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| 1 | Role of ethanol in the regulation of hepatic stellate cell function显示文摘Evidence has accumulated to suggest an important role of ethanol and/or its metabolites in the pathogenesis of alcohol-related liver disease. In this review, the fibrogenic effects of ethanol and its metabolites on hepatic stellate cells (HSCs) are discussed. In brief, ethanol interferes with retinoid metabolism and its signaling, induces the release of fibrogenic cytokines such as transforming growth factor β-1 (TGFβ-1) from HSCs, up-regulates the gene expression of collagen I and enhances type I collagen protein production by HSCs. Ethanol further perpetuates an activated HSC phenotype through extracellular matrix remodeling. The underlying pathophysiologic mechanisms by which ethanol exerts these pro-fibrogenic effects on HSCs are reviewed. | Jian-Hua Wang Robert G Batey Jacob George | 2006 | World Journal of Gastroenterology2006，12，43： | 16 |
| 2 | Short-Root1 Plays a Role in the Development of Vascular Tissue and Kranz Anatomy in Maize Leaves显示文摘 | Thomas L. Slewinski Alyssa A. Anderson Simara Price Jacob R. Withee Kimberly Gallagher Robert Turgeon | 2014 | Molecular Plant2014，7，8： | 4 |
| 3 | Hypoxic training methods for improving endurance exercise performance显示文摘耐力运动表现与很多因素都高度相关,这些因素可以通过高原训练和低氧训练改变,包括增加红细胞量、提高最大有氧运动能力、增加毛细血管密度和提高有氧运动的经济性。针对短期和长期暴露在低氧环境中的生理适应性已有很多研究,发现从短期的不利影响到长期适应的过程可提高在高原和海平面比赛的运动表现。许多高原和低氧训练方案逐步被改良,包括通过在海平面、低、中、高不同海拔,以及自然或人工的海拔中生活和训练的各种组合,产生不同程度的训练效果。部分因素已被证实与低氧训练的个体反应有关,鉴定这些运动员最有可能受益于低氧训练的技术值得进一步研究。本研究建议的高住低练方案为;低海拔地区训练的同时,在足够的高度(2 000-3 000 m)每天至少生活12 h,周期最少为21天。尽管此类高住低练建议普遍存在.但有关高原训练时间和比赛运动表现的关系仍存在争论。 | Jacob A. Sinex Robert E Chapman | 2015 | Journal of Sport and Health Science2015，4，4： | 3 |
| 4 | Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection显示文摘 | Matthew T. Kitson Gregory J. Dore Jacob George Peter Button Geoffrey W. McCaughan Darrell H.G. Crawford William Sievert Martin D. Weltman Wendy S. Cheng Stuart K. Roberts | 2012 | Journal of Hepatology2012，，： | 2 |
| 5 | Operative treatment of scapular fractures: A systematic review显示文摘 | Jacob M. Lantry Craig S. Roberts Peter V. Giannoudis | 2007 | Injury2007，，3： | 2 |
| 6 | Threshold Chloride Concentrations and Passivity Breakdown of Rebar Steel in Real Concrete Solution at Different pH Conditions with the Addition of Glycerol显示文摘Addition of glycerol as a viscosity modifier in concrete is proposed to decrease the permeability of corrosioninducing ions such as chloride and sulfate.In addition to controlling the permeabiUty of concrete,glycerol could perform as an inhibitor of corrosion of rebar steel.Cyclic polarization studies were carried out on metallographically polished rebar steel specimens in actual concrete solutions at two different pH conditions(pH 12.5 and 9.0) and different chloride concentrations.The threshold concentration of chloride for passivity breakdown at pH 12.5 was greater than50 × 10^(-3) mol/L in the absence of glycerol addition.The threshold increased to 81 × 10^(-3)mol/L upon addition of 2 wt%glycerol.The threshold chloride concentration for passivity breakdown in pH 9.0 cement solution was 0.2 × 10^(-3) mol/L without glycerol addition.No beneficial effect of glycerol was observed in the low pH condition.However,glycerol enhanced the passivation kinetics of the rebar steel in saturated cement solution,but did not affect the electronic properties of the passive layer.The passive layers exhibited n-type semiconductivity with a charge carrier density in the range of2-7.5× 10^(20) cm^(-3).Polarization of the specimens to potentials is higher than oxygen evolution potential,resulted in transition top-type semiconducting character due to an accumulation of holes.This phenomenon could be related to the passivity breakdown. | Robert Blair Batric Pesic Jacob Kline Ian Ehrsam Krishnan Raja | 2017 | Acta Metallurgica Sinica(English Letters)2017，30，4： | 2 |
