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| 1 | 游走脾:手术之謎显示文摘Wandering spleen,also referred to as‘ptotic spleen’,is a rare clinical condition characterized by splenicmigration form its normal left hypochondrial position to any other abdominal or pelvic position.Among themultifactorial etiologies proposed,laxity of the spleen’s primary supporting ligaments is themost agreed-upon hypothesis.We present one rare case of wandering spleen in an 11-year-old girl who presented with recurrent abdominal pain with no localizing features.Her abdominal examination revealed an intra-abdominal left iliac fossa lump with restrictedmobility,which was confirmed as a wandering spleen by abdominal sonography and contrast-enhanced computed tomography.Intraoperatively,an infarcted spleen was encountered with tortuous,elongated,torsional splenic pedicle and a single dense adhesive band with descending colon.Splenectomy was offered to the patient.Post-operatively,the patient is healthy and symptom free at one-year follow-up.The rare clinical diagnosis of this condition,particularly in the paediatric age-group,makes it an enigma for the surgical world. | Ashok Kumar Puranik Rohit Mehra Sushila Chauhan Rahul Pandey | 2017 | Gastroenterology Report2017，5，3： | 2 |
| 2 | Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer显示文摘 | J. Chad Brenner Bushra Ateeq Yong Li Anastasia K. Yocum Qi Cao Irfan A. Asangani Sonam Patel Xiaoju Wang Hallie Liang Jindan Yu Nallasivam Palanisamy Javed Siddiqui Wei Yan Xuhong Cao Rohit Mehra Aaron Sabolch Venkatesha Basrur Robert J. Lonigro Jun Yang | 2011 | Cancer Cell2011，，5： | 1 |
| 3 | Molecular and Immunohistochemical Characterization Reveals Novel BRAF Mutations in Metanephric Adenoma显示文摘 | Aaron M. Udager Jincheng Pan Martin J. Magers Ganesh S. Palapattu Todd M. Morgan Jeffrey S. Montgomery Alon Z. Weizer Khaled S. Hafez David C. Miller James S. Wolf Jonathan B. McHugh Arul M. Chinnaiyan Saravana M. Dhanasekaran Rohit Mehra | 2015 | The American Journal of Surgical Pathology2015，，： | 1 |
| 4 | Chromophobe renal cell carcinoma: Novel molecular insights and clinicopathologic updates显示文摘Chromophobe renal cell carcinoma(ChRCC)is the third most common renal cell carcinoma(RCC)subtype,which predominantly occurs in sporadic setting.ChRCCs are considered to originate from the intercalated cell of distal tubules with two main morphological variants,classic and eosinophilic.Most ChRCCs carry a favorable clinical outcome.Histology alone is limited in predicting the behavior of ChRCCs that do not have overtly aggressive morphologic findings such as necrosis and sarcomatoid features.Along with positive CD117 expression,classic ChRCCs generally express diffuse and uniform CK7,while eosinophilic variant demonstrates more heterogeneous CK7 expression(rare or patchy).Multiple losses of chromosomes 1,2,6,10,13,17,and 21 are considered to be the genetic hallmarks of classic and eosinophilic ChRCCs,while chromosomal gains are known to be associated with sarcomatoid ChRCCs.TP53 and PTEN are the two most frequently mutated genes in ChRCCs.The major challenge in the differential diagnosis of ChRCCs includes considerations around the eosinophilic variant(of ChRCCs),where it may share overlapping features with oncocytoma or other recent emergent oncocytic tumors.Most eosinophilic ChRCCs share expression of the recently described biomarkers,LINC01187 and FOXI1,with classic ChRCCs,however,a subset of eosinophilic-like ChRCCs with lower biomarker expression have been demonstrated to harbor MTOR gene mutations.Overall,the morphologic features of ChRCCs and genetic profile with combinations of chromosomal losses and gains suggest this tumor entity to represent a distinct,yet heterogeneous group of renal neoplasms. | Reza Alaghehbandan G.Przybycin Christopher Virginie Verkarre Rohit Mehra | 2022 | Asian Journal of Urology2022，9，1： | 1 |
