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| 1 | 中国塔里木地块的视极移曲线显示文摘塔里木地块的视极移曲线由泥盆纪,晚石炭世,二叠纪,早三叠世和侏罗-白垩纪古地磁极联线构成。(D:P_(lat)=16,P_(long)=165,A_(95)=4;C_3:P_(lat)=41,P_(long)=160,A_(95)=4;P:P_(lat)=61,P_(long)=177,A_(95)=9;T_3:P_(lat)=69,P_(long)=183,A_(95)=11;J-K:P_(lat)=65,P_(long)=214,A_(95)=6)根据古地磁研究,塔里木地块在泥盆和二叠纪之间俯冲到哈萨克斯坦地块之下。塔里木,华北和华南的缝合年代在早三叠世和早白垩世之间,相对于西伯利亚,塔里木地块自白垩纪之后有较大的东向运动。 | 李燕平 李永安 张正坤 翟永健 李强 高振家 Robert Sharps Michael McWilliams | 1989 | 地质学报1989，63，3： | 13 |
| 2 | 塔里木地块侏罗、白垩纪的古地磁显示文摘本文对塔里木地块西北缘库车、拜城一带中新生代剖面进行了古地磁研究。库车与拜城两剖面具有不同方向产状,经产状校正之后,均为同一方向,表明磁性是在第三系褶皱之前获得的。热退磁结果表明500℃之前为现代地磁场方向,解阻温度为675℃,说明磁性载体为赤铁矿。 古地磁结果表明,塔里木地块在晚侏罗—晚白垩世之间没有经历大规模的构造运动。有可能自晚白垩世之后相对西伯利亚地块向北东方向移动过。 | 张正坤 李永安 李强 翟永建 李燕平 Michael McWilliams Allan cox Robert sharps | 1989 | 地震地质1989，11，3： | 7 |
| 3 | Systematic review and meta-analysis on the association of tuberculosis in Crohn's disease patients treated with tumor necrosis factor-α inhibitors(Anti-TNFα)显示文摘AIM To perform a meta-analysis on the risk of developing Mycobacterium tuberculosis(TB) infection in Crohn's disease(CD) patients treated with tumor necrosis factoralpha(TNFα) inhibitors.METHODS A meta-analysis of randomized, double-blind, placebocontrolled trials of TNFα inhibitors for treatment of CD in adults was conducted. Arcsine transformation of TB incidence was performed to estimate risk difference. A novel epidemiologically-based correction(EBC) enabling inclusions of studies reporting no TB infection cases in placebo and treatment groups was developed to estimate relative odds.RESULTS Twenty-three clinical trial studies were identified, including 5669 patients. Six TB infection cases were reported across 5 studies, all from patients receiving TNFα inhibitors. Eighteen studies reported no TB infection cases in placebo and TNFα inhibitor treatment arms. TB infection risk was significantly increased among patients receiving TNFα inhibitors, with a risk difference of 0.028(95%CI: 0.0011-0.055). The odds ratio was 4.85(95%CI: 1.02-22.99) with EBC and 5.85(95%CI: 1.13-30.38) without EBC.CONCLUSION The risk of TB infection is higher among CD patients receiving TNFα inhibitors. Understanding the immunopathogenesis of CD is crucial, since using TNFα inhibitors in these patients could favor mycobacterial infections, particularly Mycobacterium avium subspecies paratuberculosis, which ultimately could worsen their clinical condition. | Brent L Cao Ahmad Qasem Robert C Sharp Latifa S Abdelli Saleh A Naser | 2018 | World Journal of Gastroenterology2018，24，25： | 4 |
| 4 | Efficacy of selective laser trabeculoplasty following incisional glaucoma surgery显示文摘AIM: To evaluate the efficacy of selective laser trabeculoplasty(SLT) in glaucomatous eyes with previous incisional glaucoma surgery. METHODS: A retrospective cohort of eyes that underwent SLT at a single institution from 2013-2015 were followed for 1 y. Reduction in intraocular pressure(IOP) following SLT was evaluated in eyes with prior trabeculectomy with Ex Press mini shunt(Alcon, Ft Worth, TX, USA), Ahmed valve(New World Medical, Cucamonga, CA, USA), or combined phacoemulsification-trabeculectomy. A control group was included with eyes without prior surgery that underwent SLT. Success was defined as >20% drop in IOP from pre-SLT baseline. RESULTS: One-hundred and six eyes were included with 53 in both the prior glaucoma surgery(PGS) and no prior glaucoma surgery(NPGS) groups. Mean pre-SLT IOP was 19.2±4.3 and 20.6±6.0 mm Hg for PGS and NPGS groups, respectively(P=0.17). Both groups produced statistically significant IOP reductions at 1 and 6 mo(P<0.04). At 6 mo, mean IOP reduction reached 7.3% and 10.8% for the PGS and NPGS groups, respectively(P=0.42). Overall, 27.9% and 31.7% of eyes in PGS and NPGS groups met