| 7 | Differentiation of malignant and benign proximal bile duct strictures: The diagnostic dilemma显示文摘AIM: To identify the criteria for the differentiation of hilar cholangiocarcinoma (HCCA) from benign strictures. METHODS: A total of 68 patients underwent resection of lesions suspicious for HCCA between 1998 and 2006. The results of laboratory investigations, imaging studies and brush cytology were collected. These fi ndings were analyzed to obtain the fi nal diagnosis. RESULTS: Histological examination of the resected specimens confirmed HCCA in 58 patients (85%, group Ⅰ) whereas 10 patients (15%, groupⅡ) were diagnosed to have benign strictures. The most common presenting symptom was obstructive jaundice in 77% patients (79% group Ⅰvs 60% group Ⅱ P = 0.23). Laboratory findings showed greater elevation of transaminase levels in group Ⅰcompared to group Ⅱ The various imaging modalities showed vascular involvement exclusively in the malignant group (36%,P < 0.05). Brush cytology was positive for malignant cells in only 50% patients in group Ⅰ whereas none in group Ⅱ showed malignant cells. CONCLUSION: Despite improvements in imaging techniques, 10 patients (15%) with a presumptive diagnosis of HCCA were ultimately found to have benign strictures. Except for vascular involvement which was associated significantly with malignancy, there were no conclusive features of malignancy on regular imaging modalities. This uncertainty should be taken into account when patients with a suspicious lesion at the liver hilum are considered for resection. | Jaap Jacob Kloek Otto Marinus van Delden Deha Erdogan Fibo Jan ten Kate Erik Anthoni Rauws Olivier Robert Busch Dirk Joan Gouma Thomas Mathijs van Gulik | 2008 | World Journal of Gastroenterology2008，14，32： | 2 |
| 8 | Fisheries monitoring: Perspectives from the United States显示文摘Fisheries monitoring in the United States exists in many forms and serves many functions due to geographically varying objectives,practices,technology,institutional structures,and funding.In the U.S and abroad,diverse catch methods commonly exist for the same stock,thus monitoring and reporting strategies need to be tailored to unique operational needs.Common management challenges include funding limitation,survey design,coverage,and implementation.We describe three innovative examples of fisheries monitoring in the United States.These stories of success and failure can inform the design and implementation of new monitoring pilots and aid crafting both regional and national policies.We explore the innovative vessel monitoring and electronic logbook practices across multiple sectors for Gulf of Mexico red snapper(Lutjanus campechanus).Then,we examine a unique monitoring program that produces critical,near real-time genetic and population surveys for sockeye salmon(Oncorhynchus nerka)in Bristol Bay,Alaska.Our final case study describes the many fishery-dependent and-independent data streams for American lobster(Homarus americanus)in New England.Across all monitoring cases exists an explicit focus on the most critical aspects of organism life history.We find strong cross-institutional working relationships and adept agency coordination are imperatives in instances of stocks occupying multiple state or federal boundaries.Our results suggest the most effective approaches address the unique data needs of a fishery,and for this,thorough understanding of both biological and socioeconomic aspects of the fishery is a prerequisite.Ultimately,the monitoring program should jointly incentivize compliance while promoting continued and evolving interaction between resources users,scientists,and management. | Robert Boenish Daniel Willard Jacob P.Kritzer Kathleen Reardon | 2020 | Aquaculture and Fisheries2020，5，3： | 2 |
