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| 1 | 欧洲卒中组织颅内动脉瘤和蛛网膜下腔出血处理指南显示文摘背景伴或不伴蛛网膜下腔出血(subarachnoidhaemorrhage,SAH)的颅内动脉瘤是一个重要的健康问题,其总体发病率约为9/10万,在不同国家存在很大差异,在某些国家可高达20/10万。采用保守治疗时,发病最初数月内病死率为50%~60%。在动脉瘤未经处理的患者中,约1剧寄在初次出血恢复后6个月内死于再次出血。此外,血管痉挛、脑积水、迟发性缺血性神经功能缺损以及其他并发症均会影响预后。本指南旨在为伴和不伴颅内动脉瘤的SAH以及未破裂颅内动脉瘤患者的处理提供全面的推荐意见。方法我们使用Medline和Embase进行广泛的文献检索(时间范围为1960年至2011年)。写作组成员通过面谈和电话会议的形式讨论各条推荐意见。按照欧洲神经科学学会联盟标准对检索结果进行分级。欧洲卒中组织指南委员会成员对本指南进行了审阅。结果本指南为SAH的流行病学、危险因素和预后提供了循证信息,并为破裂和未破裂颅内动脉瘤的诊断和治疗方法提供了循证推荐意见。我们明确了动脉瘤生长和破裂的多种危险因素,并且提供了诊断性检查、监测和一般处理(血压、血糖、体温、血栓预防、抗癫痫治疗和类固醇的使用)的推荐意见。特异性治疗干预需考虑处理时机、夹闭和弹簧圈栓塞。本指南还涉及并发症的处理,如脑积水、血管痉挛和迟发性缺血性神经功能缺损等,并对非动脉瘤性SAH和未破裂动脉瘤的处理提供了推荐意见。结论破裂颅内动脉瘤是一种严重的疾病,具有很高的继发并发症风险,需要在治疗此类患者方面有着丰富经验的医疗中心内及时治疗。本指南为破裂或未破裂颅内动脉瘤患者的处理提供了实用的循证建议。应用这些措施能改善SAH的预后。 | Thorsten Steiner Andreas Unterberg Carla Jung Michael Forsting Seppo Juvela Gabriel Rinkel 吴政政(译) 李政(译) 陈蓓蕾(译) 陈聪(译) 杨卉(译) 徐运(译) | 2013 | 国际脑血管病杂志2013,21,6: | 182 |
| 2 | 影响颅内动脉瘤破裂风险的患者个体特征(英文)显示文摘BACKGROUND AND PURPOSE Knowledge about risk factors contributes to understanding the pathophysiological mechanisms that cause intracranial aneurysm rupture and helps to develop possible treatment strategies.We aimed to study lifestyle and personal characteristics as risk factors for the rupture of intracranial aneurysms.METHODS We performed a case-control study with 250 patients with an aneurysmal subarachnoid hemorrhage and 206 patients with an unruptured intracranial aneurysm.All patients with an aneurysmal subarachnoid hemorrhage and patients with a unruptured intracranial aneurysm were asked to fill in a structured questionnaire about their lifestyle and medical history.For patients with an unruptured intracranial aneurysm,we also collected data on the indication for imaging.With logistic regression analysis,we identified independent risk factors for aneurysmal rupture.RESULTS Reasons for imaging in patients with an unruptured intracranial aneurysm were atherosclerotic disease(23%),positive family history(18%),headache(8%),preventive screening(3%),and other(46%).Factors that increased risk for aneurysmal rupture were smoking(odds ratio,1.9;95% confidence interval,1.2-3.0) and migraine(2.4;1.1-5.1);hypercholesterolemia decreased this risk(0.4;0.2-1.0),whereas a history of hypertension did not independently influence the risk.CONCLUSIONS Smoking,migraine and,inversely,hypercholesterolemia are independent risk factors for aneurysmal rupture.Data from the questionnaire are insufficient to conclude whether hypercholesterolemia or its treatment with statins exerts a risk-reducing effect.The pathophysiological mechanisms through which smoking and migraine increase the risk of aneurysmal rupture should be investigated in further studies.Although a history of hypertension does not increase risk of rupture,a sudden rise in blood pressure might still trigger aneurysmal rupture. | Vlak MH Rinkel GJ Greebe P Algra A | 2013 | 中华神经外科疾病研究杂志2013,12,3: | 17 |
