% of the patients.The hs-CRP levels did not differ between patients that responded to steroid therapy and in non-responders.CONCLUSION:The measurement of hs-CRP did not prove useful in the assessment of disease activity or glucocorticoid treatment in paediatric IBD patients that had undetectable standard CRP. | Marianne Sidoroff Riitta Karikoski Taneli Raivio Erkki Savilahti Kaija-Leena Kolho | 2010 | World Journal of Gastroenterology2010，16，23： | 3 |
| 11 | Local corticosterone production and angiotensin-Ⅰconverting enzyme shedding in a mouse model of intestinal inflammation显示文摘AIM: To investigate local corticosterone production and angiotensin-Ⅰ converting enzyme(ACE) protein expression and their interaction in healthy and inflamed intestine.METHODS: Acute intestinal inflammation was induced to six weeks old male Balb/c mice by administration of either 3% or 5% dextran sodium sulfate(DSS) in drinking water for 7 d(n = 12 in each group). Healthy controls(n = 12) were given tap water. Corticosterone production and ACE protein shedding were measured from ex vivo incubates of the small and large intestine using EIA and ELISA, respectively. Morphological changes of the intestinal wall were assessed in hematoxylin-eosin stained tissue preparations of jejunum and distal colon. Effects of angiotensin Ⅱ, captopril and metyrapone on corticosterone production was assessed by incubating pieces of small intestine of healthy mice in the presence of 0.1, 1 or 10 μmol/L angiotensin Ⅱ, 1, 10 or 100 μmol/L captopril or 1, 10 or 100 μmol/L metyrapone solutions and measuring corticosterone released to the incubation buffer after 90 min(n = 5 in each group).RESULTS: Both concentrations of DSS induced inflammation and morphological changes in large intestines but not in small intestines. Changes were observed as distortions of the crypt structure, mucosal erosion, immune cell infiltration to the mucosa and submucosal edema. Ex vivo corticosterone production(2.9 ± 1.0 ng/mL vs 2.0 ± 0.8 ng/mL, P = 0.034) and ACE shedding(269.2 ± 97.1 ng/m L vs 175.7 ± 52.2 ng/mL, P = 0.016) were increased in small intestines in 3% DSS group compared to the controls. In large intestine, corticosterone production was increased compared to the controls in both 3% DSS(229 ± 81 pg/mL vs 158 ± 30 pg/mL, P = 0.017) and 5% DSS groups(366 ± 163 pg/mL vs 158 ± 30 pg/mL, P = 0.002). Large intestine ACE shedding was increased in 5% DSS group(41.5 ± 9.0 ng/mL vs 20.9 ± 5.2 ng/mL, P = 0.034). Angiotensin Ⅱ treatment augmented corticosterone production in small intestine at concentration of 10 μmol/L(0.97 ± 0.21 ng/mg protein vs 0.40 ± 0.09 ng/mg protein, P = 0.036).CONCLUSION: Intestinal ACE shedding is increased by DSS-induced intestinal inflammation and parallels local corticosterone production. ACE product angiotensin Ⅱ stimulates corticosterone formation in healthy intestine. | Hanne Salmenkari Tomi Issakainen Heikki Vapaatalo Riitta Korpela | 2015 | World Journal of Gastroenterology2015，21，35： | 2 |
| 12 | 波罗的海蓝藻赤潮的历史显示文摘波罗的海所发生的赤潮,主要是由Nodudaria spupmigena和Aphanizomenon sp.这两种蓝藻形成的。有关这些赤潮的长期变化记录可以从过去(1887~1938年)和现代(1974~1998年)出版的浮游植物数据记录中找到。通过各种不同的收集、分析方法已经得到了大量的数据,为了提高这些数据的可比性,人们正在不断地尝试老的、新的采样方式与固定方法。100多年前,浮游生物就做为鱼类的食物来源而引起了人们的兴趣;富营养化问题主要出现在南部的礁湖(haffs)以及大城市附近的海边水域。二战前,很少有关于开阔海域赤潮的报道。在过去的营养环境中,Nodudaria spupmigena和Aphanizomenon sp.的数量还很少,从1887~1938年的137个夏季采样中表明它们的丰度还没有达到过最高峰。在现在的营养环境中,高丰度是非常普遍的,这两个物种的数目范围相对于过去的营养环境来说有了明显的增长。自20世纪60年代以来,蓝藻赤潮在波罗的海本体与芬兰湾的开阔海域是非常常见的,这表明了营养物已经高度丰富。 | Terttu Finni Kaisa Kononen Riitta Olsonen Kerstin Wallstrm 马志华 | 2001 | AMBIO-人类环境杂志2001，30，4： | 2 |
| 13 | 纤维化性间质性肺疾病急性加重患者的预后及其死亡原因显示文摘背景本研究旨在比较具有急性加重(AE)史的特发性肺纤维化(IPF)和其他纤维化性间质性肺疾病(FILD)患者的临床特点、预后影响因素和死亡原因。方法回顾性收集因AE-IPF和AE-FILD而住院治疗的患者的临床资料。评价和比较IPF和非IPF患者的临床特点和生存资料。从死亡证明中获取患者潜在的和直接死亡原因。结果共128例患者符合入选标准。本组患者中,IPF(79例,62%)、类风湿关节炎相关间质性肺疾病(RA-ILD,17例,14%)和石棉肺(11例,8.6%)是最常见的FILD亚型。因AE-IPF住院的患者的中位存活时间为2.6个月,而其他AE-FILDs患者中位存活期为21个月(P<0.001)。住院时的年龄、性别或肺功能测试结果无法解释患者存活时间的差异。非特异性间质性肺炎和RA-ILD患者的预后最佳。肺纤维化是IPF患者和其他FILD患者的最常见潜在死亡原因,分别占其死亡原因的87%和78%。结论我们发现,具有AE史的非IPF患者的存活时间明显长于AE-IPFs患者。患者的预后受肺潜在疾病的影响,这是因为肺纤维化是大部分所有经历AE的FILD患者的潜在死亡原因。 | Johanna Salonen Minna Purokivi Risto Bloigu Riitta Kaarteenaho 霍永丰(译者) | 2020 | 英国医学杂志中文版2020，23，6： | 2 |
