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| 1 | Gastroenterology case report of mesalazine-induced cardiopulmonary hypersensitivity显示文摘Mesalazine is a 5-aminosalicylic acid derivative that has been widely used to treat patients with inflammatory bowel disease. Accumulating evidence indicates that mesalazine has a very low rate of adverse drug reactions and is well tolerated by patients. However, a few cases of pulmonary and cardiac disease related to mesalazine have been reported in the past, though infrequently, preventing clinicians from diagnosing the conditions early. We describe the case of a 32-yearold man with ulcerative colitis who was admitted with a two-month history of persistent fever following mesalazine treatment initiated 14 mo earlier. At the time of admission, mesalazine dose was increased from 1.5 to 3.0 g/d, and antibiotic therapy was started with no improvement. Three weeks after admission, the patient developed dyspnea, non-productive cough, and chest pain. Severe eosinophilia was detected in laboratory tests, and a computed tomography scan revealed interstitial infiltrates in both lungs, as well as a large pericardial effusion. The bronchoalveolar lavage reported a CD4/CD8 ratio of 0.5, and an increased eosinophil count. Transbronchial biopsy examination showed a severe eosinophilic infiltrate of the lung tissue. Mesalazine-induced cardiopulmonary hypersensitivity was suspected after excluding other possible etiologies. Consequently, mesalazine treatment was suspended, and corticosteroid therapy was initiated, resulting in resolution of symptoms and radiologic abnormalities. We conclude that mesalazine-induced pulmonary and cardiac hypersensitivity should always be considered in the differential diagnosis of unexplained cardiopulmonary symptoms and radiographic abnormalities in patients with inflammatory bowel disease. | José Ferrusquía Isabel Pérez-Martínez Ricardo Gómez de la Torre María Luisa Fernández-Almira Ruth de Francisco Luis Rodrigo Sabino Riestra | 2015 | World Journal of Gastroenterology2015，21，13： | 5 |
| 2 | First Ordovician vertebrate from South America显示文摘 | Gagaer P Y Blieck A Rodrigo G S | 1986 | Geobios1986，19，： | 1 |
| 3 | Tiotropium for the treatment of adolescents with moderate tosevere symptomatic asthma:a systematic review with meta-analysis显示文摘 | Rodrigo G J Castro-Rodríguez J A | 2015 | Ann Allergy Asthma Immunol2015，115，3： | 1 |
| 4 | The role of anti leukotriene therapy in seasonal allergic rhinitis: a systematic review of randomized trials显示文摘 | RODRIGO G J YANEZ A | 2006 | Ann Allergy Asthma Immunol2006，96，： | 1 |
| 5 | Biodegradation studies of cellulose and its vinylic graft copolymers by thermal analysis and mechanical spectroscopy 显示文摘 | FLAQUE C RODRIGO L C KIBES G A | 2000 | J Appl Polym Sci2000，76，3： | 1 |
| 6 | Effects of fibre treatment on wettability and mechanical behavior of flax/polypropylene composites显示文摘 | Cantero G Arbelaiz A Rodrigo L P | 2003 | Composites Science and Technology2003，63，9： | 1 |
| 7 | E-work based collaborative optimization approach for strategic logistic显示文摘 | PABLO A M RODRIGO A G JOSE A C | 2009 | Computers & Industrial Engineering2009，57，1： | 1 |
| 8 | Tourism and cultural revival 显示文摘 | Rodrigo A G | 2002 | Annals of Tourism Research2002，29，4： | 1 |
| 9 | Diffusivity of coal and petroleum asphaltene monomers by fluorescence correlation spectroscopy显示文摘 | Rodrigo E G Kosta L A Ballard A | 2007 | Science Direct2007，86，1213： | 1 |
| 10 | Quality changes in fresh- cut pear slices as affected by controlled atmospheres and chemical preservatives显示文摘 | James R G Betty H P Rodrigo A C | 2002 | Postharvest Bio Technol2002，24，： | 1 |
| 11 | Holes with very acute angles za new paradigm of extraordinary optical trans- mission through strongly localized modes显示文摘 | Rodrigo S G Mahboub O Degiron A | 2010 | Opt Express2010，18，23： | 1 |
| 12 | Divacancies in graphene and carbon Nanotubes显示文摘 | Amorim Rodrigo G Fazzio A Antonelli Alex | 2007 | Nano Lett2007，7，： | 1 |
| 13 | Multi-Length and Time Scale Thermal Transport Using the Lat-tice Boltzmann Method With Application to ElectronicsCooling显示文摘 | Rodrigo A E Sartaj S G Myung S J | 2006 | Int J Heat Mass Transfer2006，49，： | 1 |
| 14 | Safety and efficacy of combined long-acting beta-agonists and inhaled corticosteroids vs long- acting beta-agonists monotherapy for stable COPD: a systematic review显示文摘 | Rodrigo G J Castro-Rodriguez J A Plaza V | 2009 | Chest2009，136，2： | 1 |
| 15 | Combined photovoltaic and solar thermal systems for facade in tegration and building insulation 显示文摘 | STEFAN K T RODRIGO G A SANDRA S | 1999 | Solar Energy1999，67，46： | 1 |
| 16 | Pectin methyl esterase and natural microflora of fresh mixed orange and carrot juice treated with pulsed electric fields显示文摘 | Rodrigo D Barbosa-Canovas G V Martinez A | 2003 | J Food Protect2003，66，12： | 1 |
| 17 | Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility 显示文摘 | Wang G Y Bergman M R Nguyen A P Turcato S Swigart P M Rodrigo M C | 2006 | Cardiovasc Res2006，69，： | 1 |
| 18 | Biometric Identification Systems显示文摘 | de Rodrigo L G Carlos A L Atman A | 2003 | Signal Processing2003，83，12： | 1 |
| 19 | Ten steps modeling of electrolysis precesses by using neural nerworks显示文摘 | Piuleac C G Rodrigo M A Canizares P | | 0，，01： | 1 |
| 20 | MAb contaminant re- moval with a multimodal anion exchanger 显示文摘 | Eriksson K Ljunglof A Rodrigo G | 2009 | BioProcess Int2009，7，2： | 1 |
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