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| 1 | The Role of the Innate Immune System of the Liver in the Control of HBV and HCV显示文摘Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infection are among the most frequent causes of chronic liver disease worldwide. As recent studies suggested that Toll like receptor (TLR)-based therapies may represent a promising approach in the treatment of HBV infection, we have studied the role of the local innate immune system of the liver as possible mediator of this effect. Murine non-parenchymal liver cells (NPC; Kupffer cells, KC; sinusoidal endothelial cells, LSEC) were isolated from C57/BL6 and stimulated by TLR 1-9 agonists. Supernatants were harvested and assayed for their antiviral activity against HBV in HBV-Met cells and HCV in the murine HCV replicon cell line MH1. Only supernatants from TLR 3 and -4 stimulated KC and TLR 3 stimulated LSEC were able to potently suppress HBV and HCV replication. By using neutralizing antibodies we could demonstrate that the TLR 3-but not the TLR 4 mediated effect is exclusively mediated through IFN-β. Our data indicate that TLR 3 and -4 mediated stimulation of NPC leads to production of IFN-β which can potently suppress HBV and HCV replication. This is of relevance for the local control of viral hepatitis infection by the innate immune system of the liver, the development of novel TLR-based therapeutic approaches and sheds new light on the viral crosstalk between HCV (TLR 3 stimulator) and HBV. | Ruth Brring Jrg F. Schlaak | 2008 | Virologica Sinica2008，23，2： | 4 |
| 2 | High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet显示文摘 | Günther Silbernagel Marketa Kovarova Alexander Cegan Jürgen Machann Fritz Schick Rainer Lehmann Hans-Ulrich H?ring Norbert Stefan Erwin Schleicher Andreas Fritsche Andreas Peter | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，12： | 3 |
| 3 | 广西肝癌患者乙型肝炎病毒前C区基因的突变显示文摘目的 了解乙型肝炎病毒 (HBV)前C区基因突变与HBeAg阴性的原发性肝癌患者HBV感染的关系。方法 应用套式PCR方法对广西 16例原发性肝癌患者血清HBVDNA前C区进行扩增 ,对阳性者用SangerDNA测序法分析。结果 16例肝癌患者中有 14例HBVDNA阳性 ,阳性率为87 5 % (14/16 )。其中 1例HBeAg阳性 ,1例虽然HBeAg为阴性 ,但其前C区序列正常 ;2例为HBV野毒株和突变株混合感染 ;其余 8例为HBV突变株感染。该 8例中 ,仅第 4、5、12例的第 2 8密码为终止密码 ,有 1例为HBV终止密码株和无终止密码突变株混合感染。结论 经典的 1896位核苷酸点突变株感染在广西原发性肝癌患者中并不常见 ,提示可能存在前C区以外的基因突变 ,并导致HBeAg阴性的HBV感染。 | 方钟燎 何并文 庄辉 Ling Ring Tim J Harrison | 2000 | 中华预防医学杂志2000，34，2： | 2 |
| 4 | 肝细胞肝癌肝移植的预后因素分析显示文摘目的评价肝细胞肝癌(hepatocellular carcinoma,HCC)原位肝移植后的预后相关因素。方法回顾性分析1993年11月到2006年5月期间汉诺威医科大学对117例HCC进行肝移植的经验。结果经多因素分析,肿瘤大小和肿瘤数量(米兰标准或加州标准)、微血管侵犯、移植前治疗和肿瘤复发是影响患者生存预后的重要因素。结论原位肝移植是治疗HCC的理性术式;合适的选择标准,积极的移植前治疗,复发的有效控制,是患者获得良好预后的关键。 | 赵泽明 Thomas Becker 范跃祖 Bastian Ringe Jürgen Klempnauer | 2014 | 同济大学学报(医学版)2014，35，1： | 2 |
| 5 | Benign Liver Tumors: Differential Diagnosis and Indications for Surgery显示文摘 | Arved Weimann Burckhardt Ringe Jürgen Klempnauer Peter Lamesch Klaus F. Gratz Mathias Prokop Hansj?rg Maschek Günter Tusch Rudolf Pichlmayr | 1997 | World Journal of Surgery1997，，9： | 2 |