| 14 | Stool antigen tests in the diagnosis of Helicobacter pylori infection before and after eradication therapy显示文摘Aim: To evaluate two enzyme immunoassay-based stool antigen tests, Premier Platinum HpSA and Amplified IDEIA HpStAR, and one rapid test, ImmunoCard STAT! HpSA, in the primary diagnosis of Helicobacter pylori (H pylori) infection and after eradication therapy.METHODS: Altogether 1 574 adult subjects were screened with a whole-blood H pylori antibody test and positive results were confirmed with locally validated serology and 13C-urea breath test. All 185 subjects,confirmed to be H pylori positive, and 97 H pylorinegative individuals, randomly selected from the screened study population and with negative results in serology and UBT, were enrolled. After eradication therapy the results of 182 subjects were assessed.RESULTS: At baseline, the sensitivity of HpSA and HpStAR was 91.9% and 96.2%, respectively, and specificity was 95.9% for both tests. ImmunoCard had sensitivity of 93.0% but specificity of only 88.7%. After eradication therapy, HpSA and HpStAR had sernsitivity of 81.3% and 100%, and specificity of 97.0% and 97.6%,respectively. ImmunoCard had sensitivity of 93.8% and specificity of 97.0%. HpSA, HpStAR, and ImmunoCard had PPV 77%, 80%, and 75%, and NPV 98%, 100%,and 99%, respectively.CONCLUSION: In primary diagnosis, the EIA-based tests performed well. After eradication therapy, negative results were highly accurate for all the three tests.HpStAR had the best overall performance. | Lea Veijola Eveliina Myllyluoma Riitta Korpela Hilpi Rautelin | 2005 | World Journal of Gastroenterology2005，11，46： | 2 |
| 15 | Matrix metalloproteinases in the restorative proctocolectomy pouch of pediatric ulcerative colitis显示文摘AIM:To investigate matrix metalloproteinases(MMPs) and their tissue inhibitors(TIMPs) in pouch mucosa of pediatric onset ulcerative colitis(UC).METHODS:In this cross-sectional study,28 patients with pediatric onset UC underwent ileal pouch biopsy 13 years(median) after proctocolectomy.Expression of MMPs-3,-7,-8,-9,-12 and-26 and TIMPs-1,-2 and-3 in samples was examined using immunohistochemichal methods,and another biopsy was used to evaluate the grade of histological inflammation.Two investigators independently graded the immunohistochemical specimens in a semiquantitative fashion,using a scale marking staining intensity as follows:0 = less than 20 positive cells;1 = 20-50 positive cells;2 = 50-200 positive cells;3 = over 20 positive cells.Fecal calprotectin and blood inflammatory markers [serum C-reactive protein(CRP) and erythrocyte sedimentation rate] were determined during a follow-up visit to examine correlations between these markers and the expression of MMPs and TIMPs.RESULTS:Of the 28 patients with pediatric onset UC,nine had not experienced pouchitis,whereas thirteen reported a single episode,and six had recurrent pouchitis(≥ 4 episodes).At the time of the study,six patients required metronidazole.In all of the others,the most recent episode of pouchitis had occurred over one month earlier,and none were on antibiotics.Only four samples depicted no sign of inflammation,and these were all from patients who had not had pouchitis.Two samples were too small to determine the grade of inflammation,but both had suffered pouchitis,the other recurrent.No sample depicted signs of colonic metaplasia.Most pouch samples showed expression of epithelial(e) and stromal(s) MMP-3(e,n = 22;s,n = 20),MMP-7(e,n = 28;s,n = 27),MMP-12(e,n = 20;s,n =24),TIMP-2(e,n = 23;s,n = 23) and MMP-3(e,n = 23;s,n = 28) but MMP-8(e,n = 0;s,n = 1),MMP-9(e,n = 0;s,n = 9) and MMP-26(e,n = 0;s,n = 3) and TIMP-1(n = 0,both) were lacking.In samples with low grade of inflammatory activity,the epithelial MMP-3 and MMP-7 expression was increased(r =-0.614 and r =-0.472,respectively,P < 0.05 in both).MMPs and TIMPs did not correlate with the markers of inflammation,fecal calprotectin,erythrocyte sedimentation rate,or