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| 1 | Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump显示文摘AIM: To study the association of three common ABCB11 and ABCC2 polymorphisms (ABCB11: 1331T>C V444A; ABCC2: 3563T>A V1188E and 4544G>A C1515Y) with intrahepatic cholestasis of pregnancy (ICP) and contraceptive-induced cholestasis (CIC). METHODS: ABCB11 and ABCC2 genotyping data were available from four CIC patients and from 42 and 33 ICP patients, respectively. Allele-frequencies of the studied polymorphisms were compared with those in healthy pregnant controls and Caucasian individuals. Furthermore, serum bile acid levels were correlated with the presence or absence of the 1331 C allele.RESULTS: The ABCB11 1331T>C polymorphism was significantly more frequent in cholestatic patients than in pregnant controls: C allele 76.2% (CI, 58.0-94.4) vs 51.3% (CI 35.8-66.7), respectively (P = 0.0007); and CC allele 57.1% (CI 36.0-78.3) vs 20% (CI 7.6-32.4), respectively (P = 0.0065). All four CIC patients were homozygous carriers of the C allele. In contrast, none of the studied ABCC2 polymorphism was overrepresented in ICP or CIC patients. Higher serum bile acid levels were found in carriers of the 1331CC genotype compared to carriers of the TT genotype.CONCLUSION: Our data support a role for the ABCB11 1331T>C polymorphism as a susceptibility factor for the ←←← development of estrogen-induced cholestasis, whereas no such association was found for ABCC2. Serum bile acid and γ-glutamyl transferase levels might help to distinguish ABCB4- and ABCB11-related forms of ICP and CIC. | Yvonne Meier Tina Zodan Carmen Lang Roland Zimmermann Gerd A Kullak-Ublick Peter J Meier Bruno Stieger Christiane Pauli-Magnus | 2008 | World Journal of Gastroenterology2008，14，1： | 20 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | Cognitive performance in patients with COPD显示文摘 | Jeroen J.W Liesker Dirkje S Postma Rypko J Beukema Nick H.T ten Hacken Thys van der Molen Roland A Riemersma Ed H van Zomeren Huib A.M Kerstjens | 2003 | Respiratory Medicine2003，，4： | 3 |
| 4 | 急性重症哮喘的氧疗显示文摘 | David Inwald Mark Roland Lieske Kuitert Sheila A McKenzie Andy Petros 卜小宁 | 2002 | 英国医学杂志中文版2002，5，4： | 2 |
| 5 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 6 | Noncanonical autophagy: one small step for LC3, one giant leap for immunity显示文摘 | Payal Mehta Jill Henault Roland Kolbeck Miguel A Sanjuan | 2014 | Current Opinion in Immunology2014，，： | 2 |
| 7 | Cognitive performance in patients with COPD显示文摘 | Jeroen J.W Liesker Dirkje S Postma Rypko J Beukema Nick H.T ten Hacken Thys van der Molen Roland A Riemersma Ed H van Zomeren Huib A.M Kerstjens | 2003 | Respiratory Medicine2003，，4： | 2 |
| 8 | Anti-hepatitis B virus activity of ORI-9020, a novel phosphorothioate dinucleotide, in a transgenic mouse model显示文摘 | Iyer RP Roland A Jin Y | 2004 | Antimicrob Agents Chemother2004，48，6： | 1 |
