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| 1 | Radiological response and inflammation scores predict tumour recurrence in patients treated with transarterial chemoembolization before liver transplantation显示文摘AIM To investigate the prognostic value of the radiological response after transarterial chemoembolization(TACE)and inflammatory markers in patients affected by hepatocellular carcinoma(HCC)awaiting liver transplantation(LT).METHODS We retrospectively evaluated the preoperative pre dictors of HCC recurrence in 70 patients treated with conventional(n=16)or doxorubicin-eluting bead TACE(n=54)before LT.The patient and tumour characteristics,including the static and dynamic alpha-fetoprotein,neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio( LR)measurements,were recorded.Treatment response was classified according to the modified Response Evaluation Criteria in Solid Tumours(m RECIST)and the European Association for the Study of the Liver(EASL)criteria as complete response(CR),partial response( R),stable disease o progressive disease.After examination of the explanted livers,histological necrosis was classified as complete(100%of the cumulative tumour area),partia(50%-99%)or minimal(<50%)and was correlated with the preoperative radiological findings.RESULTS According to the pre-TACE radiological evaluation,22/70(31.4%)and 12/70(17.1%)patients were beyond Milan and University of San Francisco(UCSF)criteria,respectively.After TACE procedures,the objective response(CR+ R)rates were 71.4%and 70.0%according to m RECIST and EASL criteria,respectively.The agreement between the two guidelines in defining the radiological response was rated as very good both for the overall and target lesion response(weighted k-value:0.98 and 0.93,respectively).Complete and partial histological necrosis were achieved in 14/70(20.0%)and 28/70(40.0%)patients,respectively.Using histopathology as the reference standard,m RECIST criteria correctly classified necrosis in 72.9%(51/70)of patients and EASL criteria in 68.6%(48/70)of cases.The m RECIST non-response to TACE[Exp(b)=9.2, =0.012],exceeding UCSF criteria before TACE[Exp(b)=4.7, =0.033]and a preoperative LR>150[Exp(b)=5.9, =0.046]were independent predictors of tumour recurrence.CONCLUSION The radiological response and inflammatory markers are predictive of tumour recurrence and allow the proper selection of TACE-treated candidates for LT. | Daniele Nicolini Andrea Agostini Roberto Montalti Federico Mocchegiani Cinzia Mincarelli Alessandra Mandolesi Nicola L Robertson Roberto Candelari Andrea Giovagnoni Marco Vivarelli | 2017 | World Journal of Gastroenterology2017，23，20： | 4 |
| 2 | Colonoscopy quality with Entonox? vs intravenous conscious sedation:18608 colonoscopy retrospective study显示文摘AIM To compare colonoscopy quality with nitrous oxide gas(Entonox?) against intravenous conscious sedation using midazolam plus opioid.METHODS A retrospective analysis was performed on a prospectively held database of 18608 colonoscopies carried out in Lothian health board hospitals between July 2013 and January 2016.The quality of colonoscopies performed with Entonox was compared to intravenous conscious sedation(abbreviated in this article as IVM).Furthermore,the quality of colonoscopies performed with an unmedicated group was compared to IVM.The study used the following key markers of colonoscopy quality:(1) patient comfort scores;(2) caecal intubation rates(CIRs); and (3) polyp detection rates (PDRs).We used binary logistic regression to model the data.RESULTS There was no difference in the rate of moderate-toextreme discomfort between the Entonox and IVM groups (17.9% vs 18.8%; OR = 1.06,95%CI: 0.95-1.18,P = 0.27).Patients in the unmedicated group were less likely to experience moderate-to-extreme discomfort than those in the IVM group(11.4% vs 18.8%; OR = 0.71,95%CI: 0.60-0.83,P < 0.001).There was no difference in caecal intubation between the Entonox and IVM groups(94.4% vs 