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| 1 | Gastric cancer arising from the remnant stomach after distal gastrectomy:A review显示文摘Gastric stump carcinoma was initially reported by Balfore in 1922,and many reports of this disease have since been published. We herein review previous reports of gastric stump carcinoma with respect to epidemiology,carcinogenesis,Helicobacter pylori(H. pylori) infection,Epstein-Barr virus infection,clinicopathologic characteristics and endoscopic treatment. In particular,it is noteworthy that no prognostic differences are observed between gastric stump carcinoma and primary upper third gastric cancer. In addition,endoscopic submucosal dissection has recently been used to treat gastric stump carcinoma in the early stage. In contrast,many issues concerning gastric stump carcinoma remain to be clarified,including molecular biological characteristics and the carcinogenesis of H.pylori infection.We herein review the previous pertinent literature and summarize the characteristics of gastric stump carcinoma reported to date. | Shinsuke Takeno Tatsuya Hashimoto Kenji Maki Ryosuke Shibata Hironari Shiwaku Ippei Yamana Risako Yamashita Yuichi Yamashita | 2014 | World Journal of Gastroenterology2014，20，38： | 13 |
| 2 | Extract of Yokukansan improves anxiety-like behavior and increases serum brain-derived neurotrophic factor in rats with cerebral ischemia combined with amyloid-β42 peptide显示文摘OBJECTIVE: To examine the effects of Yokukansan(YKS) extract on two endogenous modulators of anxiety, brain-derived neurotrophic factor(BDNF)and serotonin (5-HT)_(2A) receptors pharmacologically, in the ischemic rat model of dementia.METHODS: The cerebral ischemia(CI) was induced by bilateral occlusion of the vertebral and common carotid arteries(4-vessel occlusion ischemia). The CI was combined with the amyloid-β42 peptide(A42) injected intracerebroventricularly, and referreβdto as CI+Aβ. Anxiety-like behaviors were assessed by elevated plus maze(enclosed arm), light/dark transition test(dark chamber), and open-field test.Wet-dog shakes were induced by the 5-HT_(2A) receptor agonist 2, 5-dimethoxy-4-iodoamphetamine(DOI). The concentration of BDNF in serum was determined by enzyme-linked immuno sorbent assay.RESULTS: CI + Aβ increased anxiety, as demonstrated by the increase of time spent in the enclosed arms and dark chambers, and locomotion in the outer zone of the open field(thigmotaxis). CI + Adecreased the serum concentration of BDNF. YKS reβ-duced the anxiety-like behaviors, suppressed the DOI-induced wet-dog shakes and increased serum BDNF concentrations.CONCLUSION: Our findings suggest that YKS extract improves CI + Aβ-induced anxiety by antagonizing 5-HT_(2A) receptors and increasing BDNF. | Ai Nogami-Hara Kaori Kubota Kotaro Takasaki Takuya Watanabe Nobuaki Egahira Hikari Iba Risako Fujikawa Shutaro Katsurabayashi Funda Bolukbasi Hatip Izzettin Hatip-Al-Khatib Katsunori Iwasaki | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 3 |
| 3 | Feasibility of drug delivery to the eye’s posterior segment by topical instillation of PLGA nanoparticles显示文摘We investigated the delivery of drugs to the posterior segment of the eye by non-invasive topical instillation using submicron-sized poly(D,L-lactide-co-glycolide)(PLGA) nanoparticles(NPs). Surface-modified PLGA NPs were developed to improve the drug delivery efficiency to the retina and were administered as topical eye drops to mice. Chitosan(CS) and glycol chitosan(GCS), which are mucoadhesive polymers, and polysorbate 80(P80) were used as surface modifiers, and have been reported to increase the association of NPs with cells.Coumarin-6 was used as a model drug and fluorescent marker, and after ocular administration of PLGA NP eye drops, the fluorescence intensity of coumarin-6 was observed in the retina. The fluorescence image analysis indicated that there are several possible routes to the retina and fates of PLGA NPs in ocular tissue, and that these pathways involved the corneal,non-corneal, or uveal routes. Delivery to the mouse retina segments after topical administration was increased by surface modification with CS, GCS, or P80. Surface-modified PLGA NPs are a promising method for retinal drug delivery via topical instillation. | Kohei Tahara Keiichi Karasawa Risako Onodera Hirofumi Takeuchi | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，4： | 3 |
| 4 | Ocular dominance and patient satisfaction after monovision induced by intraocular lens implantation显示文摘 | Tomoya Handa Kazuo Mukuno Hiroshi Uozato Takahiro Niida Nobuyuki Shoji Risako Minei Marie Nitta Kimiya Shimizu | 2004 | Journal of Cataract & Refractive Surgery2004，，4： | 1 |
| 5 | The impact of electricity supply on economic growth in Sri Lanka显示文摘 | Risako Morimoto Chris Hope | 2003 | Energy Economics2003，，1： | 1 |