success criteria at 1 y(P=0.70). In the PGS group, eyes with baseline IOP ≥21 mm Hg had IOP reductions of 18.1%(P<0.001), 16.7%(P<0.01), and 8.4%(P=0.31) compared to eyes with baseline IOP <21 mm Hg who had IOP reductions of 2.3%(P=0.39), 3.4%(P=0.19), and 1.1%(P=0.72) at 1, 6 mo, and 1 y, respectively. CONCLUSION: SLT is efficacious in eyes with prior incisional glaucoma surgery and results in similar IOP reductions compared to eyes without PGS. A larger IOP reduction is observed following SLT in eyes with higher pre-SLT IOP. | Robert Allan Sharpe Leah L Kammerdiener David B.Williams Sudeep K.Das Matthew J.Nutaitis | 2018 | International Journal of Ophthalmology(English edition)2018，11，1： | 3 |
| 5 | Apparent Polar Wander Path from the Tarim Block in China显示文摘The apparent polar wander (APW) path from the Tarim block consists of palaeo-magnetic poles ofDevonian (λ=16°N, ψ= 165° E. A95=4°). Late Carboniferous (λ=41° N, ψ=160° E, A95=4°).Permian (λ=61°N, ψ=177° E. A95=9°). Early Triassic (λ=69° N. ψ=183° E. A95=11°) andJurassic/Cretaceous (λ=65° N, ψ=214° E. A95=6°) times. On the basis of this APW path, it is con-cluded that the Tarim block was subducted beneath the Kazakstan plate between Devonian and Permiantimes. The Tarim, North China and South China blocks were sutured between the Early Triassic and EarlyCretaceous. Tarim had moved eastward some 2000 km relative to Siberia since the Cretaceous. | Robert Sharps Michael McWilliams | 1990 | Acta Geologica Sinica(English Edition)1990，64，1： | 2 |
| 6 | Role of PTPN2/22 polymorphisms in pathophysiology of Crohn's disease显示文摘AIM To establish the relationship of protein tyrosine phosphatase non-receptor type 2 and 22(PTPN2/22) polymorphisms and mycobacterial infections in Crohn's disease(CD). METHODS All 133 subjects' blood samples were genotyped for nine single nucleotide polymorphisms(SNPs) in PTPN2/22 using TaqMan^(?) genotyping, while the effect of the SNPs on PTPN2/22 and IFN-γ gene expression was determined using RT-PCR. Detection of Mycobacterium avium subspecies paratuberculosis(MAP) IS900 gene was done by nPCR after DNA extraction from the isolated leukocytes of each subjects' blood samples. T-cells isolated from the patient samples were tested for response to phytohematoagglutonin(PHA) mitogen or mycobacterial antigens by Brd U proliferation assays for T-cell activity. RESULTS Out of the nine SNPs examined, subjects with either heterozygous(TC)/minor(CC) alleles in PTPN2:rs478582 occurred in 83% of CD subjects compared to 61% healthy controls(P-values < 0.05; OR = 3.03). Subjects with either heterozygous(GA)/minor(AA) alleles in PTPN22:rs2476601 occurred in 16% of CD compared to 6% healthy controls(OR = 2.7). Gene expression in PTPN2/22 in CD subjects was significantly decreased by 2 folds compared to healthy controls(P-values < 0.05). IFN-γ expression levels were found to be significantly increased by approxiately 2 folds in subjects when either heterozygous or minor alleles in PTPN2:rs478582 and/or PTPN22:rs2476601 were found(P-values < 0.05). MAP DNA was detected in 61% of CD compared to only 8% of healthy controls(P-values < 0.05, OR = 17.52), where subjects with either heterozygous or minor alleles in PTPN2:rs478582 and/or PTPN22:rs2476601 had more MAPbacteremia presence than subjects without SNPs did. T h e average T-cell proliferation in CD treated with PHA or mycobacteria antigens was, respectively, 1.3 folds and 1.5 folds higher than healthy controls without any significant SNP. CONCLUSION The data suggests that SNPs in PTPN2/22 affect the negative regulation of the immune response in CD patients, thus leading to an increase in inflammation/apoptosis and susceptibility of mycobacteria. | Robert C Sharp Shazia A Beg Saleh A Naser | 2018 | World Journal of Gastroenterology2018，24，6： | 2 |