93.7%; OR = 1.08,95%CI: 0.92-1.28,P = 0.34).There was no difference in caecal intubation between the unmedicated and IVM groups (94.2% vs 93.7%; OR = 0.98,95%CI: 0.79-1.22,P = 0.87).Polyp detection in the Entonox group was not different from IVM group (35.0% vs 33.1%; OR = 1.01,95%CI: 0.93-1.10,P = 0.79).Polyp detection in the unmedicated group was not significantly different from the IVM group (37.4% vs 33.1%; OR = 0.97,95%CI: 0.87-1.08,P = 0.60).CONCLUSION The use of Entonox was not associated with lower colonoscopy quality when compared to intravenous conscious sedation using midazolam plus opioid. | Alexander R Robertson Nicholas A Kennedy James A Robertson Nicholas I Church Colin L Noble | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 3 |
| 3 | Autotrophlic growth of anaerobic ammonium-oxidizing microorganisms in a fluidized bed reactor 显示文摘 | Van de Graaf A A De Bruijn P Robertson L A | 1996 | Microbiology1996，142，8： | 2 |
| 4 | Release of protein as well as activity of MMP-9 from unstable avterioscler plaques during percutaneous coronary intervention 显示文摘 | Robertson L Grip L Mattsson HL | 2007 | J Intern Med2007，26，2： | 1 |
| 5 | Optimization of Thermoelectric Green Tape Characteristics Made by the Tape Casting Method显示文摘 | Salam L A Matthews R D Robertson H | 2000 | Mater Chem Phys2000，62，： | 1 |
| 6 | Destruction of cyanobacterial toxins by semiconductor photocatalysis显示文摘 | ROBERTSON P K J LAWTON L A MANCH B | 1997 | Chem Commun1997，，4： | 1 |
| 7 | Isolation and characterization of secretions from the plant-parasitic nematode Globodera pallida 显示文摘 | ROBERTSON L ROBERTSON W M | 1997 | Source Parasitology1997，115，4： | 1 |
| 8 | Simultaneous nitrification and denitrification in aerobic chemostat culture of Thiosphaera patotropha显示文摘 | ROBERTSON L A VAN NIEL E W J TORREMANS R A M | 1988 | Applied Environmental Microbiology1988，54，11： | 1 |
| 9 | Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease显示文摘 | Rygiel K A Robertson H Marshall H L | 2008 | Laboratory Investigation2008，88，2： | 1 |
| 10 | Preservation of giardia cysts in stool samples for subsequent PCR analysis 显示文摘 | HANS W ROBERTSON L J | 2009 | Journal of Microbiological Methods2009，，78： | 1 |
| 11 | Anaerobic ammonium oxidation discovered in a denitrifying fluidized bed reactor显示文摘 | Mulder A Van de Graaf A A Robertson L A | 1995 | FEMS Microbiology Ecology1995，16，： | 1 |
| 12 | Three-dimensional analysis of the proximal part of the humerus:Relevance to arthroplasty显示文摘 | Robertson D Yuan J Bigliani L | 2000 | J Bone Joint Surg Am2000，82，11： | 1 |
| 13 | Aerobic denitrification in various heterotrophic nitrifiers显示文摘 | ROBERTSON L A CORNELISSE R De Vos P | 1989 | Antonie Van Leeuwenhoek1989，56，4： | 1 |
| 14 | Y chromosome length related to fetal loss显示文摘 | Westlake JR Robertson I L eddet SJ | 1983 | Clin Genet1983，24，6： | 1 |
| 15 | Clonal analysis and virulence of Australian isolates of Streptococcus suis type 2显示文摘 | Mwaniki C G Robertson L D Trott D J | 1994 | Epidemiol Infect1994，113，： | 1 |
| 16 | Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America显示文摘 | Arauz-Ruiz P Norder H Robertson B H Magnius L O | 2002 | J Gen Virol2002，83，8： | 1 |
| 17 | Networks and inno- vation in a modular system: lessons from the microcom-puter and stereo component industries显示文摘 | LANGLOIS R N ROBERTSON P L | 1992 | Research Poli cy1992，21，4： | 1 |
| 18 | A probotic strain of Vib- rio alginolyties effective in reducing diease caused by Aeromonas sal- monicida, Vibrio anguillrum and Vibrio ordali 显示文摘 | Austin B Stuckey L F Robertson P W | 1995 | J Fish Dis1995，18，： | 1 |
| 19 | How Inclusive Leadership Can Help Your Practice Adapt to Change显示文摘 | BOWERS K W ROBERTSON M PARCHMAN M L | 2012 | Family Practice Man- agement2012，19，1： | 1 |
| 20 | Goserelin (Zoladex)in premenopausal advanced breast cancer: duration of response and survival显示文摘 | Robertson JF Jackson L | 1990 | Br J Cancer1990，62，5： | 1 |
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