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| 1 | Accelerated regeneration of the skeletal muscle in RNF13-knockout mice is mediated by macrophage-secreted IL-4/IL-6显示文摘(RNF13 ) 戒指手指蛋白质 13 是报导在癌症开发,肌肉房间生长,和 neuronal 开发的规定机能上地重要的最新识别的 E3 ligase。在这研究,在导致 cardiotoxin 的骨胳的肌肉新生的 RNF13 的功能用 RNF13 大美人老鼠被调查。RNF13 -/- 老鼠带着野类型的老鼠由加速的卫星房间 proliferationcompared 展出了提高的肌肉 regenerationcharacterized。RNF13 的表达式显著地在肌肉损坏的早阶段在巨噬细胞而非在野类型的鼠标的卫星房间被导致。这结果显示煽动性的房间在调停 RNF13 的卫星房间功能是重要的。在骨胳的肌肉的 cytokine 层次进一步被分析并且证明 RNF13 -/- 老鼠比野类型的老鼠生产了各种各样的 cytokines 的更大的数量。在这些之中, IL-4 和 IL-6 层次显著地在 RNF13 -/- 老鼠增加了。加速的肌肉新生显型被与堵住抗体在 RNF13 -/- 老鼠禁止 IL-4/IL-6 行动废除。这些结果显示那 RNF13 缺乏在卫星房间壁龛上经由效果支持骨胳的肌肉新生由 IL-4 和 IL-6 调停了。 | Jiao Meng Xiaoting Zou Rimao Wu Ran Zhong Dahai Zhu Yong Zhang | 2014 | Protein & Cell2014，5，3： | 2 |
| 2 | miR-378-mediated glycolytic metabolism enriches the Pax7^(Hi) subpopulation of satellite cells显示文摘Adult skeletal muscle stem cells,also known satellite cells(SCs),are a highly heterogeneous population and reside between the basal lamina and the muscle fiber sarcolemma.Myofibers function as an immediate niche to support SC self-renewal and activation during muscle growth and regeneration.Herein,we demonstrate that microRNA 378(miR-378)regulates glycolytic metabolism in skeletal muscle fibers,as evidenced by analysis of myofiber-specific miR-378 transgenic mice(TG).Subsequently,we evaluate SC function and muscle regeneration using miR-378 TG mice.We demonstrate that miR-378 TG mice significantly attenuate muscle regeneration because of the delayed activation and differentiation of SCs.Furthermore,we show that the miR-378-mediated metabolic switch enriches Pax7^(Hi) SCs,accounting for impaired muscle regeneration in miR-378 TG mice.Mechanistically,our data suggest that miR-378 targets the Akt1/FoxO1 pathway,which contributes the enrichment of Pax7^(Hi) SCs in miR-378 TG mice.Together,our findings indicate that miR-378 is a target that links fiber metabolism to muscle stem cell heterogeneity and provide a genetic model to approve the metabolic niche role of myofibers in regulating muscle stem cell behavior and function. | Hu Li Lin Kang Rimao Wu Changyin Li Qianying Zhang Ran Zhong Lijing Jia Dahai Zhu Yong Zhang | 2022 | Cell Regeneration2022，11，1： | 1 |
| 3 | A comparison of cardiac post-conditioning and remote pre-conditioning in paediatric cardiac surgery显示文摘 | Wanjun Luo Ming Zhu Rimao Huang Yangde Zhang | 2011 | Cardiology in the Young2011，，： | 1 |
| 4 | Acetoacetate promotes muscle cell proliferation via the miR-133b/SRF axis through the Mek-Erk-MEF2 pathway显示文摘Acetoacetate(AA)is an important ketone body that is used as an oxidative fuel to supply energy for the cellular activities of various tissues,including the brain and skeletal muscle.We recently revealed a new signaling role for AA by showing that it promotes muscle cell proliferation in vitro,enhances muscle regeneration in vivo,and ameliorates the dystrophic muscle phenotype of Mdx mice.In this study,we provide new molecular insight into this function of AA.We show that AA promotes C2C12 cell proliferation by transcriptionally upregulating the expression of muscle-specific miR-133b,which in turn stimulates muscle cell proliferation by targeting serum response factor.Furthermore,we show that the AA-induced upregulation of miR-133b is transcriptionally mediated by MEF2 via the Mek-Erk1/2 signaling pathway.Mechanistically,our findings provide further convincing evidence that AA acts as signaling metabolite to actively regulate various cellular activities in mammalian cells. | Ran Zhong Renling Miaot Jiao Meng Rimao Wu Yong Zhang Dahai Zhu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 1 |