| 9 | Geochronological constraints on the metamorphic sole of the Semail ophiolite in the United Arab Emirates显示文摘The Semail ophiolite of Oman and the United Arab Emirates(UAE) provides the best preserved large slice of oceanic lithosphere exposed on the continental crust,and offers unique opportunities to study processes of ocean crust formation,subduction initiation and obduction.Metamorphic rocks exposed in the eastern UAE have traditionally been interpreted as a metamorphic sole to the Semail ophiolite.However,there has been some debate over the possibility that the exposures contain components of older Arabian continental crust.To help answer this question,presented here are new zircon and rutile U-Pb geochronological data from various units of the metamorphic rocks.Zircon was absent in most samples.Those that yielded zircon and rutile provide dominant single age populations that are 95-93 Ma,partially overlapping with the known age of oceanic crust formation(96.5-94.5 Ma),and partially overlapping with cooling ages of the metamorphic rocks(95-90 Ma).The data are interpreted as dating high-grade metamorphism during subduction burial of the sediments into hot mantle lithosphere,and rapid cooling during their subsequent exhumation.A few discordant zircon ages,interpreted as late Neoproterozoic and younger,represent minor detrital input from the continent.No evidence is found in favour of the existence of older Arabian continental crust within the metamorphic rocks of the UAE. | Nick M.W.Roberts Robert J.Thomas Joachim Jacobs | 2016 | Geoscience Frontiers2016，7，4： | 2 |
| 10 | Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabe-tes in older men and women显示文摘 | Marieke BS Robert JH Jacob CS | 2006 | Diabetes Care2006，29，： | 1 |
| 11 | Homocysteine as a risk factor for ischemic stroke:anepidemiological story in evolution显示文摘 | SACCO RL ROBERTS JK JACOBS BS | 1998 | Neuroepidemiol ogy1998，17，： | 1 |
| 12 | Last interglacial age for aeolian and ma- rine deposits and the Nahoon fossil human footprints, South- east Coast of South Africa 显示文摘 | Jacobs Z Roberts D L | 2009 | Quaternary Geochronology2009，4，2： | 1 |
| 13 | First -trimester or second-trimester screening, or both, for Down syndrome显示文摘 | Fergal D Malone Canick Jacob A Robert H | 2005 | N Engl Med2005，353，19： | 1 |
| 14 | Conversion of the rosin acid fraction of crude tall oil into fuels and chemicals 显示文摘 | ROBERT Coll SIDDHARTH Udas WILLIAM A Jacob | 2001 | Energy & Fuels2001，15，5： | 1 |
| 15 | Homocysteine as a risk factor for ischemic stroke in evolution显示文摘 | Sacco RL Roberts JK Jacobs BS | 1998 | Neuroepidemiology1998，17，4： | 1 |
| 16 | Homocysteine as a risk factor for ischemic stroke: an epidemiological story in evolution 显示文摘 | Sacco RL Roberts JK Jacobs BS | 1998 | Neuroepidemiology1998，17，： | 1 |
| 17 | Enterprise resource planning: developments and directions for operations management research显示文摘 | F Robert Jacobs Elliot Bendoly | 2003 | European Journal of Operational Research2003，146，： | 1 |
| 18 | Homocysteine as a risk factor for ischemic stroke: an epidemiological story in evolution显示文摘 | Sacco RL Roberts JK Jacobs BS | 1998 | Neuroepidemiology1998，17，4： | 1 |
| 19 | First-trimester or secondtrimester screening, or both, for down's syndrome 显示文摘 | Fergal DM Jacob AC Robert HB | 2005 | The New England journal of medicine2005，353，19： | 1 |
| 20 | Homicysteine as a risk factor for ischemic stroke: an epidemiological story in evolution 显示文摘 | Sacco RL Roberts JK Jacobs BS | 1998 | Neuroepidemidogy1998，17，： | 1 |
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