| 9 | Acceleration schemes with application to the EM algorithm显示文摘 | BERLINET A ROLAND C | 2007 | Computational Statistics and Data Analysis2007，51，： | 1 |
| 10 | ICAM-1 expression deter- mines malignant potential of cancer 显示文摘 | Roland C L Harken A H Sarr M G | 2007 | Surgery2007，141，6： | 1 |
| 11 | Prenatal androgenization of fe- male mice programs an increase in firing activity of gona- dotropin-rclcasing hormone (GnRH) neurons that is re- versed by metformin treatment in adulthood 显示文摘 | Roland A V Moenter S M | 2011 | Endocri- nology2011，152，2： | 1 |
| 12 | Extended time-dependent mild-slope and wave-action equations for wave-bottom and wave-current interactions显示文摘 | Toledo Y Hsu T W Roland A | 2012 | Proceedings of the Royal Society A: Mathematical Physical and Engineering Science2012，468，2137： | 1 |
| 13 | Analysis of ochratoxin A in grapes, musts and wines by LC–MS/MS: First comparison of stableisotope dilution assay and diastereomeric dilution assay methods显示文摘 | Roland A Bros P Bouisseau A | 2014 | Analytica Chimica Acta2014，818，： | 1 |
| 14 | 锐钛型钛二氧化物纳米颗粒对小鼠的影响:证据表明短时间而不是长时间的暴露会导致小鼠精子结构和功能的异常显示文摘锐钛型钛二氧化物纳米颗粒(TNPs)广泛应用在商业领域,并且存在于不同的产品中。为明确更小剂量的锐钛型钛二氧化物纳米颗粒(ATNPs)间隔一定距离进入体内到达阴囊后是否能诱导精子缺陷的发生,雄性成年小鼠持续3天腹腔内注射100%ATNP(2.5或5mg/kg),然后在注射后1周、2周、3周或5周(长时间暴露)或者是注射后24小时、48小时或120小时(短时间暴露)处死。透射电镜表明在注射后120小时收集到的阴囊脂肪组织中,附睾组织和附睾液均出现炎症反应。在注射后120小时和3周后,睾丸组织间质间隙增大。利用末端脱氧核糖核酸转移酶介导的缺口末端标记技术发现在注射后的雄鼠体内阳性(即凋亡)精子(P=0.002)和间质细胞(P=O.04)数目均显著增加。与对照组相比,短时间暴露而不是长时间暴露的附睾尾部精子鞭毛异常、过量胞浆残余(ERC)的发生率增加,精子无顶体反应的发生率增加(呈剂量依赖性)。ERC与无顶体反应是否存在相关性目前尚不清楚。与对照组相比,暴露120小时组快速运动精子数量和线粒体膜电位均显著下降(P〈0.05),同时,活性氧水平显著增加(P〈0.00001)。这些结果表明在注射后4.8天,ANTP能够引发不育的精子结构和功能的异常,并且通过氧化应激造成DNA的损伤。同时,在暴露后的10天到5周末检测到精子的异常,这表明精子的这种异常是暂时性的。 | Michelle A Smith Rowan Michael Rolands G Aravindan Soma Dash Syed I Shah Deni S Galileo Patricia A Martin-DeLeon | 2015 | Asian Journal of Andrology2015，17，2： | 1 |
| 15 | Sputum and plasma endothelin-1 levels in exacerbations of chronic obstructive pulmonary disease显示文摘 | Roland M Bhowmik A Sapsford RJ | 2001 | Thorax2001，56，1： | 1 |
| 16 | Determination of Red Blood Cell Velocity by Video Shuttering and Image Analysis 显示文摘 | Anadn A P Shruti A J Roland N P | 1999 | Annals of Biomedical Engineering1999，27，3： | 1 |
| 17 | Bacterial translocation after intraperitoneal implantation of rubber fragments in the splenectomized rat显示文摘 | Guo WD Roland A Rogar W etal | 1994 | J Surg Res1994，57，： | 1 |
| 18 | Detection of a 40- 50 Day Oscillation in the Zonal Wind in the Tropical Pacific显示文摘 | Madden Roland A Julian Paul R | 1971 | Journal of the Atmospheric Sciences1971，28，5： | 1 |
| 19 | Body weight and semen production of broiler breeder males as influenced by crude protein levels and feeding regimens during rearing显示文摘 | MCDANIE G R ROLAND D A LIU P | 1999 | Poult Sci1999，78，2： | 1 |
| 20 | Clinical significance of fever after percutaneous nephrolithotomy显示文摘 | JEFFREY A C ROLAND C JAY B | 1998 | Urology1998，52，1： | 1 |
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