| 6 | Posterior dislocation of the elbow with fractures of the radial head and coronoid显示文摘 | Ring D Jupiter JB Zilberfarb J | 2002 | J Bone Joint Surg Am2002，84，4： | 1 |
| 7 | Human Thermal Sensation:Frequency Response to Sinusoidal at the Surface of the Skin显示文摘 | de Dear R Melikov A | 1993 | Energy and Buildings1993，20，2： | 1 |
| 8 | Posterior dislocation of the elbow with fractures of the radial head and coronoid显示文摘 | Ring D Jupiter JB Zilberfarb J | 2002 | Bone Joint Surg Am(Am)2002，84，4： | 1 |
| 9 | NiO thin film formaldehyde gas sensor显示文摘 | Dirksen J A Duval K Ring T A | 2001 | Sensors and Actuators B2001，80，： | 1 |
| 10 | Evaluation of an ultrasonically guided venepuncture technique for the placement of permanent pacing eleetrodes显示文摘 | Nash A Burrell C J Ring N J | 1998 | PACE1998，21，2： | 1 |
| 11 | Type 2 diabetes risk alleles are associated with reduced size at birth diabetes 显示文摘 | Freathy RM Bennett A J Ring SM | 2009 | Diabetes2009，58，12： | 1 |
| 12 | Total serum immunoglobulins and atopic symptoms in patients with vitiligo显示文摘 | Chatain C Ring J Schallreuter KU | 1994 | Dermatology1994，189，： | 1 |
| 13 | Anaphylactoid reactions to infusions of plasma protein and human serum albumin; role of aggregated proteins and of stabilizers added during production显示文摘 | Ring J Stephan W Brendel W | 1979 | Clin & Exp Allergy1979，9，1： | 1 |
| 14 | Combined dorsal and volar plate fixation of complex fractures of the distal part of the radius显示文摘 | RING D PROMMERSBERGER K JUPITER J B | 2004 | J Bone Joint Surg Am2004，86，8： | 1 |
| 15 | A review of treatment with mepolizumab, an anti - IL - 5 mAb, in hypereosinophilic syndromes and asthma 显示文摘 | Busse WW Ring J Huss - Marp J | 2010 | J AUergy Clin Immunol2010，125，4： | 1 |
| 16 | HIV-1 Clade C Envelopes Obtained From Late Stage Symptomatic Indian Patients Varied in Their Ability Towards Relative CD4 Usages and Sensitivity to CCR5 Antagonist TAK-779显示文摘 | GHARU L RINGE R BHATTACHARYA J | 2011 | Virus Research2011，158，1： | 1 |
| 17 | Posterior dislocation of the elbow with fractures of the radial head and coronid显示文摘 | Ring D Jupiter JB Zilberfarb J | 2002 | J Bone Joint Surg(Am)2002，84，4： | 1 |
| 18 | Gender-specific effects of the Catechol-O-Methyltransferase Val108/158Met polymorphism on cognitive function in children 显示文摘 | Barnett JH Heron J Ring SM | 2007 | Am J Psychiatry2007，164，1： | 1 |
| 19 | Wrighton SA comparative metabolic capabilities of CYP3A4, CYP3AS, and CYP3A7 显示文摘 | Williams JA Ring B J Cantrell Ve | 2002 | Drug Metab Dispos2002，30，： | 1 |
| 20 | Derivation of diagnostic requirements for a distributed UAV turbofan engine control system显示文摘 | Hannius O Ring D Karlsson J | 2008 | Journal of Engineering for Gas Turbines and Power2008，130，2： | 1 |
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