CRP,with the exception of patients with low fecal calprotectin(< 100 μg/g) in whom a higher expression of epithelial MMP-7 was found no differences in MMPor TIMP-profiles were seen in patients with a history of pouchitis compared to ones with no such episodes.Anastomosis with either straight ileoanal anastomosis or ileoanal anastomosis with J-pouch did depict differences in MMP-or TIMP-expression.CONCLUSION:The expression of MMPs pediatric UC pouch in the long-term shares characteristics with inflammatory bowel disease,but inflammation cannot be classified as a reactivation of the disease. | Laura Mkitalo Maija Piekkala Merja Ashorn Mikko Pakarinen Antti Koivusalo Riitta Karikoski Johanna Natunen Ulpu Saarialho-Kere Risto Rintala Kaija-Leena Kolho | 2012 | World Journal of Gastroenterology2012，18，30： | 2 |
| 16 | Effects of the viability of Lactobacillus rhamnosus GG on rotavirus infection in neonatal rats显示文摘AIM:To study the effects of live and dead Lactobacillus rhamnosus GG(GG) on rotavirus infection in a neonatal rat model.METHODS:At the age of 2 d,suckling Lewis rat pups were supplemented with either live or dead GG and the treatment was continued daily throughout the experi-ment.At the age of 5 and 6 d the pups received oral rotavirus(RV) SA-11 strain.The pups were sacrificed at the age of 7 or 8 d by decapitation.The gastrointestinal tract was removed and macroscopic observations were done.The consistency of feces in the colon was classified using a four-tier system.RV was detected from the plasma,small intestine,colon and feces by real-time quantitative polymerase chain reaction(PCR).RESULTS:In this neonatal rat model,RV induced a mild-to-moderate diarrhea in all except one pup of the RV-inoculated rats.RV moderately reduced body weight development from day 6 onwards.On day 7,after 2 d of RV infection,live and dead GG groups gained significantly more weight than the RV group without probiotics [36%(P = 0.001) and 28%(P = 0.031),respectively].In addition,when compared with the RV control group,both live and dead GG reduced the weight ratio of colon/animal body weight to the same level as in the healthy control group,with reductions of 22%(P = 0.002) and 28%(P < 0.001),respectively.Diarrhea increased moderately in both GG groups.However,the diarrhea incidence and severity in the GG groups were not statistically significantly different as compared with the RV control group.Moreover,observed diarrhea did not provoke weight loss or death.The RV control group had the largest amount of RV PCR-positive samples among the RV-infected groups,and the live GG group had the smallest amount.Rats receiving live GG had significantly less RV in the colon(P = 0.027) when compared with the RV control group.Live GG was also more effective over dead GG in reducing the quantity of RV from plasma(P = 0.047).CONCLUSION:Both live and dead GG have beneficial effects in RV infection.GG may increase RV clearance from the body and reduce colon swelling. | Hanna Ventola Liisa Lehtoranta Mari Madetoja Marja-Leena Simonen-Tikka Leena Maunula Merja Roivainen Riitta Korpela Reetta Holma | 2012 | World Journal of Gastroenterology2012，18，41： | 2 |
| 17 | Neuroprotective Effects of Dexmedetomidine in the Gerbil Hippocampus after Transient Global Ischemia显示文摘 | Johanna Kuhmonen Jaroslav Pokorny Riitta Miettinen Antti Haapalinna Jukka Jolkkonen Paavo Sr. Riekkinen Juhani Sivenius | 1997 | Anesthesiology1997，，2： | 2 |
| 18 | Continuous Innovation and Learning in Industrial O rganizations显示文摘 | Riitta Smeds Harry Boer | 2004 | Knowledge and Process Management2004，，11： | 1 |
| 19 | Prevalence, awareness and treatment of hypertension in Finland during 1982–2007显示文摘 | Mika Kastarinen Riitta Antikainen Markku Peltonen Tiina Laatikainen Noel C Barengo Antti Jula Veikko Salomaa Pekka Jousilahti Aulikki Nissinen Erkki Vartiainen Jaakko Tuomilehto | 2009 | Journal of Hypertension2009，，8： | 1 |
| 20 | Think- aloud protocl studies into translation : An annotated biliography 显示文摘 | Jaaskelainen Riitta | 2002 | Target2002，，1： | 1 |
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