| 5 | Impact of tertiary Gleason pattern 5 on prostate cancer aggressiveness:Lessons from a contemporary single institution radical prostatectomy series显示文摘Objective:To better evaluate tertiary Gleason pattern reporting and to evaluate the impact of tertiary Gleason pattern 5(TP5)on prostate cancer pathological features and biochemical recurrence at our large single institution.Methods:We retrospectively reviewed 1962 patients who underwent radical prostatectomy(RP)for prostate cancer;TP5 was reported in 159 cases(8.1%).Men with Gleason score(GS)7 and GS 8 disease were divided into subgroups with and without TP5,and histopathological features were compared.Multivariate analyses were conducted to assess the impact on TP5 on biochemical-free survival(BFS).Results:Tumors possessing GS 3+4 with TP5 were more likely to exhibit extraprostatic extension(EPE)and had a larger tumor diameter(TD)than GS 3+4 alone.GS 3+4 with TP5 was also associated with positive surgical margins(SM),seminal vesicle involvement(SVI),and higher pre-operative prostate-specific antigen(PSA)values,but without statistical significance.GS 4+3 with TP5 more commonly presented with EPE,positive SM,SVI,and greater TD and pre-operative PSA level than GS 4+3 alone.In multivariate analysis,Gleason score,EPE,and TP5 were overall independent risk factors for PSA recurrence in this cohort.Additionally,GS 4+3 with TP5 was associated with shorter time to recurrence versus GS 4+3 alone.Conclusion:Our results emphasize the importance of TP5 and suggest that criteria for tertiary pattern reporting in prostate cancer should be standardized.Further studies are needed to evaluate the role of tertiary patterns in prognostic models. | Zachary B.Koloff Daniel A.Hamstra John T.Wei Jeffrey S.Montgomery Scott A.Tomlins Angela J.Wu Todd M.Morgan Javed Siddiqui Kellie Paich Arul M.Chinnaiyan Felix Y.Feng Alon Z.Weizer Lakshmi P.Kunju Brent K.Hollenbeck David C.Miller Ganesh S.Palapattu Rohit Mehra | 2015 | Asian Journal of Urology2015，2，1： | 1 |
| 6 | E-Cadherin Protein Expression Predicts Prostate Cancer Salvage Radiotherapy Outcomes显示文摘 | Michael E. Ray Rohit Mehra Howard M. Sandler Stephanie Daignault Rajal B. Shah | 2006 | The Journal of Urology2006，，4： | 1 |
| 7 | Golgi protein GOLM1 is tissue and urine biomarker of prostate cancer 显示文摘 | Sooryanarayana Varambally Bharathi Laxman Rohit Mehra | 2008 | Neoplasia2008，10，11： | 1 |
| 8 | Measurement of radon and thoron progeny outdoors in Malout, India, using grab aerosol sampling and beta counting显示文摘 | Kulwant Singh Surinder Singh Rohit Mehra Manmohan Singh H.S. Sahota Z. Papp | 2005 | Radiation Measurements2005，，1： | 1 |
| 9 | Duodenal heterotopic pancreatic tissue:a case report and literature review显示文摘Heterotopic pancreas is an aberration in the developmental profile of the pancreas.This entity is rarely symptomatic and its malignant transformation is even rarer.However,when present,it poses a diagnostic dilemma to clinicians,as little help comes from gastroenteroscopy and imaging.Surgical exploration remains the only option at times,and it is the histopathological examination that finally clears the mist.This case report reveals the elusive nature of malignancy in heterotopic pancreas in the duodenum. | Rohit Mehra Aswini K.Pujahari Shyam S.Jaiswal | 2015 | Gastroenterology Report2015，3，3： | 0 |
| 10 | 右侧十二指肠旁疝:两例报告和文献复习显示文摘Paraduodenal hernia(PDH),a rare congenital anomaly,is a type of internal hernia which occurs due to a defect in the reduction and rotation of the midgut.On anatomical and embryological basis,PDH can be broadly divided into right-and Left PDH.Right PDH is rarer than its counterpart.We present two cases of Right PDH.The patientsy presented with a history of recurrent intestinal obstruction since childhood,which was managed conservatively,without a definitive diagnosis.Once they presented to us,a detailed clinical history and a barium meal follow-through clinched the diagnosis of PDH.Intra-operative findings correlated well with the clinical diagnosis.The jejunal loops had herniated through the fossa of Waldeyer.Reduction of hernia contents and excision of the hernia sac was carried out.Post-operatively,the patients are healthy and symptom-free at 4 and 3 years follow-up,respectively.The rarity of this condition and the need for early diagnosis,to prevent the high risk of bowel obstruction and strangulation,makes PDH one of the difficult challenges for the clinicians. | Rohit Mehra Aswini Kumar Pujahari | 2016 | Gastroenterology Report2016，4，2： | 0 |
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