| 5 | Synthesis, Characterization, and Antifungal Evaluation of Thiolactomycin Derivatives显示文摘5-Substituted benzylidene 3-acylthiotetronic acids are antifungal.A series of 3-acylthiotetronic acid derivatives with varying substitutions at the 5-position were designed,synthesized,and characterized,based on the binding pose of 3-acyl thiolactone with the protein C171Q KasA.Fungicidal activities of these compounds were screened against Valsa Mali,Curvularia lunata,Fusarium graminearum,and Fusarium oxysporum f.sp.lycopersici.Most target compounds exhibited excellent fungicidal activities against target fungi at the concentration of 50μg·mL-1.Compounds 11c and 11i displayed the highest activity with a broad spectrum.The median effective concentration(EC50)values of 11c and 11i were 1.9–10.7 and 3.1–7.8μg·mL-1,respectively,against the tested fungi,while the EC50 values of the fungicides azoxystrobin,carbendazim,and fluopyram were respectively 0.30,4.22,and>50μg·mL-1 against V.Mali;6.7,41.7,and 0.18μg·mL-1 against C.lunata;22.4,0.42,and 0.43μg·mL-1 against F.graminearum;and 4.3,0.12,and>50μg·mL-1 against F.oxysporum f.sp.lycopersici.The structures and activities of the target compounds against C.lunata were analyzed to obtain a statistically significant comparative molecular field analysis(CoMFA)model with high prediction abilities(q2=0.9816,r2=0.8060),and its reliability was verified.The different substituents on the benzylidene at the 5-position had significant effects on the activity,while the introduction of a halogen atom at the benzene ring of benzylidene was able to improve the activity against the tested fungi. | Pei Lv Yiliang Chen Dawei Wang Xiangwei Wu Qing XLi Rimao Hua | 2020 | Engineering2020，6，5： | 0 |
| 6 | Linc-RAM promotes muscle cell differentiation via regulating glycogen phosphorylase activity显示文摘Long non-coding RNAs(lncRNAs)are important regulators of diverse biological processes,especially skeletal muscle cell differentiation.Most of the lncRNAs identified to date are localized in the nucleus and play regulatory roles in gene expression.The cytoplasmic lncRNAs are less well understood.We previously identified a long intergenic non-coding RNA(linc-RNA)activator of myogenesis(Linc-RAM)that directly binds MyoD in the nucleus to enhance muscle cell differentiation.Here,we report that a substantial fraction of Linc-RAM is localized in the cytoplasm of muscle cells.To explore the molecular functions of cytoplasmic Linc-RAM,we sought to identify Linc-RAM-binding proteins.We report here that Linc-RAM physically interacts with glycogen phosphorylase(PYGM)in the cytoplasm.Knockdown of PYGM significantly attenuates the function of Linc-RAM in promoting muscle cell differentiation.Loss-of-function and gain-of function assays demonstrated that PYGM enhances muscle cell differentiation in an enzymatic activity-dependent manner.Finally,we show that the interaction between Linc-RAM and PYGM positively regulates the enzymatic activity of PYGM in muscle cells.Collectively,our findings unveil a molecular mechanism through which cytoplasmic Linc-RAM contributes to muscle cell differentiation by regulating PYGM activity.Our findings establish that there is crosstalk between lncRNAs and cellular metabolism during myogenic cell differentiation. | Lili Zhai Xin Wan Rimao Wu Xiaohua Yu Hu Li Ran Zhong Dahai Zhu Yong Zhang | 2022 | Cell Regeneration2022，11，1： | 0 |
| 7 | Correction to: miR-378-mediated glycolytic metabolism enriches the Pax7Hi subpopulation of satellite cells显示文摘Following publication of the original article(Li et al.,2022),due to a typesetting error,the sentence below was missing in the article.Hu Li and Lin Kang contributed equally to this work.The correct information has been provided in this Correction and the original article(Li et al.,2022)has been updated. | Hu Li Lin Kang Rimao Wu Changyin Li Qianying Zhang Ran Zhong Lijing Jia Dahai Zhu Yong Zhang | 2022 | Cell Regeneration2022，11，1： | 0 |
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