| 6 | The impact of electricity supply on economic growth in Sri Lanka显示文摘 | Risako Morimoto Chris Hope | 2004 | Energy Economics2004，26，： | 1 |
| 7 | Uptake pathway and continuous removal of nitric oxide from flue gas using microalgae显示文摘 | Hiroyasu Nagase Ken-ichi Yoshihara Kaoru Eguchi Yasunobu Okamoto Sachi Murasaki Risako Yamashita Kazumasa Hirata Kazuhisa Miyamoto | 2001 | Biochemical Engineering Journal2001，，3： | 1 |
| 8 | Characterization of fish muscle typeicollagen显示文摘 | Shigeru kimura Xiao Ping Zhu Risako Matsui | 1988 | Food Science1988，53，5： | 1 |
| 9 | The impact of electricity supply on economic growth in Sri Lanka显示文摘 | Risako Morimoto Chris Hope | 2004 | Energy Economics2004，26，： | 1 |
| 10 | Anti-obesity Effect of Blumea balsanllnra Extract in 3T3-L1Preadipocytes and adipocyt cs 显示文摘 | Hiroaki Kubola Akiko Kojima Yuasa Risako Morii | 2009 | The American Journalt of Chinese Medicine2009，37，5： | 1 |
| 11 | The Impact of Electricity Supply on Economic Growth in Sri Lanka显示文摘 | Risako Morimoto Chris Hope | 2004 | Energy Economics2004，，26： | 1 |
| 12 | Urine output and resultant osmotic water shift are major determinants of plasma sodium level in syndrome of inappropriate antidiuretic hormone secretion显示文摘 | Ataru Okumura Kota Ishikawa Risako Watanabe Taku Tsunekawa Chikako Asai Atsushi Kiyota Minemori Watanabe Yutaka Oiso | 2013 | Translational Research2013，，1： | 1 |
| 13 | The Impact o显示文摘 | RISAKO M CHRIS H | 2004 | Energy Economies2004，26，1： | 1 |
| 14 | Gastric schwannoma exhibiting increased fluorodeoxyglucose uptake显示文摘 | Daisuke Komatsu Naohiko Koide Risako Hiraga Naoyuki Furuya Taiji Akamatsu Takeshi Uehara Shinichi Miyagawa | 2009 | Gastric Cancer2009，，4： | 1 |
| 15 | Novel approaches for posterior segment ocular drug delivery with folate-modified liposomal formulation显示文摘The leading causes of vision impairment and blindness are posterior segment-related diseases including age-related macular degeneration,diabetic macular edema and endophthalmitis.Recently,pharmaceutical approaches to these diseases have used steroids and oligonucleotides.These drugs are usually administered via invasive injection because noninvasive delivery method such as eye drop administration of drugs is not available.However,repeated injections are associated with potential risks of complications.Moreover,patients may not comply with such regimens. | Toshiki Hayashi Risako Onodera Kohei Tahara Hirofumi Takeuchi | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 1 |
| 16 | Applying a cost-benefit analysis model to the Three Gorges project in China显示文摘 | Risako Morimoto Chris Hope | 2004 | Impact Assessment & Project Appraisal2004，，9： | 1 |
| 17 | The impact of electricity supply on economic growth in Sri Lanka显示文摘 | Risako Morimoto Chris Hope | 2004 | Energy Economics2004，26，： | 1 |
| 18 | Baseline Features of Idiopathic Optic Neuritis as Determined by a Multicenter Treatment Trial in Japan显示文摘 | Masato Wakakura Risako Minei-Higa Shinji Oono Yoshie Matsui Akio Tabuchi Kazutaka Kani Keigo Shikishima Kazushige Kawai Yuzo Nakao Yutaka Tazawa Motohiro Kiyosawa Haruki Abe Norio Ohba Keiko Yago Shuji Maeda Minoru Sugita Satoshi Ishikawa | 1999 | Japanese Journal of Ophthalmology1999，，2： | 1 |
| 19 | Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press显示文摘We previously determined 'Tableting properties' by using a multi-functional single-punch tablet press(GTP-1). We proposed plotting 'Compactability' on the x-axis against'Manufacturability' on the y-axis to allow visual evaluation of 'Tableting properties'. Various types of tableting failure occur in commercial drug production and are influenced by the amount of lubricant used and the shape of the punch. We used the GTP-1 to measure'Tableting properties' with different amounts of lubricant and compared the results with those of tableting on a commercial rotary tableting machine. Tablets compressed with a small amount of lubricant showed bad 'Manufacturability', leading to sticking of powder on punches.We also tested various punch shapes. The GTP-1 correctly predicted the actual tableting results for all punch shapes. With punches that were more likely to cause tableting failure, our system predicted the effects of lubricant quantity in the tablet formulation and the occurrence of sticking in the rotary tableting machine. | Takashi Osamura Yoshiko Takeuchi Risako Onodera Masahiro Kitamura Yoshiteru Takahashi Kohei Tahara Hirofumi Takeuchi | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，5： | 1 |
| 20 | Charecterization of fish muscle type I collagen显示文摘 | Xiao-Ping Zhu Risako Matsui | 1988 | Food Science1988，53，5： | 1 |
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