| 7 | Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study显示文摘 | Zheng Ye Stephen J Sharp Stephen Burgess Robert A Scott Fumiaki Imamura Claudia Langenberg Nicholas J Wareham Nita G Forouhi | 2015 | The Lancet Diabetes & Endocrinology2015，，1： | 1 |
| 8 | 塔里木地块上石炭统的古地磁研究显示文摘 | 翟永建 张正坤 李永安 李强 李燕平 Michael McWilliams Allan Cox Robert sharps | 1988 | 现代地质1988，，01： | 1 |
| 9 | A cautionary case: the SynerGraft vascular prosthesis显示文摘 | Sharp MA Phillips D Roberts I | 2004 | Eur J Vasc Endovasc Surg2004，27，1： | 1 |
| 10 | Recombinant Fv-Hsp70 Protein Mediates Neuroprotection After Focal Cerebral Ischemia in Rats显示文摘 | Xinhua Zhan Bradley P. Ander Isaac H. Liao James E. Hansen Chester Kim Douglas Clements Richard H. Weisbart Robert N. Nishimura Frank R. Sharp | 2010 | Stroke2010，，3： | 1 |
| 11 | 塔里木地块上石炭统的古地磁研究显示文摘 | 翟永建 张正坤 李永安 李强 李燕平 Michael McWilliams Allan Cox Robert sharps | 1988 | 现代地质1988，，01： | 1 |
| 12 | Conserved structure and function of the Arabidopsis flowering time gene CONSTANS in Brassica napus显示文摘 | Robert L S Robson F Sharpe A | 1998 | Plant Molecular Biology1998，37，： | 1 |
| 13 | Nprl3 is required for normal development of the cardiovascular system显示文摘 | Monika Kowalczyk Jim Hughes Christian Babbs Luis Sanchez-Pulido Dorota Szumska Jacqueline Sharpe Jacqueline Sloane-Stanley Gillian Morriss-Kay Leslie Smoot Amy Roberts Hugh Watkins Shoumo Bhattacharya Richard Gibbons Chris Ponting William Wood Douglas Hig | 2012 | Mammalian Genome2012，，7： | 1 |
| 14 | Disc cell clusters in pathological human intervertebral discs are associated with in- creased stress protein immunostaining 显示文摘 | Sharp C A Roberts S Evns H | 2009 | Eur Spine J2009，18，11： | 1 |
| 15 | 利用虚拟许用值计算计算加快航空CFRP材料开发和认证显示文摘在轻量化解决方案的研究中,CFRP的使用在过去几十年中急剧增加,目前约占新型商用飞机所用材料的50%。然而,设计师们仍然面临着加速引入新材料体系以用于实际应用的挑战。主要挑战之一是缩短材料认证时间,然而材料认证时间仅依赖于实验程序。从全球范围来看,以数字形式进行材料定义和认证来满足平台要求的方法成为一种趋势。这种方法可以过用高级仿真取代手工测试来降低新材料的成本和开发时间。本文提出并加以描述一个全面的仿真方法。此方法能够定义一个完整的测试矩阵,以便生成给定材料系统的B基准许用值。该方法的实施必须考虑几个方面。第一个方面涉及材料建模以及强度和失效行为。这种建模方式结合了通过平均场均质化推导出的细观力学模型与从材料本构和微观结构描述和渐进失效中得出非线性复合属性。第二个方面考虑需要定义的测试矩阵,此方面可以涵盖铺层定义、待仿真测试类型和环境条件。有限元模型将按照相应条件生成。最后一个方面考虑了在不确定性定量方法下由参数分散度导致的材料敏感性。平均场均质化提供了一种方法,用于从材料属性(硬度和强度组成特性)、制造过程(纤维分数、空隙)和测试条件的变化(纤维方向不对中)来研究复合材料分散度的来源。具体的复合材料试片示例将说明此流程,可以在UD或woven增强聚合物的完整虚拟测试后生成B基准许用值。该过程完全集成于DIGIMAT软件包中。 | 杜伟卓 Robert Schmitz Joe Sharp Pierre Yves Lavertu Anthony Cheruet | 2019 | 纤维复合材料2019，36，4： | 1 |
| 16 | Disc cell clusters inpathological human intervertebral discs are associated withincreased stress protein immunostaining 显示文摘 | Sharp CA Roberts S Evans H | 2009 | Eur Spine J2009，18，11： | 1 |
| 17 | Root growth maintenance during water deficit: physiology to functional genomics 显示文摘 | Robert E Sharp Valerly Poroyko | 2004 | Journal of Experimental Botany2004，11，55： | 1 |
| 18 | The aetiology of symptomatic gallstones quantification of the effects of obesity, alcohol and serum lipids on risk. Epidemiological and biomarker data from a UK prospective cohort study (EPIC-Norfolk)显示文摘 | Paul J.R. Banim Robert N. Luben Heerajnarain Bulluck Stephen J. Sharp Nicholas J. Wareham Kay-Tee Khaw Andrew R. Hart | 2011 | European Journal of Gastroenterology & Hepatology2011，，8： | 1 |
| 19 | Unexpected Ebola virus in a tertiary setting: Clinical and epidemiologic aspects显示文摘 | Guy A. Richards Sandy Murphy Reeve Jobson Mervyn Mer Caron Zinman Ruth Taylor Robert Swanepoel Adrian Duse Gerry Sharp Ina C. J. De La Rey Chris Kassianides | 2000 | Critical Care Medicine2000，，1： | 1 |
| 20 | Disc cell clusters in path- ological human intervertebral discs are associated with increased stress protein immunostaining显示文摘 | Sharp CA Roberts S Evans H | 2009 | Eur Spine J2009，18，11： | 1 |
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