| 3 | Subarachnoid haemorrhage: diagnosis,causes and management显示文摘 | Van Gijn J Rinkel GJE | 2001 | Brain2001,124,2: | 2 |
| 4 | Nonaneurysmal perimesencephalic subarachnoid hemorrhage: a fellow-up study in 29 patients显示文摘 | Rinkel GJ Wijdicks FM Vermenlen M | 2002 | Surg Neurol2002,57,: | 1 |
| 5 | Effectiveness of neurosurgical clip application in patients with aneurismal subarachnoid hemorrhage 显示文摘 | Brilstra EH Algra A Rinkel GJ | 2002 | J Neurosurg2002,97,5: | 1 |
| 6 | Calcium antagonists in patients with aneurysmal subarachnoid hemorrhage: a systematic review 显示文摘 | Feigin VL Rinkel GJ | 1998 | Neurology1998,50,4: | 1 |
| 7 | Subaraehnoid hemorrhage; diaghosis, causes and management 显示文摘 | Van G J Rinkel GJ | 2001 | Brain2001,124,2: | 1 |
| 8 | Disorders of sleeP and wake in Patients after subarachnoid hemorrhage显示文摘 | SCHUILING W J RINKEL G J WALCHENBACH R | 2005 | Stroke2005,36,3: | 1 |
| 9 | The clinical course of perimesencephalic nonaneurysmal subarachnoid hemorrhage 显示文摘 | Rinkel GJ Wijdicks EF Vermeulen M | 1991 | Ann Neurol1991,29,5: | 1 |
| 10 | Genetics of intracranial aneurysms显示文摘 | Ruigrok YM Rinkel GJ Wijmenga C | 2005 | Lancet Neurol2005,4,3: | 1 |
| 11 | Subarachnoid Hemorrhage Without Detectable Aneurysm: A Review of the Causes显示文摘 | Gabriel J.E. Rinkel Jan van Gijn Eelco F.M. Wijdicks | 1993 | Stroke1993,,9: | 1 |
| 12 | Electrocardiographic abnormalities and serum magnesium in patients with sunarachnoid hemorrhage显示文摘 | Van de WA Algra A Rinkel GJ | 2004 | Stroke2004,35,: | 1 |
| 13 | Subarachnoid haemorrhage:diagnosis, causes, and management显示文摘 | Van Gijn J Rinkel GJE | 2001 | Brain2001,124,2: | 1 |
| 14 | Nonaneurysmal perimesencephalic subarachnoid hemorrhage: CT and MR patterns that differ from aneurysmal rupture 显示文摘 | Rinkel GJ Wijdicks EF Vermeulen M | 1991 | Am J Neuroradiol1991,12,: | 1 |
| 15 | Case-fatality rates and functional outcome after subarachnoid hemorrhage: a systematic review显示文摘 | Hop JW Rinkel GJ Algra A | 1997 | Stroke1997,28,3: | 1 |
| 16 | Attributable risk of common and rare determinants of subarachnoid hemorrhage显示文摘 | Ruigrok YM Buskens E Rinkel GJ | 2001 | Stroke2001,32,: | 1 |
| 17 | Calcium antagonists for aneurysmal subarachnoid haemorrhage显示文摘 | Dorhout Mees SM Rinkel GJ Feigin VL | | 0,,03: | 1 |
| 18 | Endovascular treatment of ruptured intracranial aneurysms with detachable coils:long-term clinical and serial angiographic results 显示文摘 | Sluzewski M van Rooij WJ Rinkel GJ | 2003 | Radiology2003,227,3: | 1 |
| 19 | Changes in functional outcome and quality of life in patients and earegivers after aneurismal sunarachnoid hemorrhage显示文摘 | Hop J Rinkel G Algra A | 2001 | Journal of Neurosurgery2001,95,: | 1 |
| 20 | Calcium antagonists for aneurysmal subarachnoid hemorrhage显示文摘 | Rinkel GJ Feigin VL | 2007 | Cochrane Database Syst Rev2007,3,00: | 1 |