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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Medullary sponge kidney--part of a congenital syndrome显示文摘 | Rommel D Pirson Y | | 0，，03： | 1 |
| 3 | Medullary sponge kidney-part of a congenital syndrome显示文摘 | Rommel D Pirson Y | 2001 | Nephrol Dial Transplant2001，16，3： | 1 |
| 4 | Medullary sponge kidney associated with con-genital henihypertrophy 显示文摘 | Rommel D Pirson Y | 2002 | J m Soc Nephrol2002，10，5： | 1 |
| 5 | PI3K and cancer:lessons,challenges and opportunities显示文摘 | FRUMAN D A ROMMEL C | 2014 | Nat Rev Drug Discov2014，13，2： | 1 |
| 6 | The chemical composition of animal cells reconstructed from 2D And 3D TOF-SIMS analysis显示文摘 | BREITENSTEIN D ROMMEL C E STOLWI- JK J | 2008 | Applied Surface Science2008，255，4： | 1 |
| 7 | Paucisymptomatic brainstem lesions revealing CNS schistosomiasis显示文摘 | Rage M Duprez T | 2005 | Acta Neurol Belg2005，105，： | 1 |
| 8 | Blackberry juice and wine: processing and storage effects on anthocyanin composi- tion, color and appearance 显示文摘 | Rommel A Wrolstad R E Heatherbell D A | 1992 | J Food Sci1992，57，2： | 1 |
| 9 | Rodent rhabdomyo- sarcoma: Comparison between total choline concentration at 1 H- MRS and 18F-fluoromethylcholine uptake at pet using accurate methods for collecting data 显示文摘 | Rommel D Bol A Abarca-Quinones J | 2010 | Molecular Imaging and Biology2010，29，12： | 1 |
| 10 | Gliomatosis cerebri, imaging findings of 12 cases 显示文摘 | Desclee P Rommel D Hemalsteen D | 2010 | J Neuroradiol2010，37，3： | 1 |
| 11 | Medullary sponge kidney-part of a congenital syndrome显示文摘 | Rommel D Pirson Y | 2001 | Nephrol Dial Transplant2001，16，3： | 1 |
| 12 | Substitution of 1 C-methi- onine PET by perfusion MRI during the follow-up of treated high-grade gliomas preliminary results in clinical practice显示文摘 | Dandois V Rommel D Renard L | 2010 | J Neuroradiology2010，37，2： | 1 |
| 13 | Medullary sponge kidney-part of a congenital syndrome显示文摘 | Rommel D Prison Y | 2001 | Nephrol Dial Transplant2001，16，3： | 1 |
| 14 | Paueisyrnptomatie brainstem lesions revealing CNS schistosomiasis显示文摘 | Rommel D Rage M Duprez T | 2005 | Acta Neurol Belg2005，105，2： | 1 |
| 15 | The hypodense artery sign in acute cerebral infarction显示文摘 | Bogdan J Rommel D | 2013 | JBR-BTR2013，96，6： | 1 |
| 16 | Medullary sponge kidney--part of a congenital syndrome 显示文摘 | Rommel D Pirson Y | 2001 | Nephrol Dial Transplant2001，16，3： | 1 |
| 17 | Long term outcome of psychogenic voice disorders显示文摘 | Reiter R Rommel D Brosch S | 2013 | Auris Nasus Larynx2013，40，5： | 1 |
| 18 | Medullary sponge kidney-part of a congenital syndrome 显示文摘 | Rommel D Pirson Y | 2001 | Nephrol Dial Transplant2001，16，3： | 1 |
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